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Items: 19


Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.

Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J 3rd, Dickey CA, Blair LJ.

ACS Chem Biol. 2018 Aug 17;13(8):2288-2299. doi: 10.1021/acschembio.8b00454. Epub 2018 Jun 19.


The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.

Taylor IR, Ahmad A, Wu T, Nordhues BA, Bhullar A, Gestwicki JE, Zuiderweg ERP.

J Biol Chem. 2018 Jul 6;293(27):10796-10809. doi: 10.1074/jbc.RA118.002234. Epub 2018 May 15.


Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.

Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J 3rd, Dickey CA.

Sci Rep. 2017 Dec 20;7(1):17951. doi: 10.1038/s41598-017-18344-4.


Hsp90 activator Aha1 drives production of pathological tau aggregates.

Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J 3rd, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712. doi: 10.1073/pnas.1707039114. Epub 2017 Aug 21.


Human cyclophilin 40 unravels neurotoxic amyloids.

Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J 3rd, Blair LJ.

PLoS Biol. 2017 Jun 27;15(6):e2001336. doi: 10.1371/journal.pbio.2001336. eCollection 2017 Jun.


DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.

Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA.

EMBO J. 2016 Jul 15;35(14):1537-49. doi: 10.15252/embj.201593489. Epub 2016 Jun 3.


Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.

Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA.

ACS Chem Biol. 2016 Jul 15;11(7):2041-8. doi: 10.1021/acschembio.6b00223. Epub 2016 May 26.


Nuclear Magnetic Resonance Characterization of the Type III Secretion System Tip Chaperone Protein PcrG of Pseudomonas aeruginosa.

Chaudhury S, Nordhues BA, Kaur K, Zhang N, De Guzman RN.

Biochemistry. 2015 Nov 3;54(43):6576-85. doi: 10.1021/acs.biochem.5b00664. Epub 2015 Oct 21.


The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA.

Hum Mol Genet. 2015 Jul 15;24(14):3971-81. doi: 10.1093/hmg/ddv135. Epub 2015 Apr 16.


Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA.

J Biol Chem. 2015 May 22;290(21):13115-27. doi: 10.1074/jbc.M115.637595. Epub 2015 Apr 11.


Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy.

Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica ML, Dickey CA.

Acta Neuropathol Commun. 2015 Jan 31;3:8. doi: 10.1186/s40478-015-0186-2.


Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

Sabbagh JJ, O'Leary JC 3rd, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA.

PLoS One. 2014 Sep 5;9(9):e107241. doi: 10.1371/journal.pone.0107241. eCollection 2014.


Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.

Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA.

J Neuroinflammation. 2014 Sep 3;11:152. doi: 10.1186/s12974-014-0152-0.


Hsp90-Tau complex reveals molecular basis for specificity in chaperone action.

Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG.

Cell. 2014 Feb 27;156(5):963-74. doi: 10.1016/j.cell.2014.01.037.


Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC 3rd, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA.

J Clin Invest. 2013 Oct;123(10):4158-69. doi: 10.1172/JCI69003. Epub 2013 Sep 3.


Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.

Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA.

J Neurosci. 2013 May 29;33(22):9498-507. doi: 10.1523/JNEUROSCI.5397-12.2013.


Imbalance of Hsp70 family variants fosters tau accumulation.

Jinwal UK, Akoury E, Abisambra JF, O'Leary JC 3rd, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA.

FASEB J. 2013 Apr;27(4):1450-9. doi: 10.1096/fj.12-220889. Epub 2012 Dec 27.


The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate.

Chatterjee S, Zhong D, Nordhues BA, Battaile KP, Lovell S, De Guzman RN.

Protein Sci. 2011 Jan;20(1):75-86. doi: 10.1002/pro.537.


NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile salts.

Wang Y, Nordhues BA, Zhong D, De Guzman RN.

Biochemistry. 2010 May 18;49(19):4220-6. doi: 10.1021/bi100335u.

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