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Items: 1 to 50 of 104

1.

Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.

Counihan JL, Wiggenhorn AL, Anderson KE, Nomura DK.

ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381. [Epub ahead of print]

PMID:
30004670
2.

Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception.

Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM.

Proc Natl Acad Sci U S A. 2018 Jul 2. pii: 201803389. doi: 10.1073/pnas.1803389115. [Epub ahead of print]

3.

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.

Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N.

Nat Cell Biol. 2018 Jul;20(7):811-822. doi: 10.1038/s41556-018-0122-3. Epub 2018 Jun 25.

PMID:
29941929
4.

Cancer Metabolism: Current Understanding and Therapies.

Counihan JL, Grossman EA, Nomura DK.

Chem Rev. 2018 Jun 25. doi: 10.1021/acs.chemrev.7b00775. [Epub ahead of print]

PMID:
29939018
5.

Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.

Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW.

Endocrinology. 2018 Jun 1;159(6):2408-2420. doi: 10.1210/en.2018-00040.

PMID:
29750244
6.

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.

Lin H, Long JZ, Roche AM, Svensson KJ, Dou FY, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM.

J Med Chem. 2018 Apr 12;61(7):3224-3230. doi: 10.1021/acs.jmedchem.8b00029. Epub 2018 Mar 22.

PMID:
29533650
7.

Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light.

Prasse C, Ford B, Nomura DK, Sedlak DL.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2311-2316. doi: 10.1073/pnas.1715821115. Epub 2018 Feb 20.

8.

Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells.

Tomin T, Fritz K, Gindlhuber J, Waldherr L, Pucher B, Thallinger GG, Nomura DK, Schittmayer M, Birner-Gruenberger R.

J Proteome Res. 2018 Apr 6;17(4):1415-1425. doi: 10.1021/acs.jproteome.7b00782. Epub 2018 Mar 7.

PMID:
29457907
9.

Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.

Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R.

Nature. 2018 Jan 18;553(7688):337-341. doi: 10.1038/nature25188. Epub 2018 Jan 10.

10.

Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange.

Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N.

J Chem Inf Model. 2018 Feb 26;58(2):464-471. doi: 10.1021/acs.jcim.7b00399. Epub 2018 Jan 31.

PMID:
29320178
11.

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes.

Bersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, Olzmann JA.

Dev Cell. 2018 Jan 8;44(1):97-112.e7. doi: 10.1016/j.devcel.2017.11.020. Epub 2017 Dec 21.

PMID:
29275994
12.

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors.

De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE.

Cell Rep. 2017 Nov 21;21(8):2031-2038. doi: 10.1016/j.celrep.2017.10.088.

13.

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade.

Lue HW, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, Xue CH, Rantala JK, Tyner JW, Thornburg KL, Martinez-Acevedo A, Liu JJ, Amling CL, Truillet C, Louie SM, Anderson KE, Evans MJ, O'Donnell VB, Nomura DK, Drake JM, Ritz A, Thomas GV.

Genes Dev. 2017 Oct 15;31(20):2067-2084. doi: 10.1101/gad.305292.117. Epub 2017 Nov 14.

14.

Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.

Grossman EA, Ward CC, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK.

Cell Chem Biol. 2017 Nov 16;24(11):1368-1376.e4. doi: 10.1016/j.chembiol.2017.08.013. Epub 2017 Sep 14.

PMID:
28919038
15.

Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity.

Anderson KE, To M, Olzmann JA, Nomura DK.

ACS Chem Biol. 2017 Oct 20;12(10):2522-2528. doi: 10.1021/acschembio.7b00711. Epub 2017 Sep 13.

PMID:
28892616
16.

Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae.

Chomvong K, Benjamin DI, Nomura DK, Cate JHD.

MBio. 2017 Aug 8;8(4). pii: e00855-17. doi: 10.1128/mBio.00855-17.

17.

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ.

Chen TC, Benjamin DI, Kuo T, Lee RA, Li ML, Mar DJ, Costello DE, Nomura DK, Wang JC.

Sci Signal. 2017 Jul 25;10(489). pii: eaai7905. doi: 10.1126/scisignal.aai7905.

PMID:
28743803
18.

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.

Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA.

Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003.

19.

NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.

Ward CC, Kleinman JI, Nomura DK.

ACS Chem Biol. 2017 Jun 16;12(6):1478-1483. doi: 10.1021/acschembio.7b00125. Epub 2017 May 1.

PMID:
28445029
20.

Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.

Bateman LA, Nguyen TB, Roberts AM, Miyamoto DK, Ku WM, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA, Nomura DK.

Chem Commun (Camb). 2017 Jun 29;53(53):7234-7237. doi: 10.1039/c7cc01480e.

21.

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.

Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R.

Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417.

22.

The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.

Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A.

Immunity. 2017 Mar 21;46(3):405-420. doi: 10.1016/j.immuni.2017.02.018. Epub 2017 Mar 14.

23.

Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity.

Roberts LS, Yan P, Bateman LA, Nomura DK.

ACS Chem Biol. 2017 Apr 21;12(4):1133-1140. doi: 10.1021/acschembio.6b01159. Epub 2017 Mar 8.

PMID:
28248089
24.

Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity.

Bateman LA, Ku WM, Heslin MJ, Contreras CM, Skibola CF, Nomura DK.

ACS Chem Biol. 2017 Apr 21;12(4):905-911. doi: 10.1021/acschembio.6b01158. Epub 2017 Mar 1.

PMID:
28229591
25.

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A.

EMBO Rep. 2017 Apr;18(4):569-585. doi: 10.15252/embr.201643068. Epub 2017 Feb 20.

26.

Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target.

Roberts AM, Miyamoto DK, Huffman TR, Bateman LA, Ives AN, Akopian D, Heslin MJ, Contreras CM, Rape M, Skibola CF, Nomura DK.

ACS Chem Biol. 2017 Apr 21;12(4):899-904. doi: 10.1021/acschembio.7b00020. Epub 2017 Feb 15.

PMID:
28186401
27.

Mapping Proteome-wide Targets of Glyphosate in Mice.

Ford B, Bateman LA, Gutierrez-Palominos L, Park R, Nomura DK.

Cell Chem Biol. 2017 Feb 16;24(2):133-140. doi: 10.1016/j.chembiol.2016.12.013. Epub 2017 Jan 26.

28.

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL, Näslund E, Nomura DK, Zierath JR.

Cell Rep. 2017 Jan 17;18(3):636-646. doi: 10.1016/j.celrep.2016.12.070.

29.

Chemoproteomic Profiling of Acetanilide Herbicides Reveals Their Role in Inhibiting Fatty Acid Oxidation.

Counihan JL, Duckering M, Dalvie E, Ku WM, Bateman LA, Fisher KJ, Nomura DK.

ACS Chem Biol. 2017 Mar 17;12(3):635-642. doi: 10.1021/acschembio.6b01001. Epub 2017 Jan 20.

PMID:
28094496
30.

Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis.

Sogi KM, Holsclaw CM, Fragiadakis GK, Nomura DK, Leary JA, Bertozzi CR.

ACS Infect Dis. 2016 Nov 11;2(11):800-806. Epub 2016 Aug 15.

31.

Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.

To M, Peterson CW, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA.

Mol Biol Cell. 2017 Jan 15;28(2):270-284. doi: 10.1091/mbc.E16-07-0483. Epub 2016 Nov 23.

32.

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.

Kim HE, Grant AR, Simic MS, Kohnz RA, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff S, Dillin A.

Cell. 2016 Sep 8;166(6):1539-1552.e16. doi: 10.1016/j.cell.2016.08.027.

33.

Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots.

Roberts AM, Ward CC, Nomura DK.

Curr Opin Biotechnol. 2017 Feb;43:25-33. doi: 10.1016/j.copbio.2016.08.003. Epub 2016 Aug 26. Review.

34.

HIF-1α Is an Essential Mediator of IFN-γ-Dependent Immunity to Mycobacterium tuberculosis.

Braverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA.

J Immunol. 2016 Aug 15;197(4):1287-97. doi: 10.4049/jimmunol.1600266. Epub 2016 Jul 18.

35.

Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.

Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK.

ACS Chem Biol. 2016 Aug 19;11(8):2131-9. doi: 10.1021/acschembio.6b00433. Epub 2016 Jul 22.

36.

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.

Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM.

Cell. 2016 Jul 14;166(2):424-435. doi: 10.1016/j.cell.2016.05.071. Epub 2016 Jun 30.

37.

Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose.

Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JH.

PLoS One. 2016 Jun 23;11(6):e0158111. doi: 10.1371/journal.pone.0158111. eCollection 2016.

38.

GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.

Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK.

Cell Chem Biol. 2016 May 19;23(5):567-578. doi: 10.1016/j.chembiol.2016.03.017. Epub 2016 May 12.

39.

Lipases and their inhibitors in health and disease.

Nomura DK, Casida JE.

Chem Biol Interact. 2016 Nov 25;259(Pt B):211-222. doi: 10.1016/j.cbi.2016.04.004. Epub 2016 Apr 9. Review.

PMID:
27067293
40.

The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphoma.

Zhang J, Medina-Cleghorn D, Bernal-Mizrachi L, Bracci PM, Hubbard A, Conde L, Riby J, Nomura DK, Skibola CF.

Oncoscience. 2016 Jan 30;3(1):31-41. eCollection 2016.

41.

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.

Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A.

Nat Med. 2016 Apr;22(4):427-32. doi: 10.1038/nm.4055. Epub 2016 Mar 7.

42.

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.

Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamäki J, Roivainen A, Marjamäki P, Liljenbäck H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lönnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura DK, Battersby BJ, Velagapudi V, Carroll CJ, Suomalainen A.

Cell Metab. 2016 Apr 12;23(4):635-48. doi: 10.1016/j.cmet.2016.01.019. Epub 2016 Feb 25.

43.

Editorial overview: Omics: The maturation of chemical biology.

Saghatelian A, Nomura DK, Weerapana E.

Curr Opin Chem Biol. 2016 Feb;30:v-vi. doi: 10.1016/j.cbpa.2015.12.005. Epub 2015 Dec 28. No abstract available.

PMID:
26739665
44.

Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms.

Counihan JL, Ford B, Nomura DK.

Curr Opin Chem Biol. 2016 Feb;30:68-76. doi: 10.1016/j.cbpa.2015.11.007. Epub 2015 Nov 30. Review.

45.

Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic Platforms.

Medina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK.

Chem Biol. 2015 Oct 22;22(10):1394-405. doi: 10.1016/j.chembiol.2015.09.008.

46.

Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents.

Piano V, Benjamin DI, Valente S, Nenci S, Marrocco B, Mai A, Aliverti A, Nomura DK, Mattevi A.

ACS Chem Biol. 2015 Nov 20;10(11):2589-97. doi: 10.1021/acschembio.5b00466. Epub 2015 Sep 4.

47.

Comparative metabolic profiling of mce1 operon mutant vs wild-type Mycobacterium tuberculosis strains.

Queiroz A, Medina-Cleghorn D, Marjanovic O, Nomura DK, Riley LW.

Pathog Dis. 2015 Nov;73(8):ftv066. doi: 10.1093/femspd/ftv066. Epub 2015 Aug 28.

48.

Monoacylglycerol Lipase Regulates Fever Response.

Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B.

PLoS One. 2015 Aug 19;10(8):e0134437. doi: 10.1371/journal.pone.0134437. eCollection 2015.

49.

Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.

Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK.

ACS Chem Biol. 2015 Jul 17;10(7):1624-30. doi: 10.1021/acschembio.5b00053. Epub 2015 May 7.

50.

Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells.

Benjamin DI, Li DS, Lowe W, Heuer T, Kemble G, Nomura DK.

ACS Chem Biol. 2015 Jul 17;10(7):1616-23. doi: 10.1021/acschembio.5b00240. Epub 2015 Apr 17.

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