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Items: 1 to 50 of 350

1.

Designer Palmitoylation Motif-Based Self-Localizing Ligand for Sustained Control of Protein Localization in Living Cells and Caenorhabditis elegans.

Nakamura A, Oki C, Sawada S, Yoshii T, Kuwata K, Rudd AK, Devaraj NK, Noma K, Tsukiji S.

ACS Chem Biol. 2020 Mar 20. doi: 10.1021/acschembio.0c00014. [Epub ahead of print]

PMID:
32182034
2.

Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Yamaji T, Harada T, Han Y, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.

Hypertens Res. 2020 Mar 9. doi: 10.1038/s41440-020-0420-6. [Epub ahead of print]

PMID:
32152482
3.

Increased blood pressure variability during the subacute phase in patients with ischemic stroke presenting with a low ankle-brachial index.

Naito H, Hosomi N, Kuzume D, Nezu T, Aoki S, Morimoto Y, Kinboshi M, Yoshida T, Shiga Y, Kinoshita N, Ueno H, Noma K, Maruyama H.

Geriatr Gerontol Int. 2020 Mar 5. doi: 10.1111/ggi.13897. [Epub ahead of print]

PMID:
32134185
4.

A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs.

Chen Y, Ohara T, Xing B, Qi J, Noma K, Matsukawa A.

Acta Med Okayama. 2020 Feb;74(1):1-6. doi: 10.18926/AMO/57946. Review.

5.

Epigenetic specifications of host chromosome docking sites for latent Epstein-Barr virus.

Kim KD, Tanizawa H, De Leo A, Vladimirova O, Kossenkov A, Lu F, Showe LC, Noma KI, Lieberman PM.

Nat Commun. 2020 Feb 13;11(1):877. doi: 10.1038/s41467-019-14152-8.

6.

Microanatomy-based standardization of left upper mediastinal lymph node dissection in thoracoscopic esophagectomy in the prone position.

Shirakawa Y, Noma K, Maeda N, Tanabe S, Sakurama K, Fujiwara T.

Surg Endosc. 2020 Feb 10. doi: 10.1007/s00464-020-07407-9. [Epub ahead of print]

PMID:
32043161
7.

Increased blood pressure variability during the subacute phase of ischemic stroke is associated with poor functional outcomes at 3 months.

Naito H, Hosomi N, Kuzume D, Nezu T, Aoki S, Morimoto Y, Kinboshi M, Yoshida T, Shiga Y, Kinoshita N, Ueno H, Noma K, Yamasaki M, Maruyama H.

Sci Rep. 2020 Jan 21;10(1):811. doi: 10.1038/s41598-020-57661-z.

8.

Induction chemoradiotherapy including docetaxel, cisplatin, and 5-fluorouracil for locally advanced esophageal cancer.

Hashimoto M, Shirakawa Y, Maeda N, Tanabe S, Noma K, Sakurama K, Katsui K, Nishizaki M, Fujiwara T.

Esophagus. 2020 Apr;17(2):127-134. doi: 10.1007/s10388-019-00709-5. Epub 2020 Jan 2.

PMID:
31897761
9.

Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization.

Iwasaki O, Tanizawa H, Kim KD, Kossenkov A, Nacarelli T, Tashiro S, Majumdar S, Showe LC, Zhang R, Noma KI.

Nat Commun. 2019 Dec 12;10(1):5688. doi: 10.1038/s41467-019-13604-5.

10.

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network.

Ieda T, Tazawa H, Okabayashi H, Yano S, Shigeyasu K, Kuroda S, Ohara T, Noma K, Kishimoto H, Nishizaki M, Kagawa S, Shirakawa Y, Saitou T, Imamura T, Fujiwara T.

Sci Rep. 2019 Nov 8;9(1):16378. doi: 10.1038/s41598-019-52816-z.

11.

[Characterization of Small Volume Plastic Scintillation Detector].

Fukui Y, Hamada Y, Noma K, Harada N.

Nihon Hoshasen Gijutsu Gakkai Zasshi. 2019;75(7):652-658. doi: 10.6009/jjrt.2019_JSRT_75.7.652. Japanese.

12.

Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men.

Takaeko Y, Matsui S, Kajikawa M, Maruhashi T, Kishimoto S, Hashimoto H, Kihara Y, Hida E, Chayama K, Goto C, Aibara Y, Yusoff FM, Noma K, Nakashima A, Higashi Y.

J Clin Lipidol. 2019 Jul - Aug;13(4):664-672.e1. doi: 10.1016/j.jacl.2019.06.004. Epub 2019 Jun 20.

13.

Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study.

Kajikawa M, Maruhashi T, Hidaka T, Matsui S, Hashimoto H, Takaeko Y, Nakano Y, Kurisu S, Kihara Y, Yusoff FM, Kishimoto S, Chayama K, Goto C, Noma K, Nakashima A, Hiro T, Hirayama A, Shiina K, Tomiyama H, Yagi S, Amano R, Yamada H, Sata M, Higashi Y.

Sci Rep. 2019 Jul 15;9(1):10206. doi: 10.1038/s41598-019-46726-3.

14.

Photoimmunotherapy for cancer-associated fibroblasts targeting fibroblast activation protein in human esophageal squamous cell carcinoma.

Watanabe S, Noma K, Ohara T, Kashima H, Sato H, Kato T, Urano S, Katsube R, Hashimoto Y, Tazawa H, Kagawa S, Shirakawa Y, Kobayashi H, Fujiwara T.

Cancer Biol Ther. 2019;20(9):1234-1248. doi: 10.1080/15384047.2019.1617566. Epub 2019 Jun 11.

PMID:
31185791
15.

ARID1A spatially partitions interphase chromosomes.

Wu S, Fatkhutdinov N, Rosin L, Luppino JM, Iwasaki O, Tanizawa H, Tang HY, Kossenkov AV, Gardini A, Noma KI, Speicher DW, Joyce EF, Zhang R.

Sci Adv. 2019 May 22;5(5):eaaw5294. doi: 10.1126/sciadv.aaw5294. eCollection 2019 May.

16.

Review of the Long-term Effects of Autologous Bone-Marrow Mononuclear Cell Implantation on Clinical Outcomes in Patients with Critical Limb Ischemia.

Yusoff FM, Kajikawa M, Matsui S, Hashimoto H, Kishimoto S, Maruhashi T, Chowdhury M, Noma K, Nakashima A, Kihara Y, Sueda T, Higashi Y.

Sci Rep. 2019 May 22;9(1):7711. doi: 10.1038/s41598-019-44176-5.

17.

Relationships Between Calcium Channel Blockers and Vascular Function Tests.

Maruhashi T, Kajikawa M, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Aibara Y, Yusoff FM, Hidaka T, Chayama K, Noma K, Nakashima A, Goto C, Kihara Y, Higashi Y.

Am J Hypertens. 2019 Jun 11;32(7):640-648. doi: 10.1093/ajh/hpz061.

PMID:
31089726
18.

Effects of the Dipeptidyl Peptidase 4 Inhibitor Alogliptin on Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus.

Kishimoto S, Kinoshita Y, Matsumoto T, Maruhashi T, Kajikawa M, Matsui S, Hashimoto H, Takaeko Y, Kihara Y, Chayama K, Goto C, Mohamad Yusoff F, Nakashima A, Noma K, Higashi Y.

Am J Hypertens. 2019 Jun 11;32(7):695-702. doi: 10.1093/ajh/hpz065.

PMID:
31045223
19.

Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease - Post Hoc Analysis of the FMD-J Study A.

Kajikawa M, Maruhashi T, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.

Circ J. 2019 Apr 25;83(5):1064-1071. doi: 10.1253/circj.CJ-18-1082. Epub 2019 Mar 26.

20.

Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment.

Maruhashi T, Kinoshita Y, Kajikawa M, Kishimoto S, Matsui S, Hashimoto H, Takaeko Y, Aibara Y, Yusoff FM, Hidaka T, Chayama K, Noma K, Nakashima A, Goto C, Takahashi M, Kihara Y, Higashi Y; Hiroshima NOCTURNE Research Group.

Hypertens Res. 2019 Aug;42(8):1175-1185. doi: 10.1038/s41440-019-0240-8. Epub 2019 Mar 7.

PMID:
30846869
21.

Flap Reconstruction for Esophageal Perforation Following Anterior Cervical Plate Fixation.

Morita M, Matsumoto H, Shirakawa Y, Noma K, Tanabe S, Kimata Y.

Acta Med Okayama. 2019 Feb;73(1):77-80. doi: 10.18926/AMO/56462.

22.

NAD+ metabolism governs the proinflammatory senescence-associated secretome.

Nacarelli T, Lau L, Fukumoto T, Zundell J, Fatkhutdinov N, Wu S, Aird KM, Iwasaki O, Kossenkov AV, Schultz D, Noma KI, Baur JA, Schug Z, Tang HY, Speicher DW, David G, Zhang R.

Nat Cell Biol. 2019 Mar;21(3):397-407. doi: 10.1038/s41556-019-0287-4. Epub 2019 Feb 18.

23.

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness.

Katsura Y, Ohara T, Noma K, Ninomiya T, Kashima H, Kato T, Sato H, Komoto S, Narusaka T, Tomono Y, Xing B, Chen Y, Tazawa H, Kagawa S, Shirakawa Y, Kasai T, Seno M, Matsukawa A, Fujiwara T.

Cancers (Basel). 2019 Feb 3;11(2). pii: E177. doi: 10.3390/cancers11020177.

24.

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Kuroda S, Choda Y, Otsuka S, Ueyama S, Tanaka N, Muraoka A, Hato S, Kimura T, Tanakaya K, Kikuchi S, Tanabe S, Noma K, Nishizaki M, Kagawa S, Shirakawa Y, Kamikawa Y, Fujiwara T.

Ann Gastroenterol Surg. 2018 Oct 11;3(1):96-103. doi: 10.1002/ags3.12216. eCollection 2019 Jan.

25.

Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.

Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Nagasaka T, Tazawa H, Kagawa S, Fujiwara T, Goel A.

Cancer Lett. 2019 Mar 1;444:127-135. doi: 10.1016/j.canlet.2018.12.009. Epub 2018 Dec 21.

26.

The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial.

Oki R, Izumi Y, Nodera H, Sato Y, Nokihara H, Kanai K, Sonoo M, Urushitani M, Nishinaka K, Atsuta N, Kohara N, Shimizu T, Kikuchi H, Oda M, Ikeda K, Nagai M, Komai K, Kojima Y, Kuzume D, Isose S, Shimohama S, Abe K, Ito H, Noda K, Ishihara T, Morita M, Shimohata T, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R; JETALS.

JMIR Res Protoc. 2018 Dec 21;7(12):e12046. doi: 10.2196/12046.

27.

Intra-axonal Ca2+ mobilization contributes to triphenyltin-induced facilitation in glycinergic transmission of rat spinal neurons.

Noma K, Kurauchi Y, Katsuki H, Oyama Y, Akaike N.

Toxicol In Vitro. 2019 Mar;55:11-14. doi: 10.1016/j.tiv.2018.11.003. Epub 2018 Nov 12.

PMID:
30439410
28.

Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study.

Kishimoto S, Oki K, Maruhashi T, Kajikawa M, Matsui S, Hashimoto H, Takaeko Y, Kihara Y, Chayama K, Goto C, Aibara Y, Yusoff FM, Nakashima A, Noma K, Liao JK, Higashi Y.

J Hypertens. 2019 May;37(5):1083-1095. doi: 10.1097/HJH.0000000000001989.

29.

Cancer-associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma.

Kashima H, Noma K, Ohara T, Kato T, Katsura Y, Komoto S, Sato H, Katsube R, Ninomiya T, Tazawa H, Shirakawa Y, Fujiwara T.

Int J Cancer. 2019 Feb 15;144(4):828-840. doi: 10.1002/ijc.31953. Epub 2018 Dec 3.

30.

Identifying the needs for teaching fundamental knowledge of laparoscopic surgery: a cross-sectional study in Japan.

Yokoyama S, Watanabe Y, Kurashima Y, Oshita A, Nishizawa Y, Naitoh T, Nakamura F, Kikuchi S, Noma K, Poudel S, Suzuki A, Nishihara Y, Ito M, Hirano S.

Surg Endosc. 2019 Jul;33(7):2242-2248. doi: 10.1007/s00464-018-6511-7. Epub 2018 Oct 22.

PMID:
30350098
31.

Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities.

Kurauchi Y, Noma K, Hisatsune A, Seki T, Katsuki H.

J Pharmacol Sci. 2018 Nov;138(3):167-175. doi: 10.1016/j.jphs.2018.09.004. Epub 2018 Sep 22.

32.

[The Elucidation of Tumor Immunosuppression Affected by Cancer-Associated Fibroblasts].

Kato T, Noma K, Katsura Y, Sato H, Kohmoto S, Ninomiya T, Ohara T, Tazawa H, Kagawa S, Shirakawa Y, Fujiwara T.

Gan To Kagaku Ryoho. 2018 Sep;45(9):1279-1281. Japanese.

PMID:
30237368
33.

Cilostazol for treatment of cerebral infarction.

Noma K, Higashi Y.

Expert Opin Pharmacother. 2018 Oct;19(15):1719-1726. doi: 10.1080/14656566.2018.1515199. Epub 2018 Sep 13. Review.

PMID:
30212227
34.

Evaluation of Blood Flow of the Gastric Conduit: In Reply to Fujita.

Noma K.

J Am Coll Surg. 2018 Aug;227(2):294-295. doi: 10.1016/j.jamcollsurg.2018.04.025. No abstract available.

PMID:
30053942
35.

Dec1 and CLOCK Regulate Na+/K+-ATPase β1 Subunit Expression and Blood Pressure.

Nakashima A, Kawamoto T, Noshiro M, Ueno T, Doi S, Honda K, Maruhashi T, Noma K, Honma S, Masaki T, Higashi Y, Kato Y.

Hypertension. 2018 Sep;72(3):746-754. doi: 10.1161/HYPERTENSIONAHA.118.11075.

PMID:
30012868
36.

Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD-J (Flow-Mediated Dilation Japan) Study A.

Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Mohamad Yusoff F, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Tomiyama H, Takase B, Kohro T, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A, Higashi Y.

J Am Heart Assoc. 2018 Jul 12;7(14). pii: e008588. doi: 10.1161/JAHA.118.008588.

37.

Limited Extent of Pleiotropic Effects Mediated by Dipeptidyl Peptidase-4 Inhibitors in Patients With Diabetes Mellitus.

Noma K, Kihara Y, Higashi Y.

Circ J. 2018 Jul 25;82(8):1996-1998. doi: 10.1253/circj.CJ-18-0694. Epub 2018 Jul 11. No abstract available.

38.

Clinical characteristics and management of gastric tube cancer after esophagectomy.

Shirakawa Y, Noma K, Maeda N, Ninomiya T, Tanabe S, Kikuchi S, Kuroda S, Nishizaki M, Kagawa S, Kawahara Y, Okada H, Fujiwara T.

Esophagus. 2018 Jul;15(3):180-189. doi: 10.1007/s10388-018-0611-2. Epub 2018 Mar 27.

PMID:
29951985
39.

Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment.

Kato T, Noma K, Ohara T, Kashima H, Katsura Y, Sato H, Komoto S, Katsube R, Ninomiya T, Tazawa H, Shirakawa Y, Fujiwara T.

Clin Cancer Res. 2018 Oct 1;24(19):4820-4833. doi: 10.1158/1078-0432.CCR-18-0205. Epub 2018 Jun 19.

40.

New assessment of endothelial function measured by short time flow-mediated vasodilation: Comparison with conventional flow-mediated vasodilation measurement.

Matsui S, Kajikawa M, Maruhashi T, Hashimoto H, Kihara Y, Chayama K, Goto C, Aibara Y, Yusoff FM, Kishimoto S, Nakashima A, Noma K, Kawaguchi T, Matsumoto T, Higashi Y.

Int J Cardiol. 2018 Aug 15;265:24-29. doi: 10.1016/j.ijcard.2018.05.006. Epub 2018 May 4.

PMID:
29754930
41.

Rapid Integration of Multi-copy Transgenes Using Optogenetic Mutagenesis in Caenorhabditis elegans.

Noma K, Jin Y.

G3 (Bethesda). 2018 May 31;8(6):2091-2097. doi: 10.1534/g3.118.200158.

42.

Endothelial dysfunction, abnormal vascular structure and lower urinary tract symptoms in men and women.

Matsui S, Kajikawa M, Maruhashi T, Iwamoto Y, Oda N, Kishimoto S, Hashimoto H, Hidaka T, Kihara Y, Chayama K, Hida E, Goto C, Aibara Y, Nakashima A, Yusoff FM, Noma K, Kuwahara Y, Matsubara A, Higashi Y.

Int J Cardiol. 2018 Jun 15;261:196-203. doi: 10.1016/j.ijcard.2018.02.041.

PMID:
29657043
43.

Reactive hyperemia-peripheral arterial tonometry is useful for assessment of not only endothelial function but also stenosis of the digital artery.

Kishimoto S, Matsumoto T, Maruhashi T, Iwamoto Y, Kajikawa M, Oda N, Matsui S, Hashimoto H, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Yusoff FBM, Nakashima A, Noma K, Higashi Y.

Int J Cardiol. 2018 Jun 1;260:178-183. doi: 10.1016/j.ijcard.2017.10.069.

PMID:
29622435
44.

Effects of triphenyltin on glycinergic transmission on rat spinal neurons.

Noma K, Akaike H, Kurauchi Y, Katsuki H, Oyama Y, Akaike N.

Environ Res. 2018 May;163:186-193. doi: 10.1016/j.envres.2018.02.005. Epub 2018 Feb 22.

PMID:
29453030
45.

Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction.

Iwamoto Y, Maruhashi T, Kajikawa M, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FM, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C, Higashi Y.

Int J Cardiol. 2018 Mar 1;254:284-290. doi: 10.1016/j.ijcard.2017.10.122. Epub 2018 Jan 28.

PMID:
29407110
46.

[Radical Thoracoscopic Esophagectomy for Elderly Patients with Advanced Esophageal Cancer].

Matsumi Y, Shirakawa Y, Tanabe S, Komoto S, Maeda N, Ninomiya T, Noma K, Nishizaki M, Kagawa S, Fujiwara T.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1784-1786. Japanese.

PMID:
29394775
47.

[Successful Multimodality Treatment Including Three-Stage Operation for Esophageal Cancer with Esophagorespiratory Fistula - A Case Report].

Komoto S, Noma K, Maeda N, Matsumi Y, Ninomiya T, Tanabe S, Shirakawa Y, Fujiwara T.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1053-1055. Review. Japanese.

PMID:
29394531
48.

Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.

Hiroi Y, Noma K, Kim HH, Sladojevic N, Tabit CE, Li Y, Soydan G, Salomone S, Moskowitz MA, Liao JK.

Circ J. 2018 Mar 23;82(4):1195-1204. doi: 10.1253/circj.CJ-17-0732. Epub 2018 Jan 19.

49.

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension.

Kajikawa M, Maruhashi T, Hidaka T, Nakano Y, Kurisu S, Matsumoto T, Iwamoto Y, Kishimoto S, Matsui S, Aibara Y, Yusoff FM, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Watanabe T, Tone H, Hibi M, Osaki N, Katsuragi Y, Higashi Y.

Eur J Nutr. 2019 Apr;58(3):989-996. doi: 10.1007/s00394-018-1611-7. Epub 2018 Jan 12.

50.

Effects of Ipragliflozin on Postprandial Glucose Metabolism and Gut Peptides in Type 2 Diabetes: A Pilot Study.

Ueno H, Nakazato H, Ebihara E, Noma K, Kawano T, Nagamine K, Sakoda H, Nakazato M.

Diabetes Ther. 2018 Feb;9(1):403-411. doi: 10.1007/s13300-018-0366-8. Epub 2018 Jan 10.

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