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Items: 1 to 50 of 53

1.

The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia.

Rowe RG, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, Yermalovich A, Barragan J, Mathieu R, Jha DK, Fleming MD, North TE, Daley GQ.

J Exp Med. 2019 Feb 6. pii: jem.20181765. doi: 10.1084/jem.20181765. [Epub ahead of print]

PMID:
30728174
2.

Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes.

Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Aravena M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W.

Gastroenterology. 2019 Jan 11. pii: S0016-5085(19)30031-9. doi: 10.1053/j.gastro.2019.01.010. [Epub ahead of print]

PMID:
30641053
3.

Reconstruction of complex single-cell trajectories using CellRouter.

Lummertz da Rocha E, Rowe RG, Lundin V, Malleshaiah M, Jha DK, Rambo CR, Li H, North TE, Collins JJ, Daley GQ.

Nat Commun. 2018 Mar 1;9(1):892. doi: 10.1038/s41467-018-03214-y.

4.

Regulation of embryonic haematopoietic multipotency by EZH1.

Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ.

Nature. 2018 Jan 25;553(7689):506-510. doi: 10.1038/nature25435. Epub 2018 Jan 17.

5.

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells.

Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, Kwan W, Frost I, North TE, Rajewski RA, Speck NA, Bushweller JH.

Leuk Lymphoma. 2018 Sep;59(9):2188-2200. doi: 10.1080/10428194.2017.1410882. Epub 2017 Dec 18.

6.

Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization.

Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE.

Stem Cell Reports. 2017 May 9;8(5):1226-1241. doi: 10.1016/j.stemcr.2017.03.016. Epub 2017 Apr 13.

7.

Netting Novel Regulators of Hematopoiesis and Hematologic Malignancies in Zebrafish.

Kwan W, North TE.

Curr Top Dev Biol. 2017;124:125-160. doi: 10.1016/bs.ctdb.2016.11.005. Epub 2017 Jan 17. Review.

PMID:
28335858
8.

Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis.

Frame JM, Lim SE, North TE.

Methods Cell Biol. 2017;138:165-192. doi: 10.1016/bs.mcb.2016.08.004. Epub 2016 Oct 26. Review.

PMID:
28129843
9.

Haematopoietic stem cells show their true colours.

North TE, Goessling W.

Nat Cell Biol. 2016 Dec 23;19(1):10-12. doi: 10.1038/ncb3459.

PMID:
28008181
10.

Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence.

Konantz M, Alghisi E, Müller JS, Lenard A, Esain V, Carroll KJ, Kanz L, North TE, Lengerke C.

EMBO J. 2016 Nov 2;35(21):2315-2331. Epub 2016 Sep 16.

11.

HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation.

Lim SE, Esain V, Kwan W, Theodore LN, Cortes M, Frost IM, Liu SY, North TE.

Exp Hematol. 2017 Feb;46:83-95.e6. doi: 10.1016/j.exphem.2016.10.002. Epub 2016 Oct 15.

12.

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production.

Cortes M, Chen MJ, Stachura DL, Liu SY, Kwan W, Wright F, Vo LT, Theodore LN, Esain V, Frost IM, Schlaeger TM, Goessling W, Daley GQ, North TE.

Cell Rep. 2016 Oct 4;17(2):458-468. doi: 10.1016/j.celrep.2016.09.012.

13.

Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development.

Nissim S, Weeks O, Talbot JC, Hedgepeth JW, Wucherpfennig J, Schatzman-Bone S, Swinburne I, Cortes M, Alexa K, Megason S, North TE, Amacher SL, Goessling W.

Dev Biol. 2016 Oct 1;418(1):108-123. doi: 10.1016/j.ydbio.2016.07.019. Epub 2016 Jul 26.

14.

Enumerating Hematopoietic Stem and Progenitor Cells in Zebrafish Embryos.

Esain V, Cortes M, North TE.

Methods Mol Biol. 2016;1451:191-206. doi: 10.1007/978-1-4939-3771-4_13.

PMID:
27464809
15.

The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling.

Kwan W, Cortes M, Frost I, Esain V, Theodore LN, Liu SY, Budrow N, Goessling W, North TE.

Cell Stem Cell. 2016 Sep 1;19(3):370-82. doi: 10.1016/j.stem.2016.06.004. Epub 2016 Jul 14.

16.

Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?

Luis TC, Tremblay CS, Manz MG, North TE, King KY, Challen GA.

Exp Hematol. 2016 Oct;44(10):908-12. doi: 10.1016/j.exphem.2016.06.254. Epub 2016 Jul 15. Review.

PMID:
27423816
17.

Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish.

Moore FE, Garcia EG, Lobbardi R, Jain E, Tang Q, Moore JC, Cortes M, Molodtsov A, Kasheta M, Luo CC, Garcia AJ, Mylvaganam R, Yoder JA, Blackburn JS, Sadreyev RI, Ceol CJ, North TE, Langenau DM.

J Exp Med. 2016 May 30;213(6):979-92. doi: 10.1084/jem.20152013. Epub 2016 May 2.

18.

EnaBILEing Growth in the Fetal Liver.

Goessling W, North TE.

Cell Stem Cell. 2016 Apr 7;18(4):427-8. doi: 10.1016/j.stem.2016.03.019.

19.

Endothelial-to-hematopoietic transition: Notch-ing vessels into blood.

Kanz D, Konantz M, Alghisi E, North TE, Lengerke C.

Ann N Y Acad Sci. 2016 Apr;1370(1):97-108. doi: 10.1111/nyas.13030. Epub 2016 Mar 25.

PMID:
27015586
20.

Cannabinoid receptor signaling regulates liver development and metabolism.

Liu LY, Alexa K, Cortes M, Schatzman-Bone S, Kim AJ, Mukhopadhyay B, Cinar R, Kunos G, North TE, Goessling W.

Development. 2016 Feb 15;143(4):609-22. doi: 10.1242/dev.121731.

21.

Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation.

Cortes M, Liu SY, Kwan W, Alexa K, Goessling W, North TE.

Stem Cell Reports. 2015 Oct 13;5(4):471-9. doi: 10.1016/j.stemcr.2015.08.010. Epub 2015 Sep 10.

22.

Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity.

Esain V, Kwan W, Carroll KJ, Cortes M, Liu SY, Frechette GM, Sheward LM, Nissim S, Goessling W, North TE.

Stem Cells. 2015 Aug;33(8):2596-612. doi: 10.1002/stem.2044. Epub 2015 May 26.

23.

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.

Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, Speck NA.

Genes Dev. 2014 Dec 1;28(23):2597-612. doi: 10.1101/gad.253302.114. Epub 2014 Nov 13.

24.

Repairing quite swimmingly: advances in regenerative medicine using zebrafish.

Goessling W, North TE.

Dis Model Mech. 2014 Jul;7(7):769-76. doi: 10.1242/dmm.016352. Review.

25.

Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche.

Carroll KJ, Esain V, Garnaas MK, Cortes M, Dovey MC, Nissim S, Frechette GM, Liu SY, Kwan W, Cutting CC, Harris JM, Gorelick DA, Halpern ME, Lawson ND, Goessling W, North TE.

Dev Cell. 2014 May 27;29(4):437-53. doi: 10.1016/j.devcel.2014.04.012.

26.

Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish.

Carroll KJ, North TE.

Exp Hematol. 2014 Aug;42(8):684-96. doi: 10.1016/j.exphem.2014.05.002. Epub 2014 May 9. Review.

27.

Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth.

Nissim S, Sherwood RI, Wucherpfennig J, Saunders D, Harris JM, Esain V, Carroll KJ, Frechette GM, Kim AJ, Hwang KL, Cutting CC, Elledge S, North TE, Goessling W.

Dev Cell. 2014 Feb 24;28(4):423-37. doi: 10.1016/j.devcel.2014.01.006. Epub 2014 Feb 13.

28.

S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury.

Cox AG, Saunders DC, Kelsey PB Jr, Conway AA, Tesmenitsky Y, Marchini JF, Brown KK, Stamler JS, Colagiovanni DB, Rosenthal GJ, Croce KJ, North TE, Goessling W.

Cell Rep. 2014 Jan 16;6(1):56-69. doi: 10.1016/j.celrep.2013.12.007. Epub 2014 Jan 2.

29.

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD.

Blood. 2013 Oct 24;122(17):3074-81. doi: 10.1182/blood-2013-05-503177. Epub 2013 Aug 30.

30.

Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development.

Liu LY, Fox CS, North TE, Goessling W.

Dis Model Mech. 2013 Sep;6(5):1271-8. doi: 10.1242/dmm.011726. Epub 2013 Jun 27.

31.

Identification of small molecules for human hepatocyte expansion and iPS differentiation.

Shan J, Schwartz RE, Ross NT, Logan DJ, Thomas D, Duncan SA, North TE, Goessling W, Carpenter AE, Bhatia SN.

Nat Chem Biol. 2013 Aug;9(8):514-20. doi: 10.1038/nchembio.1270. Epub 2013 Jun 2.

32.

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo.

Harris JM, Esain V, Frechette GM, Harris LJ, Cox AG, Cortes M, Garnaas MK, Carroll KJ, Cutting CC, Khan T, Elks PM, Renshaw SA, Dickinson BC, Chang CJ, Murphy MP, Paw BH, Vander Heiden MG, Goessling W, North TE.

Blood. 2013 Mar 28;121(13):2483-93. doi: 10.1182/blood-2012-12-471201. Epub 2013 Jan 22.

33.

Rargb regulates organ laterality in a zebrafish model of right atrial isomerism.

Garnaas MK, Cutting CC, Meyers A, Kelsey PB Jr, Harris JM, North TE, Goessling W.

Dev Biol. 2012 Dec 15;372(2):178-89. doi: 10.1016/j.ydbio.2012.09.001. Epub 2012 Sep 13.

34.

Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis.

Cooney JD, Hildick-Smith GJ, Shafizadeh E, McBride PF, Carroll KJ, Anderson H, Shaw GC, Tamplin OJ, Branco DS, Dalton AJ, Shah DI, Wong C, Gallagher PG, Zon LI, North TE, Paw BH.

Dev Biol. 2013 Jan 15;373(2):431-41. doi: 10.1016/j.ydbio.2012.08.015. Epub 2012 Aug 29.

35.

Mutation mapping and identification by whole-genome sequencing.

Leshchiner I, Alexa K, Kelsey P, Adzhubei I, Austin-Tse CA, Cooney JD, Anderson H, King MJ, Stottmann RW, Garnaas MK, Ha S, Drummond IA, Paw BH, North TE, Beier DR, Goessling W, Sunyaev SR.

Genome Res. 2012 Aug;22(8):1541-8. doi: 10.1101/gr.135541.111. Epub 2012 May 3.

36.

Small molecule screening identifies targetable zebrafish pigmentation pathways.

Colanesi S, Taylor KL, Temperley ND, Lundegaard PR, Liu D, North TE, Ishizaki H, Kelsh RN, Patton EE.

Pigment Cell Melanoma Res. 2012 Mar;25(2):131-43. doi: 10.1111/j.1755-148X.2012.00977.x.

PMID:
22252091
37.

Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis.

Goessling W, North TE.

Methods Cell Biol. 2011;105:117-36. doi: 10.1016/B978-0-12-381320-6.00005-9.

PMID:
21951528
38.

Endoderm specification, liver development, and regeneration.

North TE, Goessling W.

Methods Cell Biol. 2011;101:205-23. doi: 10.1016/B978-0-12-387036-0.00010-4. Review.

PMID:
21550446
39.

Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.

Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE.

Cell Stem Cell. 2011 Apr 8;8(4):445-58. doi: 10.1016/j.stem.2011.02.003.

40.

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.

North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling W.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17315-20. doi: 10.1073/pnas.1008209107. Epub 2010 Sep 20.

41.

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA.

Science. 2010 Mar 26;327(5973):1650-3. doi: 10.1126/science.1186624.

42.

Previews. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice.

North TE, Goessling W.

Cell Stem Cell. 2010 Mar 5;6(3):186-7. doi: 10.1016/j.stem.2010.02.009.

43.

Hematopoietic stem cell development is dependent on blood flow.

North TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI.

Cell. 2009 May 15;137(4):736-48. doi: 10.1016/j.cell.2009.04.023.

44.

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.

Goessling W, North TE, Loewer S, Lord AM, Lee S, Stoick-Cooper CL, Weidinger G, Puder M, Daley GQ, Moon RT, Zon LI.

Cell. 2009 Mar 20;136(6):1136-47. doi: 10.1016/j.cell.2009.01.015.

45.

Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.

Upadhyay G, Goessling W, North TE, Xavier R, Zon LI, Yajnik V.

Oncogene. 2008 Oct 2;27(44):5845-55. doi: 10.1038/onc.2008.202. Epub 2008 Jul 21.

46.

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.

Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI.

Dev Biol. 2008 Aug 1;320(1):161-74. doi: 10.1016/j.ydbio.2008.05.526. Epub 2008 May 20.

47.

Prostaglandin E2: making more of your marrow.

Lord AM, North TE, Zon LI.

Cell Cycle. 2007 Dec 15;6(24):3054-7. Epub 2007 Oct 3. Review.

PMID:
18075310
48.

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.

North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI.

Nature. 2007 Jun 21;447(7147):1007-11.

49.

Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors.

Goessling W, North TE, Zon LI.

Nat Methods. 2007 Jul;4(7):551-3. Epub 2007 Jun 17.

PMID:
17572681
50.

New waves of discovery: modeling cancer in zebrafish.

Goessling W, North TE, Zon LI.

J Clin Oncol. 2007 Jun 10;25(17):2473-9. Review. No abstract available.

PMID:
17557959

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