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Items: 16


mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation.

Norrmén C, Figlia G, Pfistner P, Pereira JA, Bachofner S, Suter U.

J Neurosci. 2018 May 16;38(20):4811-4828. doi: 10.1523/JNEUROSCI.3619-17.2018. Epub 2018 Apr 25.


De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination.

Montani L, Pereira JA, Norrmén C, Pohl HBF, Tinelli E, Trötzmüller M, Figlia G, Dimas P, von Niederhäusern B, Schwager R, Jessberger S, Semenkovich CF, Köfeler HC, Suter U.

J Cell Biol. 2018 Apr 2;217(4):1353-1368. doi: 10.1083/jcb.201706010. Epub 2018 Feb 6.


Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.

Figlia G, Norrmén C, Pereira JA, Gerber D, Suter U.

Elife. 2017 Sep 7;6. pii: e29241. doi: 10.7554/eLife.29241.


mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.

Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U.

Cell Rep. 2014 Oct 23;9(2):646-60. doi: 10.1016/j.celrep.2014.09.001. Epub 2014 Oct 9.


Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.

Lebrun-Julien F, Bachmann L, Norrmén C, Trötzmüller M, Köfeler H, Rüegg MA, Hall MN, Suter U.

J Neurosci. 2014 Jun 18;34(25):8432-48. doi: 10.1523/JNEUROSCI.1105-14.2014.


Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.

Ivanov KI, Agalarov Y, Valmu L, Samuilova O, Liebl J, Houhou N, Maby-El Hajjami H, Norrmén C, Jaquet M, Miura N, Zangger N, Ylä-Herttuala S, Delorenzi M, Petrova TV.

Mol Cell Biol. 2013 Oct;33(19):3749-61. doi: 10.1128/MCB.01387-12. Epub 2013 Jul 22.


Akt/mTOR signalling in myelination.

Norrmén C, Suter U.

Biochem Soc Trans. 2013 Aug;41(4):944-50. doi: 10.1042/BST20130046. Review.


Biological basis of therapeutic lymphangiogenesis.

Norrmén C, Tammela T, Petrova TV, Alitalo K.

Circulation. 2011 Mar 29;123(12):1335-51. doi: 10.1161/CIRCULATIONAHA.107.704098. Review. No abstract available. Erratum in: Circulation. 2011 Dec 13;124(24):e901-3.


Dicer in Schwann cells is required for myelination and axonal integrity.

Pereira JA, Baumann R, Norrmén C, Somandin C, Miehe M, Jacob C, Lühmann T, Hall-Bozic H, Mantei N, Meijer D, Suter U.

J Neurosci. 2010 May 12;30(19):6763-75. doi: 10.1523/JNEUROSCI.0801-10.2010.


Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.

Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K.

Genes Dev. 2010 May;24(9):875-80. doi: 10.1101/gad.565010.


Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.

Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV.

Blood. 2010 Jan 28;115(4):906-9. doi: 10.1182/blood-2009-03-212274. Epub 2009 Nov 30.


FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.

Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV.

J Cell Biol. 2009 May 4;185(3):439-57. doi: 10.1083/jcb.200901104. Epub 2009 Apr 27.


Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K.

Cancer Cell. 2008 May;13(5):407-19. doi: 10.1016/j.ccr.2008.02.020.


Molecular mechanisms of lymphatic vascular development.

Mäkinen T, Norrmén C, Petrova TV.

Cell Mol Life Sci. 2007 Aug;64(15):1915-29. Review.


Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.

Tammela T, Saaristo A, Lohela M, Morisada T, Tornberg J, Norrmén C, Oike Y, Pajusola K, Thurston G, Suda T, Yla-Herttuala S, Alitalo K.

Blood. 2005 Jun 15;105(12):4642-8. Epub 2005 Mar 3.


Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.

Petrova TV, Karpanen T, Norrmén C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Ylä-Herttuala S, Miura N, Alitalo K.

Nat Med. 2004 Sep;10(9):974-81. Epub 2004 Aug 22.


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