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Items: 1 to 50 of 214


The Structures of Eukaryotic Transcription Pre-initiation Complexes and Their Functional Implications.

Greber BJ, Nogales E.

Subcell Biochem. 2019;93:143-192. doi: 10.1007/978-3-030-28151-9_5. Review.


Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.

Patel AB, Moore CM, Greber BJ, Luo J, Zukin SA, Ranish J, Nogales E.

Elife. 2019 Dec 30;8. pii: e54449. doi: 10.7554/eLife.54449.


Recent insights into the structure of TFIID, its assembly, and its binding to core promoter.

Patel AB, Greber BJ, Nogales E.

Curr Opin Struct Biol. 2019 Nov 18;61:17-24. doi: 10.1016/ [Epub ahead of print] Review.


Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts.

Ghanim GE, Kellogg EH, Nogales E, Rio DC.

Nat Struct Mol Biol. 2019 Nov;26(11):1013-1022. doi: 10.1038/s41594-019-0319-6. Epub 2019 Oct 28.


High-resolution cryo-EM structures of TFIIH and their functional implications.

Nogales E, Greber BJ.

Curr Opin Struct Biol. 2019 Dec;59:188-194. doi: 10.1016/ Epub 2019 Oct 7. Review.


Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM.

Carragher B, Cheng Y, Frost A, Glaeser RM, Lander GC, Nogales E, Wang HW.

J Microsc. 2019 Oct;276(1):39-45. doi: 10.1111/jmi.12834. Epub 2019 Oct 7.


Cryo-EM studies of NAIP-NLRC4 inflammasomes.

Haloupek N, Grob P, Tenthorey J, Vance RE, Nogales E.

Methods Enzymol. 2019;625:177-204. doi: 10.1016/bs.mie.2019.04.030. Epub 2019 May 24.


Total arterial revascularization strategies: A meta-analysis of propensity score-matched observational studies.

Urso S, Sadaba R, González JM, Nogales E, Pettinari M, Tena MÁ, Paredes F, Portela F.

J Card Surg. 2019 Sep;34(9):837-845. doi: 10.1111/jocs.14169. Epub 2019 Aug 2. Review.


Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble.

Liu TY, Liu JJ, Aditham AJ, Nogales E, Doudna JA.

Nat Commun. 2019 Jul 5;10(1):3001. doi: 10.1038/s41467-019-10780-2.


Telomerase structures and regulation: shedding light on the chromosome end.

Nguyen THD, Collins K, Nogales E.

Curr Opin Struct Biol. 2019 Apr;55:185-193. doi: 10.1016/ Epub 2019 Jun 12. Review.


Effects of α-tubulin acetylation on microtubule structure and stability.

Eshun-Wilson L, Zhang R, Portran D, Nachury MV, Toso DB, Löhr T, Vendruscolo M, Bonomi M, Fraser JS, Nogales E.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10366-10371. doi: 10.1073/pnas.1900441116. Epub 2019 May 9.


Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors.

Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA.

Nature. 2019 Apr;568(7752):E8-E10. doi: 10.1038/s41586-019-1084-8.


The complete structure of the human TFIIH core complex.

Greber BJ, Toso DB, Fang J, Nogales E.

Elife. 2019 Mar 12;8. pii: e44771. doi: 10.7554/eLife.44771.


Bilateral internal thoracic artery versus single internal thoracic artery: a meta-analysis of propensity score-matched observational studies.

Urso S, Nogales E, González JM, Sadaba R, Tena MÁ, Bellot R, Ríos L, Portela F.

Interact Cardiovasc Thorac Surg. 2019 Mar 8. pii: ivz037. doi: 10.1093/icvts/ivz037. [Epub ahead of print]


CasX enzymes comprise a distinct family of RNA-guided genome editors.

Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA.

Nature. 2019 Feb;566(7743):218-223. doi: 10.1038/s41586-019-0908-x. Epub 2019 Feb 4. Erratum in: Nature. 2019 Apr;568(7752):E8-E10.


Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.

Jiang F, Liu JJ, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J, Doudna JA.

Mol Cell. 2019 Feb 7;73(3):601-610.e5. doi: 10.1016/j.molcel.2018.11.016. Epub 2018 Dec 27.


Direct observation of tunnelled intergrowth in SnO2/Ga2O3 complex nanowires.

Rigby OM, Stamp AV, Hindmarsh SA, Alonso-Orts M, Nogales E, Méndez B, Sanchez AM.

Nanotechnology. 2019 Feb 1;30(5):054004. doi: 10.1088/1361-6528/aaefc4. Epub 2018 Dec 4.


Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding.

Kasinath V, Poepsel S, Nogales E.

Biochemistry. 2019 Feb 5;58(5):346-354. doi: 10.1021/acs.biochem.8b01064. Epub 2018 Dec 3.


Structure of human TFIID and mechanism of TBP loading onto promoter DNA.

Patel AB, Louder RK, Greber BJ, Grünberg S, Luo J, Fang J, Liu Y, Ranish J, Hahn S, Nogales E.

Science. 2018 Dec 21;362(6421). pii: eaau8872. doi: 10.1126/science.aau8872. Epub 2018 Nov 15.


Who mentors whom?

Nogales E.

Mol Biol Cell. 2018 Nov 1;29(22):2606-2607. doi: 10.1091/mbc.E18-07-0451.


A unique supramolecular organization of photosystem I in the moss Physcomitrella patens.

Iwai M, Grob P, Iavarone AT, Nogales E, Niyogi KK.

Nat Plants. 2018 Nov;4(11):904-909. doi: 10.1038/s41477-018-0271-1. Epub 2018 Oct 29.



Nogales E.

Curr Biol. 2018 Oct 8;28(19):R1127-R1128. doi: 10.1016/j.cub.2018.07.016. Review.


Separating the effects of nucleotide and EB binding on microtubule structure.

Zhang R, LaFrance B, Nogales E.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6191-E6200. doi: 10.1073/pnas.1802637115. Epub 2018 Jun 18.


Size-selective breaking of the core-shell structure of gallium nanoparticles.

Catalán-Gómez S, Redondo-Cubero A, Palomares FJ, Vázquez L, Nogales E, Nucciarelli F, Méndez B, Gordillo N, Pau JL.

Nanotechnology. 2018 Aug 31;29(35):355707. doi: 10.1088/1361-6528/aacb91. Epub 2018 Jun 11.


Near-atomic model of microtubule-tau interactions.

Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E.

Science. 2018 Jun 15;360(6394):1242-1246. doi: 10.1126/science.aat1780. Epub 2018 May 10.


Cryo-EM structure of substrate-bound human telomerase holoenzyme.

Nguyen THD, Tam J, Wu RA, Greber BJ, Toso D, Nogales E, Collins K.

Nature. 2018 May;557(7704):190-195. doi: 10.1038/s41586-018-0062-x. Epub 2018 Apr 25.


Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes.

Poepsel S, Kasinath V, Nogales E.

Nat Struct Mol Biol. 2018 Feb;25(2):154-162. doi: 10.1038/s41594-018-0023-y. Epub 2018 Jan 29.


Cytoskeleton in high resolution.

Nogales E.

Nat Rev Mol Cell Biol. 2018 Mar;19(3):142. doi: 10.1038/nrm.2018.1. Epub 2018 Jan 24. No abstract available.


Structures of human PRC2 with its cofactors AEBP2 and JARID2.

Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E.

Science. 2018 Feb 23;359(6378):940-944. doi: 10.1126/science.aar5700. Epub 2018 Jan 18.


Structural and functional differences between porcine brain and budding yeast microtubules.

Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E.

Cell Cycle. 2018;17(3):278-287. doi: 10.1080/15384101.2017.1415680. Epub 2018 Jan 30.


Profile of Joachim Frank, Richard Henderson, and Jacques Dubochet, 2017 Nobel Laureates in Chemistry.

Nogales E.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):441-444. doi: 10.1073/pnas.1718898114. Epub 2017 Dec 1. No abstract available.


How Cryo-EM Became so Hot.

Cheng Y, Glaeser RM, Nogales E.

Cell. 2017 Nov 30;171(6):1229-1231. doi: 10.1016/j.cell.2017.11.016.


The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.

Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE.

Science. 2017 Nov 17;358(6365):888-893. doi: 10.1126/science.aao1140.


Structural insight into TPX2-stimulated microtubule assembly.

Zhang R, Roostalu J, Surrey T, Nogales E.

Elife. 2017 Nov 9;6. pii: e30959. doi: 10.7554/eLife.30959.


The cryo-electron microscopy structure of human transcription factor IIH.

Greber BJ, Nguyen THD, Fang J, Afonine PV, Adams PD, Nogales E.

Nature. 2017 Sep 21;549(7672):414-417. doi: 10.1038/nature23903. Epub 2017 Sep 13.


Structures of the CRISPR genome integration complex.

Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA.

Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20.


Disabling Cas9 by an anti-CRISPR DNA mimic.

Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA.

Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul.


Structural differences between yeast and mammalian microtubules revealed by cryo-EM.

Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E.

J Cell Biol. 2017 Sep 4;216(9):2669-2677. doi: 10.1083/jcb.201612195. Epub 2017 Jun 26.


Challenges and opportunities in the high-resolution cryo-EM visualization of microtubules and their binding partners.

Nogales E, Kellogg EH.

Curr Opin Struct Biol. 2017 Oct;46:65-70. doi: 10.1016/ Epub 2017 Jun 16. Review.


Towards a mechanistic understanding of core promoter recognition from cryo-EM studies of human TFIID.

Nogales E, Patel AB, Louder RK.

Curr Opin Struct Biol. 2017 Dec;47:60-66. doi: 10.1016/ Epub 2017 Jun 15. Review.


Structural Insights into the Eukaryotic Transcription Initiation Machinery.

Nogales E, Louder RK, He Y.

Annu Rev Biophys. 2017 May 22;46:59-83. doi: 10.1146/annurev-biophys-070816-033751. Review.


Enhanced FIB-SEM systems for large-volume 3D imaging.

Xu CS, Hayworth KJ, Lu Z, Grob P, Hassan AM, García-Cerdán JG, Niyogi KK, Nogales E, Weinberg RJ, Hess HF.

Elife. 2017 May 13;6. pii: e25916. doi: 10.7554/eLife.25916.


Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.

Kellogg EH, Hejab NMA, Howes S, Northcote P, Miller JH, Díaz JF, Downing KH, Nogales E.

J Mol Biol. 2017 Mar 10;429(5):633-646. doi: 10.1016/j.jmb.2017.01.001. Epub 2017 Jan 17.


Shape Engineering Driven by Selective Growth of SnO2 on Doped Ga2O3 Nanowires.

Alonso-Orts M, Sánchez AM, Hindmarsh SA, López I, Nogales E, Piqueras J, Méndez B.

Nano Lett. 2017 Jan 11;17(1):515-522. doi: 10.1021/acs.nanolett.6b04189. Epub 2016 Dec 23.


Structural dynamics and DNA interaction of human TFIID.

Nogales E, Fang J, Louder RK.

Transcription. 2017 Jan;8(1):55-60. doi: 10.1080/21541264.2016.1265701. Epub 2016 Dec 9.


Primary Breast Lymphoma: Analysis of 55 Cases of the Spanish Lymphoma Oncology Group.

Franco Pérez F, Lavernia J, Aguiar-Bujanda D, Miramón J, Gumá J, Álvarez R, Gómez-Codina J, Arroyo FG, Llanos M, Marin M, Alfaro J, Quero C, Delgado M, Nogales E, Menarguez F, Martinez N, Torrente M, Royuela A, Abreu D, Provencio M.

Clin Lymphoma Myeloma Leuk. 2017 Mar;17(3):186-191. doi: 10.1016/j.clml.2016.09.004. Epub 2016 Sep 17.


Effects of Bni5 Binding on Septin Filament Organization.

Booth EA, Sterling SM, Dovala D, Nogales E, Thorner J.

J Mol Biol. 2016 Dec 4;428(24 Pt B):4962-4980. doi: 10.1016/j.jmb.2016.10.024. Epub 2016 Oct 30.


Dear microtubule, I see you.

Nogales E.

Mol Biol Cell. 2016 Nov 1;27(21):3202-3204.


Cryo-EM in the study of challenging systems: the human transcription pre-initiation complex.

Nogales E, Louder RK, He Y.

Curr Opin Struct Biol. 2016 Oct;40:120-127. doi: 10.1016/ Epub 2016 Sep 30. Review.


Next-generation electron microscopy in autophagy research.

Hurley JH, Nogales E.

Curr Opin Struct Biol. 2016 Dec;41:211-216. doi: 10.1016/ Epub 2016 Sep 8. Review.

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