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Items: 1 to 50 of 172

1.

Modulation of Protein-Interaction States through the Cell Cycle.

Dai L, Zhao T, Bisteau X, Sun W, Prabhu N, Lim YT, Sobota RM, Kaldis P, Nordlund P.

Cell. 2018 May 31;173(6):1481-1494.e13. doi: 10.1016/j.cell.2018.03.065. Epub 2018 Apr 26.

PMID:
29706543
2.

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells.

Tan CSH, Go KD, Bisteau X, Dai L, Yong CH, Prabhu N, Ozturk MB, Lim YT, Sreekumar L, Lengqvist J, Tergaonkar V, Kaldis P, Sobota RM, Nordlund P.

Science. 2018 Mar 9;359(6380):1170-1177. doi: 10.1126/science.aan0346. Epub 2018 Feb 8.

PMID:
29439025
3.

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.

Kitagawa M, Liao PJ, Lee KH, Wong J, Shang SC, Minami N, Sampetrean O, Saya H, Lingyun D, Prabhu N, Diam GK, Sobota R, Larsson A, Nordlund P, McCormick F, Ghosh S, Epstein DM, Dymock BW, Lee SH.

Nat Commun. 2017 Dec 19;8(1):2200. doi: 10.1038/s41467-017-02287-5.

4.

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.

Chen D, Jansson A, Sim D, Larsson A, Nordlund P.

J Biol Chem. 2017 Aug 11;292(32):13449-13458. doi: 10.1074/jbc.M117.787267. Epub 2017 Jun 20.

5.

High target attainment for β-lactam antibiotics in intensive care unit patients when actual minimum inhibitory concentrations are applied.

Woksepp H, Hällgren A, Borgström S, Kullberg F, Wimmerstedt A, Oscarsson A, Nordlund P, Lindholm ML, Bonnedahl J, Brudin L, Carlsson B, Schön T.

Eur J Clin Microbiol Infect Dis. 2017 Mar;36(3):553-563. doi: 10.1007/s10096-016-2832-4. Epub 2016 Nov 4.

PMID:
27815778
6.

Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus.

Hew K, Veerappan S, Sim D, Cornvik T, Nordlund P, Dahlroth SL.

J Virol. 2017 Jan 3;91(2). pii: e01947-16. doi: 10.1128/JVI.01947-16. Print 2017 Jan 15.

7.

Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.

Quistgaard EM, Weininger U, Ural-Blimke Y, Modig K, Nordlund P, Akke M, Löw C.

BMC Biol. 2016 Sep 23;14(1):82.

8.

Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design.

Chandramohan A, Krishnamurthy S, Larsson A, Nordlund P, Jansson A, Anand GS.

PLoS Comput Biol. 2016 Jun 2;12(6):e1004840. doi: 10.1371/journal.pcbi.1004840. eCollection 2016 Jun.

9.

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P.

Nat Commun. 2016 Mar 24;7:11040. doi: 10.1038/ncomms11040.

10.

A saposin-lipoprotein nanoparticle system for membrane proteins.

Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P.

Nat Methods. 2016 Apr;13(4):345-51. doi: 10.1038/nmeth.3801. Epub 2016 Mar 7.

11.

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.

Mills SJ, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter BV.

Biochemistry. 2016 Mar 8;55(9):1384-97. doi: 10.1021/acs.biochem.5b00838. Epub 2016 Feb 29.

12.

The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.

Lim SM, Yeung K, Trésaugues L, Ling TH, Nordlund P.

FEBS J. 2016 Mar;283(6):1107-23. doi: 10.1111/febs.13655. Epub 2016 Feb 5.

13.

Understanding transport by the major facilitator superfamily (MFS): structures pave the way.

Quistgaard EM, Löw C, Guettou F, Nordlund P.

Nat Rev Mol Cell Biol. 2016 Feb;17(2):123-32. doi: 10.1038/nrm.2015.25. Epub 2016 Jan 13. Review.

PMID:
26758938
14.

Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.

Hew K, Dahlroth SL, Veerappan S, Pan LX, Cornvik T, Nordlund P.

PLoS One. 2015 Dec 2;10(12):e0143947. doi: 10.1371/journal.pone.0143947. eCollection 2015.

15.

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies.

Martinez Molina D, Nordlund P.

Annu Rev Pharmacol Toxicol. 2016;56:141-61. doi: 10.1146/annurev-pharmtox-010715-103715. Epub 2015 Nov 9. Review.

PMID:
26566155
16.

Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays.

Tan BX, Brown CJ, Ferrer FJ, Yuen TY, Quah ST, Chan BH, Jansson AE, Teo HL, Nordlund P, Lane DP.

Sci Rep. 2015 Jul 10;5:12116. doi: 10.1038/srep12116.

17.

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.

Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P.

PLoS One. 2015 Jun 29;10(6):e0131507. doi: 10.1371/journal.pone.0131507. eCollection 2015.

18.

Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1.

Patel V, Dahlroth SL, Rajakannan V, Ho HT, Cornvik T, Nordlund P.

J Virol. 2015 Sep;89(17):8828-39. doi: 10.1128/JVI.00441-15. Epub 2015 Jun 17.

19.

VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies.

Hew K, Dahlroth SL, Pan LX, Cornvik T, Nordlund P.

J Gen Virol. 2015 Jun;96(Pt 6):1436-45. doi: 10.1099/vir.0.000078. Epub 2015 Feb 24.

20.

Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.

Li Y, Jain N, Limpanawat S, To J, Quistgaard EM, Nordlund P, Thanabalu T, Torres J.

Virology. 2015 Aug;482:105-10. doi: 10.1016/j.virol.2015.03.034. Epub 2015 Apr 2.

21.

Tracking cancer drugs in living cells by thermal profiling of the proteome.

Savitski MM, Reinhard FB, Franken H, Werner T, Savitski MF, Eberhard D, Martinez Molina D, Jafari R, Dovega RB, Klaeger S, Kuster B, Nordlund P, Bantscheff M, Drewes G.

Science. 2014 Oct 3;346(6205):1255784. doi: 10.1126/science.1255784. Epub 2014 Oct 2.

22.

The cellular thermal shift assay for evaluating drug target interactions in cells.

Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundbäck T, Nordlund P, Martinez Molina D.

Nat Protoc. 2014 Sep;9(9):2100-22. doi: 10.1038/nprot.2014.138. Epub 2014 Aug 7.

PMID:
25101824
23.

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.

Guettou F, Quistgaard EM, Raba M, Moberg P, Löw C, Nordlund P.

Nat Struct Mol Biol. 2014 Aug;21(8):728-31. doi: 10.1038/nsmb.2860. Epub 2014 Jul 27.

PMID:
25064511
24.

Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A.

Dovega R, Tsutakawa S, Quistgaard EM, Anandapadamanaban M, Löw C, Nordlund P.

PLoS One. 2014 Jul 9;9(7):e101846. doi: 10.1371/journal.pone.0101846. eCollection 2014.

25.

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.

Löw C, Quistgaard EM, Kovermann M, Anandapadamanaban M, Balbach J, Nordlund P.

Biol Chem. 2014 Jul;395(7-8):881-9. doi: 10.1515/hsz-2014-0106.

PMID:
25003389
26.

Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases.

Trésaugues L, Silvander C, Flodin S, Welin M, Nyman T, Gräslund S, Hammarström M, Berglund H, Nordlund P.

Structure. 2014 May 6;22(5):744-55. doi: 10.1016/j.str.2014.01.013. Epub 2014 Apr 3.

27.

Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell.

Asial I, Cheng YX, Engman H, Dollhopf M, Wu B, Nordlund P, Cornvik T.

Nat Commun. 2013;4:2901. doi: 10.1038/ncomms3901.

PMID:
24352381
28.

Nanobody mediated crystallization of an archeal mechanosensitive channel.

Löw C, Yau YH, Pardon E, Jegerschöld C, Wåhlin L, Quistgaard EM, Moberg P, Geifman-Shochat S, Steyaert J, Nordlund P.

PLoS One. 2013 Oct 21;8(10):e77984. doi: 10.1371/journal.pone.0077984. eCollection 2013.

29.

A prospective longitudinal multicentre study of health related quality of life in ICU survivors with COPD.

Berkius J, Engerström L, Orwelius L, Nordlund P, Sjöberg F, Fredrikson M, Walther SM.

Crit Care. 2013 Sep 24;17(5):R211. doi: 10.1186/cc13019.

30.

Metal-mediated crystallization of the xylose transporter XylE from Escherichia coli in three different crystal forms.

Quistgaard EM, Löw C, Moberg P, Nordlund P.

J Struct Biol. 2013 Nov;184(2):375-8. doi: 10.1016/j.jsb.2013.09.009. Epub 2013 Sep 21.

PMID:
24060988
31.

Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31.

Quistgaard EM, Löw C, Moberg P, Guettou F, Maddi K, Nordlund P.

PLoS One. 2013 Aug 13;8(8):e71111. doi: 10.1371/journal.pone.0071111. eCollection 2013.

32.

Structural insights into substrate recognition in proton-dependent oligopeptide transporters.

Guettou F, Quistgaard EM, Trésaugues L, Moberg P, Jegerschöld C, Zhu L, Jong AJ, Nordlund P, Löw C.

EMBO Rep. 2013 Sep;14(9):804-10. doi: 10.1038/embor.2013.107. Epub 2013 Jul 19.

33.

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, Sreekumar L, Cao Y, Nordlund P.

Science. 2013 Jul 5;341(6141):84-7. doi: 10.1126/science.1233606.

34.

Substrate specificity and oligomerization of human GMP synthetase.

Welin M, Lehtiö L, Johansson A, Flodin S, Nyman T, Trésaugues L, Hammarström M, Gräslund S, Nordlund P.

J Mol Biol. 2013 Nov 15;425(22):4323-33. doi: 10.1016/j.jmb.2013.06.032. Epub 2013 Jun 28.

35.

Fragment-based ligand design of novel potent inhibitors of tankyrases.

Larsson EA, Jansson A, Ng FM, Then SW, Panicker R, Liu B, Sangthongpitag K, Pendharkar V, Tai SJ, Hill J, Dan C, Ho SY, Cheong WW, Poulsen A, Blanchard S, Lin GR, Alam J, Keller TH, Nordlund P.

J Med Chem. 2013 Jun 13;56(11):4497-508. doi: 10.1021/jm400211f. Epub 2013 Jun 4.

PMID:
23672613
36.

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.

Quistgaard EM, Löw C, Moberg P, Trésaugues L, Nordlund P.

Nat Struct Mol Biol. 2013 Jun;20(6):766-8. doi: 10.1038/nsmb.2569. Epub 2013 Apr 28.

PMID:
23624861
37.

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.

Lim SM, Chen D, Teo H, Roos A, Jansson AE, Nyman T, Trésaugues L, Pervushin K, Nordlund P.

J Lipid Res. 2013 Jun;54(6):1630-43. doi: 10.1194/jlr.M035410. Epub 2013 Mar 22.

38.

The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor.

Hew K, Dahlroth SL, Venkatachalam R, Nasertorabi F, Lim BT, Cornvik T, Nordlund P.

Nucleic Acids Res. 2013 Apr;41(7):4295-306. doi: 10.1093/nar/gkt082. Epub 2013 Feb 21.

39.

High-throughput analytical gel filtration screening of integral membrane proteins for structural studies.

Löw C, Moberg P, Quistgaard EM, Hedrén M, Guettou F, Frauenfeld J, Haneskog L, Nordlund P.

Biochim Biophys Acta. 2013 Jun;1830(6):3497-508. doi: 10.1016/j.bbagen.2013.02.001. Epub 2013 Feb 9.

PMID:
23403133
40.

Retraction of mechanistic basis for Epstein-Barr Virus ribonucleotide-reductase small-subunit function.

Schmitzberger F, Gurmu D, Dahlroth SL, Nordlund P.

ACS Chem Biol. 2012 Oct 19;7(10):1764. doi: 10.1021/cb300098t. Epub 2012 Jul 23. No abstract available.

PMID:
22824004
41.

High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA.

Quistgaard EM, Nordlund P, Löw C.

FASEB J. 2012 Oct;26(10):4003-13. doi: 10.1096/fj.12-208397. Epub 2012 Jun 26.

PMID:
22735173
42.

Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1.

Löw C, Jegerschöld C, Kovermann M, Moberg P, Nordlund P.

PLoS One. 2012;7(6):e38244. doi: 10.1371/journal.pone.0038244. Epub 2012 Jun 1.

43.

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

Egeblad L, Welin M, Flodin S, Gräslund S, Wang L, Balzarini J, Eriksson S, Nordlund P.

PLoS One. 2012;7(5):e37724. doi: 10.1371/journal.pone.0037724. Epub 2012 May 25.

44.

Physical effects of trauma and the psychological consequences of preexisting diseases account for a significant portion of the health-related quality of life patterns of former trauma patients.

Orwelius L, Bergkvist M, Nordlund A, Simonsson E, Nordlund P, Bäckman C, Sjöberg F.

J Trauma Acute Care Surg. 2012 Feb;72(2):504-12.

PMID:
22439224
45.

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery.

Mills SJ, Persson C, Cozier G, Thomas MP, Trésaugues L, Erneux C, Riley AM, Nordlund P, Potter BV.

ACS Chem Biol. 2012 May 18;7(5):822-8. doi: 10.1021/cb200494d. Epub 2012 Feb 27.

46.

Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.

Patton GC, Stenmark P, Gollapalli DR, Sevastik R, Kursula P, Flodin S, Schuler H, Swales CT, Eklund H, Himo F, Nordlund P, Hedstrom L.

Nat Chem Biol. 2011 Oct 30;7(12):950-8. doi: 10.1038/nchembio.693.

47.

HF-EPR, Raman, UV/VIS light spectroscopic, and DFT studies of the ribonucleotide reductase R2 tyrosyl radical from Epstein-Barr virus.

Tomter AB, Zoppellaro G, Schmitzberger F, Andersen NH, Barra AL, Engman H, Nordlund P, Andersson KK.

PLoS One. 2011;6(9):e25022. doi: 10.1371/journal.pone.0025022. Epub 2011 Sep 27.

48.

Efficiency of hit generation and structural characterization in fragment-based ligand discovery.

Larsson A, Jansson A, Åberg A, Nordlund P.

Curr Opin Chem Biol. 2011 Aug;15(4):482-8. doi: 10.1016/j.cbpa.2011.06.008. Epub 2011 Jul 1. Review.

PMID:
21724447
49.

Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II.

Walldén K, Nordlund P.

J Mol Biol. 2011 May 13;408(4):684-96. doi: 10.1016/j.jmb.2011.02.059. Epub 2011 Mar 17.

PMID:
21396942
50.

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.

Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG.

Nat Struct Mol Biol. 2011 Mar;18(3):316-22. doi: 10.1038/nsmb.2007. Epub 2011 Feb 20.

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