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Items: 37

1.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Jun 28. doi: 10.1021/acschembio.8b00466. [Epub ahead of print]

PMID:
29953201
2.

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando N, Casford S, Nollen EAA, Vendruscolo M, Dobson CM, Knowles TPJ.

J Neurosci Methods. 2018 Aug 1;306:57-67. doi: 10.1016/j.jneumeth.2018.02.005. Epub 2018 Feb 13.

PMID:
29452179
3.

MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions.

Yoshimura Y, Holmberg MA, Kukic P, Andersen CB, Mata-Cabana A, Falsone SF, Vendruscolo M, Nollen EAA, Mulder FAA.

J Biol Chem. 2017 May 19;292(20):8269-8278. doi: 10.1074/jbc.M116.764886. Epub 2017 Mar 23.

4.

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.

Sin O, de Jong T, Mata-Cabana A, Kudron M, Zaini MA, Aprile FA, Seinstra RI, Stroo E, Prins RW, Martineau CN, Wang HH, Hogewerf W, Steinhof A, Wanker EE, Vendruscolo M, Calkhoven CF, Reinke V, Guryev V, Nollen EA.

Mol Cell. 2017 Mar 16;65(6):1096-1108.e6. doi: 10.1016/j.molcel.2017.02.022.

5.

Cellular Regulation of Amyloid Formation in Aging and Disease.

Stroo E, Koopman M, Nollen EA, Mata-Cabana A.

Front Neurosci. 2017 Feb 14;11:64. doi: 10.3389/fnins.2017.00064. eCollection 2017. Review.

6.

Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.

Jansen IE, Ye H, Heetveld S, Lechler MC, Michels H, Seinstra RI, Lubbe SJ, Drouet V, Lesage S, Majounie E, Gibbs JR, Nalls MA, Ryten M, Botia JA, Vandrovcova J, Simon-Sanchez J, Castillo-Lizardo M, Rizzu P, Blauwendraat C, Chouhan AK, Li Y, Yogi P, Amin N, van Duijn CM; International Parkinson’s Disease Genetics Consortium (IPGDC), Morris HR, Brice A, Singleton AB, David DC, Nollen EA, Jain S, Shulman JM, Heutink P.

Genome Biol. 2017 Jan 30;18(1):22. doi: 10.1186/s13059-017-1147-9.

7.

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.

Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M, Dobson CM.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1009-E1017. doi: 10.1073/pnas.1610586114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 21;114(12 ):E2543. Limboker, Ryan [corrected to Limbocker, Ryan].

8.

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase.

Michels H, Seinstra RI, Uitdehaag JC, Koopman M, van Faassen M, Martineau CN, Kema IP, Buijsman R, Nollen EA.

Sci Rep. 2016 Dec 20;6:39199. doi: 10.1038/srep39199.

9.

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease.

Visscher M, De Henau S, Wildschut MHE, van Es RM, Dhondt I, Michels H, Kemmeren P, Nollen EA, Braeckman BP, Burgering BMT, Vos HR, Dansen TB.

Cell Rep. 2016 Sep 13;16(11):3041-3051. doi: 10.1016/j.celrep.2016.08.025.

10.

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

Koopman M, Michels H, Dancy BM, Kamble R, Mouchiroud L, Auwerx J, Nollen EA, Houtkooper RH.

Nat Protoc. 2016 Oct;11(10):1798-816. doi: 10.1038/nprot.2016.106. Epub 2016 Sep 1.

11.

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.

Habchi J, Arosio P, Perni M, Costa AR, Yagi-Utsumi M, Joshi P, Chia S, Cohen SI, Müller MB, Linse S, Nollen EA, Dobson CM, Knowles TP, Vendruscolo M.

Sci Adv. 2016 Feb 12;2(2):e1501244. doi: 10.1126/sciadv.1501244. eCollection 2016 Feb.

12.

Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.

Srinivasan B, Baratashvili M, van der Zwaag M, Kanon B, Colombelli C, Lambrechts RA, Schaap O, Nollen EA, Podgoršek A, Kosec G, Petković H, Hayflick S, Tiranti V, Reijngoud DJ, Grzeschik NA, Sibon OC.

Nat Chem Biol. 2015 Oct;11(10):784-92. doi: 10.1038/nchembio.1906. Epub 2015 Aug 31.

PMID:
26322826
13.

Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes.

Sin O, Nollen EA.

Cell Mol Life Sci. 2015 Nov;72(21):4027-47. doi: 10.1007/s00018-015-1985-0. Epub 2015 Jul 21. Review.

14.

Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases.

Sin O, Michels H, Nollen EA.

Biochim Biophys Acta. 2014 Oct;1842(10):1951-1959. doi: 10.1016/j.bbadis.2014.01.015. Epub 2014 Feb 11. Review.

15.

Analyzing modifiers of protein aggregation in C. elegans by native agarose gel electrophoresis.

Holmberg M, Nollen EA.

Methods Mol Biol. 2013;1017:193-9. doi: 10.1007/978-1-62703-438-8_14.

PMID:
23719917
16.

Tryptophan metabolism: entering the field of aging and age-related pathologies.

van der Goot AT, Nollen EA.

Trends Mol Med. 2013 Jun;19(6):336-44. doi: 10.1016/j.molmed.2013.02.007. Epub 2013 Apr 2. Review.

PMID:
23562344
17.

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.

van der Goot AT, Zhu W, Vázquez-Manrique RP, Seinstra RI, Dettmer K, Michels H, Farina F, Krijnen J, Melki R, Buijsman RC, Ruiz Silva M, Thijssen KL, Kema IP, Neri C, Oefner PJ, Nollen EA.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14912-7. doi: 10.1073/pnas.1203083109. Epub 2012 Aug 27.

18.

SERF protein is a direct modifier of amyloid fiber assembly.

Falsone SF, Meyer NH, Schrank E, Leitinger G, Pham CL, Fodero-Tavoletti MT, Holmberg M, Dulle M, Scicluna B, Gesslbauer B, Rückert HM, Wagner GE, Merle DA, Nollen EA, Kungl AJ, Hill AF, Cappai R, Zangger K.

Cell Rep. 2012 Aug 30;2(2):358-71. doi: 10.1016/j.celrep.2012.06.012. Epub 2012 Jul 26.

19.

Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.

Siudeja K, Srinivasan B, Xu L, Rana A, de Jong J, Nollen EA, Jackowski S, Sanford L, Hayflick S, Sibon OC.

EMBO Mol Med. 2011 Dec;3(12):755-66. doi: 10.1002/emmm.201100180. Epub 2011 Oct 14.

20.

A FRET sensor for non-invasive imaging of amyloid formation in vivo.

Kaminski Schierle GS, Bertoncini CW, Chan FTS, van der Goot AT, Schwedler S, Skepper J, Schlachter S, van Ham T, Esposito A, Kumita JR, Nollen EAA, Dobson CM, Kaminski CF.

Chemphyschem. 2011 Feb 25;12(3):673-680. doi: 10.1002/cphc.201000996. Epub 2011 Feb 9.

21.

Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.

van Ham TJ, Holmberg MA, van der Goot AT, Teuling E, Garcia-Arencibia M, Kim HE, Du D, Thijssen KL, Wiersma M, Burggraaff R, van Bergeijk P, van Rheenen J, Jerre van Veluw G, Hofstra RM, Rubinsztein DC, Nollen EA.

Cell. 2010 Aug 20;142(4):601-12. doi: 10.1016/j.cell.2010.07.020.

22.

Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms.

van Ham TJ, Breitling R, Swertz MA, Nollen EA.

EMBO Mol Med. 2009 Nov;1(8-9):360-70. doi: 10.1002/emmm.200900051. Review.

23.

Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation.

van Ham TJ, Esposito A, Kumita JR, Hsu ST, Kaminski Schierle GS, Kaminski CF, Dobson CM, Nollen EA, Bertoncini CW.

J Mol Biol. 2010 Jan 22;395(3):627-42. doi: 10.1016/j.jmb.2009.10.066. Epub 2009 Nov 3.

PMID:
19891973
24.

Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.

Roodveldt C, Bertoncini CW, Andersson A, van der Goot AT, Hsu ST, Fernández-Montesinos R, de Jong J, van Ham TJ, Nollen EA, Pozo D, Christodoulou J, Dobson CM.

EMBO J. 2009 Dec 2;28(23):3758-70. doi: 10.1038/emboj.2009.298. Epub 2009 Oct 29.

25.

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.

van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterk RH, Nollen EA.

PLoS Genet. 2008 Mar 21;4(3):e1000027. doi: 10.1371/journal.pgen.1000027.

26.

Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality.

van Haaften G, Vastenhouw NL, Nollen EA, Plasterk RH, Tijsterman M.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12992-6. Epub 2004 Aug 23.

27.

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.

Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6403-8. Epub 2004 Apr 14.

28.

Polyglutamine protein aggregates are dynamic.

Kim S, Nollen EA, Kitagawa K, Bindokas VP, Morimoto RI.

Nat Cell Biol. 2002 Oct;4(10):826-31.

PMID:
12360295
29.

Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins.

Nollen EA, Morimoto RI.

J Cell Sci. 2002 Jul 15;115(Pt 14):2809-16. Review.

30.

Dynamic changes in the localization of thermally unfolded nuclear proteins associated with chaperone-dependent protection.

Nollen EA, Salomons FA, Brunsting JF, van der Want JJ, Sibon OC, Kampinga HH.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12038-43. Epub 2001 Sep 25.

31.

Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1.

Nollen EA, Kabakov AE, Brunsting JF, Kanon B, Höhfeld J, Kampinga HH.

J Biol Chem. 2001 Feb 16;276(7):4677-82. Epub 2000 Nov 13.

32.

Confocal laser scanning microscopy of human skin fibroblasts showing transient expression of a green fluorescent carnitine palmitoyltransferase 1 fusion protein.

van der Leij FR, Roelofsen H, Niezen-Koning KE, Nollen EA, Kuipers JR.

Adv Exp Med Biol. 1999;466:111-5. No abstract available.

PMID:
10709634
33.

Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity.

Nollen EA, Brunsting JF, Song J, Kampinga HH, Morimoto RI.

Mol Cell Biol. 2000 Feb;20(3):1083-8.

34.

In vivo chaperone activity of heat shock protein 70 and thermotolerance.

Nollen EA, Brunsting JF, Roelofsen H, Weber LA, Kampinga HH.

Mol Cell Biol. 1999 Mar;19(3):2069-79.

35.

Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers.

Martens DE, Nollen EA, Hardeveld M, Velden-de Groot CA, Gooijer CD, Beuvery EC, Tramper J.

Cytotechnology. 1997 Jan;23(1-3):61-75. doi: 10.1023/B:CYTO.0000010399.23373.65.

36.

Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers.

Martens DE, Nollen EA, Hardeveld M, van der Velden-de Groot CA, de Gooijer CD, Beuvery EC, Tramper J.

Cytotechnology. 1996 Jan;21(1):45-59. doi: 10.1007/BF00364836.

PMID:
22358606
37.

The NTP-binding motif in cowpea mosaic virus B polyprotein is essential for viral replication.

Peters SA, Verver J, Nollen EA, van Lent JW, Wellink J, van Kammen A.

J Gen Virol. 1994 Nov;75 ( Pt 11):3167-76.

PMID:
7964626

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