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Design and engineering of E. coli metabolic sensor strains with a wide sensitivity range for glycerate.

Aslan S, Noor E, Vaquerizo SB, Lindner SN, Bar-Even A.

Metab Eng. 2019 Sep 3. pii: S1096-7176(19)30198-3. doi: 10.1016/j.ymben.2019.09.002. [Epub ahead of print]


High-Sensitivity Cardiac Troponin I Levels in Normal and Hypertensive Pregnancy.

Ravichandran J, Woon SY, Quek YS, Lim YC, Noor EM, Suresh K, Vigneswaran R, Vasile V, Shah A, Mills NL, Sickan J, Beshiri A, Jaffe AS.

Am J Med. 2019 Mar;132(3):362-366. doi: 10.1016/j.amjmed.2018.11.017. Epub 2018 Nov 30.


Synthesis and degradation of FtsZ quantitatively predict the first cell division in starved bacteria.

Sekar K, Rusconi R, Sauls JT, Fuhrer T, Noor E, Nguyen J, Fernandez VI, Buffing MF, Berney M, Jun S, Stocker R, Sauer U.

Mol Syst Biol. 2018 Nov 5;14(11):e8623. doi: 10.15252/msb.20188623.


Quantum chemistry reveals thermodynamic principles of redox biochemistry.

Jinich A, Flamholz A, Ren H, Kim SJ, Sanchez-Lengeling B, Cotton CAR, Noor E, Aspuru-Guzik A, Bar-Even A.

PLoS Comput Biol. 2018 Oct 24;14(10):e1006471. doi: 10.1371/journal.pcbi.1006471. eCollection 2018 Oct.


Twenty-four hour versus extended antibiotic administration after surgery in complicated appendicitis: A randomized controlled trial.

Saar S, Mihnovitš V, Lustenberger T, Rauk M, Noor EH, Lipping E, Isand KG, Lepp J, Lomp A, Lepner U, Talving P.

J Trauma Acute Care Surg. 2019 Jan;86(1):36-42. doi: 10.1097/TA.0000000000002086.


The opportunity cost of animal based diets exceeds all food losses.

Shepon A, Eshel G, Noor E, Milo R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3804-3809. doi: 10.1073/pnas.1713820115. Epub 2018 Mar 26.


Metabolic enzyme cost explains variable trade-offs between microbial growth rate and yield.

Wortel MT, Noor E, Ferris M, Bruggeman FJ, Liebermeister W.

PLoS Comput Biol. 2018 Feb 16;14(2):e1006010. doi: 10.1371/journal.pcbi.1006010. eCollection 2018 Feb.


A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication.

Piazza I, Kochanowski K, Cappelletti V, Fuhrer T, Noor E, Sauer U, Picotti P.

Cell. 2018 Jan 11;172(1-2):358-372.e23. doi: 10.1016/j.cell.2017.12.006. Epub 2018 Jan 4.


Holistic bioengineering: rewiring central metabolism for enhanced bioproduction.

Aslan S, Noor E, Bar-Even A.

Biochem J. 2017 Nov 16;474(23):3935-3950. doi: 10.1042/BCJ20170377. Review.


Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity.

Reznik E, Christodoulou D, Goldford JE, Briars E, Sauer U, Segrè D, Noor E.

Cell Rep. 2017 Sep 12;20(11):2666-2677. doi: 10.1016/j.celrep.2017.08.066.


Characterization of maize genotypes for genetic diversity on the basis of inter simple sequence repeats.

Muhammad RW, Qayyum A, Ahmad MQ, Hamza A, Yousaf M, Ahmad B, Younas M, Malik W, Liaqat S, Noor E.

Genet Mol Res. 2017 Mar 30;16(1). doi: 10.4238/gmr16019438.


Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points.

Barenholz U, Davidi D, Reznik E, Bar-On Y, Antonovsky N, Noor E, Milo R.

Elife. 2017 Feb 7;6. pii: e20667. doi: 10.7554/eLife.20667.


The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization.

Noor E, Flamholz A, Bar-Even A, Davidi D, Milo R, Liebermeister W.

PLoS Comput Biol. 2016 Nov 3;12(11):e1005167. doi: 10.1371/journal.pcbi.1005167. eCollection 2016 Nov.


Environmentally Optimal, Nutritionally Aware Beef Replacement Plant-Based Diets.

Eshel G, Shepon A, Noor E, Milo R.

Environ Sci Technol. 2016 Aug 2;50(15):8164-8. doi: 10.1021/acs.est.6b01006. Epub 2016 Jul 14.


Sugar Synthesis from CO2 in Escherichia coli.

Antonovsky N, Gleizer S, Noor E, Zohar Y, Herz E, Barenholz U, Zelcbuch L, Amram S, Wides A, Tepper N, Davidi D, Bar-On Y, Bareia T, Wernick DG, Shani I, Malitsky S, Jona G, Bar-Even A, Milo R.

Cell. 2016 Jun 30;166(1):115-25. doi: 10.1016/j.cell.2016.05.064. Epub 2016 Jun 23.


Integrated In Silico Analysis of Pathway Designs for Synthetic Photo-Electro-Autotrophy.

Volpers M, Claassens NJ, Noor E, van der Oost J, de Vos WM, Kengen SW, Martins Dos Santos VA.

PLoS One. 2016 Jun 23;11(6):e0157851. doi: 10.1371/journal.pone.0157851. eCollection 2016.


SBtab: a flexible table format for data exchange in systems biology.

Lubitz T, Hahn J, Bergmann FT, Noor E, Klipp E, Liebermeister W.

Bioinformatics. 2016 Aug 15;32(16):2559-61. doi: 10.1093/bioinformatics/btw179. Epub 2016 Apr 8.


Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data.

Gerosa L, Haverkorn van Rijsewijk BR, Christodoulou D, Kochanowski K, Schmidt TS, Noor E, Sauer U.

Cell Syst. 2015 Oct 28;1(4):270-82. doi: 10.1016/j.cels.2015.09.008. Epub 2015 Oct 22.


Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements.

Davidi D, Noor E, Liebermeister W, Bar-Even A, Flamholz A, Tummler K, Barenholz U, Goldenfeld M, Shlomi T, Milo R.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3401-6. doi: 10.1073/pnas.1514240113. Epub 2016 Mar 7.


Analysis of genetic traits for drought tolerance in maize.

Muhammad RW, Qayyum A, Hamza A, Ahmad MQ, Naseer NS, Liaqat S, Ahmad B, Malik W, Noor E.

Genet Mol Res. 2015 Oct 28;14(4):13545-65. doi: 10.4238/2015.October.28.15.


The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness.

Bar-Even A, Milo R, Noor E, Tawfik DS.

Biochemistry. 2015 Aug 18;54(32):4969-77. doi: 10.1021/acs.biochem.5b00621. Epub 2015 Aug 6. Review.


Posttranslational regulation of microbial metabolism.

Kochanowski K, Sauer U, Noor E.

Curr Opin Microbiol. 2015 Oct;27:10-7. doi: 10.1016/j.mib.2015.05.007. Epub 2015 Jun 3. Review.


Computational protein design enables a novel one-carbon assimilation pathway.

Siegel JB, Smith AL, Poust S, Wargacki AJ, Bar-Even A, Louw C, Shen BW, Eiben CB, Tran HM, Noor E, Gallaher JL, Bale J, Yoshikuni Y, Gelb MH, Keasling JD, Stoddard BL, Lidstrom ME, Baker D.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3704-9. doi: 10.1073/pnas.1500545112. Epub 2015 Mar 9.


Molecular markers and cotton genetic improvement: current status and future prospects.

Malik W, Ashraf J, Iqbal MZ, Khan AA, Qayyum A, Ali Abid M, Noor E, Ahmad MQ, Abbasi GH.

ScientificWorldJournal. 2014;2014:607091. doi: 10.1155/2014/607091. Epub 2014 Oct 23. Review.


Quantum chemical approach to estimating the thermodynamics of metabolic reactions.

Jinich A, Rappoport D, Dunn I, Sanchez-Lengeling B, Olivares-Amaya R, Noor E, Even AB, Aspuru-Guzik A.

Sci Rep. 2014 Nov 12;4:7022. doi: 10.1038/srep07022.


Intravenous thrombolysis in a patient using factor Xa inhibitor.

Korya D, Dababneh H, Moussavi M, Panezai S, Noor E, Kirmani JF.

J Vasc Interv Neurol. 2014 Sep;7(3):1-4.


Visual account of protein investment in cellular functions.

Liebermeister W, Noor E, Flamholz A, Davidi D, Bernhardt J, Milo R.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8488-93. doi: 10.1073/pnas.1314810111. Epub 2014 Jun 2.


Pathway thermodynamics highlights kinetic obstacles in central metabolism.

Noor E, Bar-Even A, Flamholz A, Reznik E, Liebermeister W, Milo R.

PLoS Comput Biol. 2014 Feb 20;10(2):e1003483. doi: 10.1371/journal.pcbi.1003483. eCollection 2014 Feb.


Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.

Tepper N, Noor E, Amador-Noguez D, Haraldsdóttir HS, Milo R, Rabinowitz J, Liebermeister W, Shlomi T.

PLoS One. 2013 Sep 26;8(9):e75370. doi: 10.1371/journal.pone.0075370. eCollection 2013.


A note on the kinetics of enzyme action: a decomposition that highlights thermodynamic effects.

Noor E, Flamholz A, Liebermeister W, Bar-Even A, Milo R.

FEBS Lett. 2013 Sep 2;587(17):2772-7. doi: 10.1016/j.febslet.2013.07.028. Epub 2013 Jul 23. Review.


Consistent estimation of Gibbs energy using component contributions.

Noor E, Haraldsdóttir HS, Milo R, Fleming RM.

PLoS Comput Biol. 2013;9(7):e1003098. doi: 10.1371/journal.pcbi.1003098. Epub 2013 Jul 11.


Quantifying translational coupling in E. coli synthetic operons using RBS modulation and fluorescent reporters.

Levin-Karp A, Barenholz U, Bareia T, Dayagi M, Zelcbuch L, Antonovsky N, Noor E, Milo R.

ACS Synth Biol. 2013 Jun 21;2(6):327-36. doi: 10.1021/sb400002n. Epub 2013 Apr 16.


Glycolytic strategy as a tradeoff between energy yield and protein cost.

Flamholz A, Noor E, Bar-Even A, Liebermeister W, Milo R.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):10039-44. doi: 10.1073/pnas.1215283110. Epub 2013 Apr 29.


Spanning high-dimensional expression space using ribosome-binding site combinatorics.

Zelcbuch L, Antonovsky N, Bar-Even A, Levin-Karp A, Barenholz U, Dayagi M, Liebermeister W, Flamholz A, Noor E, Amram S, Brandis A, Bareia T, Yofe I, Jubran H, Milo R.

Nucleic Acids Res. 2013 May;41(9):e98. doi: 10.1093/nar/gkt151. Epub 2013 Mar 6.


A proof for loop-law constraints in stoichiometric metabolic networks.

Noor E, Lewis NE, Milo R.

BMC Syst Biol. 2012 Nov 12;6:140. doi: 10.1186/1752-0509-6-140.


Design and analysis of metabolic pathways supporting formatotrophic growth for electricity-dependent cultivation of microbes.

Bar-Even A, Noor E, Flamholz A, Milo R.

Biochim Biophys Acta. 2013 Aug-Sep;1827(8-9):1039-47. doi: 10.1016/j.bbabio.2012.10.013. Epub 2012 Oct 30.


Evolution. Efficiency in evolutionary trade-offs.

Noor E, Milo R.

Science. 2012 Jun 1;336(6085):1114-5. doi: 10.1126/science.1223193. No abstract available.


An integrated open framework for thermodynamics of reactions that combines accuracy and coverage.

Noor E, Bar-Even A, Flamholz A, Lubling Y, Davidi D, Milo R.

Bioinformatics. 2012 Aug 1;28(15):2037-44. doi: 10.1093/bioinformatics/bts317. Epub 2012 May 29.


Thermodynamic constraints shape the structure of carbon fixation pathways.

Bar-Even A, Flamholz A, Noor E, Milo R.

Biochim Biophys Acta. 2012 Sep;1817(9):1646-59. doi: 10.1016/j.bbabio.2012.05.002. Epub 2012 May 17.


Rethinking glycolysis: on the biochemical logic of metabolic pathways.

Bar-Even A, Flamholz A, Noor E, Milo R.

Nat Chem Biol. 2012 May 17;8(6):509-17. doi: 10.1038/nchembio.971. Review.


A survey of carbon fixation pathways through a quantitative lens.

Bar-Even A, Noor E, Milo R.

J Exp Bot. 2012 Mar;63(6):2325-42. doi: 10.1093/jxb/err417. Epub 2011 Dec 26. Review.


eQuilibrator--the biochemical thermodynamics calculator.

Flamholz A, Noor E, Bar-Even A, Milo R.

Nucleic Acids Res. 2012 Jan;40(Database issue):D770-5. doi: 10.1093/nar/gkr874. Epub 2011 Nov 7.


Hydrophobicity and charge shape cellular metabolite concentrations.

Bar-Even A, Noor E, Flamholz A, Buescher JM, Milo R.

PLoS Comput Biol. 2011 Oct;7(10):e1002166. doi: 10.1371/journal.pcbi.1002166. Epub 2011 Oct 6. Review.


The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters.

Bar-Even A, Noor E, Savir Y, Liebermeister W, Davidi D, Tawfik DS, Milo R.

Biochemistry. 2011 May 31;50(21):4402-10. doi: 10.1021/bi2002289. Epub 2011 May 4.


Wheat hybridization and polyploidization results in deregulation of small RNAs.

Kenan-Eichler M, Leshkowitz D, Tal L, Noor E, Melamed-Bessudo C, Feldman M, Levy AA.

Genetics. 2011 Jun;188(2):263-72. doi: 10.1534/genetics.111.128348. Epub 2011 Apr 5.


Suppression of Plasmodium berghei parasitemia by LiCl in an animal infection model.

Nurul Aiezzah Z, Noor E, Hasidah MS.

Trop Biomed. 2010 Dec;27(3):624-31.


Central carbon metabolism as a minimal biochemical walk between precursors for biomass and energy.

Noor E, Eden E, Milo R, Alon U.

Mol Cell. 2010 Sep 10;39(5):809-20. doi: 10.1016/j.molcel.2010.08.031.


Design and analysis of synthetic carbon fixation pathways.

Bar-Even A, Noor E, Lewis NE, Milo R.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8889-94. doi: 10.1073/pnas.0907176107. Epub 2010 Apr 21.


Cross-species analysis traces adaptation of Rubisco toward optimality in a low-dimensional landscape.

Savir Y, Noor E, Milo R, Tlusty T.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3475-80. doi: 10.1073/pnas.0911663107. Epub 2010 Feb 8.


Varying environments can speed up evolution.

Kashtan N, Noor E, Alon U.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13711-6. Epub 2007 Aug 14.

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