Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 255

1.

Purification and interactions of the MucA' and MucB proteins constituting the DNA polymerase RI.

Grúz P, Sugiyama KI, Honma M, Nohmi T.

Genes Environ. 2019 May 2;41:10. doi: 10.1186/s41021-019-0125-8. eCollection 2019.

2.

DNA polymerase kappa counteracts inflammation-induced mutagenesis in multiple organs of mice.

Hakura A, Sui H, Sonoda J, Matsuda T, Nohmi T.

Environ Mol Mutagen. 2019 May;60(4):320-330. doi: 10.1002/em.22272. Epub 2019 Jan 21.

PMID:
30620413
3.

Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area.

Aoki Y, Nakajima D, Matsumoto M, Yagishita M, Matsumoto M, Yanagisawa R, Goto S, Masumura K, Nohmi T.

Genes Environ. 2018 Nov 29;40:25. doi: 10.1186/s41021-018-0113-4. eCollection 2018.

4.

Thresholds of Genotoxic and Non-Genotoxic Carcinogens.

Nohmi T.

Toxicol Res. 2018 Oct;34(4):281-290. doi: 10.5487/TR.2018.34.4.281. Epub 2018 Oct 15. Review.

5.

In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats.

Gi M, Fujioka M, Kakehashi A, Okuno T, Masumura K, Nohmi T, Matsumoto M, Omori M, Wanibuchi H, Fukushima S.

Arch Toxicol. 2018 Oct;92(10):3207-3221. doi: 10.1007/s00204-018-2282-0. Epub 2018 Aug 27.

PMID:
30155721
6.

Chemically-Induced DNA Damage, Mutagenesis, and Cancer.

Basu AK, Nohmi T.

Int J Mol Sci. 2018 Jun 14;19(6). pii: E1767. doi: 10.3390/ijms19061767. No abstract available.

7.

Impact of DNA polymerase ζ mutations on genotoxic thresholds of oxidative mutagens.

Suzuki T, Matsumoto K, Honma M, Nohmi T.

Mutat Res Genet Toxicol Environ Mutagen. 2018 Apr;828:10-14. doi: 10.1016/j.mrgentox.2018.02.001. Epub 2018 Feb 7.

PMID:
29555059
8.

Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene-induced genotoxicity in vivo.

Masumura K, Toyoda-Hokaiwado N, Niimi N, Grúz P, Wada NA, Takeiri A, Jishage KI, Mishima M, Nohmi T.

Environ Mol Mutagen. 2017 Dec;58(9):644-653. doi: 10.1002/em.22146. Epub 2017 Oct 27.

PMID:
29076178
9.

Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis.

Ishii Y, Kuroda K, Matsushita K, Yokoo Y, Takasu S, Kijima A, Nohmi T, Ogawa K, Umemura T.

Toxicol Appl Pharmacol. 2017 Dec 1;336:75-83. doi: 10.1016/j.taap.2017.10.009. Epub 2017 Oct 17.

PMID:
29054680
10.

Transgenic rat models for mutagenesis and carcinogenesis.

Nohmi T, Masumura K, Toyoda-Hokaiwado N.

Genes Environ. 2017 Feb 1;39:11. doi: 10.1186/s41021-016-0072-6. eCollection 2017. Review.

11.

DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis.

Kanemaru Y, Suzuki T, Sassa A, Matsumoto K, Adachi N, Honma M, Numazawa S, Nohmi T.

Genes Environ. 2017 Jan 7;39:6. doi: 10.1186/s41021-016-0067-3. eCollection 2017.

12.

Dose-dependent de novo germline mutations detected by whole-exome sequencing in progeny of ENU-treated male gpt delta mice.

Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T.

Mutat Res. 2016 Nov 1;810:30-39. doi: 10.1016/j.mrgentox.2016.09.009. Epub 2016 Sep 28.

13.

Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine.

Sassa A, Çağlayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M.

J Biol Chem. 2016 Nov 11;291(46):24314-24323. Epub 2016 Sep 22.

14.

The role of DNA polymerase ζ in translesion synthesis across bulky DNA adducts and cross-links in human cells.

Suzuki T, Grúz P, Honma M, Adachi N, Nohmi T.

Mutat Res. 2016 Sep - Oct;791-792:35-41. doi: 10.1016/j.mrfmmm.2016.08.004. Epub 2016 Aug 25.

PMID:
27591392
15.

Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice.

Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T.

Genes Environ. 2016 Apr 1;38:10. doi: 10.1186/s41021-016-0035-y. eCollection 2016.

16.

Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ζ to genotoxic stresses.

Suzuki T, Grúz P, Honma M, Adachi N, Nohmi T.

DNA Repair (Amst). 2016 Sep;45:34-43. doi: 10.1016/j.dnarep.2016.06.002. Epub 2016 Jun 7.

PMID:
27338670
17.

Lack of genotoxic mechanisms in early-stage furan-induced hepatocellular tumorigenesis in gpt delta rats.

Hibi D, Yokoo Y, Suzuki Y, Ishii Y, Jin M, Kijima A, Nohmi T, Nishikawa A, Umemura T.

J Appl Toxicol. 2017 Feb;37(2):142-149. doi: 10.1002/jat.3331. Epub 2016 May 3.

PMID:
27143483
18.

Catalytic and non-catalytic roles of DNA polymerase κ in the protection of human cells against genotoxic stresses.

Kanemaru Y, Suzuki T, Niimi N, Grúz P, Matsumoto K, Adachi N, Honma M, Nohmi T.

Environ Mol Mutagen. 2015 Oct;56(8):650-62. doi: 10.1002/em.21961. Epub 2015 Jul 21.

PMID:
26031400
19.

Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.

Kijima A, Ishii Y, Takasu S, Matsushita K, Kuroda K, Hibi D, Suzuki Y, Nohmi T, Umemura T.

Toxicology. 2015 May 4;331:125-35. doi: 10.1016/j.tox.2015.03.003. Epub 2015 Mar 12.

PMID:
25772432
20.

Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats.

Akagi J, Toyoda T, Cho YM, Mizuta Y, Nohmi T, Nishikawa A, Ogawa K.

Cancer Sci. 2015 May;106(5):529-41. doi: 10.1111/cas.12634. Epub 2015 Apr 10.

21.

Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.

Kuroda K, Hibi D, Ishii Y, Yokoo Y, Takasu S, Kijima A, Matsushita K, Masumura K, Kodama Y, Yanai T, Sakai H, Nohmi T, Ogawa K, Umemura T.

Toxicol Sci. 2015 Mar;144(1):65-76. doi: 10.1093/toxsci/kfu267. Epub 2015 Jan 29.

PMID:
25636497
22.

Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents.

Masumura K, Sakamoto Y, Kumita W, Honma M, Nishikawa A, Nohmi T.

Genes Environ. 2015 Dec 1;37:24. doi: 10.1186/s41021-015-0024-6. eCollection 2015.

23.

Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages.

Aoki Y, Hashimoto AH, Sugawara Y, Hiyoshi-Arai K, Goto S, Masumura K, Nohmi T.

Genes Environ. 2015 Jun 16;37:7. doi: 10.1186/s41021-015-0004-x. eCollection 2015.

24.

Greetings from The International Association of Environmental Mutagenesis and Genomics Societies.

Nohmi T.

Genes Environ. 2015 Jun 16;37:2. doi: 10.1186/s41021-015-0006-8. eCollection 2015.

25.

A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action.

Matsushita K, Ishii Y, Takasu S, Kuroda K, Kijima A, Tsuchiya T, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Nishikawa A, Umemura T.

Exp Toxicol Pathol. 2015 Jan;67(1):31-9. doi: 10.1016/j.etp.2014.09.006. Epub 2014 Oct 16.

PMID:
25446801
26.

Vasopressin does not raise cardiac enzymes following cardiac surgery: a randomized double-blind clinical trial.

Okamoto Y, Nohmi T, Higa Y, Seki K, Yamashita A.

J Cardiothorac Vasc Anesth. 2015 Feb;29(1):46-51. doi: 10.1053/j.jvca.2014.07.007. Epub 2014 Oct 30.

PMID:
25440643
27.

In vivo evidence that DNA polymerase kappa is responsible for error-free bypass across DNA cross-links induced by mitomycin C.

Takeiri A, Wada NA, Motoyama S, Matsuzaki K, Tateishi H, Matsumoto K, Niimi N, Sassa A, Grúz P, Masumura K, Yamada M, Mishima M, Jishage KI, Nohmi T.

DNA Repair (Amst). 2014 Dec;24:113-121. doi: 10.1016/j.dnarep.2014.09.002. Epub 2014 Oct 7.

PMID:
25303778
28.

Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies.

Kawamura Y, Hayashi H, Masumura K, Numazawa S, Nohmi T.

Toxicology. 2014 Oct 3;324:10-7. doi: 10.1016/j.tox.2014.07.003. Epub 2014 Jul 15.

PMID:
25047350
29.

Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action.

Matsushita K, Kuroda K, Ishii Y, Takasu S, Kijima A, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Nishikawa A, Umemura T.

Exp Toxicol Pathol. 2014 Sep;66(7):313-21. doi: 10.1016/j.etp.2014.05.002. Epub 2014 Jun 11.

PMID:
24929978
30.

Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats.

Onami S, Cho YM, Toyoda T, Horibata K, Ishii Y, Umemura T, Honma M, Nohmi T, Nishikawa A, Ogawa K.

Mutagenesis. 2014 Jul;29(4):295-302. doi: 10.1093/mutage/geu018. Epub 2014 May 14.

PMID:
24831098
31.

Combined application of comprehensive analysis for DNA modification and reporter gene mutation assay to evaluate kidneys of gpt delta rats given madder color or its constituents.

Ishii Y, Takasu S, Kuroda K, Matsushita K, Kijima A, Nohmi T, Ogawa K, Umemura T.

Anal Bioanal Chem. 2014 Apr;406(9-10):2467-75. doi: 10.1007/s00216-014-7621-2. Epub 2014 Feb 4.

PMID:
24493334
32.

In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ.

Sassa A, Suzuki T, Kanemaru Y, Niimi N, Fujimoto H, Katafuchi A, Grúz P, Yasui M, Gupta RC, Johnson F, Ohta T, Honma M, Adachi N, Nohmi T.

DNA Repair (Amst). 2014 Mar;15:21-8. doi: 10.1016/j.dnarep.2013.12.008. Epub 2014 Jan 21.

PMID:
24461735
33.

[Planning of cardiothoracic surgery for chronic kidney disease patients].

Okamoto Y, Nohmi T, Seki K, Higa Y.

Masui. 2013 Nov;62(11):1320-5. Review. Japanese.

PMID:
24364273
34.

In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.

Takumi S, Aoki Y, Sano T, Suzuki T, Nohmi T, Nohara K.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Jan 15;760:42-7. doi: 10.1016/j.mrgentox.2013.12.001. Epub 2013 Dec 10.

PMID:
24333349
35.

Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats.

Kuroda K, Hibi D, Ishii Y, Takasu S, Kijima A, Matsushita K, Masumura K, Watanabe M, Sugita-Konishi Y, Sakai H, Yanai T, Nohmi T, Ogawa K, Umemura T.

Mutagenesis. 2014 Jan;29(1):27-36. doi: 10.1093/mutage/get054. Epub 2013 Nov 16.

PMID:
24243707
36.

Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.

Horibata K, Ukai A, Kimoto T, Suzuki T, Kamoshita N, Masumura K, Nohmi T, Honma M.

Environ Mol Mutagen. 2013 Dec;54(9):747-54. doi: 10.1002/em.21818. Epub 2013 Sep 18.

PMID:
24105957
37.

Evaluation of the genotoxicity of tamoxifen in the liver and kidney of F344 gpt delta transgenic rat in 3-week and 13-week repeated dose studies.

Kawamura Y, Hayashi H, Kurata Y, Hiratsuka K, Masumura K, Nohmi T.

Toxicology. 2013 Oct 4;312:56-62. doi: 10.1016/j.tox.2013.07.014. Epub 2013 Jul 30.

PMID:
23907062
38.

Cell cycle progression, but not genotoxic activity, mainly contributes to citrinin-induced renal carcinogenesis.

Kuroda K, Ishii Y, Takasu S, Kijima A, Matsushita K, Watanabe M, Takahashi H, Sugita-Konishi Y, Sakai H, Yanai T, Nohmi T, Ogawa K, Umemura T.

Toxicology. 2013 Sep 15;311(3):216-24. doi: 10.1016/j.tox.2013.07.003. Epub 2013 Jul 12.

PMID:
23856526
39.

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS.

EMBO J. 2013 Jul 31;32(15):2172-85. doi: 10.1038/emboj.2013.148. Epub 2013 Jun 25.

40.

Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity.

Matsushita K, Kijima A, Ishii Y, Takasu S, Jin M, Kuroda K, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Umemura T.

J Toxicol Pathol. 2013 Mar;26(1):19-27. doi: 10.1293/tox.26.19. Epub 2013 Apr 22.

41.

Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting.

Suzuki T, Ukai A, Honma M, Adachi N, Nohmi T.

PLoS One. 2013 Apr 15;8(4):e61189. doi: 10.1371/journal.pone.0061189. Print 2013.

42.

Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression.

Hibi D, Kijima A, Kuroda K, Suzuki Y, Ishii Y, Jin M, Nakajima M, Sugita-Konishi Y, Yanai T, Nohmi T, Nishikawa A, Umemura T.

J Toxicol Sci. 2013 Feb;38(1):57-69.

43.

Radiation induced COX-2 expression and mutagenesis at non-targeted lung tissues of gpt delta transgenic mice.

Chai Y, Calaf GM, Zhou H, Ghandhi SA, Elliston CD, Wen G, Nohmi T, Amundson SA, Hei TK.

Br J Cancer. 2013 Jan 15;108(1):91-8. doi: 10.1038/bjc.2012.498. Epub 2012 Nov 29.

44.

Miscoding properties of 8-chloro-2'-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases.

Sassa A, Kamoshita N, Matsuda T, Ishii Y, Kuraoka I, Nohmi T, Ohta T, Honma M, Yasui M.

Mutagenesis. 2013 Jan;28(1):81-8. doi: 10.1093/mutage/ges056. Epub 2012 Oct 17.

PMID:
23076070
45.

In vivo genotoxicity of methyleugenol in gpt delta transgenic rats following medium-term exposure.

Jin M, Kijima A, Hibi D, Ishii Y, Takasu S, Matsushita K, Kuroda K, Nohmi T, Nishikawa A, Umemura T.

Toxicol Sci. 2013 Feb;131(2):387-94. doi: 10.1093/toxsci/kfs294. Epub 2012 Oct 16.

PMID:
23074021
46.

Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains.

Yamada M, Shimizu M, Katafuchi A, Grúz P, Fujii S, Usui Y, Fuchs RP, Nohmi T.

Mol Microbiol. 2012 Dec;86(6):1364-75. doi: 10.1111/mmi.12061. Epub 2012 Nov 1.

47.

Oxidative DNA damage and in vivo mutagenicity caused by reactive oxygen species generated in the livers of p53-proficient or -deficient gpt delta mice treated with non-genotoxic hepatocarcinogens.

Tasaki M, Kuroiwa Y, Inoue T, Hibi D, Matsushita K, Ishii Y, Maruyama S, Nohmi T, Nishikawa A, Umemura T.

J Appl Toxicol. 2013 Dec;33(12):1433-41. doi: 10.1002/jat.2807. Epub 2012 Sep 12.

PMID:
22972318
48.

Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice.

Suzuki Y, Umemura T, Ishii Y, Hibi D, Inoue T, Jin M, Sakai H, Kodama Y, Nohmi T, Yanai T, Nishikawa A, Ogawa K.

Mutat Res. 2012 Dec 12;749(1-2):23-8. doi: 10.1016/j.mrgentox.2012.07.002. Epub 2012 Aug 4.

PMID:
22885592
49.

In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice.

Jin M, Kijima A, Suzuki Y, Hibi D, Ishii Y, Nohmi T, Nishikawa A, Ogawa K, Umemura T.

J Toxicol Sci. 2012;37(4):711-21. Erratum in: J Toxicol Sci. 2014 Aug;39(4):685.

50.

The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis.

Luan Y, Xing G, Qi X, Wu M, Li C, Yao J, Gong L, Nohmi T, Gu J, Zhou W, Zheng S, Ren J.

Arch Toxicol. 2012 Nov;86(11):1753-61. doi: 10.1007/s00204-012-0891-6. Epub 2012 Jun 19.

PMID:
22710403

Supplemental Content

Support Center