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Items: 46


Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes.

Wu X, Dayanand KK, Thylur RP, Norbury CC, Gowda DC.

J Biol Chem. 2017 Aug 18;292(33):13615-13634. doi: 10.1074/jbc.M116.770313. Epub 2017 Jul 5.


A systemic macrophage response is required to contain a peripheral poxvirus infection.

Davies ML, Parekh NJ, Kaminsky LW, Soni C, Reider IE, Krouse TE, Fischer MA, van Rooijen N, Rahman ZSM, Norbury CC.

PLoS Pathog. 2017 Jun 14;13(6):e1006435. doi: 10.1371/journal.ppat.1006435. eCollection 2017 Jun.


Editorial overview: Antigen processing.

Norbury CC, Eisenlohr LC.

Curr Opin Immunol. 2016 Jun;40:v-vi. doi: 10.1016/j.coi.2016.04.006. Epub 2016 May 10. Review. No abstract available.


Defining cross presentation for a wider audience.

Norbury CC.

Curr Opin Immunol. 2016 Jun;40:110-6. doi: 10.1016/j.coi.2016.04.003. Epub 2016 Apr 18. Review.


Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection.

Kaminsky LW, Sei JJ, Parekh NJ, Davies ML, Reider IE, Krouse TE, Norbury CC.

J Virol. 2015 Oct;89(19):9974-85. doi: 10.1128/JVI.01024-15. Epub 2015 Jul 22.


Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.

Sei JJ, Haskett S, Kaminsky LW, Lin E, Truckenmiller ME, Bellone CJ, Buller RM, Norbury CC.

PLoS Pathog. 2015 Jun 24;11(6):e1004941. doi: 10.1371/journal.ppat.1004941. eCollection 2015 Jun.


Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation.

Heipertz EL, Davies ML, Lin E, Norbury CC.

J Immunol. 2014 Oct 15;193(8):4169-77. doi: 10.4049/jimmunol.1302565. Epub 2014 Sep 15.


MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2.

Davies ML, Sei JJ, Siciliano NA, Xu RH, Roscoe F, Sigal LJ, Eisenlohr LC, Norbury CC.

J Virol. 2014 Mar;88(6):3557-67. doi: 10.1128/JVI.02776-13. Epub 2014 Jan 8.


Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection.

Rubio D, Xu RH, Remakus S, Krouse TE, Truckenmiller ME, Thapa RJ, Balachandran S, Alcamí A, Norbury CC, Sigal LJ.

Cell Host Microbe. 2013 Jun 12;13(6):701-10. doi: 10.1016/j.chom.2013.04.015.


Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.

Xu RH, Rubio D, Roscoe F, Krouse TE, Truckenmiller ME, Norbury CC, Hudson PN, Damon IK, Alcamí A, Sigal LJ.

PLoS Pathog. 2012 Jan;8(1):e1002475. doi: 10.1371/journal.ppat.1002475. Epub 2012 Jan 5.


Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina.

Heuss ND, Lehmann U, Norbury CC, McPherson SW, Gregerson DS.

J Immunol. 2012 Feb 1;188(3):1191-200. doi: 10.4049/jimmunol.1101621. Epub 2012 Jan 4.


CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection.

Fischer MA, Davies ML, Reider IE, Heipertz EL, Epler MR, Sei JJ, Ingersoll MA, Rooijen NV, Randolph GJ, Norbury CC.

PLoS Pathog. 2011 Nov;7(11):e1002374. doi: 10.1371/journal.ppat.1002374. Epub 2011 Nov 10.


A marked reduction in priming of cytotoxic CD8+ T cells mediated by stress-induced glucocorticoids involves multiple deficiencies in cross-presentation by dendritic cells.

Hunzeker JT, Elftman MD, Mellinger JC, Princiotta MF, Bonneau RH, Truckenmiller ME, Norbury CC.

J Immunol. 2011 Jan 1;186(1):183-94. doi: 10.4049/jimmunol.1001737. Epub 2010 Nov 22.


Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function.

Elftman MD, Hunzeker JT, Mellinger JC, Bonneau RH, Norbury CC, Truckenmiller ME.

J Immunol. 2010 Feb 15;184(4):1867-75. doi: 10.4049/jimmunol.0902469. Epub 2010 Jan 20.


Dendritic cell migration limits the duration of CD8+ T-cell priming to peripheral viral antigen.

Schell AM, Granger EL, Koczot F, Fischer MA, Norbury CC.

J Virol. 2010 Apr;84(7):3586-94. doi: 10.1128/JVI.01975-09. Epub 2010 Jan 20.


Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

Hong EG, Ko HJ, Cho YR, Kim HJ, Ma Z, Yu TY, Friedline RH, Kurt-Jones E, Finberg R, Fischer MA, Granger EL, Norbury CC, Hauschka SD, Philbrick WM, Lee CG, Elias JA, Kim JK.

Diabetes. 2009 Nov;58(11):2525-35. doi: 10.2337/db08-1261. Epub 2009 Aug 18.


Viral sequestration of antigen subverts cross presentation to CD8(+) T cells.

Tewalt EF, Grant JM, Granger EL, Palmer DC, Heuss ND, Gregerson DS, Restifo NP, Norbury CC.

PLoS Pathog. 2009 May;5(5):e1000457. doi: 10.1371/journal.ppat.1000457. Epub 2009 May 29.


Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.

Tewalt EF, Maynard JC, Walters JJ, Schell AM, Berwin BL, Nicchitta CV, Norbury CC.

Immunology. 2008 Dec;125(4):480-91. doi: 10.1111/j.1365-2567.2008.02861.x. Epub 2008 May 15.


Corticosterone impairs dendritic cell maturation and function.

Elftman MD, Norbury CC, Bonneau RH, Truckenmiller ME.

Immunology. 2007 Oct;122(2):279-90.


Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming.

Fischer MA, Tscharke DC, Donohue KB, Truckenmiller ME, Norbury CC.

J Gen Virol. 2007 Sep;88(Pt 9):2378-86.


Initiation of primary anti-vaccinia virus immunity in vivo.

Fischer MA, Norbury CC.

Immunol Res. 2007;37(2):113-33. Review.


Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses.

Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC.

J Exp Med. 2007 Jun 11;204(6):1475-85. Epub 2007 Jun 4.


Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells.

Zhang B, Ramesh G, Norbury CC, Reeves WB.

Kidney Int. 2007 Jul;72(1):37-44. Epub 2007 Mar 28.


Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA; JDRF Diabetic Retinopathy Center Group.

Diabetes. 2006 Sep;55(9):2401-11.


Cross-priming utilizes antigen not available to the direct presentation pathway.

Donohue KB, Grant JM, Tewalt EF, Palmer DC, Theoret MR, Restifo NP, Norbury CC.

Immunology. 2006 Sep;119(1):63-73. Epub 2006 Jun 8.


Upstream toward the "DRiP"-ing source of the MHC class I pathway.

Norbury CC, Tewalt EF.

Immunity. 2006 May;24(5):503-6. Review.


Drinking a lot is good for dendritic cells.

Norbury CC.

Immunology. 2006 Apr;117(4):443-51. Review.


Stress presents a problem for dendritic cells: corticosterone and the fate of MHC class I antigen processing and presentation.

Truckenmiller ME, Bonneau RH, Norbury CC.

Brain Behav Immun. 2006 May;20(3):210-8. Epub 2006 Feb 28. Review.


Regulation of T cell development by the deubiquitinating enzyme CYLD.

Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC, Sun SC.

Nat Immunol. 2006 Apr;7(4):411-7. Epub 2006 Feb 26.


Corticosterone impairs MHC class I antigen presentation by dendritic cells via reduction of peptide generation.

Truckenmiller ME, Princiotta MF, Norbury CC, Bonneau RH.

J Neuroimmunol. 2005 Mar;160(1-2):48-60. Epub 2004 Dec 23.


Viral vectors for inducing CD8+ T cell responses.

Truckenmiller ME, Norbury CC.

Expert Opin Biol Ther. 2004 Jun;4(6):861-8. Review.


CD8+ T cell cross-priming via transfer of proteasome substrates.

Norbury CC, Basta S, Donohue KB, Tscharke DC, Princiotta MF, Berglund P, Gibbs J, Bennink JR, Yewdell JW.

Science. 2004 May 28;304(5675):1318-21.


Cross priming or direct priming: is that really the question?

Norbury CC, Sigal LJ.

Curr Opin Immunol. 2003 Feb;15(1):82-8. Review. No abstract available.


Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo.

Norbury CC, Malide D, Gibbs JS, Bennink JR, Yewdell JW.

Nat Immunol. 2002 Mar;3(3):265-71. Epub 2002 Feb 4.


Multiple paths for activation of naive CD8+ T cells: CD4-independent help.

Wang B, Norbury CC, Greenwood R, Bennink JR, Yewdell JW, Frelinger JA.

J Immunol. 2001 Aug 1;167(3):1283-9.


Multiple antigen-specific processing pathways for activating naive CD8+ T cells in vivo.

Norbury CC, Princiotta MF, Bacik I, Brutkiewicz RR, Wood P, Elliott T, Bennink JR, Yewdell JW.

J Immunol. 2001 Apr 1;166(7):4355-62.


Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

Schubert U, Antón LC, Gibbs J, Norbury CC, Yewdell JW, Bennink JR.

Nature. 2000 Apr 13;404(6779):770-4.


Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages.

Norbury CC, Hewlett LJ, Prescott AR, Shastri N, Watts C.

Immunity. 1995 Dec;3(6):783-91.

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