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A Combination Of Approved Antibodies Overcomes Resistance Of Lung Cancer To Osimertinib By Blocking Bypass Pathways.

Romaniello D, Mazzeo L, Mancini M, Marrocco I, Noronha A, Kreitman MS, Srivastava S, Ghosh S, Lindzen M, Salame TM, Onn A, Bar J, Yarden Y.

Clin Cancer Res. 2018 Jul 2. pii: clincanres.0450.2018. doi: 10.1158/1078-0432.CCR-18-0450. [Epub ahead of print]


Leishmanicidal and fungicidal activity of lipases obtained from endophytic fungi extracts.

Alves DR, Morais SM, Tomiotto-Pellissier F, Vasconcelos FR, Freire FDCO, Silva INGD, Cataneo AHD, Miranda-Sapla MM, Pinto GAS, Conchon-Costa I, Noronha AAA, Pavanelli WR.

PLoS One. 2018 Jun 18;13(6):e0196796. doi: 10.1371/journal.pone.0196796. eCollection 2018.


Irreversible modifications of receptor tyrosine kinases.

Kreitman M, Noronha A, Yarden Y.

FEBS Lett. 2018 May 22. doi: 10.1002/1873-3468.13095. [Epub ahead of print]


Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis.

Nunes S, Silva IB, Ampuero MR, de Noronha ALL, de Souza LCL, Correia TC, Khouri R, Boaventura VS, Barral A, Ramos PIP, Brodskyn C, Oliveira PRS, Tavares NM.

Front Immunol. 2018 Apr 4;9:640. doi: 10.3389/fimmu.2018.00640. eCollection 2018.


Recon3D enables a three-dimensional view of gene variation in human metabolism.

Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Dräger A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlić A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO.

Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19.


SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors.

Roth L, Srivastava S, Lindzen M, Sas-Chen A, Sheffer M, Lauriola M, Enuka Y, Noronha A, Mancini M, Lavi S, Tarcic G, Pines G, Nevo N, Heyman O, Ziv T, Rueda OM, Gnocchi D, Pikarsky E, Admon A, Caldas C, Yarden Y.

Sci Signal. 2018 Jan 30;11(515). pii: eaan0949. doi: 10.1126/scisignal.aan0949.


An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors.

Mancini M, Gal H, Gaborit N, Mazzeo L, Romaniello D, Salame TM, Lindzen M, Mahlknecht G, Enuka Y, Burton DG, Roth L, Noronha A, Marrocco I, Adreka D, Altstadter RE, Bousquet E, Downward J, Maraver A, Krizhanovsky V, Yarden Y.

EMBO Mol Med. 2018 Feb;10(2):294-308. doi: 10.15252/emmm.201708076.


Medications for alcohol use disorders: An overview.

Akbar M, Egli M, Cho YE, Song BJ, Noronha A.

Pharmacol Ther. 2018 May;185:64-85. doi: 10.1016/j.pharmthera.2017.11.007. Epub 2017 Dec 2. Review.


Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein.

Schoonhoven NM, O'Flaherty DK, McManus FP, Sacre L, Noronha AM, Kornblatt MJ, Wilds CJ.

Molecules. 2017 Nov 11;22(11). pii: E1948. doi: 10.3390/molecules22111948.


Comparative evaluation of atom mapping algorithms for balanced metabolic reactions: application to Recon 3D.

Preciat Gonzalez GA, El Assal LRP, Noronha A, Thiele I, Haraldsdóttir HS, Fleming RMT.

J Cheminform. 2017 Jun 14;9(1):39. doi: 10.1186/s13321-017-0223-1.


The conception of the ABCD study: From substance use to a broad NIH collaboration.

Volkow ND, Koob GF, Croyle RT, Bianchi DW, Gordon JA, Koroshetz WJ, Pérez-Stable EJ, Riley WT, Bloch MH, Conway K, Deeds BG, Dowling GJ, Grant S, Howlett KD, Matochik JA, Morgan GD, Murray MM, Noronha A, Spong CY, Wargo EM, Warren KR, Weiss SRB.

Dev Cogn Neurosci. 2018 Aug;32:4-7. doi: 10.1016/j.dcn.2017.10.002. Epub 2017 Oct 10. Review.


Influence of nucleotide modifications at the C2' position on the Hoogsteen base-paired parallel-stranded duplex of poly(A) RNA.

Copp W, Denisov AY, Xie J, Noronha AM, Liczner C, Safaee N, Wilds CJ, Gehring K.

Nucleic Acids Res. 2017 Sep 29;45(17):10321-10331. doi: 10.1093/nar/gkx713.


Structural basis of interstrand cross-link repair by O6-alkylguanine DNA alkyltransferase.

Denisov AY, McManus FP, O'Flaherty DK, Noronha AM, Wilds CJ.

Org Biomol Chem. 2017 Oct 11;15(39):8361-8370. doi: 10.1039/c7ob02093g.


Fertility Life Table of Tetranychus palmarum Flechtmann & Noronha (Acari: Tetranychidae) in Oil Palm.

Noronha ACS, Ferreira CT, Tavares EJM, Lima DB.

Neotrop Entomol. 2017 Aug 13. doi: 10.1007/s13744-017-0550-y. [Epub ahead of print]


Phytoseiid mites (Acari: Phytoseiidae) associated with tropical ornamental plants, with a checklist and a key to the species of Bahia, Brazil.

Argolo PS, Santos RMV, Bittencourt MAL, Noronha ACDS, Moraes GJ, Oliveira AR.

Zootaxa. 2017 May 1;4258(4):345-364. doi: 10.11646/zootaxa.4258.4.3.


Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.

Vogel Ciernia A, Pride MC, Durbin-Johnson B, Noronha A, Chang A, Yasui DH, Crawley JN, LaSalle JM.

Hum Mol Genet. 2017 May 15;26(10):1839-1854. doi: 10.1093/hmg/ddx087.


Genetic studies of alcohol dependence in the context of the addiction cycle.

Reilly MT, Noronha A, Goldman D, Koob GF.

Neuropharmacology. 2017 Aug 1;122:3-21. doi: 10.1016/j.neuropharm.2017.01.017. Epub 2017 Jan 22. Review.


ReconMap: an interactive visualization of human metabolism.

Noronha A, Daníelsdóttir AD, Gawron P, Jóhannsson F, Jónsdóttir S, Jarlsson S, Gunnarsson JP, Brynjólfsson S, Schneider R, Thiele I, Fleming RM.

Bioinformatics. 2017 Feb 15;33(4):605-607. doi: 10.1093/bioinformatics/btw667.


Perceptions of adolescents' family members about therapeutic workshops in a child psychosocial care center.

Noronha AA, Folle D, Guimarães AN, Brum ML, Schneider JF, Motta MD.

Rev Gaucha Enferm. 2016 Dec 15;37(4):e56061. doi: 10.1590/1983-1447.2016.04.56061. Portuguese, English.


Brain mechanisms of Change in Addictions Treatment: Models, Methods, and Emerging Findings.

Chung T, Noronha A, Carroll KM, Potenza MN, Hutchison K, Calhoun VD, Gabrieli JD, Morgenstern J, Nixon SJ, Wexler BE, Brewer J, Ray L, Filbey F, Strauman TJ, Kober H, Feldstein Ewing SW.

Curr Addict Rep. 2016 Sep;3(3):332-342. Epub 2016 Jul 9.


Leigh map: A novel computational diagnostic resource for mitochondrial disease.

Rahman J, Noronha A, Thiele I, Rahman S.

Ann Neurol. 2017 Jan;81(1):9-16. doi: 10.1002/ana.24835. No abstract available.


Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota.

Magnúsdóttir S, Heinken A, Kutt L, Ravcheev DA, Bauer E, Noronha A, Greenhalgh K, Jäger C, Baginska J, Wilmes P, Fleming RM, Thiele I.

Nat Biotechnol. 2017 Jan;35(1):81-89. doi: 10.1038/nbt.3703. Epub 2016 Nov 28.


O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.

Xu W, Kool D, O'Flaherty DK, Keating AM, Sacre L, Egli M, Noronha A, Wilds CJ, Zhao L.

Chem Res Toxicol. 2016 Nov 21;29(11):1872-1882. Epub 2016 Nov 4.


Transcultural adaptation of the Johns Hopkins Fall Risk Assessment Tool.

Martinez MC, Iwamoto VE, Latorre Mdo R, Noronha AM, Oliveira AP, Cardoso CE, Marques IA, Vendramim P, Lopes PC, Sant'Ana TH.

Rev Lat Am Enfermagem. 2016 Aug 29;24:e2783. doi: 10.1590/1518-8345.1158.2783. English, Portuguese, Spanish.


Punctuated Shutdown of Atlantic Meridional Overturning Circulation during Greenland Stadial 1.

Hogg A, Southon J, Turney C, Palmer J, Bronk Ramsey C, Fenwick P, Boswijk G, Friedrich M, Helle G, Hughen K, Jones R, Kromer B, Noronha A, Reynard L, Staff R, Wacker L.

Sci Rep. 2016 May 19;6:25902. doi: 10.1038/srep25902.


Influenza and Pneumococcal Vaccination Rates in Patients With Inflammatory Bowel Disease.

Reich JS, Miller HL, Wasan SK, Noronha A, Ardagna E, Sullivan K, Jacobson B, Farraye FA.

Gastroenterol Hepatol (N Y). 2015 Jun;11(6):396-401.


Scale Insects (Hemiptera: Coccoidea) on Myrciaria dubia (Myrtaceae) in Brazil.

Wolff VR, Kondo T, Peronti AL, Noronha AC.

Neotrop Entomol. 2016 Jun;45(3):274-9. doi: 10.1007/s13744-016-0365-2. Epub 2016 Mar 8.


How Mental Health Is Shortchanged by Lack of Reimbursement for Vagus Nerve Stimulation.

Meyer JP, Noronha AM, Brozak S.

Brain Stimul. 2016 Mar-Apr;9(2):163-5. doi: 10.1016/j.brs.2015.12.002. Epub 2015 Dec 30. No abstract available.


Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer.

Bhat S, Kabekkodu SP, Noronha A, Satyamoorthy K.

Biochimie. 2016 Feb;121:298-311. doi: 10.1016/j.biochi.2015.12.018. Epub 2015 Dec 29. Review.


Elective colectomy for severe ulcerative colitis may reduce mortality more than medical therapy.

Naidu H, Farraye FA, Noronha A.

Evid Based Med. 2016 Feb;21(1):29. doi: 10.1136/ebmed-2015-110311. Epub 2015 Dec 7. No abstract available.


Do genome-scale models need exact solvers or clearer standards?

Ebrahim A, Almaas E, Bauer E, Bordbar A, Burgard AP, Chang RL, Dräger A, Famili I, Feist AM, Fleming RM, Fong SS, Hatzimanikatis V, Herrgård MJ, Holder A, Hucka M, Hyduke D, Jamshidi N, Lee SY, Le Novère N, Lerman JA, Lewis NE, Ma D, Mahadevan R, Maranas C, Nagarajan H, Navid A, Nielsen J, Nielsen LK, Nogales J, Noronha A, Pal C, Palsson BO, Papin JA, Patil KR, Price ND, Reed JL, Saunders M, Senger RS, Sonnenschein N, Sun Y, Thiele I.

Mol Syst Biol. 2015 Oct 14;11(10):831. doi: 10.15252/msb.20156157. No abstract available.


Brain pathways to recovery from alcohol dependence.

Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV.

Alcohol. 2015 Aug;49(5):435-52. doi: 10.1016/j.alcohol.2015.04.006. Epub 2015 May 14.


Antibacterial action of doped CoFe2O4 nanocrystals on multidrug resistant bacterial strains.

Velho-Pereira S, Noronha A, Mathias A, Zakane R, Naik V, Naik P, Salker AV, Naik SR.

Mater Sci Eng C Mater Biol Appl. 2015;52:282-7. doi: 10.1016/j.msec.2015.03.046. Epub 2015 Mar 25.


Synthesis of building blocks and oligonucleotides containing {T}O4-alkylene-O4{T} interstrand cross-links.

O'Flaherty DK, McManus FP, Noronha AM, Wilds CJ.

Curr Protoc Nucleic Acid Chem. 2014 Dec 19;55:5.13.1-19. doi: 10.1002/0471142700.nc0513s55. Review.


Reductively-sheddable cationic nanocarriers for dual chemotherapy and gene therapy with enhanced release.

Ko NR, Cheong J, Noronha A, Wilds CJ, Oh JK.

Colloids Surf B Biointerfaces. 2015 Feb 1;126:178-87. doi: 10.1016/j.colsurfb.2014.12.010. Epub 2014 Dec 18.


An integrated network visualization framework towards metabolic engineering applications.

Noronha A, Vilaça P, Rocha M.

BMC Bioinformatics. 2014 Dec 30;15:420. doi: 10.1186/s12859-014-0420-0.


Perspectives on the neuroscience of alcohol from the National Institute on Alcohol Abuse and Alcoholism.

Reilly MT, Noronha A, Warren K.

Handb Clin Neurol. 2014;125:15-29. doi: 10.1016/B978-0-444-62619-6.00002-1. Review.


Bender-gradual scoring system: performance of Brazilian and Peruvian children.

dos Santos AA, Noronha AP, Rueda FJ, Segovia JL.

Percept Mot Skills. 2014 Jun;118(3):897-908. doi: 10.2466/03.10.PMS.118k25w7. Epub 2014 Apr 25.


NMR structure of an ethylene interstrand cross-linked DNA which mimics the lesion formed by 1,3-bis(2-chloroethyl)-1-nitrosourea.

O'Flaherty DK, Denisov AY, Noronha AM, Wilds CJ.

ChemMedChem. 2014 Sep;9(9):2099-103. doi: 10.1002/cmdc.201402121. Epub 2014 Jun 16.


A 21st century nosocomial issue with endoscopes.

Noronha AM, Brozak S.

BMJ. 2014 Mar 19;348:g2047. doi: 10.1136/bmj.g2047. No abstract available.


The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment.

Robinson AP, Harp CT, Noronha A, Miller SD.

Handb Clin Neurol. 2014;122:173-89. doi: 10.1016/B978-0-444-52001-2.00008-X. Review.


Systematic review of human papillomavirus vaccine coadministration.

Noronha AS, Markowitz LE, Dunne EF.

Vaccine. 2014 May 13;32(23):2670-4. doi: 10.1016/j.vaccine.2013.12.037. Epub 2014 Jan 8. Review.


Structure of the parallel duplex of poly(A) RNA: evaluation of a 50 year-old prediction.

Safaee N, Noronha AM, Rodionov D, Kozlov G, Wilds CJ, Sheldrick GM, Gehring K.

Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10370-3. doi: 10.1002/anie.201303461. Epub 2013 Jun 27. No abstract available.


Multichange isothermal mutagenesis: a new strategy for multiple site-directed mutations in plasmid DNA.

Mitchell LA, Cai Y, Taylor M, Noronha AM, Chuang J, Dai L, Boeke JD.

ACS Synth Biol. 2013 Aug 16;2(8):473-7. doi: 10.1021/sb300131w. Epub 2013 Mar 11.


Carcinoma ex pleomorphic adenoma in a Brazilian population: clinico-pathological analysis of 38 cases.

Mariano FV, Noronha AL, Gondak RO, Altemani AM, de Almeida OP, Kowalski LP.

Int J Oral Maxillofac Surg. 2013 Jun;42(6):685-92. doi: 10.1016/j.ijom.2013.02.012. Epub 2013 Apr 2.


B cells secrete eotaxin-1 in human inflammatory bowel disease.

Rehman MQ, Beal D, Liang Y, Noronha A, Winter H, Farraye FA, Ganley-Leal L.

Inflamm Bowel Dis. 2013 Apr;19(5):922-33. doi: 10.1097/MIB.0b013e3182802950.


Treatments for invasive carcinoma of the cervix: what are their impacts on the pelvic floor functions?

Noronha AF, Mello de Figueiredo E, Rossi de Figueiredo Franco TM, Cândido EB, Silva-Filho AL.

Int Braz J Urol. 2013 Jan-Feb;39(1):46-54. doi: 10.1590/S1677-5538.IBJU.2013.01.07.


Preparation of covalently linked complexes between DNA and O(6)-alkylguanine-DNA alkyltransferase using interstrand cross-linked DNA.

McManus FP, Khaira A, Noronha AM, Wilds CJ.

Bioconjug Chem. 2013 Feb 20;24(2):224-33. doi: 10.1021/bc300553u. Epub 2013 Jan 24.


CD8(+) granzyme B(+)-mediated tissue injury vs. CD4(+)IFNγ(+)-mediated parasite killing in human cutaneous leishmaniasis.

Santos Cda S, Boaventura V, Ribeiro Cardoso C, Tavares N, Lordelo MJ, Noronha A, Costa J, Borges VM, de Oliveira CI, Van Weyenbergh J, Barral A, Barral-Netto M, Brodskyn CI.

J Invest Dermatol. 2013 Jun;133(6):1533-40. doi: 10.1038/jid.2013.4. Epub 2013 Jan 15. Erratum in: J Invest Dermatol. 2014 Nov;134(11):2850.


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