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Items: 1 to 50 of 65

1.

Unusual origins of isotope effects in enzyme-catalysed reactions.

Northrop DB.

Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1341-9.

2.

Effect of pressure on a heavy-atom isotope effect of yeast alcohol dehydrogenase.

Park H, Girdaukas GG, Northrop DB.

J Am Chem Soc. 2006 Feb 15;128(6):1868-72.

PMID:
16464086
3.

Unusual solute protection against pressure inactivation of yeast alcohol dehydrogenase.

Kidman G, Northrop DB.

Protein Pept Lett. 2005 Nov;12(8):801-3.

PMID:
16305552
4.

Effects of trehalose on pressure-induced inactivation of yeast alcohol dehydrogenase.

Park H, Kidman G, Northrop DB.

Protein Pept Lett. 2005 Aug;12(6):597-9.

PMID:
16101402
5.

Effect of pressure on nucleotide binding to yeast alcohol dehydrogenase.

Kidman G, Northrop DB.

Protein Pept Lett. 2005 Jul;12(5):495-7.

PMID:
16029165
6.

Effects of pressure on deuterium isotope effects of yeast alcohol dehydrogenase using alternative substrates.

Park H, Kidman G, Northrop DB.

Arch Biochem Biophys. 2005 Jan 1;433(1):335-40. Review.

PMID:
15581588
7.

Pressure stability of proteins at their isoelectric points.

Kidman G, Park H, Northrop DB.

Protein Pept Lett. 2004 Dec;11(6):543-6.

PMID:
15579123
9.

Effects of high pressure on enzymatic activity.

Northrop DB.

Biochim Biophys Acta. 2002 Mar 25;1595(1-2):71-9. Review.

PMID:
11983387
10.
11.

Uses of isotope effects in the study of enzymes.

Northrop DB.

Methods. 2001 Jun;24(2):117-24.

PMID:
11384187
12.

Effect of pressure on deuterium isotope effects of formate dehydrogenase.

Quirk DJ, Northrop DB.

Biochemistry. 2001 Jan 23;40(3):847-51.

PMID:
11170403
13.
14.
15.

Energetics of substrate binding, catalysis, and product release.

Cleland WW, Northrop DB.

Methods Enzymol. 1999;308:3-27. No abstract available.

PMID:
10506998
16.

Effects of pressure on the kinetics of capture by yeast alcohol dehydrogenase

Cho YK, Northrop DB.

Biochemistry. 1999 Aug 17;38(33):10908. No abstract available.

PMID:
10451387
17.

Effects of pressure on the kinetics of capture by yeast alcohol dehydrogenase.

Cho YK, Northrop DB.

Biochemistry. 1999 Jun 8;38(23):7470-5.

PMID:
10360944
18.

Rethinking fundamentals of enzyme action.

Northrop DB.

Adv Enzymol Relat Areas Mol Biol. 1999;73:25-55, ix.

PMID:
10218105
19.
21.

Kinetics of enzymes with iso-mechanisms: solvent isotope effects.

Northrop DB, Rebholz KL.

Arch Biochem Biophys. 1997 Jun 15;342(2):317-21.

PMID:
9186493
22.

Beyond enzyme kinetics: direct determination of mechanisms by stopped-flow mass spectrometry.

Northrop DB, Simpson FB.

Bioorg Med Chem. 1997 Apr;5(4):641-4. Review.

PMID:
9158861
23.

Kinetics of iso mechanisms.

Rebholz KL, Northrop DB.

Methods Enzymol. 1995;249:211-40. No abstract available.

PMID:
7791613
24.

Solvent isotope effects on the onset of inhibition of porcine pepsin by pepstatin.

Cho YK, Rebholz KL, Northrop DB.

Biochemistry. 1994 Aug 16;33(32):9637-42.

PMID:
8068640
25.

Problems in defining limits: how slow is very slow?

Northrop DB.

Biochem J. 1994 Jul 15;301(Pt 2):623. No abstract available.

26.

Kinetics of enzymes with iso-mechanisms: dead-end inhibition of fumarase and carbonic anhydrase II.

Rebholz KL, Northrop DB.

Arch Biochem Biophys. 1994 Jul;312(1):227-33. Erratum in: Arch Biochem Biophys 1999 Apr 15;364(2):294.

PMID:
8031132
27.

Kinetics of enzymes with iso-mechanisms: analysis and display of progress curves.

Northrop DB, Rebholz KL.

Anal Biochem. 1994 Feb 1;216(2):285-90.

PMID:
8179183
28.

Kinetics of enzymes with iso-mechanisms: analysis of product inhibition.

Rebholz KL, Northrop DB.

Biochem J. 1993 Dec 1;296 ( Pt 2):355-60.

29.

Research funding.

Northrop DB.

FASEB J. 1991 Jul;5(10):2486-7. No abstract available.

PMID:
2065897
30.

Slow step after bond-breaking by porcine pepsin identified using solvent deuterium isotope effects.

Rebholz KL, Northrop DB.

Biochem Biophys Res Commun. 1991 Apr 15;176(1):65-9.

PMID:
2018546
31.

Effects of viscosity and solvent deuterium identify multiple partially rate-limiting steps in the kinetics of porcine pepsin.

Rebholz KL, Northrop DB.

Adv Exp Med Biol. 1991;306:139-42. No abstract available.

PMID:
1812701
32.
33.

Determination of the rate-limiting segment of aminoglycoside nucleotidyltransferase 2''-I by pH and viscosity-dependent kinetics.

Gates CA, Northrop DB.

Biochemistry. 1988 May 17;27(10):3834-42. Erratum in: Biochemistry 1989 Feb 21;28(4):1930.

PMID:
2841977
34.

Alternative substrate and inhibition kinetics of aminoglycoside nucleotidyltransferase 2''-I in support of a Theorell-Chance kinetic mechanism.

Gates CA, Northrop DB.

Biochemistry. 1988 May 17;27(10):3826-33. Erratum in: Biochemistry 1989 Feb 21;28(4):1930.

PMID:
2841976
36.

Kinetic distinction between rapid-equilibrium random and abortive ordered enzymatic mechanisms using alternative substrates or kinetic isotope effects.

Gates CA, Northrop DB.

Biochem Biophys Res Commun. 1988 Apr 15;152(1):406-10. Erratum in: Biochem Biophys Res Commun 1989 Feb 28;159(1):368-9.

PMID:
2833895
37.

Preparation and storage of isotopically labeled reduced nicotinamide adenine dinucleotide.

Northrop DB, Duggleby RG.

Anal Biochem. 1987 Sep;165(2):362-4.

PMID:
3425905
38.

Desalting of nucleotides by reverse-phase high-performance liquid chromatography.

Northrop DB, Newton CJ.

Methods Enzymol. 1986;122:155-6. No abstract available.

PMID:
3702686
39.

Purification of reduced nicotinamide adenine dinucleotide by ion-exchange and high-performance liquid chromatography.

Northrop DB, Newton CJ, Faynor SM.

Methods Enzymol. 1986;122:152-4. No abstract available.

PMID:
3702685
40.
41.
42.

Purification of two forms of kanamycin acetyltransferase from Escherichia coli.

Radika K, Northrop DB.

Arch Biochem Biophys. 1984 Aug 15;233(1):272-85.

PMID:
6380414
43.
45.

Isotope and pH effects on the dehydration of acetaldehyde hydrate by carbonic anhydrase.

Northrop DB, Bayley PM.

Ann N Y Acad Sci. 1984;429:109-11. No abstract available.

PMID:
6430146
46.

Fitting enzyme-kinetic data to V/K.

Northrop DB.

Anal Biochem. 1983 Jul 15;132(2):457-61.

PMID:
6625178
47.
48.

Deuterium and tritium kinetic isotope effects on initial rates.

Northrop DB.

Methods Enzymol. 1982;87:607-25. No abstract available.

PMID:
7176927
50.

The expression of isotope effects on enzyme-catalyzed reactions.

Northrop DB.

Annu Rev Biochem. 1981;50:103-31. Review. No abstract available.

PMID:
7023356

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