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Complexity of phenotypes induced by p.Asn1303Lys-CFTR correlates with difficulty to rescue and activate this protein.

Farhat R, El-Seedy A, Norez C, Talbot H, Pasquet MC, Adolphe C, Kitzis A, Ladevèze V.

Cell Mol Biol (Noisy-le-grand). 2017 Nov 30;63(11):106-110. doi: 10.14715/cmb/2017.63.11.18.


In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.

Farhat R, El-Seedy A, Sari AIP, Norez C, Pasquet MC, Becq F, Kitzis A, Ladevèze V.

C R Biol. 2017 Aug;340(8):367-371. doi: 10.1016/j.crvi.2017.06.001. Epub 2017 Aug 4.


Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

Philippe R, Antigny F, Buscaglia P, Norez C, Huguet F, Castelbou C, Trouvé P, Becq F, Frieden M, Férec C, Mignen O.

Cell Calcium. 2017 Mar;62:47-59. doi: 10.1016/j.ceca.2017.01.011. Epub 2017 Feb 4.


Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.

Meijer L, Nelson DJ, Riazanski V, Gabdoulkhakova AG, Hery-Arnaud G, Le Berre R, Loaëc N, Oumata N, Galons H, Nowak E, Gueganton L, Dorothée G, Prochazkova M, Hall B, Kulkarni AB, Gray RD, Rossi AG, Witko-Sarsat V, Norez C, Becq F, Ravel D, Mottier D, Rault G.

J Innate Immun. 2016;8(4):330-49. doi: 10.1159/000444256. Epub 2016 Mar 18. Review.


Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes.

Nocquet PA, Hensienne R, Wencel-Delord J, Laigre E, Sidelarbi K, Becq F, Norez C, Hazelard D, Compain P.

Org Biomol Chem. 2016 Mar 7;14(9):2780-96. doi: 10.1039/c5ob02602d.


Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

Cendret V, Legigan T, Mingot A, Thibaudeau S, Adachi I, Forcella M, Parenti P, Bertrand J, Becq F, Norez C, Désiré J, Kato A, Blériot Y.

Org Biomol Chem. 2015 Nov 21;13(43):10734-44. doi: 10.1039/c5ob01526j.


A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

Bertrand J, Dannhoffer L, Antigny F, Vachel L, Jayle C, Vandebrouck C, Becq F, Norez C.

Eur J Pharmacol. 2015 Oct 15;765:337-45. doi: 10.1016/j.ejphar.2015.08.005. Epub 2015 Aug 8.


Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells.

Ferru-Clément R, Fresquet F, Norez C, Métayé T, Becq F, Kitzis A, Thoreau V.

PLoS One. 2015 Mar 13;10(3):e0118943. doi: 10.1371/journal.pone.0118943. eCollection 2015.


SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

Philippe R, Antigny F, Buscaglia P, Norez C, Becq F, Frieden M, Mignen O.

Biochim Biophys Acta. 2015 May;1853(5):892-903. doi: 10.1016/j.bbamcr.2015.01.010. Epub 2015 Feb 4.


The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

Vachel L, Norez C, Jayle C, Becq F, Vandebrouck C.

Cell Calcium. 2015 Jan;57(1):38-48. doi: 10.1016/j.ceca.2014.11.005. Epub 2014 Nov 18.


N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

Désiré J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, Iwaki R, Fleet GW, Alonzi DS, Twigg G, Butters TD, Bertrand J, Cendret V, Becq F, Norez C, Marrot J, Kato A, Blériot Y.

Org Biomol Chem. 2014 Nov 28;12(44):8977-96. doi: 10.1039/c4ob00325j.


Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism.

Norez C, Vandebrouck C, Bertrand J, Noel S, Durieu E, Oumata N, Galons H, Antigny F, Chatelier A, Bois P, Meijer L, Becq F.

Br J Pharmacol. 2014 Nov;171(21):4831-49. doi: 10.1111/bph.12859.


A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

Boucherle B, Bertrand J, Maurin B, Renard BL, Fortuné A, Tremblier B, Becq F, Norez C, Décout JL.

Eur J Med Chem. 2014 Aug 18;83:455-65. doi: 10.1016/j.ejmech.2014.06.028. Epub 2014 Jun 14.


Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

Payet LA, Kadri L, Giraud S, Norez C, Berjeaud JM, Jayle C, Mirval S, Becq F, Vandebrouck C, Ferreira T.

PLoS One. 2014 Feb 19;9(2):e89044. doi: 10.1371/journal.pone.0089044. eCollection 2014.


Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.

Benz N, Le Hir S, Norez C, Kerbiriou M, Calvez ML, Becq F, Trouvé P, Férec C.

PLoS One. 2014 Feb 19;9(2):e88964. doi: 10.1371/journal.pone.0088964. eCollection 2014.


ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts.

El Chemaly A, Norez C, Magaud C, Bescond J, Chatelier A, Fares N, Findlay I, Jayle C, Becq F, Faivre JF, Bois P.

J Mol Cell Cardiol. 2014 Mar;68:12-9. doi: 10.1016/j.yjmcc.2013.12.027. Epub 2014 Jan 9.


Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors.

Compain P, Decroocq C, Joosten A, de Sousa J, Rodríguez-Lucena D, Butters TD, Bertrand J, Clément R, Boinot C, Becq F, Norez C.

Chembiochem. 2013 Oct 11;14(15):2050-8. doi: 10.1002/cbic.201300312. Epub 2013 Sep 13.


Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.

Odolczyk N, Fritsch J, Norez C, Servel N, da Cunha MF, Bitam S, Kupniewska A, Wiszniewski L, Colas J, Tarnowski K, Tondelier D, Roldan A, Saussereau EL, Melin-Heschel P, Wieczorek G, Lukacs GL, Dadlez M, Faure G, Herrmann H, Ollero M, Becq F, Zielenkiewicz P, Edelman A.

EMBO Mol Med. 2013 Oct;5(10):1484-501. doi: 10.1002/emmm.201302699. Epub 2013 Aug 27.


Bronchorelaxation of the human bronchi by CFTR activators.

Norez C, Jayle C, Becq F, Vandebrouck C.

Pulm Pharmacol Ther. 2014 Feb;27(1):38-43. doi: 10.1016/j.pupt.2013.06.008. Epub 2013 Jul 1.


Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

Vachel L, Norez C, Becq F, Vandebrouck C.

J Cyst Fibros. 2013 Dec;12(6):584-91. doi: 10.1016/j.jcf.2013.05.008. Epub 2013 Jun 10.


C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.

Jenkinson SF, Best D, Saville AW, Mui J, Martínez RF, Nakagawa S, Kunimatsu T, Alonzi DS, Butters TD, Norez C, Becq F, Blériot Y, Wilson FX, Weymouth-Wilson AC, Kato A, Fleet GW.

J Org Chem. 2013 Aug 2;78(15):7380-97. doi: 10.1021/jo4005487. Epub 2013 Jun 5.


Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia.

Dirami T, Rode B, Jollivet M, Da Silva N, Escalier D, Gaitch N, Norez C, Tuffery P, Wolf JP, Becq F, Ray PF, Dulioust E, Gacon G, Bienvenu T, Touré A.

Am J Hum Genet. 2013 May 2;92(5):760-6. doi: 10.1016/j.ajhg.2013.03.016. Epub 2013 Apr 11.


CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

El-Seedy A, Girodon E, Norez C, Pajaud J, Pasquet MC, de Becdelièvre A, Bienvenu T, des Georges M, Cabet F, Lalau G, Bieth E, Blayau M, Becq F, Kitzis A, Fanen P, Ladeveze V.

Hum Mutat. 2012 Nov;33(11):1557-65. doi: 10.1002/humu.22129. Epub 2012 Jul 2.


Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis.

Gimenez-Maitre A, Le Henaff C, Norez C, Guillaume C, Ravoninjatovo B, Laurent-Maquin D, Becq F, Jacquot J.

Eur Respir J. 2012 Mar;39(3):780-1. doi: 10.1183/09031936.00104111. No abstract available.


The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation.

Rode B, Dirami T, Bakouh N, Rizk-Rabin M, Norez C, Lhuillier P, Lorès P, Jollivet M, Melin P, Zvetkova I, Bienvenu T, Becq F, Planelles G, Edelman A, Gacon G, Touré A.

Hum Mol Genet. 2012 Mar 15;21(6):1287-98. doi: 10.1093/hmg/ddr558. Epub 2011 Nov 25.


CFTR and Ca Signaling in Cystic Fibrosis.

Antigny F, Norez C, Becq F, Vandebrouck C.

Front Pharmacol. 2011 Oct 25;2:67. doi: 10.3389/fphar.2011.00067. eCollection 2011.


Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype.

Fresquet F, Clement R, Norez C, Sterlin A, Melin P, Becq F, Kitzis A, Thoreau V, Bilan F.

J Mol Diagn. 2011 Sep;13(5):520-7. doi: 10.1016/j.jmoldx.2011.05.004. Epub 2011 Jun 25.


Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.

Ardes-Guisot N, Alonzi DS, Reinkensmeier G, Butters TD, Norez C, Becq F, Shimada Y, Nakagawa S, Kato A, Blériot Y, Sollogoub M, Vauzeilles B.

Org Biomol Chem. 2011 Aug 7;9(15):5373-88. doi: 10.1039/c1ob05119a. Epub 2011 Apr 21.


An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

Renard BL, Boucherle B, Maurin B, Molina MC, Norez C, Becq F, Décout JL.

Eur J Med Chem. 2011 May;46(5):1935-41. doi: 10.1016/j.ejmech.2011.02.037. Epub 2011 Feb 23.


4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.

da Cruz FP, Newberry S, Jenkinson SF, Wormald MR, Butters TD, Alonzi DS, Nakagawa S, Becq F, Norez C, Nash RJ, Kato A, Fleet GW.

Tetrahedron Lett. 2011 Jan 12;52(2):219-223.


Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

Antigny F, Norez C, Dannhoffer L, Bertrand J, Raveau D, Corbi P, Jayle C, Becq F, Vandebrouck C.

Am J Respir Cell Mol Biol. 2011 Jan;44(1):83-90. doi: 10.1165/rcmb.2009-0347OC. Epub 2010 Mar 4.


Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a.

Bertrand J, Boucherle B, Billet A, Melin-Heschel P, Dannhoffer L, Vandebrouck C, Jayle C, Routaboul C, Molina MC, Décout JL, Becq F, Norez C.

Eur Respir J. 2010 Aug;36(2):311-22. doi: 10.1183/09031936.00122509. Epub 2010 Jan 28.


Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

Granio O, Ashbourne Excoffon KJ, Henning P, Melin P, Norez C, Gonzalez G, Karp PH, Magnusson MK, Habib N, Lindholm L, Becq F, Boulanger P, Zabner J, Hong SS.

Hum Gene Ther. 2010 Mar;21(3):251-69. doi: 10.1089/hum.2009.056.


Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15.

Rafferty S, Alcolado N, Norez C, Chappe F, Pelzer S, Becq F, Chappe V.

J Pharmacol Exp Ther. 2009 Oct;331(1):2-13. doi: 10.1124/jpet.109.155341. Epub 2009 Jul 7.


A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.

Norez C, Antigny F, Noel S, Vandebrouck C, Becq F.

Am J Respir Cell Mol Biol. 2009 Aug;41(2):217-25. doi: 10.1165/rcmb.2008-0285OC. Epub 2009 Jan 8.


Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

Antigny F, Norez C, Cantereau A, Becq F, Vandebrouck C.

Respir Res. 2008 Oct 30;9:70. doi: 10.1186/1465-9921-9-70.


Anti-inflammatory effect of miglustat in bronchial epithelial cells.

Dechecchi MC, Nicolis E, Norez C, Bezzerri V, Borgatti M, Mancini I, Rizzotti P, Ribeiro CM, Gambari R, Becq F, Cabrini G.

J Cyst Fibros. 2008 Nov;7(6):555-65. doi: 10.1016/j.jcf.2008.06.002. Epub 2008 Sep 23.


Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells.

Norez C, Vandebrouck C, Antigny F, Dannhoffer L, Blondel M, Becq F.

Eur J Pharmacol. 2008 Sep 11;592(1-3):33-40. doi: 10.1016/j.ejphar.2008.06.103. Epub 2008 Jul 4.


Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.

Bilan F, Nacfer M, Fresquet F, Norez C, Melin P, Martin-Berge A, Costa de Beauregard MA, Becq F, Kitzis A, Thoreau V.

Exp Cell Res. 2008 Jul 1;314(11-12):2199-211. doi: 10.1016/j.yexcr.2008.04.012. Epub 2008 May 4.


Chemical conjugation of DeltaF508-CFTR corrector deoxyspergualin to transporter human serum albumin enhances its ability to rescue Cl- channel functions.

Norez C, Pasetto M, Dechecchi MC, Barison E, Anselmi C, Tamanini A, Quiri F, Cattel L, Rizzotti P, Dosio F, Cabrini G, Colombatti M.

Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L336-47. doi: 10.1152/ajplung.00059.2008. Epub 2008 May 30.


9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

Grand T, Demion M, Norez C, Mettey Y, Launay P, Becq F, Bois P, Guinamard R.

Br J Pharmacol. 2008 Apr;153(8):1697-705. doi: 10.1038/bjp.2008.38. Epub 2008 Feb 25.


Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

Norez C, Bilan F, Kitzis A, Mettey Y, Becq F.

J Pharmacol Exp Ther. 2008 Apr;325(1):89-99. doi: 10.1124/jpet.107.134502. Epub 2008 Jan 29.


Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel.

Auzanneau C, Norez C, Antigny F, Thoreau V, Jougla C, Cantereau A, Becq F, Vandebrouck C.

Biochem Pharmacol. 2008 Jan 15;75(2):476-83. Epub 2007 Sep 8.


Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

Granio O, Norez C, Ashbourne Excoffon KJ, Karp PH, Lusky M, Becq F, Boulanger P, Zabner J, Hong SS.

Am J Respir Cell Mol Biol. 2007 Dec;37(6):631-9. Epub 2007 Jul 19.


Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries.

Robert R, Savineau JP, Norez C, Becq F, Guibert C.

Eur Respir J. 2007 Nov;30(5):857-64. Epub 2007 Jun 27.


Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

Antigny F, Norez C, Becq F, Vandebrouck C.

Cell Calcium. 2008 Feb;43(2):175-83. Epub 2007 Jun 27.


Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

Routaboul C, Norez C, Melin P, Molina MC, Boucherle B, Bossard F, Noel S, Robert R, Gauthier C, Becq F, Décout JL.

J Pharmacol Exp Ther. 2007 Sep;322(3):1023-35. Epub 2007 Jun 19.


Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Vandebrouck C, Melin P, Norez C, Robert R, Guibert C, Mettey Y, Becq F.

Respir Res. 2006 Aug 28;7:113.


Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells.

Auzanneau C, Norez C, Noël S, Jougla C, Becq F, Vandebrouck C.

Reprod Nutr Dev. 2006 May-Jun;46(3):241-55. Epub 2006 May 30.

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