Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 119

1.

Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.

Berdan CA, Ho R, Lehtola HS, To M, Hu X, Huffman TR, Petri Y, Altobelli CR, Demeulenaere SG, Olzmann JA, Maimone TJ, Nomura DK.

Cell Chem Biol. 2019 Apr 11. pii: S2451-9456(19)30112-6. doi: 10.1016/j.chembiol.2019.03.016. [Epub ahead of print]

PMID:
31080076
2.

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.

Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK.

ACS Chem Biol. 2019 May 13. doi: 10.1021/acschembio.8b01083. [Epub ahead of print]

PMID:
31059647
3.

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.

Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR.

Nature. 2019 Apr;568(7751):254-258. doi: 10.1038/s41586-019-1005-x. Epub 2019 Mar 6.

PMID:
30842661
4.

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer.

Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, Matzaris M, Montgomery MK, Papargiris M, Norden S, Febbraio M, Risbridger GP, Frydenberg M, Nomura DK, Taylor RA.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau5758. doi: 10.1126/scitranslmed.aau5758.

PMID:
30728288
5.

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State.

Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ.

Cell Chem Biol. 2019 Mar 21;26(3):420-432.e9. doi: 10.1016/j.chembiol.2018.11.016. Epub 2019 Jan 24.

PMID:
30686757
6.

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.

Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA.

Nat Commun. 2019 Jan 11;10(1):163. doi: 10.1038/s41467-018-08046-4.

7.

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.

Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC.

J Cell Sci. 2019 Jan 16;132(2). pii: jcs223453. doi: 10.1242/jcs.223453.

8.

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells.

Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, Valente S.

Eur J Med Chem. 2019 Feb 1;163:722-735. doi: 10.1016/j.ejmech.2018.11.050. Epub 2018 Nov 28.

PMID:
30576903
9.

Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women.

Zhou M, Ford B, Lee D, Tindula G, Huen K, Tran V, Bradman A, Gunier R, Eskenazi B, Nomura DK, Holland N.

Front Public Health. 2018 Oct 22;6:298. doi: 10.3389/fpubh.2018.00298. eCollection 2018.

10.

Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain.

Fernandez RF, Kim SQ, Zhao Y, Foguth RM, Weera MM, Counihan JL, Nomura DK, Chester JA, Cannon JR, Ellis JM.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12525-12530. doi: 10.1073/pnas.1807958115. Epub 2018 Nov 6.

11.

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.

Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM.

Nat Chem Biol. 2018 Nov;14(11):1021-1031. doi: 10.1038/s41589-018-0132-2. Epub 2018 Oct 16.

12.

Target Identification of Bioactive Covalently Acting Natural Products.

Nomura DK, Maimone TJ.

Curr Top Microbiol Immunol. 2019;420:351-374. doi: 10.1007/82_2018_121.

PMID:
30105423
13.

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms.

Tam AB, Roberts LS, Chandra V, Rivera IG, Nomura DK, Forbes DJ, Niwa M.

Dev Cell. 2018 Aug 6;46(3):327-343.e7. doi: 10.1016/j.devcel.2018.04.023.

PMID:
30086303
14.

Virtual Issue on the Work of John Casida.

Nomura DK.

Chem Res Toxicol. 2018 Aug 20;31(8):637-638. doi: 10.1021/acs.chemrestox.8b00195. Epub 2018 Aug 6. No abstract available.

PMID:
30080400
15.

Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms.

Van Dalfsen KM, Hodapp S, Keskin A, Otto GM, Berdan CA, Higdon A, Cheunkarndee T, Nomura DK, Jovanovic M, Brar GA.

Dev Cell. 2018 Jul 16;46(2):219-235.e8. doi: 10.1016/j.devcel.2018.06.016.

PMID:
30016623
16.

Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.

Counihan JL, Wiggenhorn AL, Anderson KE, Nomura DK.

ACS Chem Biol. 2018 Aug 17;13(8):1970-1977. doi: 10.1021/acschembio.8b00381. Epub 2018 Jul 23.

17.

Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception.

Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945. doi: 10.1073/pnas.1803389115. Epub 2018 Jul 2.

18.

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.

Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N.

Nat Cell Biol. 2018 Jul;20(7):811-822. doi: 10.1038/s41556-018-0122-3. Epub 2018 Jun 25.

19.

Cancer Metabolism: Current Understanding and Therapies.

Counihan JL, Grossman EA, Nomura DK.

Chem Rev. 2018 Jul 25;118(14):6893-6923. doi: 10.1021/acs.chemrev.7b00775. Epub 2018 Jun 25.

PMID:
29939018
20.

Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.

Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW.

Endocrinology. 2018 Jun 1;159(6):2408-2420. doi: 10.1210/en.2018-00040.

PMID:
29750244
21.

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.

Lin H, Long JZ, Roche AM, Svensson KJ, Dou FY, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM.

J Med Chem. 2018 Apr 12;61(7):3224-3230. doi: 10.1021/acs.jmedchem.8b00029. Epub 2018 Mar 22.

22.

Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light.

Prasse C, Ford B, Nomura DK, Sedlak DL.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2311-2316. doi: 10.1073/pnas.1715821115. Epub 2018 Feb 20.

23.

Deletion of Adipose Triglyceride Lipase Links Triacylglycerol Accumulation to a More-Aggressive Phenotype in A549 Lung Carcinoma Cells.

Tomin T, Fritz K, Gindlhuber J, Waldherr L, Pucher B, Thallinger GG, Nomura DK, Schittmayer M, Birner-Gruenberger R.

J Proteome Res. 2018 Apr 6;17(4):1415-1425. doi: 10.1021/acs.jproteome.7b00782. Epub 2018 Mar 7.

PMID:
29457907
24.

Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.

Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R.

Nature. 2018 Jan 18;553(7688):337-341. doi: 10.1038/nature25188. Epub 2018 Jan 10.

25.

Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange.

Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N.

J Chem Inf Model. 2018 Feb 26;58(2):464-471. doi: 10.1021/acs.jcim.7b00399. Epub 2018 Jan 31.

26.

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes.

Bersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, Olzmann JA.

Dev Cell. 2018 Jan 8;44(1):97-112.e7. doi: 10.1016/j.devcel.2017.11.020. Epub 2017 Dec 21.

27.

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors.

De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE.

Cell Rep. 2017 Nov 21;21(8):2031-2038. doi: 10.1016/j.celrep.2017.10.088.

28.

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade.

Lue HW, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, Xue CH, Rantala JK, Tyner JW, Thornburg KL, Martinez-Acevedo A, Liu JJ, Amling CL, Truillet C, Louie SM, Anderson KE, Evans MJ, O'Donnell VB, Nomura DK, Drake JM, Ritz A, Thomas GV.

Genes Dev. 2017 Oct 15;31(20):2067-2084. doi: 10.1101/gad.305292.117. Epub 2017 Nov 14.

29.

Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.

Grossman EA, Ward CC, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK.

Cell Chem Biol. 2017 Nov 16;24(11):1368-1376.e4. doi: 10.1016/j.chembiol.2017.08.013. Epub 2017 Sep 14.

30.

Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity.

Anderson KE, To M, Olzmann JA, Nomura DK.

ACS Chem Biol. 2017 Oct 20;12(10):2522-2528. doi: 10.1021/acschembio.7b00711. Epub 2017 Sep 13.

31.

Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae.

Chomvong K, Benjamin DI, Nomura DK, Cate JHD.

MBio. 2017 Aug 8;8(4). pii: e00855-17. doi: 10.1128/mBio.00855-17.

32.

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ.

Chen TC, Benjamin DI, Kuo T, Lee RA, Li ML, Mar DJ, Costello DE, Nomura DK, Wang JC.

Sci Signal. 2017 Jul 25;10(489). pii: eaai7905. doi: 10.1126/scisignal.aai7905.

33.

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.

Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA.

Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003.

34.

NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.

Ward CC, Kleinman JI, Nomura DK.

ACS Chem Biol. 2017 Jun 16;12(6):1478-1483. doi: 10.1021/acschembio.7b00125. Epub 2017 May 1.

PMID:
28445029
35.

Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.

Bateman LA, Nguyen TB, Roberts AM, Miyamoto DK, Ku WM, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA, Nomura DK.

Chem Commun (Camb). 2017 Jun 29;53(53):7234-7237. doi: 10.1039/c7cc01480e.

36.

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.

Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R.

Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417.

37.

The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.

Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A.

Immunity. 2017 Mar 21;46(3):405-420. doi: 10.1016/j.immuni.2017.02.018. Epub 2017 Mar 14.

38.

Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity.

Roberts LS, Yan P, Bateman LA, Nomura DK.

ACS Chem Biol. 2017 Apr 21;12(4):1133-1140. doi: 10.1021/acschembio.6b01159. Epub 2017 Mar 8.

PMID:
28248089
39.

Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity.

Bateman LA, Ku WM, Heslin MJ, Contreras CM, Skibola CF, Nomura DK.

ACS Chem Biol. 2017 Apr 21;12(4):905-911. doi: 10.1021/acschembio.6b01158. Epub 2017 Mar 1.

PMID:
28229591
40.

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A.

EMBO Rep. 2017 Apr;18(4):569-585. doi: 10.15252/embr.201643068. Epub 2017 Feb 20.

41.

Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target.

Roberts AM, Miyamoto DK, Huffman TR, Bateman LA, Ives AN, Akopian D, Heslin MJ, Contreras CM, Rape M, Skibola CF, Nomura DK.

ACS Chem Biol. 2017 Apr 21;12(4):899-904. doi: 10.1021/acschembio.7b00020. Epub 2017 Feb 15.

PMID:
28186401
42.

Mapping Proteome-wide Targets of Glyphosate in Mice.

Ford B, Bateman LA, Gutierrez-Palominos L, Park R, Nomura DK.

Cell Chem Biol. 2017 Feb 16;24(2):133-140. doi: 10.1016/j.chembiol.2016.12.013. Epub 2017 Jan 26.

43.

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL, Näslund E, Nomura DK, Zierath JR.

Cell Rep. 2017 Jan 17;18(3):636-646. doi: 10.1016/j.celrep.2016.12.070.

44.

Chemoproteomic Profiling of Acetanilide Herbicides Reveals Their Role in Inhibiting Fatty Acid Oxidation.

Counihan JL, Duckering M, Dalvie E, Ku WM, Bateman LA, Fisher KJ, Nomura DK.

ACS Chem Biol. 2017 Mar 17;12(3):635-642. doi: 10.1021/acschembio.6b01001. Epub 2017 Jan 20.

45.

Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis.

Sogi KM, Holsclaw CM, Fragiadakis GK, Nomura DK, Leary JA, Bertozzi CR.

ACS Infect Dis. 2016 Nov 11;2(11):800-806. Epub 2016 Aug 15.

46.

Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.

To M, Peterson CW, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA.

Mol Biol Cell. 2017 Jan 15;28(2):270-284. doi: 10.1091/mbc.E16-07-0483. Epub 2016 Nov 23.

47.

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.

Kim HE, Grant AR, Simic MS, Kohnz RA, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff S, Dillin A.

Cell. 2016 Sep 8;166(6):1539-1552.e16. doi: 10.1016/j.cell.2016.08.027.

48.

Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots.

Roberts AM, Ward CC, Nomura DK.

Curr Opin Biotechnol. 2017 Feb;43:25-33. doi: 10.1016/j.copbio.2016.08.003. Epub 2016 Aug 26. Review.

49.

HIF-1α Is an Essential Mediator of IFN-γ-Dependent Immunity to Mycobacterium tuberculosis.

Braverman J, Sogi KM, Benjamin D, Nomura DK, Stanley SA.

J Immunol. 2016 Aug 15;197(4):1287-97. doi: 10.4049/jimmunol.1600266. Epub 2016 Jul 18.

50.

Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.

Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK.

ACS Chem Biol. 2016 Aug 19;11(8):2131-9. doi: 10.1021/acschembio.6b00433. Epub 2016 Jul 22.

Supplemental Content

Loading ...
Support Center