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Items: 50

1.

Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.

Oballa RM, Belair L, Black WC, Bleasby K, Chan CC, Desroches C, Du X, Gordon R, Guay J, Guiral S, Hafey MJ, Hamelin E, Huang Z, Kennedy B, Lachance N, Landry F, Li CS, Mancini J, Normandin D, Pocai A, Powell DA, Ramtohul YK, Skorey K, Sørensen D, Sturkenboom W, Styhler A, Waddleton DM, Wang H, Wong S, Xu L, Zhang L.

J Med Chem. 2011 Jul 28;54(14):5082-96. doi: 10.1021/jm200319u. Epub 2011 Jun 28.

PMID:
21661758
2.

Coronary left ventricular outflow tract fistula after resection of a subaortic valve membrane.

Coutu S, de Médicis E, Normandin D, Perrault MA.

Can J Anaesth. 2009 Aug;56(8):614-5. doi: 10.1007/s12630-009-9115-9. Epub 2009 Jul 1. No abstract available.

PMID:
19568824
3.

In vivo inhibition of serine protease processing requires a high fractional inhibition of cathepsin C.

Méthot N, Guay D, Rubin J, Ethier D, Ortega K, Wong S, Normandin D, Beaulieu C, Reddy TJ, Riendeau D, Percival MD.

Mol Pharmacol. 2008 Jun;73(6):1857-65. doi: 10.1124/mol.108.045682. Epub 2008 Mar 6.

PMID:
18326050
4.

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.

Hangeland JJ, Cheney DL, Friends TJ, Swartz S, Levesque PC, Rich AJ, Sun L, Bridal TR, Adam LP, Normandin DE, Murugesan N, Ewing WR.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):474-8. Epub 2007 Dec 3.

PMID:
18160281
5.

Function and health status in surgically treated bone metastases.

Talbot M, Turcotte RE, Isler M, Normandin D, Iannuzzi D, Downer P.

Clin Orthop Relat Res. 2005 Sep;438:215-20.

PMID:
16131894
6.

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Bi Y, Stoy P, Adam L, He B, Krupinski J, Normandin D, Pongrac R, Seliger L, Watson A, Macor JE.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1577-80.

PMID:
15006407
7.

Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.

Ahmad S, Doweyko L, Ashfaq A, Ferrara FN, Bisaha SN, Schmidt JB, DiMarco J, Conder ML, Jenkins-West T, Normandin DE, Russell AD, Smith MA, Levesque PC, Lodge NJ, Lloyd J, Stein PD, Atwal KS.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):99-102.

PMID:
14684307
8.

Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

Yu G, Mason H, Wu X, Wang J, Chong S, Beyer B, Henwood A, Pongrac R, Seliger L, He B, Normandin D, Ferrer P, Zhang R, Adam L, Humphrey WG, Krupinski J, Macor JE.

J Med Chem. 2003 Feb 13;46(4):457-60.

PMID:
12570368
9.

Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey.

Lamontagne S, Meadows E, Luk P, Normandin D, Muise E, Boulet L, Pon DJ, Robichaud A, Robertson GS, Metters KM, Nantel F.

Brain Res. 2001 Nov 30;920(1-2):84-96.

PMID:
11716814
10.

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.

Lloyd J, Schmidt JB, Rovnyak G, Ahmad S, Atwal KS, Bisaha SN, Doweyko LM, Stein PD, Traeger SC, Mathur A, Conder ML, DiMarco J, Harper TW, Jenkins-West T, Levesque PC, Normandin DE, Russell AD, Serafino RP, Smith MA, Lodge NJ.

J Med Chem. 2001 Nov 8;44(23):3764-7.

PMID:
11689063
11.

The discovery of novel, potent and selective PDE5 inhibitors.

Bi Y, Stoy P, Adam L, He B, Krupinski J, Normandin D, Pongrac R, Seliger L, Watson A, Macor JE.

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2461-4.

PMID:
11549447
12.

Cyclooxygenase-2--specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients.

Whelton A, Fort JG, Puma JA, Normandin D, Bello AE, Verburg KM; SUCCESS VI Study Group.

Am J Ther. 2001 Mar-Apr;8(2):85-95. Erratum in: Am J Ther 2001 May-Jun;8(3):220.

PMID:
11304662
13.

Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

Yu G, Mason HJ, Wu X, Wang J, Chong S, Dorough G, Henwood A, Pongrac R, Seliger L, He B, Normandin D, Adam L, Krupinski J, Macor JE.

J Med Chem. 2001 Mar 29;44(7):1025-7. No abstract available.

PMID:
11297448
15.

N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE.

J Med Chem. 2000 Apr 6;43(7):1257-63.

PMID:
10753463
16.

Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE.

J Med Chem. 2000 Dec 28;43(26):5037-43.

PMID:
11150175
17.

Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.

Ding CZ, Rovnyak GC, Misra RN, Grover GJ, Miller AV, Ahmed SZ, Kelly Y, Normandin DE, Sleph PG, Atwal KS.

J Med Chem. 1999 Sep 9;42(18):3711-7.

PMID:
10479302
18.

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP.

Science. 1999 Mar 5;283(5407):1544-8.

19.

Alterations in Ito1, IKr and Ik1 density in the BIO TO-2 strain of syrian myopathic hamsters.

Lodge NJ, Normandin DE.

J Mol Cell Cardiol. 1997 Dec;29(12):3211-21.

PMID:
9441828
20.

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

Atwal KS, Grover GJ, Lodge NJ, Normandin DE, Traeger SC, Sleph PG, Cohen RB, Bryson CC, Dickinson KE.

J Med Chem. 1998 Jan 29;41(3):271-5. No abstract available.

PMID:
9464357
21.

Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.

Rovnyak GC, Ahmed SZ, Ding CZ, Dzwonczyk S, Ferrara FN, Humphreys WG, Grover GJ, Santafianos D, Atwal KS, Baird AJ, McLaughlin LG, Normandin DE, Sleph PG, Traeger SC.

J Med Chem. 1997 Jan 3;40(1):24-34.

PMID:
9016325
22.

Aortoesophageal fistula: repair with transluminal placement of a thoracic aortic stent-graft.

Oliva VL, Bui BT, Leclerc G, Gravel D, Normandin D, Prenovault J, Guimond JG.

J Vasc Interv Radiol. 1997 Jan-Feb;8(1 Pt 1):35-8. No abstract available.

PMID:
9025036
23.

Pharmacological characterization of the isolated canine prostate.

Normandin DE, Lodge NJ.

J Urol. 1996 May;155(5):1758-61.

PMID:
8627879
24.

Cardioselective antiischemic ATP-sensitive potassium channel openers. 4. Structure-activity studies on benzopyranylcyanoguanidines: replacement of the benzopyran portion.

Atwal KS, Ferrara FN, Ding CZ, Grover GJ, Sleph PG, Dzwonczyk S, Baird AJ, Normandin DE.

J Med Chem. 1996 Jan 5;39(1):304-13.

PMID:
8568821
25.

A comparison between the effects of BMS-180448, a novel K+ channel opener, and cromakalim in rat and dog.

D'Alonzo AJ, Darbenzio RB, Sewter JC, Hess TA, Grover GJ, Sleph PG, Normandin DE, Lodge NJ.

Eur J Pharmacol. 1995 Dec 27;294(1):271-80.

PMID:
8788441
26.

Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion.

Atwal KS, Grover GJ, Ahmed SZ, Sleph PG, Dzwonczyk S, Baird AJ, Normandin DE.

J Med Chem. 1995 Aug 18;38(17):3236-45.

PMID:
7650676
27.

Transesophageal echocardiographic diagnosis of sinus venosus-type atrial septal defect associated with partial anomalous venous connections during cardiac surgery in adults.

Jean D, Girard F, Couture P, Normandin D, Poirier NL, Prénovault J, Girard D.

J Cardiothorac Vasc Anesth. 1995 Aug;9(4):438-41. No abstract available.

PMID:
7579117
28.

Pharmacologic profile of the dihydropyrimidine calcium channel blockers SQ 32,547 and SQ 32,926 [correction of SQ 32,946].

Grover GJ, Dzwonczyk S, McMullen DM, Normandin DE, Parham CS, Sleph PG, Moreland S.

J Cardiovasc Pharmacol. 1995 Aug;26(2):289-94.

PMID:
7475054
29.

Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring.

Atwal KS, Grover GJ, Ferrara FN, Ahmed SZ, Sleph PG, Dzwonczyk S, Normandin DE.

J Med Chem. 1995 May 26;38(11):1966-73.

PMID:
7783128
30.

Reduced contractile function after balloon denudation of rat carotid arteries.

Antonaccio MJ, Normandin D, Ferrer P.

Eur J Pharmacol. 1994 Apr 11;256(1):17-21.

PMID:
8026560
31.

Role of Ca2+ in the vascular contraction caused by a thrombin receptor activating peptide.

Antonaccio MJ, Normandin D.

Eur J Pharmacol. 1994 Apr 11;256(1):37-44.

PMID:
7517890
32.

Involvement of the "tethered ligand" receptor in thrombin-induced endothelium-mediated relaxations.

Tesfamariam B, Allen GT, Normandin D, Antonaccio MJ.

Am J Physiol. 1993 Nov;265(5 Pt 2):H1744-9.

PMID:
8238588
33.

Protective effect of serotonin (5-HT2) receptor antagonists in ischemic rat hearts.

Grover GJ, Sargent CA, Dzwonczyk S, Normandin DE, Antonaccio MJ.

J Cardiovasc Pharmacol. 1993 Oct;22(4):664-72.

PMID:
7505371
34.

Cardioprotective effects of the cyanoguanidine potassium channel opener P-1075.

Sargent CA, Sleph PG, Dzwonczyk S, Normandin D, Antonaccio MJ, Grover GJ.

J Cardiovasc Pharmacol. 1993 Oct;22(4):564-70.

PMID:
7505358
35.

Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle.

Antonaccio MJ, Normandin D, Serafino R, Moreland S.

J Pharmacol Exp Ther. 1993 Jul;266(1):125-32.

PMID:
8331553
36.

Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel.

Sargent CA, Sleph PG, Dzwonczyk S, Smith MA, Normandin D, Antonaccio MJ, Grover GJ.

J Pharmacol Exp Ther. 1993 May;265(2):609-18.

PMID:
8496812
37.

Cross-sectional and longitudinal comparisons of adolescent self-esteem.

Mullis AK, Mullis RL, Normandin D.

Adolescence. 1992 Spring;27(105):51-61.

PMID:
1539501
38.

[The intermittent "warm" blood cardioplegia].

Doyle D, Dagenais F, Poirier N, Normandin D, Cartier P.

Ann Chir. 1992;46(9):800-4. French.

PMID:
1299157
39.

Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate.

McCullough JR, Normandin DE, Conder ML, Sleph PG, Dzwonczyk S, Grover GJ.

Circ Res. 1991 Oct;69(4):949-58.

PMID:
1934346
40.

[Dysautonomia. A clinical study of a case, ultrastructural data].

Fontan D, Normandin D, Brechenmacher C, Dufillot D, Vital C, Guillard JM.

Ann Pediatr (Paris). 1990 May;37(5):306-9. French.

PMID:
2369047
41.

Sampling of lung interstitial fluid in intact dog.

Normandin D, Tung H, Hargens AR, Peters RM.

J Surg Res. 1990 Jan;48(1):91-8.

PMID:
2296187
42.

Postpneumonectomy pulmonary edema.

Zeldin RA, Normandin D, Landtwing D, Peters RM.

J Thorac Cardiovasc Surg. 1984 Mar;87(3):359-65.

PMID:
6700243
43.

[Portal hypertension of extra-hepatic origin in children (author's transl)].

Blanchard H, Beauchamps G, Normandin D, Montupet P, Bensoussan AL.

Chir Pediatr. 1982 May-Jun;23(3):221-5. French.

PMID:
6979408
44.

A proposed ultramicroscopic structure of the mammalian glomerular basement membrane.

Normandin DK.

Trans Am Microsc Soc. 1980 Jan;99(1):60-78. No abstract available.

PMID:
6445118
45.

Confirmatory evidence of a slit pore theory of mammalian glomerular capillary filtration.

Normandin DK.

Trans Am Microsc Soc. 1977 Oct;96(4):438-52. No abstract available.

PMID:
910322
46.

B(enjamin) Vincent Hall 1907-1975.

Normandin DK, Watterson RL.

Anat Rec. 1975 Sep;183(1):134-6. No abstract available.

PMID:
1101739
47.

Direct deposition at high resolution of specific metals from solutions at radioactive sites in tissue sections.

Normandin DK.

Trans Am Microsc Soc. 1973 Jul;92(3):381-98. No abstract available.

PMID:
4731809
48.

A pattern demonstrated by microvillar length within the crypt of Lieberkühn of mouse small intestine.

Normandin DK.

Trans Am Microsc Soc. 1967 Oct;86(4):494-7. No abstract available.

PMID:
6076122
49.

Cytoplasmic changes in the crypt cells of the mouse small intestine.

Normandin DK.

Trans Am Microsc Soc. 1966 Oct;85(4):571-3. No abstract available.

PMID:
4166987
50.

Regeneration of Hydra from the Endoderm.

Normandin DK.

Science. 1960 Sep 9;132(3428):678.

PMID:
17776189

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