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Items: 1 to 50 of 64

1.

The Streptococcus agalactiae complement interfering protein combines multiple complement-inhibitory mechanisms by interacting with both C4 and C3 ligands.

Giussani S, Pietrocola G, Donnarumma D, Norais N, Speziale P, Fabbrini M, Margarit I.

FASEB J. 2019 Mar;33(3):4448-4457. doi: 10.1096/fj.201801991R. Epub 2018 Dec 19.

2.

Generation and characterization of a bivalent protein boost for future clinical trials: HIV-1 subtypes CR01_AE and B gp120 antigens with a potent adjuvant.

Wen Y, Trinh HV, Linton CE, Tani C, Norais N, Martinez-Guzman D, Ramesh P, Sun Y, Situ F, Karaca-Griffin S, Hamlin C, Onkar S, Tian S, Hilt S, Malyala P, Lodaya R, Li N, Otten G, Palladino G, Friedrich K, Aggarwal Y, LaBranche C, Duffy R, Shen X, Tomaras GD, Montefiori DC, Fulp W, Gottardo R, Burke B, Ulmer JB, Zolla-Pazner S, Liao HX, Haynes BF, Michael NL, Kim JH, Rao M, O'Connell RJ, Carfi A, Barnett SW.

PLoS One. 2018 Apr 26;13(4):e0194266. doi: 10.1371/journal.pone.0194266. eCollection 2018.

3.

Native State Organization of Outer Membrane Porins Unraveled by HDx-MS.

Donnarumma D, Maestri C, Giammarinaro PI, Capriotti L, Bartolini E, Veggi D, Petracca R, Scarselli M, Norais N.

J Proteome Res. 2018 May 4;17(5):1794-1800. doi: 10.1021/acs.jproteome.7b00830. Epub 2018 Apr 17.

4.

Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes.

Giuliani M, Bartolini E, Galli B, Santini L, Lo Surdo P, Buricchi F, Bruttini M, Benucci B, Pacchiani N, Alleri L, Donnarumma D, Pansegrau W, Peschiera I, Ferlenghi I, Cozzi R, Norais N, Giuliani MM, Maione D, Pizza M, Rappuoli R, Finco O, Masignani V.

Sci Rep. 2018 Feb 27;8(1):3700. doi: 10.1038/s41598-018-22057-7.

5.

Outer Membrane Vesicles (OMV)-based and Proteomics-driven Antigen Selection Identifies Novel Factors Contributing to Bordetella pertussis Adhesion to Epithelial Cells.

Gasperini G, Biagini M, Arato V, Gianfaldoni C, Vadi A, Norais N, Bensi G, Delany I, Pizza M, Aricò B, Leuzzi R.

Mol Cell Proteomics. 2018 Feb;17(2):205-215. doi: 10.1074/mcp.RA117.000045. Epub 2017 Dec 4.

6.

Structural basis for potent antibody-mediated neutralization of human cytomegalovirus.

Chandramouli S, Malito E, Nguyen T, Luisi K, Donnarumma D, Xing Y, Norais N, Yu D, Carfi A.

Sci Immunol. 2017 Jun 30;2(12). pii: eaan1457. doi: 10.1126/sciimmunol.aan1457.

PMID:
28783665
7.

Surface and Exoproteomes of Gram-Positive Pathogens for Vaccine Discovery.

Biagini M, Bagnoli F, Norais N.

Curr Top Microbiol Immunol. 2017;404:309-337. doi: 10.1007/82_2016_50. Review.

PMID:
28204975
8.

Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries.

Domina M, Lanza Cariccio V, Benfatto S, Venza M, Venza I, Donnarumma D, Bartolini E, Borgogni E, Bruttini M, Santini L, Midiri A, Galbo R, Romeo L, Patanè F, Biondo C, Norais N, Masignani V, Teti G, Felici F, Beninati C.

PLoS One. 2016 Aug 10;11(8):e0160702. doi: 10.1371/journal.pone.0160702. eCollection 2016.

9.

Phage display revisited: Epitope mapping of a monoclonal antibody directed against Neisseria meningitidis adhesin A using the PROFILER technology.

Cariccio VL, Domina M, Benfatto S, Venza M, Venza I, Faleri A, Bruttini M, Bartolini E, Giuliani MM, Santini L, Brunelli B, Norais N, Borgogni E, Midiri A, Galbo R, Romeo L, Biondo C, Masignani V, Teti G, Felici F, Beninati C.

MAbs. 2016 May-Jun;8(4):741-50. doi: 10.1080/19420862.2016.1158371. Epub 2016 Mar 10.

10.

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Biagini M, Spinsanti M, De Angelis G, Tomei S, Ferlenghi I, Scarselli M, Rigat F, Messuti N, Biolchi A, Muzzi A, Anderloni G, Brunelli B, Cartocci E, Buricchi F, Tani C, Stella M, Moschioni M, Del Tordello E, Colaprico A, Savino S, Giuliani MM, Delany I, Pizza M, Costantino P, Norais N, Rappuoli R, Masignani V.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2714-9. doi: 10.1073/pnas.1521142113. Epub 2016 Feb 17.

11.

The role of structural proteomics in vaccine development: recent advances and future prospects.

Donnarumma D, Faleri A, Costantino P, Rappuoli R, Norais N.

Expert Rev Proteomics. 2016;13(1):55-68. doi: 10.1586/14789450.2016.1121113. Review.

PMID:
26714563
12.

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies.

Ciferri C, Chandramouli S, Leitner A, Donnarumma D, Cianfrocco MA, Gerrein R, Friedrich K, Aggarwal Y, Palladino G, Aebersold R, Norais N, Settembre EC, Carfi A.

PLoS Pathog. 2015 Oct 20;11(10):e1005230. doi: 10.1371/journal.ppat.1005230. eCollection 2015 Oct.

13.

Exploiting chimeric human antibodies to characterize a protective epitope of Neisseria adhesin A, one of the Bexsero vaccine components.

Bertoldi I, Faleri A, Galli B, Lo Surdo P, Liguori A, Norais N, Santini L, Masignani V, Pizza M, Giuliani MM.

FASEB J. 2016 Jan;30(1):93-101. doi: 10.1096/fj.15-273813. Epub 2015 Aug 24.

PMID:
26304221
14.

The Human Pathogen Streptococcus pyogenes Releases Lipoproteins as Lipoprotein-rich Membrane Vesicles.

Biagini M, Garibaldi M, Aprea S, Pezzicoli A, Doro F, Becherelli M, Taddei AR, Tani C, Tavarini S, Mora M, Teti G, D'Oro U, Nuti S, Soriani M, Margarit I, Rappuoli R, Grandi G, Norais N.

Mol Cell Proteomics. 2015 Aug;14(8):2138-49. doi: 10.1074/mcp.M114.045880. Epub 2015 May 27.

15.

Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus.

Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, Lofano G, Marchi S, Galletti B, Mariotti P, Bacconi M, Torre A, Maccari S, Scarselli M, Rinaudo CD, Inoshima N, Savino S, Mori E, Rossi-Paccani S, Baudner B, Pallaoro M, Swennen E, Petracca R, Brettoni C, Liberatori S, Norais N, Monaci E, Bubeck Wardenburg J, Schneewind O, O'Hagan DT, Valiante NM, Bensi G, Bertholet S, De Gregorio E, Rappuoli R, Grandi G.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3680-5. doi: 10.1073/pnas.1424924112. Epub 2015 Mar 9.

16.

LytM proteins play a crucial role in cell separation, outer membrane composition, and pathogenesis in nontypeable Haemophilus influenzae.

Ercoli G, Tani C, Pezzicoli A, Vacca I, Martinelli M, Pecetta S, Petracca R, Rappuoli R, Pizza M, Norais N, Soriani M, Aricò B.

MBio. 2015 Feb 24;6(2):e02575. doi: 10.1128/mBio.02575-14.

17.

Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein.

Donnarumma D, Golfieri G, Brier S, Castagnini M, Veggi D, Bottomley MJ, Delany I, Norais N.

FASEB J. 2015 Jun;29(6):2260-7. doi: 10.1096/fj.14-263954. Epub 2015 Feb 20.

PMID:
25713028
18.

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes.

Ciferri C, Chandramouli S, Donnarumma D, Nikitin PA, Cianfrocco MA, Gerrein R, Feire AL, Barnett SW, Lilja AE, Rappuoli R, Norais N, Settembre EC, Carfi A.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1767-72. doi: 10.1073/pnas.1424818112. Epub 2015 Jan 26.

19.

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.

Malito E, Biancucci M, Faleri A, Ferlenghi I, Scarselli M, Maruggi G, Lo Surdo P, Veggi D, Liguori A, Santini L, Bertoldi I, Petracca R, Marchi S, Romagnoli G, Cartocci E, Vercellino I, Savino S, Spraggon G, Norais N, Pizza M, Rappuoli R, Masignani V, Bottomley MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17128-33. doi: 10.1073/pnas.1419686111. Epub 2014 Nov 17.

20.

Multidisciplinary analysis of a nontoxigenic Clostridium difficile strain with stable resistance to metronidazole.

Moura I, Monot M, Tani C, Spigaglia P, Barbanti F, Norais N, Dupuy B, Bouza E, Mastrantonio P.

Antimicrob Agents Chemother. 2014 Aug;58(8):4957-60. doi: 10.1128/AAC.02350-14. Epub 2014 Jun 9.

21.

Identification of glycosylated regions in pneumococcal PspA conjugated to serotype 6B capsular polysaccharide.

Barazzone GC, Pinto V, Donnarumma D, Tanizaki MM, Norais N, Berti F.

Glycoconj J. 2014 Apr;31(3):259-69.

PMID:
24658681
22.

Quantification by LC-MS(E) of outer membrane vesicle proteins of the Bexsero® vaccine.

Tani C, Stella M, Donnarumma D, Biagini M, Parente P, Vadi A, Magagnoli C, Costantino P, Rigat F, Norais N.

Vaccine. 2014 Mar 5;32(11):1273-9. doi: 10.1016/j.vaccine.2014.01.011. Epub 2014 Jan 23.

PMID:
24462403
23.

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties.

Faleri A, Santini L, Brier S, Pansegrau W, Lo Surdo P, Scarselli M, Buricchi F, Volpini G, Genovese A, van der Veen S, Lea S, Tang CM, Savino S, Pizza M, Finco O, Norais N, Masignani V.

FASEB J. 2014 Apr;28(4):1644-53. doi: 10.1096/fj.13-239012. Epub 2013 Dec 26.

PMID:
24371123
24.

Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteins.

Cafardi V, Biagini M, Martinelli M, Leuzzi R, Rubino JT, Cantini F, Norais N, Scarselli M, Serruto D, Unnikrishnan M.

PLoS One. 2013 Nov 26;8(11):e81306. doi: 10.1371/journal.pone.0081306. eCollection 2013.

25.

Recombinant outer membrane vesicles carrying Chlamydia muridarum HtrA induce antibodies that neutralize chlamydial infection in vitro.

Bartolini E, Ianni E, Frigimelica E, Petracca R, Galli G, Berlanda Scorza F, Norais N, Laera D, Giusti F, Pierleoni A, Donati M, Cevenini R, Finco O, Grandi G, Grifantini R.

J Extracell Vesicles. 2013 May 6;2. doi: 10.3402/jev.v2i0.20181. eCollection 2013.

26.

Auto ADP-ribosylation of NarE, a Neisseria meningitidis ADP-ribosyltransferase, regulates its catalytic activities.

Picchianti M, Del Vecchio M, Di Marcello F, Biagini M, Veggi D, Norais N, Rappuoli R, Pizza M, Balducci E.

FASEB J. 2013 Dec;27(12):4723-30. doi: 10.1096/fj.13-229955. Epub 2013 Aug 20.

PMID:
23964075
27.

Group B Streptococcus pilus sortase regulation: a single mutation in the lid region induces pilin protein polymerization in vitro.

Cozzi R, Zerbini F, Assfalg M, D'Onofrio M, Biagini M, Martinelli M, Nuccitelli A, Norais N, Telford JL, Maione D, Rinaudo CD.

FASEB J. 2013 Aug;27(8):3144-54. doi: 10.1096/fj.13-227793. Epub 2013 Apr 30.

PMID:
23631841
28.

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

Malito E, Faleri A, Lo Surdo P, Veggi D, Maruggi G, Grassi E, Cartocci E, Bertoldi I, Genovese A, Santini L, Romagnoli G, Borgogni E, Brier S, Lo Passo C, Domina M, Castellino F, Felici F, van der Veen S, Johnson S, Lea SM, Tang CM, Pizza M, Savino S, Norais N, Rappuoli R, Bottomley MJ, Masignani V.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3304-9. doi: 10.1073/pnas.1222845110. Epub 2013 Feb 8.

29.

Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine.

Fagnocchi L, Biolchi A, Ferlicca F, Boccadifuoco G, Brunelli B, Brier S, Norais N, Chiarot E, Bensi G, Kroll JS, Pizza M, Donnelly J, Giuliani MM, Delany I.

Infect Immun. 2013 Feb;81(2):560-9. doi: 10.1128/IAI.01085-12. Epub 2012 Dec 10.

30.

Arginine-specific mono ADP-ribosylation in vitro of antimicrobial peptides by ADP-ribosylating toxins.

Castagnini M, Picchianti M, Talluri E, Biagini M, Del Vecchio M, Di Procolo P, Norais N, Nardi-Dei V, Balducci E.

PLoS One. 2012;7(8):e41417. doi: 10.1371/journal.pone.0041417. Epub 2012 Aug 7.

31.

Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid.

Brier S, Fagnocchi L, Donnarumma D, Scarselli M, Rappuoli R, Nissum M, Delany I, Norais N.

Biochemistry. 2012 Aug 28;51(34):6738-52. Epub 2012 Aug 15.

PMID:
22834735
32.

High yield production process for Shigella outer membrane particles.

Berlanda Scorza F, Colucci AM, Maggiore L, Sanzone S, Rossi O, Ferlenghi I, Pesce I, Caboni M, Norais N, Di Cioccio V, Saul A, Gerke C.

PLoS One. 2012;7(6):e35616. doi: 10.1371/journal.pone.0035616. Epub 2012 Jun 6.

33.

Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case.

Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G.

Mol Cell Proteomics. 2012 Jun;11(6):M111.015693. doi: 10.1074/mcp.M111.015693. Epub 2012 Jan 27.

34.

New insights into the role of the glutamic acid of the E-box motif in group B Streptococcus pilus 2a assembly.

Cozzi R, Nuccitelli A, D'Onofrio M, Necchi F, Rosini R, Zerbini F, Biagini M, Norais N, Beier C, Telford JL, Grandi G, Assfalg M, Zacharias M, Maione D, Rinaudo CD.

FASEB J. 2012 May;26(5):2008-18. doi: 10.1096/fj.11-196378. Epub 2012 Jan 17.

PMID:
22253480
35.

Surface interactome in Streptococcus pyogenes.

Galeotti CL, Bove E, Pezzicoli A, Nogarotto R, Norais N, Pileri S, Lelli B, Falugi F, Balloni S, Tedde V, Chiarot E, Bombaci M, Soriani M, Bracci L, Grandi G, Grifantini R.

Mol Cell Proteomics. 2012 Apr;11(4):M111.015206. doi: 10.1074/mcp.M111.015206. Epub 2011 Dec 22.

36.

Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion.

Montanari P, Bozza G, Capecchi B, Caproni E, Barrile R, Norais N, Capitani M, Sallese M, Cecchini P, Ciucchi L, Gao Z, Rappuoli R, Pizza M, Aricò B, Merola M.

Cell Microbiol. 2012 Mar;14(3):368-85. doi: 10.1111/j.1462-5822.2011.01722.x. Epub 2011 Dec 8.

PMID:
22066472
37.

Sortase A substrate specificity in GBS pilus 2a cell wall anchoring.

Necchi F, Nardi-Dei V, Biagini M, Assfalg M, Nuccitelli A, Cozzi R, Norais N, Telford JL, Rinaudo CD, Grandi G, Maione D.

PLoS One. 2011;6(10):e25300. doi: 10.1371/journal.pone.0025300. Epub 2011 Oct 4.

38.

Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections.

Nuccitelli A, Cozzi R, Gourlay LJ, Donnarumma D, Necchi F, Norais N, Telford JL, Rappuoli R, Bolognesi M, Maione D, Grandi G, Rinaudo CD.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10278-83. doi: 10.1073/pnas.1106590108. Epub 2011 May 18.

39.

The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo.

Moschioni M, Emolo C, Biagini M, Maccari S, Pansegrau W, Donati C, Hilleringmann M, Ferlenghi I, Ruggiero P, Sinisi A, Pizza M, Norais N, Barocchi MA, Masignani V.

Infect Immun. 2010 Dec;78(12):5033-42. doi: 10.1128/IAI.00601-10. Epub 2010 Sep 7.

40.

Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus.

Spraggon G, Koesema E, Scarselli M, Malito E, Biagini M, Norais N, Emolo C, Barocchi MA, Giusti F, Hilleringmann M, Rappuoli R, Lesley S, Covacci A, Masignani V, Ferlenghi I.

PLoS One. 2010 Jun 15;5(6):e10919. doi: 10.1371/journal.pone.0010919.

41.

A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements.

Metruccio MM, Pigozzi E, Roncarati D, Berlanda Scorza F, Norais N, Hill SA, Scarlato V, Delany I.

PLoS Pathog. 2009 Dec;5(12):e1000710. doi: 10.1371/journal.ppat.1000710. Epub 2009 Dec 24.

42.

CT043, a protective antigen that induces a CD4+ Th1 response during Chlamydia trachomatis infection in mice and humans.

Meoni E, Faenzi E, Frigimelica E, Zedda L, Skibinski D, Giovinazzi S, Bonci A, Petracca R, Bartolini E, Galli G, Agnusdei M, Nardelli F, Buricchi F, Norais N, Ferlenghi I, Donati M, Cevenini R, Finco O, Grandi G, Grifantini R.

Infect Immun. 2009 Sep;77(9):4168-76. doi: 10.1128/IAI.00344-09. Epub 2009 Jul 13.

43.

Surfome analysis as a fast track to vaccine discovery: identification of a novel protective antigen for Group B Streptococcus hypervirulent strain COH1.

Doro F, Liberatori S, Rodríguez-Ortega MJ, Rinaudo CD, Rosini R, Mora M, Scarselli M, Altindis E, D'Aurizio R, Stella M, Margarit I, Maione D, Telford JL, Norais N, Grandi G.

Mol Cell Proteomics. 2009 Jul;8(7):1728-37. doi: 10.1074/mcp.M800486-MCP200. Epub 2009 Apr 28.

44.

Proteomics characterization of outer membrane vesicles from the extraintestinal pathogenic Escherichia coli DeltatolR IHE3034 mutant.

Berlanda Scorza F, Doro F, Rodríguez-Ortega MJ, Stella M, Liberatori S, Taddei AR, Serino L, Gomes Moriel D, Nesta B, Fontana MR, Spagnuolo A, Pizza M, Norais N, Grandi G.

Mol Cell Proteomics. 2008 Mar;7(3):473-85. Epub 2007 Nov 2.

45.

In vitro transcription and translation coupled to two-dimensional electrophoresis for bacterial proteome analysis.

Norais N, Garaguso I, Ferrari G, Grandi G.

Methods Mol Biol. 2007;375:183-209. Review.

PMID:
17634603
46.

Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles.

Ferrari G, Garaguso I, Adu-Bobie J, Doro F, Taddei AR, Biolchi A, Brunelli B, Giuliani MM, Pizza M, Norais N, Grandi G.

Proteomics. 2006 Mar;6(6):1856-66.

PMID:
16456881
47.

Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome.

Rodríguez-Ortega MJ, Norais N, Bensi G, Liberatori S, Capo S, Mora M, Scarselli M, Doro F, Ferrari G, Garaguso I, Maggi T, Neumann A, Covre A, Telford JL, Grandi G.

Nat Biotechnol. 2006 Feb;24(2):191-7. Epub 2006 Jan 15.

PMID:
16415855
48.

Identification of new potential vaccine candidates against Chlamydia pneumoniae by multiple screenings.

Finco O, Bonci A, Agnusdei M, Scarselli M, Petracca R, Norais N, Ferrari G, Garaguso I, Donati M, Sambri V, Cevenini R, Ratti G, Grandi G.

Vaccine. 2005 Jan 19;23(9):1178-88.

PMID:
15629361
49.

GNA33 of Neisseria meningitidis is a lipoprotein required for cell separation, membrane architecture, and virulence.

Adu-Bobie J, Lupetti P, Brunelli B, Granoff D, Norais N, Ferrari G, Grandi G, Rappuoli R, Pizza M.

Infect Immun. 2004 Apr;72(4):1914-9.

50.

Combined automated PCR cloning, in vitro transcription/translation and two-dimensional electrophoresis for bacterial proteome analysis.

Norais N, Nogarotto R, Lacobini ET, Garaguso I, Grifantini R, Gauli G, Grandi G.

Proteomics. 2001 Nov;1(11):1378-89.

PMID:
11922598

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