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Low Postseroconversion CD4+ T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection.

Palm AA, Lemey P, Jansson M, Månsson F, Kvist A, Szojka Z, Biague A, da Silva ZJ, Rowland-Jones SL, Norrgren H, Esbjörnsson J, Medstrand P.

MBio. 2019 Jan 8;10(1). pii: e01245-18. doi: 10.1128/mBio.01245-18.


Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study.

Esbjörnsson J, Månsson F, Kvist A, da Silva ZJ, Andersson S, Fenyö EM, Isberg PE, Biague AJ, Lindman J, Palm AA, Rowland-Jones SL, Jansson M, Medstrand P, Norrgren H; Sweden and Guinea-Bissau Cohort Research Group.

Lancet HIV. 2018 Nov 1. pii: S2352-3018(18)30254-6. doi: 10.1016/S2352-3018(18)30254-6. [Epub ahead of print]


Prevalence of HIV-1 pretreatment drug resistance among treatment naïve pregnant women in Bissau, Guinea Bissau.

Wilhelmson S, Månsson F, Lopatko Lindman J, Biai A, Esbjörnsson J, Norrgren H, Jansson M, Medstrand P; SWEGUB CORE group.

PLoS One. 2018 Oct 31;13(10):e0206406. doi: 10.1371/journal.pone.0206406. eCollection 2018.


Increase in transmitted drug resistance in migrants from sub-Saharan Africa diagnosed with HIV-1 in Sweden.

Andersson E, Nordquist A, Esbjörnsson J, Flamholc L, Gisslén M, Hejdeman B, Marrone G, Norrgren H, Svedhem V, Wendahl S, Albert J, Sönnerborg A.

AIDS. 2018 Apr 24;32(7):877-884. doi: 10.1097/QAD.0000000000001763.


Cartilage oligomeric matrix protein associates with hepatic inflammation and fibrosis in hepatitis C virus infection.

Andréasson K, Waldenström J, Westin J, Norrgren H, Jönsson G, Nyström K, Lagging M.

J Hepatol. 2017 Sep;67(3):649-651. doi: 10.1016/j.jhep.2017.03.043. Epub 2017 May 18. No abstract available.


CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection.

Buggert M, Frederiksen J, Lund O, Betts MR, Biague A, Nielsen M, Tauriainen J, Norrgren H, Medstrand P, Karlsson AC, Jansson M; SWEGUB CORE group.

AIDS. 2016 Oct 23;30(16):2415-2426.


Sweden, the first country to achieve the Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 continuum of HIV care targets.

Gisslén M, Svedhem V, Lindborg L, Flamholc L, Norrgren H, Wendahl S, Axelsson M, Sönnerborg A.

HIV Med. 2017 Apr;18(4):305-307. doi: 10.1111/hiv.12431. Epub 2016 Aug 18.


Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection.

Waldenström J, Westin J, Nyström K, Christensen P, Dalgard O, Färkkilä M, Lindahl K, Nilsson S, Norkrans G, Krarup H, Norrgren H, Rauning Buhl M, Stenmark S, Lagging M.

PLoS One. 2016 May 11;11(5):e0155142. doi: 10.1371/journal.pone.0155142. eCollection 2016.


Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections.

Bächle SM, Malone DF, Buggert M, Karlsson AC, Isberg PE, Biague AJ, Norrgren H, Medstrand P, Moll M, Sandberg JK, Jansson M; SWEGUB CORE group.

AIDS. 2016 Jul 17;30(11):1713-22. doi: 10.1097/QAD.0000000000001147.


Analytical evaluation of nine serological assays for diagnosis of syphilis.

Malm K, Andersson S, Fredlund H, Norrgren H, Biague A, Månsson F, Ballard R, Unemo M.

J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2369-76. doi: 10.1111/jdv.13237. Epub 2015 Sep 14.


Cartilage oligomeric matrix protein: a new promising biomarker of liver fibrosis in chronic hepatitis C.

Andréasson K, Hesselstrand R, Saxne T, Holmberg A, Norrgren H, Jönsson G.

Infect Dis (Lond). 2015;47(12):915-8. Epub 2015 Aug 12.


Cocirculation of several similar but unique HIV-1 recombinant forms in Guinea-Bissau revealed by near full-length genomic sequencing.

Palm AA, Esbjörnsson J, Månsson F, Biague A, da Silva ZJ, Norrgren H, Jansson M, Medstrand P.

AIDS Res Hum Retroviruses. 2015 Sep;31(9):938-45. doi: 10.1089/AID.2015.0073. Epub 2015 Jul 16.


Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals.

Esbjörnsson J, Månsson F, Kvist A, Isberg PE, Biague AJ, da Silva ZJ, Jansson M, Fenyö EM, Norrgren H, Medstrand P.

AIDS. 2014 Apr 24;28(7):949-57.


Effect of HIV-2 infection on HIV-1 disease progression and mortality.

Esbjörnsson J, Månsson F, Kvist A, Isberg PE, Nowroozalizadeh S, Biague AJ, da Silva ZJ, Jansson M, Fenyö EM, Norrgren H, Medstrand P.

AIDS. 2014 Feb 20;28(4):614-5. doi: 10.1097/QAD.0000000000000142. No abstract available.


Declining prevalence rates of syphilis among police officers in Guinea-Bissau, West Africa, 1990-2010.

Lindman JL, Månsson F, Biague A, Da Silva ZJ, Andersson S, Norrgren H.

Sex Transm Dis. 2013 Oct;40(10):794-6. doi: 10.1097/OLQ.0000000000000012.


Impact of Il28b-related single nucleotide polymorphisms on liver transient elastography in chronic hepatitis C infection.

Ydreborg M, Westin J, Rembeck K, Lindh M, Norrgren H, Holmberg A, Wejstål R, Norkrans G, Cardell K, Weiland O, Lagging M.

PLoS One. 2013 Nov 14;8(11):e80172. doi: 10.1371/journal.pone.0080172. eCollection 2013.


Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02_AG compared with sub-subtype A3.

Palm AA, Esbjörnsson J, Månsson F, Kvist A, Isberg PE, Biague A, da Silva ZJ, Jansson M, Norrgren H, Medstrand P.

J Infect Dis. 2014 Mar 1;209(5):721-8. doi: 10.1093/infdis/jit416. Epub 2013 Aug 9.


A risk for hepatocellular carcinoma persists long-term after sustained virologic response in patients with hepatitis C-associated liver cirrhosis.

Aleman S, Rahbin N, Weiland O, Davidsdottir L, Hedenstierna M, Rose N, Verbaan H, Stål P, Carlsson T, Norrgren H, Ekbom A, Granath F, Hultcrantz R.

Clin Infect Dis. 2013 Jul;57(2):230-6. doi: 10.1093/cid/cit234. Epub 2013 Apr 24.


Frequent intratype neutralization by plasma immunoglobulin a identified in HIV type 2 infection.

Özkaya Şahin G, Månsson F, Palm AA, Vincic E, da Silva Z, Medstrand P, Norrgren H, Fenyö EM, Jansson M.

AIDS Res Hum Retroviruses. 2013 Mar;29(3):470-8. doi: 10.1089/AID.2012.0219. Epub 2012 Nov 21.


Effect of complement on HIV-2 plasma antiviral activity is intratype specific and potent.

Özkaya Şahin G, Holmgren B, Sheik-Khalil E, da Silva Z, Nielsen J, Nowroozalizadeh S, Månsson F, Norrgren H, Aaby P, Fenyö EM, Jansson M.

J Virol. 2013 Jan;87(1):273-81. doi: 10.1128/JVI.01640-12. Epub 2012 Oct 17.


Eradication of nasopharyngeal carriage of penicillin-non-susceptible Streptococcus pneumoniae--is it possible?

Hellberg M, Johansson S, Odenholt I, Holmdahl T, Ringberg H, Nilsson WP, Norrgren H, Ahl J.

Scand J Infect Dis. 2012 Dec;44(12):909-14. doi: 10.3109/00365548.2012.697636. Epub 2012 Sep 19.


Inhibition of HIV-1 disease progression by contemporaneous HIV-2 infection.

Esbjörnsson J, Månsson F, Kvist A, Isberg PE, Nowroozalizadeh S, Biague AJ, da Silva ZJ, Jansson M, Fenyö EM, Norrgren H, Medstrand P.

N Engl J Med. 2012 Jul 19;367(3):224-32. doi: 10.1056/NEJMoa1113244.


Phenotypic and genetic characterisation of bacterial sexually transmitted infections in Bissau, Guinea-Bissau, West Africa: a prospective cohort study.

Olsen B, Månsson F, Camara C, Monteiro M, Biai A, Alves A, Andersson S, Norrgren H, Unemo M.

BMJ Open. 2012 Mar 20;2(2):e000636. doi: 10.1136/bmjopen-2011-000636. Print 2012.


Potent intratype neutralizing activity distinguishes human immunodeficiency virus type 2 (HIV-2) from HIV-1.

Ozkaya Sahin G, Holmgren B, da Silva Z, Nielsen J, Nowroozalizadeh S, Esbjörnsson J, Månsson F, Andersson S, Norrgren H, Aaby P, Jansson M, Fenyö EM.

J Virol. 2012 Jan;86(2):961-71. doi: 10.1128/JVI.06315-11. Epub 2011 Nov 9.


HIV-1 molecular epidemiology in Guinea-Bissau, West Africa: origin, demography and migrations.

Esbjörnsson J, Mild M, Månsson F, Norrgren H, Medstrand P.

PLoS One. 2011 Feb 18;6(2):e17025. doi: 10.1371/journal.pone.0017025.


High prevalence of HIV-1, HIV-2 and other sexually transmitted infections among women attending two sexual health clinics in Bissau, Guinea-Bissau, West Africa.

Månsson F, Camara C, Biai A, Monteiro M, da Silva ZJ, Dias F, Alves A, Andersson S, Fenyö EM, Norrgren H, Unemo M.

Int J STD AIDS. 2010 Sep;21(9):631-5. doi: 10.1258/ijsa.2010.009584.


High sexual risk taking and diverging trends of HIV-1 and HIV-2 in the military of Guinea Bissau.

Biague A, Månsson F, da Silva Z, Dias F, Nantote Q, Costa J, Andersson S, Nauclér A, Biberfeld G, Fenyö EM, Norrgren H.

J Infect Dev Ctries. 2010 Jun 3;4(5):301-8.


Human exposure to persistent organic pollutants in West Africa--a temporal trend study from Guinea-Bissau.

Linderholm L, Biague A, Månsson F, Norrgren H, Bergman A, Jakobsson K.

Environ Int. 2010 Oct;36(7):675-82. doi: 10.1016/j.envint.2010.04.020.


Higher mortality in HIV-2/HTLV-1 co-infected patients with pulmonary tuberculosis in Guinea-Bissau, West Africa, compared to HIV-2-positive HTLV-1-negative patients.

Norrgren H, Bamba S, Da Silva ZJ, Koivula T, Andersson S.

Int J Infect Dis. 2010 Sep;14 Suppl 3:e142-7. doi: 10.1016/j.ijid.2009.11.040. Epub 2010 Apr 14.


Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease--indication of an evolving epidemic in West Africa.

Esbjörnsson J, Månsson F, Martínez-Arias W, Vincic E, Biague AJ, da Silva ZJ, Fenyö EM, Norrgren H, Medstrand P.

Retrovirology. 2010 Mar 22;7:23. doi: 10.1186/1742-4690-7-23.


Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections.

Nowroozalizadeh S, Månsson F, da Silva Z, Repits J, Dabo B, Pereira C, Biague A, Albert J, Nielsen J, Aaby P, Fenyö EM, Norrgren H, Holmgren B, Jansson M.

J Infect Dis. 2010 Apr 15;201(8):1150-4. doi: 10.1086/651430.


Prevalence and incidence of HIV-1 and HIV-2 before, during and after a civil war in an occupational cohort in Guinea-Bissau, West Africa.

Månsson F, Biague A, da Silva ZJ, Dias F, Nilsson LA, Andersson S, Fenyö EM, Norrgren H.

AIDS. 2009 Jul 31;23(12):1575-82. doi: 10.1097/QAD.0b013e32832cedfb.


Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infections.

Nowroozalizadeh S, Månsson F, da Silva Z, Repits J, Dabo B, Pereira C, Biague A, Albert J, Nielsen J, Aaby P, Fenyö EM, Norrgren H, Holmgren B, Jansson M.

Cytokine. 2009 Jun;46(3):325-31. doi: 10.1016/j.cyto.2009.03.003. Epub 2009 Apr 17.


Increased prevalence of HTLV-1 in patients with pulmonary tuberculosis coinfected with HIV, but not in HIV-negative patients with tuberculosis.

Norrgren HR, Bamba S, Larsen O, Da Silva Z, Aaby P, Koivula T, Andersson S.

J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):607-10. doi: 10.1097/QAI.0b013e31817efb83.


Trends of HIV-1 and HIV-2 prevalence among pregnant women in Guinea-Bissau, West Africa: possible effect of the civil war 1998 1999.

Månsson F, Alves A, Silva ZJ, Dias F, Andersson S, Biberfeld G, Fenyö EM, Norrgren H.

Sex Transm Infect. 2007 Oct;83(6):463-7. Epub 2007 Jul 4.


Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses in HIV-2-infected and in HIV-2-exposed but uninfected individuals in Guinea-Bissau.

Andersson S, Larsen O, Da Silva Z, Linder H, Norrgren H, Dias F, Thorstensson R, Aaby P, Biberfeld G.

Clin Exp Immunol. 2005 Mar;139(3):483-9.


Antigen-specific beta-chemokine production and CD8 T-cell noncytotoxic antiviral activity in HIV-2-infected individuals.

Ahmed RK, Norrgren H, da Silva Z, Blaxhult A, Fredriksson EL, Biberfeld G, Andersson S, Thorstensson R.

Scand J Immunol. 2005 Jan;61(1):63-71.


Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau.

Norrgren H, da Silva Z, Biague A, Andersson S, Biberfeld G.

Scand J Infect Dis. 2003;35(4):265-72.


Intestinal parasites in HIV-2 associated AIDS cases with chronic diarrhoea in Guinea-Bissau.

Lebbad M, Norrgren H, Nauclér A, Dias F, Andersson S, Linder E.

Acta Trop. 2001 Sep 1;80(1):45-9.


High mortality and severe immunosuppression in hospitalized patients with pulmonary tuberculosis and HIV-2 infection in Guinea-Bissau.

Norrgren H, Bamba S, da Silva ZJ, Andersson S, Koivula T, Biberfeld G.

Scand J Infect Dis. 2001;33(6):450-6.


Plasma viral load in HIV-1 and HIV-2 singly and dually infected individuals in Guinea-Bissau, West Africa: significantly lower plasma virus set point in HIV-2 infection than in HIV-1 infection.

Andersson S, Norrgren H, da Silva Z, Biague A, Bamba S, Kwok S, Christopherson C, Biberfeld G, Albert J.

Arch Intern Med. 2000 Nov 27;160(21):3286-93.


[Reduced frequency of resistant pneumococci in Southern Sweden. Community based disease control projects to minimize antibiotic resistance].

Ekdahl K, Persson K, Mölstad S, Melander E, Norrgren H, Söderström M, Hansson HB.

Lakartidningen. 1999 Jun 16;96(24):2962-5. Review. Swedish.


Trends and interaction of HIV-1 and HIV-2 in Guinea-Bissau, west Africa: no protection of HIV-2 against HIV-1 infection.

Norrgren H, Andersson S, Biague AJ, da Silva ZJ, Dias F, Nauclér A, Biberfeld G.

AIDS. 1999 Apr 16;13(6):701-7.


Child survival in children born to HIV-2 infected women in Guinea-Bissau, West Africa.

Norrgren H, Fonseca A, Andersson S, Dias F, Nauclér A, Biberfeld G.

Acta Trop. 1999 Apr 30;72(3):309-15.


[Staphylococcal epidermal necrolysis occasionally affects children].

Persson G, Norrgren H, Hanson C, Moëll C, Ljungh A.

Lakartidningen. 1999 Mar 24;96(12):1475-6. Swedish. No abstract available.


Clinical features, immunological changes and mortality in a cohort of HIV-2-infected individuals in Bissau, Guinea-Bissau.

Norrgren H, Da Silva ZJ, Andersson S, Biague AJ, Dias F, Biberfeld G, Nauclér A.

Scand J Infect Dis. 1998;30(4):323-9.


Similar birthweight in children born to HIV-2 infected and HIV-negative women in Guinea-Bissau.

Norrgren H, Andersson S, Dias F, Alves A, Nauclér A, Biberfeld G.

Acta Paediatr. 1998 Jul;87(7):816-7. No abstract available.


HIV-2 genetic variation and DNA load in asymptomatic carriers and AIDS cases in Guinea-Bissau.

Norrgren H, Marquina S, Leitner T, Aaby P, Melbye M, Poulsen AG, Larsen O, Dias F, Escanilla D, Andersson S, Albert J, Nauclér A.

J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Sep 1;16(1):31-8.


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