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Items: 43

1.

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.

Zhu W, Radadiya A, Bisson C, Wenzel S, Nordin BE, Martínez-Márquez F, Imasaki T, Sedelnikova SE, Coricello A, Baumann P, Berry AH, Nomanbhoy TK, Kozarich JW, Jin Y, Rice DW, Takagi Y, Richards NGJ.

Commun Biol. 2019 Sep 17;2:345. doi: 10.1038/s42003-019-0587-z. eCollection 2019.

2.

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.

Okerberg ES, Dagbay KB, Green JL, Soni I, Aban A, Nomanbhoy TK, Savinov SN, Hardy JA, Kozarich JW.

Biochemistry. 2019 May 24. doi: 10.1021/acs.biochem.9b00290. [Epub ahead of print]

PMID:
31095371
3.

Direct CDKN2 Modulation of CDK4 Alters Target Engagement of CDK4 Inhibitor Drugs.

Green JL, Okerberg ES, Sejd J, Palafox M, Monserrat L, Alemayehu S, Wu J, Sykes M, Aban A, Serra V, Nomanbhoy T.

Mol Cancer Ther. 2019 Apr;18(4):771-779. doi: 10.1158/1535-7163.MCT-18-0755. Epub 2019 Mar 5.

PMID:
30837298
4.

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS.

Nat Chem Biol. 2018 Feb;14(2):163-170. doi: 10.1038/nchembio.2538. Epub 2017 Dec 18.

5.

Correction: Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.

Okerberg ES, Hainley A, Brown H, Aban A, Alemayehu S, Shih A, Wu J, Patricelli MP, Kozarich JW, Nomanbhoy T, Rosenblum JS.

PLoS One. 2017 Feb 15;12(2):e0172649. doi: 10.1371/journal.pone.0172649. eCollection 2017.

6.

ERK5 kinase activity is dispensable for cellular immune response and proliferation.

Lin EC, Amantea CM, Nomanbhoy TK, Weissig H, Ishiyama J, Hu Y, Sidique S, Li B, Kozarich JW, Rosenblum JS.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870. Epub 2016 Sep 27.

7.

Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.

Nomanbhoy TK, Sharma G, Brown H, Wu J, Aban A, Vogeti S, Alemayehu S, Sykes M, Rosenblum JS, Kozarich JW.

Biochemistry. 2016 Sep 27;55(38):5434-41. doi: 10.1021/acs.biochem.6b00629. Epub 2016 Sep 13.

PMID:
27571378
8.

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.

Matthews JM, Bhatt S, Patricelli MP, Nomanbhoy TK, Jiang X, Natkunam Y, Gentles AJ, Martinez E, Zhu D, Chapman JR, Cortizas E, Shyam R, Chinichian S, Advani R, Tan L, Zhang J, Choi HG, Tibshirani R, Buhrlage SJ, Gratzinger D, Verdun R, Gray NS, Lossos IS.

Blood. 2016 Jul 14;128(2):239-48. doi: 10.1182/blood-2016-02-696856. Epub 2016 May 5.

9.

Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.

Okerberg ES, Hainley A, Brown H, Aban A, Alemayehu S, Shih A, Wu J, Patricelli MP, Kozarich JW, Nomanbhoy T, Rosenblum JS.

PLoS One. 2016 Mar 31;11(3):e0152934. doi: 10.1371/journal.pone.0152934. eCollection 2016. Erratum in: PLoS One. 2017 Feb 15;12 (2):e0172649.

10.

ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement.

Nordin BE, Liu Y, Aban A, Brown HE, Wu J, Hainley AK, Rosenblum JS, Nomanbhoy TK, Kozarich JW.

Biochemistry. 2015 May 19;54(19):3024-36.

PMID:
25905789
11.

Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).

Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS.

J Med Chem. 2015 Jan 8;58(1):183-96. doi: 10.1021/jm500480k. Epub 2014 Jul 30.

12.

Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe.

Okerberg ES, Brown HE, Minimo L, Alemayehu S, Rosenblum J, Patricelli M, Nomanbhoy T, Kozarich JW.

J Am Chem Soc. 2014 Mar 26;136(12):4664-9. doi: 10.1021/ja4129907. Epub 2014 Mar 17.

PMID:
24601623
13.

Profiling native kinases by immuno-assisted activity-based profiling.

Okerberg E, Shih A, Brown H, Alemayehu S, Aban A, Nomanbhoy TK.

Curr Protoc Chem Biol. 2013;5(3):213-26. doi: 10.1002/9780470559277.ch130084.

PMID:
24391084
14.

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.

Li B, Cociorva OM, Nomanbhoy T, Weissig H, Li Q, Nakamura K, Liyanage M, Zhang MC, Shih AY, Aban A, Hu Y, Cajica J, Pham L, Kozarich JW, Shreder KR.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5217-22. doi: 10.1016/j.bmcl.2013.06.087. Epub 2013 Jul 8.

PMID:
23916259
15.

Functional interrogation of kinases and other nucleotide-binding proteins.

Rosenblum JS, Nomanbhoy TK, Kozarich JW.

FEBS Lett. 2013 Jun 27;587(13):1870-7. doi: 10.1016/j.febslet.2013.05.008. Epub 2013 May 15. Review.

16.

Discovery of potent and selective covalent inhibitors of JNK.

Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS.

Chem Biol. 2012 Jan 27;19(1):140-54. doi: 10.1016/j.chembiol.2011.11.010.

17.

6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3β: discovery of nitrile derivatives with picomolar potency.

Li B, Cociorva OM, Nomanbhoy T, Li Q, Nakamura K, Nomura M, Okada K, Yumoto K, Liyanage M, Zhang MC, Aban A, Szardenings AK, Kozarich JW, Kohno Y, Shreder KR.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1005-8. doi: 10.1016/j.bmcl.2011.12.006. Epub 2011 Dec 8.

PMID:
22202172
18.

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β.

Cociorva OM, Li B, Nomanbhoy T, Li Q, Nakamura A, Nakamura K, Nomura M, Okada K, Seto S, Yumoto K, Liyanage M, Zhang MC, Aban A, Leen B, Szardenings AK, Rosenblum JS, Kozarich JW, Kohno Y, Shreder KR.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5948-51. doi: 10.1016/j.bmcl.2011.07.073. Epub 2011 Aug 5.

PMID:
21873061
19.

In situ kinase profiling reveals functionally relevant properties of native kinases.

Patricelli MP, Nomanbhoy TK, Wu J, Brown H, Zhou D, Zhang J, Jagannathan S, Aban A, Okerberg E, Herring C, Nordin B, Weissig H, Yang Q, Lee JD, Gray NS, Kozarich JW.

Chem Biol. 2011 Jun 24;18(6):699-710. doi: 10.1016/j.chembiol.2011.04.011.

20.

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

Johnson DS, Stiff C, Lazerwith SE, Kesten SR, Fay LK, Morris M, Beidler D, Liimatta MB, Smith SE, Dudley DT, Sadagopan N, Bhattachar SN, Kesten SJ, Nomanbhoy TK, Cravatt BF, Ahn K.

ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.

21.

Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF.

J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19.

22.

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS.

Nat Chem Biol. 2011 Apr;7(4):203-5. doi: 10.1038/nchembio.538. Epub 2011 Mar 6.

23.

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).

Johnson DS, Ahn K, Kesten S, Lazerwith SE, Song Y, Morris M, Fay L, Gregory T, Stiff C, Dunbar JB Jr, Liimatta M, Beidler D, Smith S, Nomanbhoy TK, Cravatt BF.

Bioorg Med Chem Lett. 2009 May 15;19(10):2865-9. doi: 10.1016/j.bmcl.2009.03.080. Epub 2009 Mar 24.

24.

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.

Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP, Cravatt BF.

Biochemistry. 2007 Nov 13;46(45):13019-30. Epub 2007 Oct 19.

PMID:
17949010
25.

Functional interrogation of the kinome using nucleotide acyl phosphates.

Patricelli MP, Szardenings AK, Liyanage M, Nomanbhoy TK, Wu M, Weissig H, Aban A, Chun D, Tanner S, Kozarich JW.

Biochemistry. 2007 Jan 16;46(2):350-8.

PMID:
17209545
26.

Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7.

Hu Y, Ma L, Wu M, Wong MS, Li B, Corral S, Yu Z, Nomanbhoy T, Alemayehu S, Fuller SR, Rosenblum JS, Rozenkrants N, Minimo LC, Ripka WC, Szardenings AK, Kozarich JW, Shreder KR.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4239-42.

PMID:
16085416
27.

Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors.

Shreder KR, Wong MS, Corral S, Yu Z, Winn DT, Wu M, Hu Y, Nomanbhoy T, Alemayehu S, Fuller SR, Rosenblum JS, Kozarich JW.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4256-60.

PMID:
16084722
28.

Synthesis of AX7593, a quinazoline-derived photoaffinity probe for EGFR.

Shreder KR, Wong MS, Nomanbhoy T, Leventhal PS, Fuller SR.

Org Lett. 2004 Oct 14;6(21):3715-8.

PMID:
15469331
29.

Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes.

Nomanbhoy TK, Rosenblum J, Aban A, Burbaum JJ.

Assay Drug Dev Technol. 2003 Feb;1(1 Pt 2):137-46.

PMID:
15090140
30.

Mutational separation of two pathways for editing by a class I tRNA synthetase.

Hendrickson TL, Nomanbhoy TK, de Crécy-Lagard V, Fukai S, Nureki O, Yokoyama S, Schimmel P.

Mol Cell. 2002 Feb;9(2):353-62.

31.

Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase.

Bishop AC, Nomanbhoy TK, Schimmel P.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):585-90. Epub 2002 Jan 8.

32.

Active site of an aminoacyl-tRNA synthetase dissected by energy-transfer-dependent fluorescence.

Nomanbhoy TK, Schimmel P.

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1485-91.

PMID:
11412966
33.

Simultaneous binding of two proteins to opposite sides of a single transfer RNA.

Nomanbhoy T, Morales AJ, Abraham AT, Vörtler CS, Giegé R, Schimmel P.

Nat Struct Biol. 2001 Apr;8(4):344-8.

PMID:
11276256
34.

Errors from selective disruption of the editing center in a tRNA synthetase.

Hendrickson TL, Nomanbhoy TK, Schimmel P.

Biochemistry. 2000 Jul 18;39(28):8180-6.

PMID:
10889024
35.

Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase.

Nomanbhoy TK, Schimmel PR.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5119-22.

36.

Fluorescence assays of Cdc42 interactions with target/effector proteins.

Nomanbhoy T, Cerione RA.

Biochemistry. 1999 Nov 30;38(48):15878-84.

PMID:
10625453
37.

Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis.

Nomanbhoy TK, Hendrickson TL, Schimmel P.

Mol Cell. 1999 Oct;4(4):519-28.

38.

Kinetics of Cdc42 membrane extraction by Rho-GDI monitored by real-time fluorescence resonance energy transfer.

Nomanbhoy TK, Erickson JW, Cerione RA.

Biochemistry. 1999 Feb 9;38(6):1744-50.

PMID:
10026253
39.

Use of fluorescence spectroscopy to study the regulation of small G proteins.

Nomanbhoy T, Cerione RA.

Methods Mol Biol. 1998;84:237-47.

PMID:
9666453
40.

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases.

Gosser YQ, Nomanbhoy TK, Aghazadeh B, Manor D, Combs C, Cerione RA, Rosen MK.

Nature. 1997 Jun 19;387(6635):814-9.

PMID:
9194563
41.

Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein.

Glaven JA, Whitehead IP, Nomanbhoy T, Kay R, Cerione RA.

J Biol Chem. 1996 Nov 1;271(44):27374-81.

42.
43.

Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence.

Nomanbhoy TK, Leonard DA, Manor D, Cerione RA.

Biochemistry. 1996 Apr 9;35(14):4602-8.

PMID:
8605211

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