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Necrotizing Soft Tissue Infections S.aureus - but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

Baude J, Bastien S, Gillet Y, Leblanc P, Itzek A, Tristan A, Bes M, Duguez S, Moreau K, Diep BA, Norrby-Teglund A, Henry T, Vandenesch F; INFECT Study Group.

J Infect Dis. 2019 Apr 19. pii: jiz167. doi: 10.1093/infdis/jiz167. [Epub ahead of print]


Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response.

Keller N, Woytschak J, Heeb LEM, Marques Maggio E, Mairpady Shambat S, Snäll J, Hyldegaard O, Boyman O, Norrby-Teglund A, Zinkernagel AS.

J Invest Dermatol. 2019 Jun;139(6):1284-1293. doi: 10.1016/j.jid.2018.11.027. Epub 2018 Dec 10.


High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia.

Alpkvist H, Athlin S, Mölling P, Norrby-Teglund A, Strålin K.

Sci Rep. 2018 Sep 7;8(1):13428. doi: 10.1038/s41598-018-31504-4.


Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

Tarnutzer A, Andreoni F, Keller N, Zürcher C, Norrby-Teglund A, Schüpbach RA, Zinkernagel AS.

Clin Microbiol Infect. 2019 Apr;25(4):512.e7-512.e13. doi: 10.1016/j.cmi.2018.07.007. Epub 2018 Jul 17.


Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis.

Parks T, Wilson C, Curtis N, Norrby-Teglund A, Sriskandan S.

Clin Infect Dis. 2018 Oct 15;67(9):1434-1436. doi: 10.1093/cid/ciy401.


Diabetes and necrotizing soft tissue infections-A prospective observational cohort study: Statistical analysis plan.

Rosén A, Arnell P, Madsen MB, Nedrebø BG, Norrby-Teglund A, Hyldegaard O, Dos Santos VM, Bergey F, Saccenti E; INFECT Study Group, Skrede S.

Acta Anaesthesiol Scand. 2018 Apr 19. doi: 10.1111/aas.13130. [Epub ahead of print]


Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production.

Westman J, Chakrakodi B, Snäll J, Mörgelin M, Bruun Madsen M, Hyldegaard O, Neumann A, Frick IM, Norrby-Teglund A, Björck L, Herwald H.

Front Immunol. 2018 Feb 22;9:236. doi: 10.3389/fimmu.2018.00236. eCollection 2018.


Necrotizing soft tissue infections - a multicentre, prospective observational study (INFECT): protocol and statistical analysis plan.

Madsen MB, Skrede S, Bruun T, Arnell P, Rosén A, Nekludov M, Karlsson Y, Bergey F, Saccenti E, Martins Dos Santos VAP, Perner A, Norrby-Teglund A, Hyldegaard O.

Acta Anaesthesiol Scand. 2018 Feb;62(2):272-279. doi: 10.1111/aas.13024. Epub 2017 Oct 29.


Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

Neumann A, Papareddy P, Westman J, Hyldegaard O, Snäll J, Norrby-Teglund A, Herwald H.

J Innate Immun. 2018;10(1):30-43. doi: 10.1159/000480386. Epub 2017 Oct 17.


Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis.

Kyriazopoulou E, Leventogiannis K, Norrby-Teglund A, Dimopoulos G, Pantazi A, Orfanos SE, Rovina N, Tsangaris I, Gkavogianni T, Botsa E, Chassiou E, Kotanidou A, Kontouli C, Chaloulis P, Velissaris D, Savva A, Cullberg JS, Akinosoglou K, Gogos C, Armaganidis A, Giamarellos-Bourboulis EJ; Hellenic Sepsis Study Group.

BMC Med. 2017 Sep 18;15(1):172. doi: 10.1186/s12916-017-0930-5.


Shocking superantigens promote establishment of bacterial infection.

Siemens N, Norrby-Teglund A.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10000-10002. doi: 10.1073/pnas.1713451114. Epub 2017 Sep 12. No abstract available.


Bacterial deception of MAIT cells in a cloud of superantigen and cytokines.

Sandberg JK, Norrby-Teglund A, Leeansyah E.

PLoS Biol. 2017 Jul 24;15(7):e2003167. doi: 10.1371/journal.pbio.2003167. eCollection 2017 Jul. Review.


Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial.

Madsen MB, Hjortrup PB, Hansen MB, Lange T, Norrby-Teglund A, Hyldegaard O, Perner A.

Intensive Care Med. 2017 Nov;43(11):1585-1593. doi: 10.1007/s00134-017-4786-0. Epub 2017 Apr 18.


Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study.

Hansen MB, Rasmussen LS, Svensson M, Chakrakodi B, Bruun T, Madsen MB, Perner A, Garred P, Hyldegaard O, Norrby-Teglund A; INFECT study group.

Sci Rep. 2017 Feb 8;7:42179. doi: 10.1038/srep42179.


Neutrophils acquire the capacity for antigen presentation to memory CD4+ T cells in vitro and ex vivo.

Vono M, Lin A, Norrby-Teglund A, Koup RA, Liang F, Loré K.

Blood. 2017 Apr 6;129(14):1991-2001. doi: 10.1182/blood-2016-10-744441. Epub 2017 Jan 31.


Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU.

Sundén-Cullberg J, Rylance R, Svefors J, Norrby-Teglund A, Björk J, Inghammar M.

Crit Care Med. 2017 Apr;45(4):591-599. doi: 10.1097/CCM.0000000000002249.


Biofilm in group A streptococcal necrotizing soft tissue infections.

Siemens N, Chakrakodi B, Shambat SM, Morgan M, Bergsten H, Hyldegaard O, Skrede S, Arnell P, Madsen MB, Johansson L; INFECT Study Group, Juarez J, Bosnjak L, Mörgelin M, Svensson M, Norrby-Teglund A.

JCI Insight. 2016 Jul 7;1(10):e87882. doi: 10.1172/jci.insight.87882.


In tribute to Singh Chhatwal.

Norrby-Teglund A.

Environ Microbiol Rep. 2016 Oct;8(5):555. doi: 10.1111/1758-2229.12463. No abstract available.


Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation.

Uhlmann J, Siemens N, Kai-Larsen Y, Fiedler T, Bergman P, Johansson L, Norrby-Teglund A.

J Infect Dis. 2016 Dec 15;214(12):1876-1883. Epub 2016 Sep 28.


A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains.

Mairpady Shambat S, Siemens N, Monk IR, Mohan DB, Mukundan S, Krishnan KC, Prabhakara S, Snäll J, Kearns A, Vandenesch F, Svensson M, Kotb M, Gopal B, Arakere G, Norrby-Teglund A.

Sci Rep. 2016 Aug 11;6:31360. doi: 10.1038/srep31360.


Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse.

Chella Krishnan K, Mukundan S, Alagarsamy J, Hur J, Nookala S, Siemens N, Svensson M, Hyldegaard O, Norrby-Teglund A, Kotb M.

PLoS Pathog. 2016 Jul 11;12(7):e1005732. doi: 10.1371/journal.ppat.1005732. eCollection 2016 Jul.


Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release.

Snäll J, Linnér A, Uhlmann J, Siemens N, Ibold H, Janos M, Linder A, Kreikemeyer B, Herwald H, Johansson L, Norrby-Teglund A.

Sci Rep. 2016 Feb 18;6:21288. doi: 10.1038/srep21288.


Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

Westman J, Papareddy P, Dahlgren MW, Chakrakodi B, Norrby-Teglund A, Smeds E, Linder A, Mörgelin M, Johansson-Lindbom B, Egesten A, Herwald H.

PLoS Pathog. 2015 Dec 8;11(12):e1005319. doi: 10.1371/journal.ppat.1005319. eCollection 2015 Dec.


LL-37 Triggers Formation of Streptococcus pyogenes Extracellular Vesicle-Like Structures with Immune Stimulatory Properties.

Uhlmann J, Rohde M, Siemens N, Kreikemeyer B, Bergman P, Johansson L, Norrby-Teglund A.

J Innate Immun. 2016;8(3):243-57. doi: 10.1159/000441896. Epub 2015 Dec 8.


Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections.

Siemens N, Kittang BR, Chakrakodi B, Oppegaard O, Johansson L, Bruun T, Mylvaganam H; INFECT Study Group, Svensson M, Skrede S, Norrby-Teglund A.

Sci Rep. 2015 Nov 25;5:16945. doi: 10.1038/srep16945.


Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology.

Mairpady Shambat S, Chen P, Nguyen Hoang AT, Bergsten H, Vandenesch F, Siemens N, Lina G, Monk IR, Foster TJ, Arakere G, Svensson M, Norrby-Teglund A.

Dis Model Mech. 2015 Nov;8(11):1413-25. doi: 10.1242/dmm.021923. Epub 2015 Sep 3.


Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein.

Lannergård J, Kristensen BM, Gustafsson MC, Persson JJ, Norrby-Teglund A, Stålhammar-Carlemalm M, Lindahl G.

Microbiologyopen. 2015 Oct;4(5):774-89. doi: 10.1002/mbo3.278. Epub 2015 Jul 15.


Reply to Arends and Harkisoen.

Linnér A, Sjölin J, Darenberg J, Henriques-Normark B, Norrby-Teglund A.

Clin Infect Dis. 2015 Jan 15;60(2):324-5. doi: 10.1093/cid/ciu800. Epub 2014 Oct 13. No abstract available.


Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community-associated Staphylococcus aureus isolates.

Mairpady Shambat S, Haggar A, Vandenesch F, Lina G, van Wamel WJ, Arakere G, Svensson M, Norrby-Teglund A.

PLoS One. 2014 Aug 28;9(8):e106107. doi: 10.1371/journal.pone.0106107. eCollection 2014.


Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study.

Linnér A, Darenberg J, Sjölin J, Henriques-Normark B, Norrby-Teglund A.

Clin Infect Dis. 2014 Sep 15;59(6):851-7. doi: 10.1093/cid/ciu449. Epub 2014 Jun 13.


HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes.

Johansson L, Snäll J, Sendi P, Linnér A, Thulin P, Linder A, Treutiger CJ, Norrby-Teglund A.

Front Cell Infect Microbiol. 2014 Jan 30;4:4. doi: 10.3389/fcimb.2014.00004. eCollection 2014.


Short- and long-term mortality in severe sepsis/septic shock in a setting with low antibiotic resistance: a prospective observational study in a Swedish university hospital.

Linnér A, Sundén-Cullberg J, Johansson L, Hjelmqvist H, Norrby-Teglund A, Treutiger CJ.

Front Public Health. 2013 Nov 15;1:51. doi: 10.3389/fpubh.2013.00051. eCollection 2013.


Beyond the traditional immune response: bacterial interaction with phagocytic cells.

Norrby-Teglund A, Johansson L.

Int J Antimicrob Agents. 2013 Jun;42 Suppl:S13-6. doi: 10.1016/j.ijantimicag.2013.04.005. Epub 2013 May 16. Review.


Prognostic value and therapeutic potential of TREM-1 in Streptococcus pyogenes- induced sepsis.

Horst SA, Linnér A, Beineke A, Lehne S, Höltje C, Hecht A, Norrby-Teglund A, Medina E, Goldmann O.

J Innate Immun. 2013;5(6):581-90. doi: 10.1159/000348283. Epub 2013 Apr 4.


Genome sequencing unveils a novel sea enterotoxin-carrying PVL phage in Staphylococcus aureus ST772 from India.

Prabhakara S, Khedkar S, Shambat SM, Srinivasan R, Basu A, Norrby-Teglund A, Seshasayee AS, Arakere G.

PLoS One. 2013;8(3):e60013. doi: 10.1371/journal.pone.0060013. Epub 2013 Mar 27.


Immunopathogenesis of streptococcal deep tissue infections.

Johansson L, Norrby-Teglund A.

Curr Top Microbiol Immunol. 2013;368:173-88. doi: 10.1007/82_2012_282. Review.


Risk assessment in sepsis: a new prognostication rule by APACHE II score and serum soluble urokinase plasminogen activator receptor.

Giamarellos-Bourboulis EJ, Norrby-Teglund A, Mylona V, Savva A, Tsangaris I, Dimopoulou I, Mouktaroudi M, Raftogiannis M, Georgitsi M, Linnér A, Adamis G, Antonopoulou A, Apostolidou E, Chrisofos M, Katsenos C, Koutelidakis I, Kotzampassi K, Koratzanis G, Koupetori M, Kritselis I, Lymberopoulou K, Mandragos K, Marioli A, Sundén-Cullberg J, Mega A, Prekates A, Routsi C, Gogos C, Treutiger CJ, Armaganidis A, Dimopoulos G.

Crit Care. 2012 Aug 8;16(4):R149. doi: 10.1186/cc11463.


Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile.

Hertzén E, Johansson L, Kansal R, Hecht A, Dahesh S, Janos M, Nizet V, Kotb M, Norrby-Teglund A.

PLoS One. 2012;7(4):e35218. doi: 10.1371/journal.pone.0035218. Epub 2012 Apr 12.


Clinical and microbiologic characteristics of invasive Streptococcus pyogenes infections in north and south India.

Haggar A, Nerlich A, Kumar R, Abraham VJ, Brahmadathan KN, Ray P, Dhanda V, Joshua JM, Mehra N, Bergmann R, Chhatwal GS, Norrby-Teglund A.

J Clin Microbiol. 2012 May;50(5):1626-31. doi: 10.1128/JCM.06697-11. Epub 2012 Feb 22.


The Hypervariable region of Streptococcus pyogenes M protein escapes antibody attack by antigenic variation and weak immunogenicity.

Lannergård J, Gustafsson MC, Waldemarsson J, Norrby-Teglund A, Stålhammar-Carlemalm M, Lindahl G.

Cell Host Microbe. 2011 Aug 18;10(2):147-57. doi: 10.1016/j.chom.2011.06.011.


Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense.

Loof TG, Mörgelin M, Johansson L, Oehmcke S, Olin AI, Dickneite G, Norrby-Teglund A, Theopold U, Herwald H.

Blood. 2011 Sep 1;118(9):2589-98. doi: 10.1182/blood-2011-02-337568. Epub 2011 May 25.


Reduced iNOS expression in adenoids from children with otitis media with effusion.

Granath A, Norrby-Teglund A, Uddman R, Cardell LO.

Pediatr Allergy Immunol. 2010 Dec;21(8):1151-6. doi: 10.1111/j.1399-3038.2010.01020.x.


M1 protein-dependent intracellular trafficking promotes persistence and replication of Streptococcus pyogenes in macrophages.

Hertzén E, Johansson L, Wallin R, Schmidt H, Kroll M, Rehn AP, Kotb M, Mörgelin M, Norrby-Teglund A.

J Innate Immun. 2010;2(6):534-45. doi: 10.1159/000317635. Epub 2010 Aug 27.


Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes.

Goldmann O, Hertzén E, Hecht A, Schmidt H, Lehne S, Norrby-Teglund A, Medina E.

J Immunol. 2010 Aug 15;185(4):2372-81. doi: 10.4049/jimmunol.1000838. Epub 2010 Jul 19.


Getting under the skin: the immunopathogenesis of Streptococcus pyogenes deep tissue infections.

Johansson L, Thulin P, Low DE, Norrby-Teglund A.

Clin Infect Dis. 2010 Jul 1;51(1):58-65. doi: 10.1086/653116. Review.


Erysipelas caused by group A streptococcus activates the contact system and induces the release of heparin-binding protein.

Linder A, Johansson L, Thulin P, Hertzén E, Mörgelin M, Christensson B, Björck L, Norrby-Teglund A, Akesson P.

J Invest Dermatol. 2010 May;130(5):1365-72. doi: 10.1038/jid.2009.437. Epub 2010 Jan 28.


Protein C inhibitor--a novel antimicrobial agent.

Malmström E, Mörgelin M, Malmsten M, Johansson L, Norrby-Teglund A, Shannon O, Schmidtchen A, Meijers JC, Herwald H.

PLoS Pathog. 2009 Dec;5(12):e1000698. doi: 10.1371/journal.ppat.1000698. Epub 2009 Dec 18.


Severe group A streptococcal infections in Uppsala County, Sweden: clinical and molecular characterization of a case cluster from 2006 to 2007.

Vikerfors A, Haggar A, Darenberg J, Low A, Melhus A, Hedlund J, Sylvan S, Norrby-Teglund A, Eriksson BM.

Scand J Infect Dis. 2009;41(11-12):823-30. doi: 10.3109/00365540903179749.


Extracellular adherence protein (Eap) from Staphylococcus aureus does not function as a superantigen.

Haggar A, Flock JI, Norrby-Teglund A.

Clin Microbiol Infect. 2010 Aug;16(8):1155-8. doi: 10.1111/j.1469-0691.2009.03058.x. Epub 2009 Sep 21.


Neutrophil-derived hyperresistinemia in severe acute streptococcal infections.

Johansson L, Linnér A, Sundén-Cullberg J, Haggar A, Herwald H, Loré K, Treutiger CJ, Norrby-Teglund A.

J Immunol. 2009 Sep 15;183(6):4047-54. doi: 10.4049/jimmunol.0901541. Epub 2009 Aug 28.

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