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The rise of hyper-virulence.

Aschtgen MS, Henriques-Normark B, Normark S.

J Intern Med. 2020 Jan 19. doi: 10.1111/joim.13018. [Epub ahead of print] No abstract available.


Emerging concepts in the pathogenesis of the Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen.

Subramanian K, Henriques-Normark B, Normark S.

Cell Microbiol. 2019 Nov;21(11):e13077. doi: 10.1111/cmi.13077. Epub 2019 Jul 17.


Pathogenesis and prevention of risk of cardiovascular events in patients with pneumococcal community-acquired pneumonia.

Feldman C, Normark S, Henriques-Normark B, Anderson R.

J Intern Med. 2019 Jun;285(6):635-652. doi: 10.1111/joim.12875. Epub 2019 Jan 29. Review.


Impact of AmpC Derepression on Fitness and Virulence: the Mechanism or the Pathway?

Pérez-Gallego M, Torrens G, Castillo-Vera J, Moya B, Zamorano L, Cabot G, Hultenby K, Albertí S, Mellroth P, Henriques-Normark B, Normark S, Oliver A, Juan C.

mBio. 2016 Oct 25;7(5). pii: e01783-16. doi: 10.1128/mBio.01783-16.


Streptococcal M1 Strikes by Neutralizing Cathelicidins.

Henriques-Normark B, Normark S.

Cell Host Microbe. 2015 Oct 14;18(4):390-1. doi: 10.1016/j.chom.2015.10.002.


Introducing npj Biofilms and Microbiomes.

Normark S.

NPJ Biofilms Microbiomes. 2015 Mar 25;1:15004. doi: 10.1038/npjbiofilms.2015.4. eCollection 2015. No abstract available.


Uptake of extracellular DNA: competence induced pili in natural transformation of Streptococcus pneumoniae.

Muschiol S, Balaban M, Normark S, Henriques-Normark B.

Bioessays. 2015 Apr;37(4):426-35. doi: 10.1002/bies.201400125. Epub 2015 Jan 15.


Microbial biofilm formation: a need to act.

Römling U, Kjelleberg S, Normark S, Nyman L, Uhlin BE, Åkerlund B.

J Intern Med. 2014 Aug;276(2):98-110. doi: 10.1111/joim.12242. Epub 2014 May 6. Review. No abstract available. Erratum in: J Intern Med. 2015 Oct;278(4):427.


Bacterial vaccines and antibiotic resistance.

Henriques-Normark B, Normark S.

Ups J Med Sci. 2014 May;119(2):205-8. doi: 10.3109/03009734.2014.903324. Epub 2014 Apr 3. Review.


Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation.

Balaban M, Bättig P, Muschiol S, Tirier SM, Wartha F, Normark S, Henriques-Normark B.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):E758-65. doi: 10.1073/pnas.1313860111. Epub 2014 Feb 3.


Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae.

Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A.

mBio. 2014 Feb 11;5(1):e01120-13. doi: 10.1128/mBio.01120-13.


Emergence of hypervirulent mutants resistant to early clearance during systemic serotype 1 pneumococcal infection in mice and humans.

Syk A, Norman M, Fernebro J, Gallotta M, Farmand S, Sandgren A, Normark S, Henriques-Normark B.

J Infect Dis. 2014 Jul 1;210(1):4-13. Epub 2014 Jan 16.


The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.

Schulte T, Löfling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A.

Open Biol. 2014 Jan 15;4:130090. doi: 10.1098/rsob.130090. Erratum in: Open Biol. 2014;4:140172.


Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis.

Kandaswamy K, Liew TH, Wang CY, Huston-Warren E, Meyer-Hoffert U, Hultenby K, Schröder JM, Caparon MG, Normark S, Henriques-Normark B, Hultgren SJ, Kline KA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20230-5. doi: 10.1073/pnas.1319066110. Epub 2013 Nov 4.


Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection.

Croucher NJ, Mitchell AM, Gould KA, Inverarity D, Barquist L, Feltwell T, Fookes MC, Harris SR, Dordel J, Salter SJ, Browall S, Zemlickova H, Parkhill J, Normark S, Henriques-Normark B, Hinds J, Mitchell TJ, Bentley SD.

PLoS Genet. 2013;9(10):e1003868. doi: 10.1371/journal.pgen.1003868. Epub 2013 Oct 10.


Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children.

Browall S, Norman M, Tångrot J, Galanis I, Sjöström K, Dagerhamn J, Hellberg C, Pathak A, Spadafina T, Sandgren A, Bättig P, Franzén O, Andersson B, Örtqvist Å, Normark S, Henriques-Normark B.

J Infect Dis. 2014 Feb 1;209(3):377-88. doi: 10.1093/infdis/jit481. Epub 2013 Sep 5.


Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.

Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.

J Bacteriol. 2013 Oct;195(19):4484-95. doi: 10.1128/JB.00451-13. Epub 2013 Aug 2.


Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae.

Kuri T, Sörensen AS, Thomas S, Karlsson Hedestam GB, Normark S, Henriques-Normark B, McInerney GM, Plant L.

Cell Microbiol. 2013 Aug;15(8):1385-400. doi: 10.1111/cmi.12122. Epub 2013 Mar 14.


Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease.

Orrskog S, Rounioja S, Spadafina T, Gallotta M, Norman M, Hentrich K, Fälker S, Ygberg-Eriksson S, Hasenberg M, Johansson B, Uotila LM, Gahmberg CG, Barocchi M, Gunzer M, Normark S, Henriques-Normark B.

mBio. 2012 Dec 26;4(1):e00535-12. doi: 10.1128/mBio.00535-12.


The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.

Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ.

mBio. 2012 Jul 24;3(4):e00177-12. doi: 10.1128/mBio.00177-12. Print 2012.


LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan.

Mellroth P, Daniels R, Eberhardt A, Rönnlund D, Blom H, Widengren J, Normark S, Henriques-Normark B.

J Biol Chem. 2012 Mar 30;287(14):11018-29. doi: 10.1074/jbc.M111.318584. Epub 2012 Feb 9.


Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients.

Cederlund A, Olliver M, Rekha RS, Lindh M, Lindbom L, Normark S, Henriques-Normark B, Andersson J, Agerberth B, Bergman P.

PLoS One. 2011;6(12):e29316. doi: 10.1371/journal.pone.0029316. Epub 2011 Dec 27.


A method for metagenomics of Helicobacter pylori from archived formalin-fixed gastric biopsies permitting longitudinal studies of carcinogenic risk.

Zheng Z, Andersson AF, Ye W, Nyrén O, Normark S, Engstrand L.

PLoS One. 2011;6(10):e26442. doi: 10.1371/journal.pone.0026442. Epub 2011 Oct 21.


Studies on the antibacterial effects of statins--in vitro and in vivo.

Bergman P, Linde C, Pütsep K, Pohanka A, Normark S, Henriques-Normark B, Andersson J, Björkhem-Bergman L.

PLoS One. 2011;6(8):e24394. doi: 10.1371/journal.pone.0024394. Epub 2011 Aug 30.


Identification of a family of effectors secreted by the type III secretion system that are conserved in pathogenic Chlamydiae.

Muschiol S, Boncompain G, Vromman F, Dehoux P, Normark S, Henriques-Normark B, Subtil A.

Infect Immun. 2011 Feb;79(2):571-80. doi: 10.1128/IAI.00825-10. Epub 2010 Nov 15.


Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes.

Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW.

Mucosal Immunol. 2011 May;4(3):325-34. doi: 10.1038/mi.2010.71. Epub 2010 Oct 27.


Commensal pathogens, with a focus on Streptococcus pneumoniae, and interactions with the human host.

Henriques-Normark B, Normark S.

Exp Cell Res. 2010 May 1;316(8):1408-14. doi: 10.1016/j.yexcr.2010.03.003. Epub 2010 Mar 19. Review.


Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression.

Littmann M, Albiger B, Frentzen A, Normark S, Henriques-Normark B, Plant L.

EMBO Mol Med. 2009 Jul;1(4):211-22. doi: 10.1002/emmm.200900025.


Disulfide bond formation and cysteine exclusion in gram-positive bacteria.

Daniels R, Mellroth P, Bernsel A, Neiers F, Normark S, von Heijne G, Henriques-Normark B.

J Biol Chem. 2010 Jan 29;285(5):3300-9. doi: 10.1074/jbc.M109.081398. Epub 2009 Nov 24.


Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity.

Neiers F, Madhurantakam C, Fälker S, Manzano C, Dessen A, Normark S, Henriques-Normark B, Achour A.

J Mol Biol. 2009 Oct 30;393(3):704-16. doi: 10.1016/j.jmb.2009.08.058. Epub 2009 Aug 31.


Bacterial adhesins in host-microbe interactions.

Kline KA, Fälker S, Dahlberg S, Normark S, Henriques-Normark B.

Cell Host Microbe. 2009 Jun 18;5(6):580-92. doi: 10.1016/j.chom.2009.05.011. Review.


A changing gastric environment leads to adaptation of lipopolysaccharide variants in Helicobacter pylori populations during colonization.

Skoglund A, Bäckhed HK, Nilsson C, Björkholm B, Normark S, Engstrand L.

PLoS One. 2009 Jun 11;4(6):e5885. doi: 10.1371/journal.pone.0005885.


Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells.

Muschiol S, Normark S, Henriques-Normark B, Subtil A.

BMC Microbiol. 2009 Apr 21;9:75. doi: 10.1186/1471-2180-9-75.


High abundance of virulence gene homologues in marine bacteria.

Persson OP, Pinhassi J, Riemann L, Marklund BI, Rhen M, Normark S, González JM, Hagström A.

Environ Microbiol. 2009 Jun;11(6):1348-57. doi: 10.1111/j.1462-2920.2008.01861.x. Epub 2009 Feb 4.


Pattern of accessory regions and invasive disease potential in Streptococcus pneumoniae.

Blomberg C, Dagerhamn J, Dahlberg S, Browall S, Fernebro J, Albiger B, Morfeldt E, Normark S, Henriques-Normark B.

J Infect Dis. 2009 Apr 1;199(7):1032-42. doi: 10.1086/597205.


Cloning, expression, purification, crystallization and preliminary X-ray analysis of the pilus-associated sortase C from Streptococcus pneumoniae.

Neiers F, Madhurantakam C, Fälker S, Normark S, Henriques-Normark B, Achour A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jan 1;65(Pt 1):55-8. doi: 10.1107/S1744309108040025. Epub 2008 Dec 25.


Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases.

Nilsson C, Skoglund A, Moran AP, Annuk H, Engstrand L, Normark S.

PLoS One. 2008;3(11):e3811. doi: 10.1371/journal.pone.0003811. Epub 2008 Nov 26.


The rise and fall of bacterial clones: Streptococcus pneumoniae.

Henriques-Normark B, Blomberg C, Dagerhamn J, Bättig P, Normark S.

Nat Rev Microbiol. 2008 Nov;6(11):827-37. doi: 10.1038/nrmicro2011. Review.


Sortase-mediated assembly and surface topology of adhesive pneumococcal pili.

Fälker S, Nelson AL, Morfeldt E, Jonas K, Hultenby K, Ries J, Melefors O, Normark S, Henriques-Normark B.

Mol Microbiol. 2008 Nov;70(3):595-607. doi: 10.1111/j.1365-2958.2008.06396.x. Epub 2008 Sep 17.


Twin ushers guide pili across the bacterial outer membrane.

Daniels R, Normark S.

Cell. 2008 May 16;133(4):574-6. doi: 10.1016/j.cell.2008.04.032.


The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3.

Beiter K, Wartha F, Hurwitz R, Normark S, Zychlinsky A, Henriques-Normark B.

Infect Immun. 2008 Aug;76(8):3710-6. doi: 10.1128/IAI.01748-07. Epub 2008 May 12.


The function and biological role of toll-like receptors in infectious diseases: an update.

Hornef MW, Henriques-Normark B, Normark S.

Curr Opin Infect Dis. 2008 Jun;21(3):304-12. doi: 10.1097/QCO.0b013e3282f88ba3. Review.


The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease.

Fernebro J, Blomberg C, Morfeldt E, Wolf-Watz H, Normark S, Normark BH.

BMC Microbiol. 2008 Apr 18;8:65. doi: 10.1186/1471-2180-8-65.


Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine.

Meyer-Hoffert U, Hornef M, Henriques-Normark B, Normark S, Andersson M, Pütsep K.

FASEB J. 2008 Jul;22(7):2427-34. doi: 10.1096/fj.07-103440. Epub 2008 Feb 25.


Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related.

Moschioni M, Donati C, Muzzi A, Masignani V, Censini S, Hanage WP, Bishop CJ, Reis JN, Normark S, Henriques-Normark B, Covacci A, Rappuoli R, Barocchi MA.

J Infect Dis. 2008 Mar 15;197(6):888-96. doi: 10.1086/528375.


RrgA is a pilus-associated adhesin in Streptococcus pneumoniae.

Nelson AL, Ries J, Bagnoli F, Dahlberg S, Fälker S, Rounioja S, Tschöp J, Morfeldt E, Ferlenghi I, Hilleringmann M, Holden DW, Rappuoli R, Normark S, Barocchi MA, Henriques-Normark B.

Mol Microbiol. 2007 Oct;66(2):329-40. Epub 2007 Sep 10.


Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy.

Jonas K, Tomenius H, Kader A, Normark S, Römling U, Belova LM, Melefors O.

BMC Microbiol. 2007 Jul 24;7:70.


Clonal success of piliated penicillin nonsusceptible pneumococci.

Sjöström K, Blomberg C, Fernebro J, Dagerhamn J, Morfeldt E, Barocchi MA, Browall S, Moschioni M, Andersson M, Henriques F, Albiger B, Rappuoli R, Normark S, Henriques-Normark B.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12907-12. Epub 2007 Jul 20.


Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors.

Albiger B, Dahlberg S, Henriques-Normark B, Normark S.

J Intern Med. 2007 Jun;261(6):511-28. Review.


Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps.

Wartha F, Beiter K, Albiger B, Fernebro J, Zychlinsky A, Normark S, Henriques-Normark B.

Cell Microbiol. 2007 May;9(5):1162-71. Epub 2007 Jan 9.


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