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Biophysical insights into a highly selective l-arginine-binding lipoprotein of a pathogenic treponeme.

Deka RK, Liu WZ, Tso SC, Norgard MV, Brautigam CA.

Protein Sci. 2018 Dec;27(12):2037-2050. doi: 10.1002/pro.3510. Epub 2018 Oct 27.


MyD88 Signaling in T Cells Is Critical for Effector CD4 T Cell Differentiation following a Transitional T Follicular Helper Cell Stage.

Mandraju R, Jain A, Gao Y, Ouyang Z, Norgard MV, Pasare C.

Infect Immun. 2018 Apr 23;86(5). pii: e00791-17. doi: 10.1128/IAI.00791-17. Print 2018 May.


Crystal stuctures of MglB-2 (TP0684), a topologically variant d-glucose-binding protein from Treponema pallidum, reveal a ligand-induced conformational change.

Brautigam CA, Deka RK, Liu WZ, Norgard MV.

Protein Sci. 2018 Apr;27(4):880-885. doi: 10.1002/pro.3373. Epub 2018 Feb 1.


Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum.

Brautigam CA, Deka RK, Liu WZ, Tomchick DR, Norgard MV.

Protein Sci. 2017 Apr;26(4):847-856. doi: 10.1002/pro.3133. Epub 2017 Mar 23.


Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen.

Radolf JD, Deka RK, Anand A, Šmajs D, Norgard MV, Yang XF.

Nat Rev Microbiol. 2016 Dec;14(12):744-759. doi: 10.1038/nrmicro.2016.141. Epub 2016 Oct 10. Review.


The Tp0684 (MglB-2) Lipoprotein of Treponema pallidum: A Glucose-Binding Protein with Divergent Topology.

Brautigam CA, Deka RK, Liu WZ, Norgard MV.

PLoS One. 2016 Aug 18;11(8):e0161022. doi: 10.1371/journal.pone.0161022. eCollection 2016.


Evidence that BosR (BB0647) Is a Positive Autoregulator in Borrelia burgdorferi.

Ouyang Z, Zhou J, Norgard MV.

Infect Immun. 2016 Aug 19;84(9):2566-74. doi: 10.1128/IAI.00297-16. Print 2016 Sep.


Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.

Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV.

Microbiologyopen. 2016 Feb;5(1):21-38. doi: 10.1002/mbo3.306. Epub 2015 Dec 2.


Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi.

Ouyang Z, Zhou J, Brautigam CA, Deka RK, Norgard MV.

Microbiology. 2015 Apr;161(Pt 4):931. doi: 10.1099/mic.0.000060. No abstract available.


Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia burgdorferi.

Ouyang Z, Zhou J, Norgard MV.

PLoS One. 2014 May 8;9(5):e96917. doi: 10.1371/journal.pone.0096917. eCollection 2014.


FTT0831c/FTL_0325 contributes to Francisella tularensis cell division, maintenance of cell shape, and structural integrity.

Robertson GT, Case ED, Dobbs N, Ingle C, Balaban M, Celli J, Norgard MV.

Infect Immun. 2014 Jul;82(7):2935-48. doi: 10.1128/IAI.00102-14. Epub 2014 Apr 28.


Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi.

Ouyang Z, Zhou J, Brautigam CA, Deka R, Norgard MV.

Microbiology. 2014 May;160(Pt 5):851-862. doi: 10.1099/mic.0.075655-0. Epub 2014 Mar 7. Erratum in: Microbiology. 2015 Apr;161(Pt 4):931.


CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi.

Ouyang Z, Zhou J, Norgard MV.

Infect Immun. 2014 Apr;82(4):1511-22. doi: 10.1128/IAI.01555-13. Epub 2014 Jan 22.


IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A Francisella tularensis.

Robertson GT, Child R, Ingle C, Celli J, Norgard MV.

Infect Immun. 2013 Nov;81(11):4026-40. doi: 10.1128/IAI.00595-13. Epub 2013 Aug 19.


Purification, crystallization and preliminary X-ray analysis of TP0435 (Tp17) from the syphilis spirochete Treponema pallidum.

Brautigam CA, Deka RK, Norgard MV.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Apr 1;69(Pt 4):453-5. doi: 10.1107/S1744309113006246. Epub 2013 Mar 28.


The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis.

Deka RK, Brautigam CA, Liu WZ, Tomchick DR, Norgard MV.

J Biol Chem. 2013 Apr 19;288(16):11106-21. doi: 10.1074/jbc.M113.449975. Epub 2013 Feb 27.


Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes.

Deka RK, Brautigam CA, Biddy BA, Liu WZ, Norgard MV.

mBio. 2013 Feb 12;4(1):e00615-12. doi: 10.1128/mBio.00615-12.


Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis.

Brautigam CA, Deka RK, Ouyang Z, Machius M, Knutsen G, Tomchick DR, Norgard MV.

J Bacteriol. 2012 Dec;194(24):6771-81. doi: 10.1128/JB.01494-12. Epub 2012 Oct 5.


Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).

Brautigam CA, Deka RK, Schuck P, Tomchick DR, Norgard MV.

J Mol Biol. 2012 Jun 29;420(1-2):70-86. doi: 10.1016/j.jmb.2012.04.001. Epub 2012 Apr 11.


Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi.

Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard MV.

BMC Microbiol. 2012 Mar 23;12:44. doi: 10.1186/1471-2180-12-44.


Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter.

Deka RK, Brautigam CA, Goldberg M, Schuck P, Tomchick DR, Norgard MV.

J Mol Biol. 2012 Mar 9;416(5):678-96. doi: 10.1016/j.jmb.2012.01.015. Epub 2012 Jan 27.


Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks.

He M, Ouyang Z, Troxell B, Xu H, Moh A, Piesman J, Norgard MV, Gomelsky M, Yang XF.

PLoS Pathog. 2011 Jun;7(6):e1002133. doi: 10.1371/journal.ppat.1002133. Epub 2011 Jun 30.


BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism.

Ouyang Z, Deka RK, Norgard MV.

PLoS Pathog. 2011 Feb 10;7(2):e1001272. doi: 10.1371/journal.ppat.1001272.


Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.

Padrick SB, Deka RK, Chuang JL, Wynn RM, Chuang DT, Norgard MV, Rosen MK, Brautigam CA.

Anal Biochem. 2010 Dec 1;407(1):89-103. doi: 10.1016/j.ab.2010.07.017. Epub 2010 Jul 25.


Method for the isolation of Francisella tularensis outer membranes.

Huntley JF, Robertson GT, Norgard MV.

J Vis Exp. 2010 Jun 29;(40). pii: 2044. doi: 10.3791/2044.


Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs.

Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS.

J Immunol. 2010 Jun 15;184(12):6822-32. doi: 10.4049/jimmunol.0902058. Epub 2010 May 14.


Analysis of the dbpBA upstream regulatory region controlled by RpoS in Borrelia burgdorferi.

Ouyang Z, Haq S, Norgard MV.

J Bacteriol. 2010 Apr;192(7):1965-74. doi: 10.1128/JB.01616-09. Epub 2010 Jan 29. Erratum in: J Bacteriol. 2010 May;192(10):2653-4.


BosR (BB0647) governs virulence expression in Borrelia burgdorferi.

Ouyang Z, Kumar M, Kariu T, Haq S, Goldberg M, Pal U, Norgard MV.

Mol Microbiol. 2009 Dec;74(6):1331-43. doi: 10.1111/j.1365-2958.2009.06945.x. Epub 2009 Nov 2.


A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi.

Ouyang Z, He M, Oman T, Yang XF, Norgard MV.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3449-54. doi: 10.1073/pnas.0812999106. Epub 2009 Feb 13.


Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner.

Blevins JS, Xu H, He M, Norgard MV, Reitzer L, Yang XF.

J Bacteriol. 2009 Apr;191(8):2902-5. doi: 10.1128/JB.01721-08. Epub 2009 Feb 6.


The effect of progesterone levels and pregnancy on HIV-1 coreceptor expression.

Sheffield JS, Wendel GD Jr, McIntire DD, Norgard MV.

Reprod Sci. 2009 Jan;16(1):20-31. doi: 10.1177/1933719108325510.


Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi.

He M, Oman T, Xu H, Blevins J, Norgard MV, Yang XF.

Mol Microbiol. 2008 Dec;70(6):1453-64. doi: 10.1111/j.1365-2958.2008.06491.x. Epub 2008 Oct 23.


Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi.

Ouyang Z, Blevins JS, Norgard MV.

Microbiology. 2008 Sep;154(Pt 9):2641-2658. doi: 10.1099/mic.0.2008/019992-0.


Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi.

Yang XF, Goldberg MS, He M, Xu H, Blevins JS, Norgard MV.

Infect Immun. 2008 Oct;76(10):4439-44. doi: 10.1128/IAI.00740-08. Epub 2008 Jul 28.


Characterization of fig operon mutants of Francisella novicida U112.

Kiss K, Liu W, Huntley JF, Norgard MV, Hansen EJ.

FEMS Microbiol Lett. 2008 Aug;285(2):270-7. doi: 10.1111/j.1574-6968.2008.01237.x. Epub 2008 Jun 18.


Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection.

Blevins JS, Hagman KE, Norgard MV.

BMC Microbiol. 2008 May 28;8:82. doi: 10.1186/1471-2180-8-82.


Native outer membrane proteins protect mice against pulmonary challenge with virulent type A Francisella tularensis.

Huntley JF, Conley PG, Rasko DA, Hagman KE, Apicella MA, Norgard MV.

Infect Immun. 2008 Aug;76(8):3664-71. doi: 10.1128/IAI.00374-08. Epub 2008 May 27.


Effect of genital ulcer disease on HIV-1 coreceptor expression in the female genital tract.

Sheffield JS, Wendel GD Jr, McIntire DD, Norgard MV.

J Infect Dis. 2007 Nov 15;196(10):1509-16. Epub 2007 Oct 31.


Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins.

Tomson FL, Conley PG, Norgard MV, Hagman KE.

Microbes Infect. 2007 Sep;9(11):1267-75. Epub 2007 Jun 3.


Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor.

Machius M, Brautigam CA, Tomchick DR, Ward P, Otwinowski Z, Blevins JS, Deka RK, Norgard MV.

J Mol Biol. 2007 Oct 26;373(3):681-94. Epub 2007 Aug 21.


Adaptation of a luciferase gene reporter and lac expression system to Borrelia burgdorferi.

Blevins JS, Revel AT, Smith AH, Bachlani GN, Norgard MV.

Appl Environ Microbiol. 2007 Mar;73(5):1501-13. Epub 2007 Jan 12.


Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin.

Deka RK, Brautigam CA, Tomson FL, Lumpkins SB, Tomchick DR, Machius M, Norgard MV.

J Biol Chem. 2007 Feb 23;282(8):5944-58. Epub 2006 Dec 27.


Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN).

Smith AH, Blevins JS, Bachlani GN, Yang XF, Norgard MV.

J Bacteriol. 2007 Mar;189(5):2139-44. Epub 2006 Dec 8.


Characterization of Francisella tularensis outer membrane proteins.

Huntley JF, Conley PG, Hagman KE, Norgard MV.

J Bacteriol. 2007 Jan;189(2):561-74. Epub 2006 Nov 17.


The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum.

Deka RK, Brautigam CA, Yang XF, Blevins JS, Machius M, Tomchick DR, Norgard MV.

J Biol Chem. 2006 Mar 24;281(12):8072-81. Epub 2006 Jan 16.


The Lyme disease agent exploits a tick protein to infect the mammalian host.

Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E.

Nature. 2005 Jul 28;436(7050):573-7.


Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi.

Yang XF, Lybecker MC, Pal U, Alani SM, Blevins J, Revel AT, Samuels DS, Norgard MV.

J Bacteriol. 2005 Jul;187(14):4822-9.

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