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Items: 1 to 50 of 321

1.

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines.

Linnane E, Davey P, Zhang P, Puri S, Edbrooke M, Chiarparin E, Revenko AS, Macleod AR, Norman JC, Ross SJ.

Nucleic Acids Res. 2019 May 21;47(9):4375-4392. doi: 10.1093/nar/gkz214.

2.

A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression.

Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH.

Cancer Discov. 2019 May;9(5):617-627. doi: 10.1158/2159-8290.CD-18-1212. Epub 2019 Mar 5.

PMID:
30837243
3.

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels.

Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, Charlton L, Knight J, Calka M, McGhee E, Dornier E, Sumpton D, Mason S, Echard A, Klinkert K, Secklehner J, Kruiswijk F, Vousden K, Macpherson IR, Blyth K, Bailey P, Yin H, Carlin LM, Morton J, Zanivan S, Norman JC.

Nat Commun. 2018 Nov 29;9(1):5069. doi: 10.1038/s41467-018-07339-y.

4.

Cancer cells with trapped nuclei cut their way through the extracellular matrix.

Dornier E, Norman JC.

Nat Commun. 2018 Sep 27;9(1):3954. doi: 10.1038/s41467-018-06351-6. No abstract available.

5.

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.

Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, Mackay G, Sumpton D, Pallares M, Nixon C, Blyth K, Macpherson IR, Rainero E, Norman JC.

Nat Commun. 2017 Dec 21;8(1):2255. doi: 10.1038/s41467-017-02101-2.

6.

Tensin links energy metabolism to extracellular matrix assembly.

Dornier E, Norman JC.

J Cell Biol. 2017 Apr 3;216(4):867-869. doi: 10.1083/jcb.201702025. Epub 2017 Mar 21.

7.

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.

Gundry C, Marco S, Rainero E, Miller B, Dornier E, Mitchell L, Caswell PT, Campbell AD, Hogeweg A, Sansom OJ, Morton JP, Norman JC.

Nat Commun. 2017 Mar 15;8:14646. doi: 10.1038/ncomms14646.

8.

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, MacPherson IR, McNeish I, Ennis D, Ali H, Kugeratski FG, Al Khamici H, van den Biggelaar M, van den Berghe PV, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela SM, Blyth K, Yin H, Mazzone M, Norman JC, Zanivan S.

Nat Commun. 2017 Feb 15;8:14206. doi: 10.1038/ncomms14206.

9.

A proteomic approach to identify endosomal cargoes controlling cancer invasiveness.

Diaz-Vera J, Palmer S, Hernandez-Fernaud JR, Dornier E, Mitchell LE, Macpherson I, Edwards J, Zanivan S, Norman JC.

J Cell Sci. 2017 Feb 15;130(4):697-711. doi: 10.1242/jcs.190835. Epub 2017 Jan 6.

10.

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma.

Birch J, Clarke CJ, Campbell AD, Campbell K, Mitchell L, Liko D, Kalna G, Strathdee D, Sansom OJ, Neilson M, Blyth K, Norman JC.

Biol Open. 2016 Oct 15;5(10):1371-1379. doi: 10.1242/bio.019075.

11.

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.

Clarke CJ, Berg TJ, Birch J, Ennis D, Mitchell L, Cloix C, Campbell A, Sumpton D, Nixon C, Campbell K, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Jones JL, Haywood L, Pulleine E, Yin H, Strathdee D, Sansom O, Blyth K, McNeish I, Zanivan S, Reynolds AR, Norman JC.

Curr Biol. 2016 Mar 21;26(6):755-65. doi: 10.1016/j.cub.2016.01.045. Epub 2016 Mar 3.

12.

Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression.

Boulay PL, Mitchell L, Turpin J, Huot-Marchand JÉ, Lavoie C, Sanguin-Gendreau V, Jones L, Mitra S, Livingstone JM, Campbell S, Hallett M, Mills GB, Park M, Chodosh L, Strathdee D, Norman JC, Muller WJ.

Cancer Res. 2016 May 1;76(9):2662-74. doi: 10.1158/0008-5472.CAN-15-2782. Epub 2016 Mar 1.

13.

Endosomal integrin signals for survival.

Rainero E, Norman JC.

Nat Cell Biol. 2015 Nov;17(11):1373-5. doi: 10.1038/ncb3261.

14.

Polystyrene microspheres enable 10-color compensation for immunophenotyping of primary human leukocytes.

Byrd T, Carr KD, Norman JC, Huye L, Hegde M, Ahmed N.

Cytometry A. 2015 Nov;87(11):1038-46. doi: 10.1002/cyto.a.22717. Epub 2015 Jul 22.

15.

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration.

Rainero E, Howe JD, Caswell PT, Jamieson NB, Anderson K, Critchley DR, Machesky L, Norman JC.

Cell Rep. 2015 Jan 20;10(3):398-413. doi: 10.1016/j.celrep.2014.12.037. Epub 2015 Jan 15.

16.

Effect of corneal contact lens wear on healing time and comfort post LGK for treatment of SCCEDs in boxers.

Wooff PJ, Norman JC.

Vet Ophthalmol. 2015 Sep;18(5):364-70. doi: 10.1111/vop.12202. Epub 2014 Sep 1.

PMID:
25176178
17.

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer.

Macpherson IR, Rainero E, Mitchell LE, van den Berghe PV, Speirs C, Dozynkiewicz MA, Chaudhary S, Kalna G, Edwards J, Timpson P, Norman JC.

J Cell Sci. 2014 Sep 15;127(Pt 18):3893-901. doi: 10.1242/jcs.135947. Epub 2014 Jul 11.

18.

The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.

Rainero E, Cianflone C, Porporato PE, Chianale F, Malacarne V, Bettio V, Ruffo E, Ferrara M, Benecchia F, Capello D, Paster W, Locatelli I, Bertoni A, Filigheddu N, Sinigaglia F, Norman JC, Baldanzi G, Graziani A.

PLoS One. 2014 Jun 2;9(6):e97144. doi: 10.1371/journal.pone.0097144. eCollection 2014.

19.

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells.

Macagno JP, Diaz Vera J, Yu Y, MacPherson I, Sandilands E, Palmer R, Norman JC, Frame M, Vidal M.

PLoS Genet. 2014 Mar 27;10(3):e1004262. doi: 10.1371/journal.pgen.1004262. eCollection 2014 Mar.

20.

Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling.

Haugsten EM, Brech A, Liestøl K, Norman JC, Wesche J.

Traffic. 2014 Jun;15(6):665-83. doi: 10.1111/tra.12168. Epub 2014 Mar 31.

21.

Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

Muller PA, Trinidad AG, Caswell PT, Norman JC, Vousden KH.

J Biol Chem. 2014 Jan 3;289(1):122-32. doi: 10.1074/jbc.M113.502138. Epub 2013 Nov 12.

22.

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex.

Jacquemet G, Green DM, Bridgewater RE, von Kriegsheim A, Humphries MJ, Norman JC, Caswell PT.

J Cell Biol. 2013 Sep 16;202(6):917-35. doi: 10.1083/jcb.201302041. Epub 2013 Sep 9.

24.

P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.

Campbell AD, Lawn S, McGarry LC, Welch HC, Ozanne BW, Norman JC.

PLoS One. 2013;8(1):e53982. doi: 10.1371/journal.pone.0053982. Epub 2013 Jan 30.

25.

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.

Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futó K, Timpson P, Nixon C, Ma Y, Anton IM, Visegrády B, Insall RH, Oien K, Blyth K, Norman JC, Machesky LM.

J Cell Biol. 2012 Oct 29;199(3):527-44. doi: 10.1083/jcb.201203025. Epub 2012 Oct 22.

26.

Integrin trafficking at a glance.

Bridgewater RE, Norman JC, Caswell PT.

J Cell Sci. 2012 Aug 15;125(Pt 16):3695-701. doi: 10.1242/jcs.095810. Review. No abstract available.

27.

PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5.

Christoforides C, Rainero E, Brown KK, Norman JC, Toker A.

Dev Cell. 2012 Sep 11;23(3):560-72. doi: 10.1016/j.devcel.2012.08.008.

28.

Aquaporin 2 promotes cell migration and epithelial morphogenesis.

Chen Y, Rice W, Gu Z, Li J, Huang J, Brenner MB, Van Hoek A, Xiong J, Gundersen GG, Norman JC, Hsu VW, Fenton RA, Brown D, Lu HA.

J Am Soc Nephrol. 2012 Sep;23(9):1506-17. doi: 10.1681/ASN.2012010079. Epub 2012 Aug 2.

29.

ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons.

Eva R, Crisp S, Marland JR, Norman JC, Kanamarlapudi V, ffrench-Constant C, Fawcett JW.

J Neurosci. 2012 Jul 25;32(30):10352-64.

30.

Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking.

Margadant C, Kreft M, de Groot DJ, Norman JC, Sonnenberg A.

Curr Biol. 2012 Sep 11;22(17):1554-63. doi: 10.1016/j.cub.2012.06.060. Epub 2012 Jul 12.

31.

Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.

Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H.

J Cell Biol. 2012 Jun 25;197(7):983-96. doi: 10.1083/jcb.201201065.

32.

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.

Muller PA, Trinidad AG, Timpson P, Morton JP, Zanivan S, van den Berghe PV, Nixon C, Karim SA, Caswell PT, Noll JE, Coffill CR, Lane DP, Sansom OJ, Neilsen PM, Norman JC, Vousden KH.

Oncogene. 2013 Mar 7;32(10):1252-65. doi: 10.1038/onc.2012.148. Epub 2012 May 14.

33.

Electroretinogram responses of the normal thoroughbred horse sedated with detomidine hydrochloride.

Church ML, Norman JC.

Vet Ophthalmol. 2012 Sep;15 Suppl 2:77-83. doi: 10.1111/j.1463-5224.2012.01022.x. Epub 2012 Apr 12.

PMID:
22498137
34.

ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.

von Thun A, Birtwistle M, Kalna G, Grindlay J, Strachan D, Kolch W, von Kriegsheim A, Norman JC.

J Cell Sci. 2012 Mar 15;125(Pt 6):1465-77. doi: 10.1242/jcs.092916. Epub 2012 Feb 10.

35.

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

Rainero E, Caswell PT, Muller PA, Grindlay J, McCaffrey MW, Zhang Q, Wakelam MJ, Vousden KH, Graziani A, Norman JC.

J Cell Biol. 2012 Jan 23;196(2):277-95. doi: 10.1083/jcb.201109112.

36.

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

Dozynkiewicz MA, Jamieson NB, Macpherson I, Grindlay J, van den Berghe PV, von Thun A, Morton JP, Gourley C, Timpson P, Nixon C, McKay CJ, Carter R, Strachan D, Anderson K, Sansom OJ, Caswell PT, Norman JC.

Dev Cell. 2012 Jan 17;22(1):131-45. doi: 10.1016/j.devcel.2011.11.008. Epub 2011 Dec 22.

37.

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.

Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ.

Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560.

38.

Mechanisms of integrin activation and trafficking.

Margadant C, Monsuur HN, Norman JC, Sonnenberg A.

Curr Opin Cell Biol. 2011 Oct;23(5):607-14. doi: 10.1016/j.ceb.2011.08.005. Epub 2011 Sep 14. Review.

PMID:
21924601
39.

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.

Murdoch H, Vadrevu S, Prinz A, Dunlop AJ, Klussmann E, Bolger GB, Norman JC, Houslay MD.

J Cell Sci. 2011 Jul 1;124(Pt 13):2253-66. doi: 10.1242/jcs.082982. Epub 2011 Jun 7.

40.

New roles for lysosomal trafficking in morphogen gradient sensing.

Rainero E, Norman JC.

Sci Signal. 2011 May 3;4(171):pe24. doi: 10.1126/scisignal.2002053. Review.

PMID:
21540453
41.

p53 and its mutants in tumor cell migration and invasion.

Muller PA, Vousden KH, Norman JC.

J Cell Biol. 2011 Jan 24;192(2):209-18. doi: 10.1083/jcb.201009059. Review.

42.

Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.

Eva R, Dassie E, Caswell PT, Dick G, ffrench-Constant C, Norman JC, Fawcett JW.

J Neurosci. 2010 Sep 1;30(35):11654-69. doi: 10.1523/JNEUROSCI.2425-10.2010.

43.

Mutant p53 drives invasion by promoting integrin recycling.

Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH.

Cell. 2009 Dec 24;139(7):1327-41. doi: 10.1016/j.cell.2009.11.026.

44.

hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration.

Moran-Jones K, Grindlay J, Jones M, Smith R, Norman JC.

Cancer Res. 2009 Dec 15;69(24):9219-27. doi: 10.1158/0008-5472.CAN-09-1852.

45.

Integrins: masters and slaves of endocytic transport.

Caswell PT, Vadrevu S, Norman JC.

Nat Rev Mol Cell Biol. 2009 Dec;10(12):843-53. doi: 10.1038/nrm2799. Review.

PMID:
19904298
46.

Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase.

Kelly EE, Horgan CP, Adams C, Patzer TM, Ní Shúilleabháin DM, Norman JC, McCaffrey MW.

Biol Cell. 2009 Oct 12;102(1):51-62. doi: 10.1042/BC20090068.

PMID:
19702578
47.

Genomic amplicons target vesicle recycling in breast cancer.

Mills GB, Jurisica I, Yarden Y, Norman JC.

J Clin Invest. 2009 Aug;119(8):2123-7. doi: 10.1172/JCI40256. Epub 2009 Jul 20.

48.

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM.

Nat Med. 2009 Apr;15(4):392-400. doi: 10.1038/nm.1941. Epub 2009 Mar 22.

PMID:
19305413
49.

VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching.

Jones MC, Caswell PT, Moran-Jones K, Roberts M, Barry ST, Gampel A, Mellor H, Norman JC.

Traffic. 2009 Jun;10(6):754-66. doi: 10.1111/j.1600-0854.2009.00898.x.

50.

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

Valdembri D, Caswell PT, Anderson KI, Schwarz JP, König I, Astanina E, Caccavari F, Norman JC, Humphries MJ, Bussolino F, Serini G.

PLoS Biol. 2009 Jan 27;7(1):e25. doi: 10.1371/journal.pbio.1000025.

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