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Items: 47

1.

A unique class of lignin derivatives displays broad anti-HIV activity by interacting with the viral envelope.

Oeyen M, Noppen S, Vanhulle E, Claes S, Myrvold BO, Vermeire K, Schols D.

Virus Res. 2019 Dec;274:197760. doi: 10.1016/j.virusres.2019.197760. Epub 2019 Oct 13.

PMID:
31618614
2.

Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity.

Rybakin V, Stas M, Ugarte-Berzal E, Noppen S, Vandooren J, Van Aelst I, Liekens S, Proost P, Opdenakker G.

Biochem J. 2019 Aug 9;476(15):2191-2208. doi: 10.1042/BCJ20180382.

PMID:
31262730
3.

Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.

Gondim ACS, Roberta da Silva S, Mathys L, Noppen S, Liekens S, Holanda Sampaio A, Nagano CS, Renata Costa Rocha C, Nascimento KS, Cavada BS, Sadler PJ, Balzarini J.

Medchemcomm. 2019 Jan 14;10(3):390-398. doi: 10.1039/c8md00508g. eCollection 2019 Mar 1.

PMID:
30996857
4.

Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway.

Vrijens P, Noppen S, Boogaerts T, Vanstreels E, Ronca R, Chiodelli P, Laporte M, Vanderlinden E, Liekens S, Stevaert A, Naesens L.

J Gen Virol. 2019 Apr;100(4):583-601. doi: 10.1099/jgv.0.001235. Epub 2019 Feb 14.

PMID:
30762518
5.

CCL20, a direct-acting pro-angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV-related liver cancer.

Benkheil M, Van Haele M, Roskams T, Laporte M, Noppen S, Abbasi K, Delang L, Neyts J, Liekens S.

Exp Cell Res. 2018 Nov 15;372(2):168-177. doi: 10.1016/j.yexcr.2018.09.023. Epub 2018 Oct 2.

PMID:
30287142
6.

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity.

Janssens R, Boff D, Ruytinx P, Mortier A, Vanheule V, Larsen O, Daugvilaite V, Rosenkilde MM, Noppen S, Liekens S, Schols D, De Meester I, Opdenakker G, Struyf S, Teixeira MM, Amaral FA, Proost P.

Front Immunol. 2018 Aug 28;9:1933. doi: 10.3389/fimmu.2018.01933. eCollection 2018.

7.

Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.

Hulpia F, Noppen S, Schols D, Andrei G, Snoeck R, Liekens S, Vervaeke P, Van Calenbergh S.

Eur J Med Chem. 2018 Sep 5;157:248-267. doi: 10.1016/j.ejmech.2018.07.062. Epub 2018 Jul 29.

PMID:
30098481
8.

Anti-HIV activity of new higher order G-quadruplex aptamers obtained from tetra-end-linked oligonucleotides.

Nici F, Oliviero G, Falanga AP, D'Errico S, Marzano M, Musumeci D, Montesarchio D, Noppen S, Pannecouque C, Piccialli G, Borbone N.

Org Biomol Chem. 2018 Mar 28;16(13):2349-2355. doi: 10.1039/C7OB02346D.

PMID:
29543291
9.

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.

Bueno O, Tobajas G, Quesada E, Estévez-Gallego J, Noppen S, Camarasa MJ, Díaz JF, Liekens S, Priego EM, Pérez-Pérez MJ.

Eur J Med Chem. 2018 Mar 25;148:337-348. doi: 10.1016/j.ejmech.2018.02.019. Epub 2018 Feb 10.

PMID:
29471122
10.

2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.

El-Gazzar A, Noppen S, Thomas J, Dehaen W, Balzarini J, Liekens S.

Oncotarget. 2017 Dec 15;9(5):6259-6269. doi: 10.18632/oncotarget.23501. eCollection 2018 Jan 19.

11.

New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity.

Romanucci V, Zarrelli A, Liekens S, Noppen S, Pannecouque C, Di Fabio G.

Eur J Med Chem. 2018 Feb 10;145:425-430. doi: 10.1016/j.ejmech.2018.01.005. Epub 2018 Jan 5.

PMID:
29335208
12.

Modulation of BACE1 Activity by Chemically Modified Aptamers.

Gasse C, Zaarour M, Noppen S, Abramov M, Marlière P, Liekens S, De Strooper B, Herdewijn P.

Chembiochem. 2018 Apr 4;19(7):754-763. doi: 10.1002/cbic.201700461. Epub 2018 Feb 19.

PMID:
29327496
13.

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.

Delbart F, Brams M, Gruss F, Noppen S, Peigneur S, Boland S, Chaltin P, Brandao-Neto J, von Delft F, Touw WG, Joosten RP, Liekens S, Tytgat J, Ulens C.

J Biol Chem. 2018 Feb 16;293(7):2534-2545. doi: 10.1074/jbc.M117.815316. Epub 2017 Dec 13.

14.

Interferon lambda (IFN-λ) efficiently blocks norovirus transmission in a mouse model.

Rocha-Pereira J, Jacobs S, Noppen S, Verbeken E, Michiels T, Neyts J.

Antiviral Res. 2018 Jan;149:7-15. doi: 10.1016/j.antiviral.2017.10.017. Epub 2017 Nov 10.

PMID:
29080649
15.

Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes.

Janssens R, Mortier A, Boff D, Ruytinx P, Gouwy M, Vantilt B, Larsen O, Daugvilaite V, Rosenkilde MM, Parmentier M, Noppen S, Liekens S, Van Damme J, Struyf S, Teixeira MM, Amaral FA, Proost P.

Biochem Pharmacol. 2017 May 15;132:92-101. doi: 10.1016/j.bcp.2017.03.009. Epub 2017 Mar 18.

PMID:
28322746
16.

Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid.

Martínez-Gualda B, Sun L, Rivero-Buceta E, Flores A, Quesada E, Balzarini J, Noppen S, Liekens S, Schols D, Neyts J, Leyssen P, Mirabelli C, Camarasa MJ, San-Félix A.

Antiviral Res. 2017 Mar;139:32-40. doi: 10.1016/j.antiviral.2016.12.010. Epub 2016 Dec 23.

17.

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.

Malik S, Petrova MI, Imholz NC, Verhoeven TL, Noppen S, Van Damme EJ, Liekens S, Balzarini J, Schols D, Vanderleyden J, Lebeer S.

Sci Rep. 2016 Nov 17;6:37339. doi: 10.1038/srep37339.

18.

Bioluminescent avian pathogenic Escherichia coli for monitoring colibacillosis in experimentally infected chickens.

Oosterik LH, Tuntufye HN, Tsonos J, Luyten T, Noppen S, Liekens S, Lavigne R, Butaye P, Goddeeris BM.

Vet J. 2016 Oct;216:87-92. doi: 10.1016/j.tvjl.2016.07.011. Epub 2016 Jul 20.

PMID:
27687932
19.

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.

Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S.

Oncotarget. 2017 Feb 28;8(9):14325-14342. doi: 10.18632/oncotarget.9527.

20.

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition.

Reiser K, Mathys L, Curbo S, Pannecouque C, Noppen S, Liekens S, Engman L, Lundberg M, Balzarini J, Karlsson A.

PLoS One. 2016 Jan 27;11(1):e0147773. doi: 10.1371/journal.pone.0147773. eCollection 2016.

21.

Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques.

Oliviero G, Stornaiuolo M, D'Atri V, Nici F, Yousif AM, D'Errico S, Piccialli G, Mayol L, Novellino E, Marinelli L, Grieco P, Carotenuto A, Noppen S, Liekens S, Balzarini J, Borbone N.

Anal Chem. 2016 Feb 16;88(4):2327-34. doi: 10.1021/acs.analchem.5b04268. Epub 2016 Feb 5.

PMID:
26810800
22.

Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus.

Vanheule V, Vervaeke P, Mortier A, Noppen S, Gouwy M, Snoeck R, Andrei G, Van Damme J, Liekens S, Proost P.

Biochem Pharmacol. 2016 Jan 15;100:73-85. doi: 10.1016/j.bcp.2015.11.001. Epub 2015 Nov 10.

PMID:
26551597
23.

Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

Rivero-Buceta E, Carrero P, Casanova E, Doyagüez EG, Madrona A, Quesada E, Peréz-Pérez MJ, Mateos R, Bravo L, Mathys L, Noppen S, Kiselev E, Marchand C, Pommier Y, Liekens S, Balzarini J, Camarasa MJ, San-Félix A.

Eur J Med Chem. 2015 Dec 1;106:132-43. doi: 10.1016/j.ejmech.2015.10.027. Epub 2015 Oct 21.

PMID:
26540494
24.

Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.

Rivero-Buceta E, Doyagüez EG, Colomer I, Quesada E, Mathys L, Noppen S, Liekens S, Camarasa MJ, Pérez-Pérez MJ, Balzarini J, San-Félix A.

Eur J Med Chem. 2015 Dec 1;106:34-43. doi: 10.1016/j.ejmech.2015.10.031. Epub 2015 Oct 21.

PMID:
26513643
25.

Antiviral Activity of Synthetic Aminopyrrolic Carbohydrate Binding Agents: Targeting the Glycans of Viral gp120 to Inhibit HIV Entry.

Francesconi O, Nativi C, Gabrielli G, De Simone I, Noppen S, Balzarini J, Liekens S, Roelens S.

Chemistry. 2015 Jul 6;21(28):10089-93. doi: 10.1002/chem.201501030. Epub 2015 Jun 1.

PMID:
26033383
26.

The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors.

Liekens S, Noppen S, Gijsbers S, Sienaert R, Ronca R, Tobia C, Presta M.

Oncotarget. 2015 Mar 10;6(7):4633-48.

27.

Hairpin oligonucleotides forming G-quadruplexes: new aptamers with anti-HIV activity.

Romanucci V, Gaglione M, Messere A, Potenza N, Zarrelli A, Noppen S, Liekens S, Balzarini J, Di Fabio G.

Eur J Med Chem. 2015 Jan 7;89:51-8. doi: 10.1016/j.ejmech.2014.10.030. Epub 2014 Oct 14.

PMID:
25462225
28.

Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation.

Vermeire K, Bell TW, Van Puyenbroeck V, Giraut A, Noppen S, Liekens S, Schols D, Hartmann E, Kalies KU, Marsh M.

PLoS Biol. 2014 Dec 2;12(12):e1002011. doi: 10.1371/journal.pbio.1002011. eCollection 2014 Dec.

29.

Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family.

Férir G, Huskens D, Noppen S, Koharudin LM, Gronenborn AM, Schols D.

J Antimicrob Chemother. 2014 Oct;69(10):2746-58. doi: 10.1093/jac/dku220. Epub 2014 Jun 25.

30.

Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.

Canela MD, Pérez-Pérez MJ, Noppen S, Sáez-Calvo G, Díaz JF, Camarasa MJ, Liekens S, Priego EM.

J Med Chem. 2014 May 22;57(10):3924-38. doi: 10.1021/jm401939g. Epub 2014 May 9.

31.

Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine.

Vande Voorde J, Sabuncuoğlu S, Noppen S, Hofer A, Ranjbarian F, Fieuws S, Balzarini J, Liekens S.

J Biol Chem. 2014 May 9;289(19):13054-65. doi: 10.1074/jbc.M114.558924. Epub 2014 Mar 25.

32.

Sulfated Escherichia coli K5 polysaccharide derivatives inhibit dengue virus infection of human microvascular endothelial cells by interacting with the viral envelope protein E domain III.

Vervaeke P, Alen M, Noppen S, Schols D, Oreste P, Liekens S.

PLoS One. 2013 Aug 28;8(8):e74035. doi: 10.1371/journal.pone.0074035. eCollection 2013.

33.

2-Aminothiophene-3-carboxylic acid ester derivatives as novel highly selective cytostatic agents.

Balzarini J, Thomas J, Liekens S, Noppen S, Dehaen W, Romagnoli R.

Invest New Drugs. 2014 Feb;32(1):200-10. doi: 10.1007/s10637-013-9981-4. Epub 2013 Jun 4.

PMID:
23733228
34.

Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents.

Petrova MI, Mathys L, Lebeer S, Noppen S, Van Damme EJ, Tanaka H, Igarashi Y, Vaneechoutte M, Vanderleyden J, Balzarini J.

J Antimicrob Chemother. 2013 Sep;68(9):2026-37. doi: 10.1093/jac/dkt152. Epub 2013 May 2.

PMID:
23640125
35.

Hemozoin induces lung inflammation and correlates with malaria-associated acute respiratory distress syndrome.

Deroost K, Tyberghein A, Lays N, Noppen S, Schwarzer E, Vanstreels E, Komuta M, Prato M, Lin JW, Pamplona A, Janse CJ, Arese P, Roskams T, Daelemans D, Opdenakker G, Van den Steen PE.

Am J Respir Cell Mol Biol. 2013 May;48(5):589-600. doi: 10.1165/rcmb.2012-0450OC.

PMID:
23328641
36.

Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice.

Deroost K, Lays N, Noppen S, Martens E, Opdenakker G, Van den Steen PE.

Malar J. 2012 May 14;11:166. doi: 10.1186/1475-2875-11-166.

37.

Glycosaminoglycan mimicry by COAM reduces melanoma growth through chemokine induction and function.

Piccard H, Berghmans N, Korpos E, Dillen C, Aelst IV, Li S, Martens E, Liekens S, Noppen S, Damme JV, Sorokin L, Opdenakker G.

Int J Cancer. 2012 Aug 15;131(4):E425-36. doi: 10.1002/ijc.26465. Epub 2011 Nov 9.

38.

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation.

Remijsen Q, Vanden Berghe T, Wirawan E, Asselbergh B, Parthoens E, De Rycke R, Noppen S, Delforge M, Willems J, Vandenabeele P.

Cell Res. 2011 Feb;21(2):290-304. doi: 10.1038/cr.2010.150. Epub 2010 Nov 9.

39.

Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3.

Struyf S, Salogni L, Burdick MD, Vandercappellen J, Gouwy M, Noppen S, Proost P, Opdenakker G, Parmentier M, Gerard C, Sozzani S, Strieter RM, Van Damme J.

Blood. 2011 Jan 13;117(2):480-8. doi: 10.1182/blood-2009-11-253591. Epub 2010 Oct 27.

40.

Colocalization analysis in fluorescence micrographs: verification of a more accurate calculation of pearson's correlation coefficient.

Barlow AL, Macleod A, Noppen S, Sanderson J, Guérin CJ.

Microsc Microanal. 2010 Dec;16(6):710-24. doi: 10.1017/S143192761009389X. Epub 2010 Oct 15.

PMID:
20946701
41.

Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer.

Verbeke H, De Hertogh G, Li S, Vandercappellen J, Noppen S, Schutyser E, El-Asrar AA, Opdenakker G, Van Damme J, Geboes K, Struyf S.

Hum Pathol. 2010 Jul;41(7):990-1001. doi: 10.1016/j.humpath.2009.09.021. Epub 2010 Mar 23.

PMID:
20334899
42.

The COOH-terminal peptide of platelet factor-4 variant (CXCL4L1/PF-4var47-70) strongly inhibits angiogenesis and suppresses B16 melanoma growth in vivo.

Vandercappellen J, Liekens S, Bronckaers A, Noppen S, Ronsse I, Dillen C, Belleri M, Mitola S, Proost P, Presta M, Struyf S, Van Damme J.

Mol Cancer Res. 2010 Mar;8(3):322-34. doi: 10.1158/1541-7786.MCR-09-0176. Epub 2010 Mar 9.

43.

The transcriptional repressor Kaiso localizes at the mitotic spindle and is a constituent of the pericentriolar material.

Soubry A, Staes K, Parthoens E, Noppen S, Stove C, Bogaert P, van Hengel J, van Roy F.

PLoS One. 2010 Feb 15;5(2):e9203. doi: 10.1371/journal.pone.0009203.

44.

Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.

Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P.

J Immunol. 2009 Jan 1;182(1):666-74.

45.

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.

Proost P, Loos T, Mortier A, Schutyser E, Gouwy M, Noppen S, Dillen C, Ronsse I, Conings R, Struyf S, Opdenakker G, Maudgal PC, Van Damme J.

J Exp Med. 2008 Sep 1;205(9):2085-97. doi: 10.1084/jem.20080305. Epub 2008 Aug 18.

46.

Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.

Gouwy M, Struyf S, Noppen S, Schutyser E, Springael JY, Parmentier M, Proost P, Van Damme J.

Mol Pharmacol. 2008 Aug;74(2):485-95. doi: 10.1124/mol.108.045146. Epub 2008 May 9.

PMID:
18469140
47.

Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells.

Vandercappellen J, Noppen S, Verbeke H, Put W, Conings R, Gouwy M, Schutyser E, Proost P, Sciot R, Geboes K, Opdenakker G, Van Damme J, Struyf S.

J Leukoc Biol. 2007 Dec;82(6):1519-30. Epub 2007 Sep 7.

PMID:
17827342

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