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Co-temporal Force and Fluorescence Measurements Reveal a Ribosomal Gear Shift Mechanism of Translation Regulation by Structured mRNAs.

Desai VP, Frank F, Lee A, Righini M, Lancaster L, Noller HF, Tinoco I Jr, Bustamante C.

Mol Cell. 2019 Sep 5;75(5):1007-1019.e5. doi: 10.1016/j.molcel.2019.07.024. Epub 2019 Aug 27.


On demand delivery and analysis of single molecules on a programmable nanopore-optofluidic device.

Rahman M, Stott MA, Harrington M, Li Y, Sampad MJN, Lancaster L, Yuzvinsky TD, Noller HF, Hawkins AR, Schmidt H.

Nat Commun. 2019 Aug 16;10(1):3712. doi: 10.1038/s41467-019-11723-7.


A tandem active site model for the ribosomal helicase.

Amiri H, Noller HF.

FEBS Lett. 2019 May;593(10):1009-1019. doi: 10.1002/1873-3468.13383. Epub 2019 Apr 24.


Spontaneous ribosomal translocation of mRNA and tRNAs into a chimeric hybrid state.

Zhou J, Lancaster L, Donohue JP, Noller HF.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7813-7818. doi: 10.1073/pnas.1901310116. Epub 2019 Apr 1.


Structural evidence for product stabilization by the ribosomal mRNA helicase.

Amiri H, Noller HF.

RNA. 2019 Mar;25(3):364-375. doi: 10.1261/rna.068965.118. Epub 2018 Dec 14.


Ribosome structural dynamics in translocation: yet another functional role for ribosomal RNA.

Noller HF, Lancaster L, Mohan S, Zhou J.

Q Rev Biophys. 2017 Jan;50:e12. doi: 10.1017/S0033583517000117. Review.


The ribosome moves: RNA mechanics and translocation.

Noller HF, Lancaster L, Zhou J, Mohan S.

Nat Struct Mol Biol. 2017 Dec 7;24(12):1021-1027. doi: 10.1038/nsmb.3505.


Recurring RNA structural motifs underlie the mechanics of L1 stalk movement.

Mohan S, Noller HF.

Nat Commun. 2017 Feb 8;8:14285. doi: 10.1038/ncomms14285.


The parable of the caveman and the Ferrari: protein synthesis and the RNA world.

Noller HF.

Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19;372(1716). pii: 20160187. doi: 10.1098/rstb.2016.0187. Review.


Brave new RNA world.

Noller HF.

RNA. 2015 Apr;21(4):478-9. doi: 10.1261/rna.049643.115. No abstract available.


Initiation of translation in bacteria by a structured eukaryotic IRES RNA.

Colussi TM, Costantino DA, Zhu J, Donohue JP, Korostelev AA, Jaafar ZA, Plank TD, Noller HF, Kieft JS.

Nature. 2015 Mar 5;519(7541):110-3. doi: 10.1038/nature14219. Epub 2015 Feb 4.


How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocation.

Zhou J, Lancaster L, Donohue JP, Noller HF.

Science. 2014 Sep 5;345(6201):1188-91. doi: 10.1126/science.1255030.


Molecular mechanics of 30S subunit head rotation.

Mohan S, Donohue JP, Noller HF.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13325-30. doi: 10.1073/pnas.1413731111. Epub 2014 Sep 3.


Secondary structure adventures with Carl Woese.

Noller HF.

RNA Biol. 2014;11(3):225-31. doi: 10.4161/rna.27970. Epub 2014 Mar 5. Review.


A new system for naming ribosomal proteins.

Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR, Lafontaine DL, Lindahl L, Liljas A, Lipton JM, McAlear MA, Moore PB, Noller HF, Ortega J, Panse VG, Ramakrishnan V, Spahn CM, Steitz TA, Tchorzewski M, Tollervey D, Warren AJ, Williamson JR, Wilson D, Yonath A, Yusupov M.

Curr Opin Struct Biol. 2014 Feb;24:165-9. doi: 10.1016/ Epub 2014 Feb 10. Review.


Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation.

Ramrath DJ, Lancaster L, Sprink T, Mielke T, Loerke J, Noller HF, Spahn CM.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20964-9. doi: 10.1073/pnas.1320387110. Epub 2013 Dec 9.


How does the ribosome sense a cognate tRNA?

Noller HF.

J Mol Biol. 2013 Oct 23;425(20):3776-7. doi: 10.1016/j.jmb.2013.07.003. Epub 2013 Jul 11. No abstract available.


By ribosome possessed.

Noller HF.

J Biol Chem. 2013 Aug 23;288(34):24872-85. doi: 10.1074/jbc.X113.497511. Epub 2013 Jun 27. No abstract available.


Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.

Zhou J, Lancaster L, Donohue JP, Noller HF.

Science. 2013 Jun 28;340(6140):1236086. doi: 10.1126/science.1236086.


Crystal structure of the 70S ribosome bound with the Q253P mutant form of release factor RF2.

Santos N, Zhu J, Donohue JP, Korostelev AA, Noller HF.

Structure. 2013 Jul 2;21(7):1258-63. doi: 10.1016/j.str.2013.04.028. Epub 2013 Jun 13.


Ira G. Wool (1925-2012).

Noller HF.

RNA. 2013 Feb;19(2):v-vi. No abstract available.


Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation.

Ermolenko DN, Cornish PV, Ha T, Noller HF.

RNA. 2013 Feb;19(2):158-66. doi: 10.1261/rna.035964.112. Epub 2012 Dec 17.


Rotation of the head of the 30S ribosomal subunit during mRNA translocation.

Guo Z, Noller HF.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20391-4. doi: 10.1073/pnas.1218999109. Epub 2012 Nov 27.


Crystal structures of 70S ribosomes bound to release factors RF1, RF2 and RF3.

Zhou J, Korostelev A, Lancaster L, Noller HF.

Curr Opin Struct Biol. 2012 Dec;22(6):733-42. doi: 10.1016/ Epub 2012 Sep 19. Review.


Ribosomal protein S1 unwinds double-stranded RNA in multiple steps.

Qu X, Lancaster L, Noller HF, Bustamante C, Tinoco I Jr.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14458-63. doi: 10.1073/pnas.1208950109. Epub 2012 Aug 20.


Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome.

Zhou J, Lancaster L, Trakhanov S, Noller HF.

RNA. 2012 Feb;18(2):230-40. doi: 10.1261/rna.031187.111. Epub 2011 Dec 20.


Controlled gating and electrical detection of single 50S ribosomal subunits through a solid-state nanopore in a microfluidic chip.

Rudenko MI, Holmes MR, Ermolenko DN, Lunt EJ, Gerhardt S, Noller HF, Deamer DW, Hawkins A, Schmidt H.

Biosens Bioelectron. 2011 Nov 15;29(1):34-9. doi: 10.1016/j.bios.2011.07.047. Epub 2011 Aug 5.


The ribosome uses two active mechanisms to unwind messenger RNA during translation.

Qu X, Wen JD, Lancaster L, Noller HF, Bustamante C, Tinoco I Jr.

Nature. 2011 Jul 6;475(7354):118-21. doi: 10.1038/nature10126.


mRNA translocation occurs during the second step of ribosomal intersubunit rotation.

Ermolenko DN, Noller HF.

Nat Struct Mol Biol. 2011 Apr;18(4):457-62. doi: 10.1038/nsmb.2011. Epub 2011 Mar 13.


Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome.

Zhu J, Korostelev A, Costantino DA, Donohue JP, Noller HF, Kieft JS.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1839-44. doi: 10.1073/pnas.1018582108. Epub 2011 Jan 18.


Evolution of protein synthesis from an RNA world.

Noller HF.

Cold Spring Harb Perspect Biol. 2012 Apr 1;4(4):a003681. doi: 10.1101/cshperspect.a003681.


Recognition of the amber UAG stop codon by release factor RF1.

Korostelev A, Zhu J, Asahara H, Noller HF.

EMBO J. 2010 Aug 4;29(15):2577-85. doi: 10.1038/emboj.2010.139. Epub 2010 Jun 29.


Multistart simulated annealing refinement of the crystal structure of the 70S ribosome.

Korostelev A, Laurberg M, Noller HF.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18195-200. doi: 10.1073/pnas.0909287106. Epub 2009 Oct 12.


Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding.

Llano-Sotelo B, Hickerson RP, Lancaster L, Noller HF, Mankin AS.

RNA. 2009 Aug;15(8):1597-604. doi: 10.1261/rna.1681609. Epub 2009 Jun 24.


Following movement of the L1 stalk between three functional states in single ribosomes.

Cornish PV, Ermolenko DN, Staple DW, Hoang L, Hickerson RP, Noller HF, Ha T.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2571-6. doi: 10.1073/pnas.0813180106. Epub 2009 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5448.


Crystal structure of a translation termination complex formed with release factor RF2.

Korostelev A, Asahara H, Lancaster L, Laurberg M, Hirschi A, Zhu J, Trakhanov S, Scott WG, Noller HF.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19684-9. doi: 10.1073/pnas.0810953105. Epub 2008 Dec 8.


Structural dynamics of the ribosome.

Korostelev A, Ermolenko DN, Noller HF.

Curr Opin Chem Biol. 2008 Dec;12(6):674-83. doi: 10.1016/j.cbpa.2008.08.037. Epub 2008 Oct 9. Review.


The sarcin-ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit.

Lancaster L, Lambert NJ, Maklan EJ, Horan LH, Noller HF.

RNA. 2008 Oct;14(10):1999-2012. doi: 10.1261/rna.1202108. Epub 2008 Aug 28.


A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA.

Martick M, Horan LH, Noller HF, Scott WG.

Nature. 2008 Aug 14;454(7206):899-902. doi: 10.1038/nature07117. Epub 2008 Jul 9.


Structural basis for translation termination on the 70S ribosome.

Laurberg M, Asahara H, Korostelev A, Zhu J, Trakhanov S, Noller HF.

Nature. 2008 Aug 14;454(7206):852-7. doi: 10.1038/nature07115. Epub 2008 Jul 2.


Spontaneous intersubunit rotation in single ribosomes.

Cornish PV, Ermolenko DN, Noller HF, Ha T.

Mol Cell. 2008 Jun 6;30(5):578-88. doi: 10.1016/j.molcel.2008.05.004.


Following translation by single ribosomes one codon at a time.

Wen JD, Lancaster L, Hodges C, Zeri AC, Yoshimura SH, Noller HF, Bustamante C, Tinoco I.

Nature. 2008 Apr 3;452(7187):598-603. doi: 10.1038/nature06716. Epub 2008 Mar 9.


Interactions and dynamics of the Shine Dalgarno helix in the 70S ribosome.

Korostelev A, Trakhanov S, Asahara H, Laurberg M, Lancaster L, Noller HF.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16840-3. Epub 2007 Oct 16.


Analysis of structural dynamics in the ribosome by TLS crystallographic refinement.

Korostelev A, Noller HF.

J Mol Biol. 2007 Nov 2;373(4):1058-70. Epub 2007 Aug 29.


The ribosome in focus: new structures bring new insights.

Korostelev A, Noller HF.

Trends Biochem Sci. 2007 Sep;32(9):434-41. Epub 2007 Aug 30. Review.


Detecting the coevolution of biosequences--an example of RNA interaction prediction.

Yeang CH, Darot JF, Noller HF, Haussler D.

Mol Biol Evol. 2007 Sep;24(9):2119-31. Epub 2007 Jul 17. Erratum in: Mol Biol Evol. 2007 Oct;24(10):2354. Mol Biol Evol. 2008 Sep;25(9):2077.


Elongation factor G stabilizes the hybrid-state conformation of the 70S ribosome.

Spiegel PC, Ermolenko DN, Noller HF.

RNA. 2007 Sep;13(9):1473-82. Epub 2007 Jul 13.


The antibiotic viomycin traps the ribosome in an intermediate state of translocation.

Ermolenko DN, Spiegel PC, Majumdar ZK, Hickerson RP, Clegg RM, Noller HF.

Nat Struct Mol Biol. 2007 Jun;14(6):493-7. Epub 2007 May 21.


Observation of intersubunit movement of the ribosome in solution using FRET.

Ermolenko DN, Majumdar ZK, Hickerson RP, Spiegel PC, Clegg RM, Noller HF.

J Mol Biol. 2007 Jul 13;370(3):530-40. Epub 2007 Apr 20.


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