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Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish.

Da'as SI, Thanassoulas A, Calver BL, Beck K, Salem R, Saleh A, Kontogianni I, Al-Maraghi A, Nasrallah GK, Safieh-Garabedian B, Toft E, Nounesis G, Lai FA, Nomikos M.

Ann N Y Acad Sci. 2019 Jul;1448(1):19-29. doi: 10.1111/nyas.14033. Epub 2019 Apr 2.


Retroperitoneal Abscess Formation Extending to the Lumbar Area After Extracorporeal Shock Wave Lithotripsy.

Nomikos M, Tsalavoutas A, Kalpaxi A, Athanasopoulos G.

J Endourol Case Rep. 2018 Dec 21;4(1):206-208. doi: 10.1089/cren.2018.0072. eCollection 2018.


Targeting inflammatory components in neuropathic pain: The analgesic effect of thymulin related peptide.

Safieh-Garabedian B, Nomikos M, Saadé N.

Neurosci Lett. 2019 May 29;702:61-65. doi: 10.1016/j.neulet.2018.11.041. Epub 2018 Nov 29. Review.


Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.

Da'as SI, Fakhro K, Thanassoulas A, Krishnamoorthy N, Saleh A, Calver BL, Safieh-Garabedian B, Toft E, Nounesis G, Lai FA, Nomikos M.

Biochem J. 2018 Dec 14;475(24):3933-3948. doi: 10.1042/BCJ20180685.


Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion.

Tavalaee M, Nomikos M, Lai FA, Nasr-Esfahani MH.

Reprod Biomed Online. 2018 Mar;36(3):348-355. doi: 10.1016/j.rbmo.2017.12.013. Epub 2017 Dec 29.


Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions.

Kashir J, Nomikos M, Lai FA.

Adv Biol Regul. 2018 Jan;67:148-162. doi: 10.1016/j.jbior.2017.10.012. Epub 2017 Oct 27. Review.


The use of Amplatz renal dilators in the minimally invasive management of complex urethral strictures.

Nomikos M, Papanikolaou S, Athanasopoulos G, Papatsoris A.

Cent European J Urol. 2017;70(3):301-305. doi: 10.5173/ceju.2017.1218. Epub 2017 Jun 23.


The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation.

Nomikos M, Kashir J, Lai FA.

Biochem J. 2017 Oct 23;474(21):3659-3673. doi: 10.1042/BCJ20160521. Review.


Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

Nomikos M, Stamatiadis P, Sanders JR, Beck K, Calver BL, Buntwal L, Lofty M, Sideratou Z, Swann K, Lai FA.

Biochem J. 2017 Mar 7;474(6):1003-1016. doi: 10.1042/BCJ20161057.


Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm.

Kashir J, Buntwal L, Nomikos M, Calver BL, Stamatiadis P, Ashley P, Vassilakopoulou V, Sanders D, Knaggs P, Livaniou E, Bunkheila A, Swann K, Lai FA.

Mol Hum Reprod. 2017 Jan;23(1):54-67. doi: 10.1093/molehr/gaw073. Epub 2016 Dec 8.


Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.

Nomikos M, Thanassoulas A, Beck K, Theodoridou M, Kew J, Kashir J, Calver BL, Matthews E, Rizkallah P, Sideratou Z, Nounesis G, Lai FA.

FEBS J. 2016 Dec;283(24):4502-4514. doi: 10.1111/febs.13939. Epub 2016 Nov 15.


Silicone-induced Penile Sclerosing Lipogranuloma: Magnetic Resonance Imaging Findings.

Tsili AC, Xiropotamou ON, Nomikos M, Argyropoulou MI.

J Clin Imaging Sci. 2016 Jan 28;6:3. doi: 10.4103/2156-7514.175084. eCollection 2016.


Ca(2+) dynamics in oocytes from naturally-aged mice.

Haverfield J, Nakagawa S, Love D, Tsichlaki E, Nomikos M, Lai FA, Swann K, FitzHarris G.

Sci Rep. 2016 Jan 20;6:19357. doi: 10.1038/srep19357.


Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).

Nomikos M, Sanders JR, Parthimos D, Buntwal L, Calver BL, Stamatiadis P, Smith A, Clue M, Sideratou Z, Swann K, Lai FA.

J Biol Chem. 2015 Dec 4;290(49):29519-30. doi: 10.1074/jbc.M115.658443. Epub 2015 Oct 1.


Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ.

Sanusi R, Yu Y, Nomikos M, Lai FA, Swann K.

Mol Hum Reprod. 2015 Oct;21(10):783-91. doi: 10.1093/molehr/gav042. Epub 2015 Jul 17.


Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease.

Vassilakopoulou V, Calver BL, Thanassoulas A, Beck K, Hu H, Buntwal L, Smith A, Theodoridou M, Kashir J, Blayney L, Livaniou E, Nounesis G, Lai FA, Nomikos M.

Biochim Biophys Acta. 2015 Nov;1850(11):2168-76. doi: 10.1016/j.bbagen.2015.07.001. Epub 2015 Jul 9.


Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation.

Nomikos M, Sanders JR, Kashir J, Sanusi R, Buntwal L, Love D, Ashley P, Sanders D, Knaggs P, Bunkheila A, Swann K, Lai FA.

Mol Hum Reprod. 2015 Sep;21(9):702-10. doi: 10.1093/molehr/gav034. Epub 2015 Jun 26.


Novel signalling mechanism and clinical applications of sperm-specific PLCζ.

Nomikos M.

Biochem Soc Trans. 2015 Jun;43(3):371-6. doi: 10.1042/BST20140291. Review.


PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis.

Kashir J, Nomikos M, Swann K, Lai FA.

Mol Hum Reprod. 2015 May;21(5):383-8. doi: 10.1093/molehr/gav009. Epub 2015 Feb 26. Review.


Is PAWP the "real" sperm factor?

Nomikos M, Swann K, Lai FA.

Asian J Androl. 2015 May-Jun;17(3):444-6. doi: 10.4103/1008-682X.142145.


A giant verrucous carcinoma of the penis presenting with urinary sepsis and angina.

Nomikos M, Barmpoutis P, Papakonstantinou E, Chousianitis Z, Ouzounoglou P, Efstathiadou P, Katsifotis C.

Case Rep Med. 2014;2014:207026. doi: 10.1155/2014/207026. Epub 2014 Nov 12.


Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.

Nomikos M, Sanders JR, Theodoridou M, Kashir J, Matthews E, Nounesis G, Lai FA, Swann K.

Mol Hum Reprod. 2014 Oct;20(10):938-47. doi: 10.1093/molehr/gau056. Epub 2014 Jul 23.


Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death.

Nomikos M, Thanassoulas A, Beck K, Vassilakopoulou V, Hu H, Calver BL, Theodoridou M, Kashir J, Blayney L, Livaniou E, Rizkallah P, Nounesis G, Lai FA.

FEBS Lett. 2014 Aug 25;588(17):2898-902. doi: 10.1016/j.febslet.2014.07.007. Epub 2014 Jul 15.


Sperm-induced Ca2+ release during egg activation in mammals.

Kashir J, Nomikos M, Lai FA, Swann K.

Biochem Biophys Res Commun. 2014 Aug 1;450(3):1204-11. doi: 10.1016/j.bbrc.2014.04.078. Epub 2014 Apr 21. Review.


The dynamics of MAPK inactivation at fertilization in mouse eggs.

Gonzalez-Garcia JR, Bradley J, Nomikos M, Paul L, Machaty Z, Lai FA, Swann K.

J Cell Sci. 2014 Jun 15;127(Pt 12):2749-60. doi: 10.1242/jcs.145045. Epub 2014 Apr 16.


Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activation.

Nomikos M, Theodoridou M, Elgmati K, Parthimos D, Calver BL, Buntwal L, Nounesis G, Swann K, Lai FA.

Mol Hum Reprod. 2014 Jun;20(6):489-98. doi: 10.1093/molehr/gau011. Epub 2014 Jan 29.


Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential.

Nomikos M, Kashir J, Swann K, Lai FA.

FEBS Lett. 2013 Nov 15;587(22):3609-16. doi: 10.1016/j.febslet.2013.10.008. Epub 2013 Oct 21. Review.


Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.

Theodoridou M, Nomikos M, Parthimos D, Gonzalez-Garcia JR, Elgmati K, Calver BL, Sideratou Z, Nounesis G, Swann K, Lai FA.

Mol Hum Reprod. 2013 Dec;19(12):852-64. doi: 10.1093/molehr/gat070. Epub 2013 Oct 23.


ATP interacts with the CPVT mutation-associated central domain of the cardiac ryanodine receptor.

Blayney L, Beck K, MacDonald E, D'Cruz L, Nomikos M, Griffiths J, Thanassoulas A, Nounesis G, Lai FA.

Biochim Biophys Acta. 2013 Oct;1830(10):4426-32. doi: 10.1016/j.bbagen.2013.05.038. Epub 2013 Jun 6.


Renal Parenchyma Perforation and Hematoma Formation following Double-J Stent Insertion in a Solitary Functioning Kidney: An Unusual Complication.

Nomikos MS, Chousianitis Z, Georgiou C, Georgellis C, Rikas P, Anagnostou T.

Case Rep Urol. 2012;2012:301275. doi: 10.1155/2012/301275. Epub 2012 Oct 2.


Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.

Nomikos M, Yu Y, Elgmati K, Theodoridou M, Campbell K, Vassilakopoulou V, Zikos C, Livaniou E, Amso N, Nounesis G, Swann K, Lai FA.

Fertil Steril. 2013 Jan;99(1):76-85. doi: 10.1016/j.fertnstert.2012.08.035. Epub 2012 Sep 21.


Studies on the essential intramolecular interaction between the A1 and A2 domains of von Willebrand factor.

Karoulia Z, Papadopoulos G, Nomikos M, Thanassoulas A, Papadopoulou TC, Nounesis G, Kontou M, Stathopoulos C, Leonidas DD.

Protein Pept Lett. 2013 Feb;20(2):231-40.


Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection.

Swann K, Windsor S, Campbell K, Elgmati K, Nomikos M, Zernicka-Goetz M, Amso N, Lai FA, Thomas A, Graham C.

Fertil Steril. 2012 Mar;97(3):742-7. doi: 10.1016/j.fertnstert.2011.12.013. Epub 2012 Jan 2.


Urothelial Carcinoma of the Urinary Bladder in Young Adults: Presentation, Clinical behavior and Outcome.

Nomikos M, Pappas A, Kopaka ME, Tzoulakis S, Volonakis I, Stavrakakis G, Avgenakis G, Anezinis P.

Adv Urol. 2011;2011:480738. doi: 10.1155/2011/480738. Epub 2011 Nov 22.


PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2).

Yu Y, Nomikos M, Theodoridou M, Nounesis G, Lai FA, Swann K.

Mol Biol Cell. 2012 Jan;23(2):371-80. doi: 10.1091/mbc.E11-08-0687. Epub 2011 Nov 23.


Novel regulation of PLCζ activity via its XY-linker.

Nomikos M, Elgmati K, Theodoridou M, Georgilis A, Gonzalez-Garcia JR, Nounesis G, Swann K, Lai FA.

Biochem J. 2011 Sep 15;438(3):427-32. doi: 10.1042/BJ20110953.


Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region.

Nomikos M, Elgmati K, Theodoridou M, Calver BL, Nounesis G, Swann K, Lai FA.

J Cell Sci. 2011 Aug 1;124(Pt 15):2582-90. doi: 10.1242/jcs.083485. Epub 2011 Jul 5.


Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs.

Phillips SV, Yu Y, Rossbach A, Nomikos M, Vassilakopoulou V, Livaniou E, Cumbes B, Lai FA, George CH, Swann K.

Biochem J. 2011 Sep 15;438(3):545-53. doi: 10.1042/BJ20101581.


Thermal and chemical denaturation of the BRCT functional module of human 53BP1.

Thanassoulas A, Nomikos M, Theodoridou M, Stavros P, Mastellos D, Nounesis G.

Int J Biol Macromol. 2011 Oct 1;49(3):297-304. doi: 10.1016/j.ijbiomac.2011.05.001. Epub 2011 May 11.


The implication of initial 24-core transrectal prostate biopsy protocol on the detection of significant prostate cancer and high grade prostatic intraepithelial neoplasia.

Nomikos M, Karyotis I, Phillipou P, Constadinides C, Delakas D.

Int Braz J Urol. 2011 Jan-Feb;37(1):87-93; discussion 93.


Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ.

Nomikos M, Elgmati K, Theodoridou M, Calver BL, Cumbes B, Nounesis G, Swann K, Lai FA.

Biochem J. 2011 Mar 1;434(2):211-7. doi: 10.1042/BJ20101772. Erratum in: Biochem J. 2011 May 1;435(3):791. Nounesis, Georg [corrected to Nounesis, George].


Could prostate biopsies be avoided in men older than 75 years with raised PSA?

Nomikos M, Mariappan P, Zachou A, McNeill A, Bollina PR.

Urol Int. 2010;85(4):410-4. doi: 10.1159/000320378. Epub 2010 Oct 20.


Thermodynamic study of the BRCT domain of BARD1 and its interaction with the -pSER-X-X-Phe- motif-containing BRIP1 peptide.

Thanassoulas A, Nomikos M, Theodoridou M, Yannoukakos D, Mastellos D, Nounesis G.

Biochim Biophys Acta. 2010 Sep;1804(9):1908-16. doi: 10.1016/j.bbapap.2010.04.012. Epub 2010 May 6.


Urothelial carcinoma of the sarcomatoid variant in a young patient with spina bifida: a case report and review of the literature.

Nomikos M, Philippou P, Glava C, Delakas D.

Cases J. 2009 Dec 22;2:9381. doi: 10.1186/1757-1626-2-9381.


Outcomes using a fourth-generation lithotripter: a new benchmark for comparison?

Nomikos MS, Sowter SJ, Tolley DA.

BJU Int. 2007 Dec;100(6):1356-60. Epub 2007 Sep 11.


Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues.

Nomikos M, Mulgrew-Nesbitt A, Pallavi P, Mihalyne G, Zaitseva I, Swann K, Lai FA, Murray D, McLaughlin S.

J Biol Chem. 2007 Jun 1;282(22):16644-53. Epub 2007 Apr 12.


Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: study in paraffin tissue sections.

Dambaki C, Kogia C, Kampa M, Darivianaki K, Nomikos M, Anezinis P, Theodoropoulos PA, Castanas E, Stathopoulos EN.

BMC Cancer. 2005 Nov 17;5:148.


Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations.

Nomikos M, Blayney LM, Larman MG, Campbell K, Rossbach A, Saunders CM, Swann K, Lai FA.

J Biol Chem. 2005 Sep 2;280(35):31011-8. Epub 2005 Jul 6.


Spontaneous renal rupture due to ureteric calculi in a paraplegic male.

Kazoulis S, Tzanakis I, Christoulakis I, Xirakis S, Nomikos M, Hatzilias P.

Nephron. 2002 Aug;91(4):766-7. No abstract available.


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