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Items: 1 to 50 of 192


Separating the effects of nucleotide and EB binding on microtubule structure.

Zhang R, LaFrance B, Nogales E.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6191-E6200. doi: 10.1073/pnas.1802637115. Epub 2018 Jun 18.


Size-selective breaking of the core-shell structure of gallium nanoparticles.

Catalán-Gómez S, Redondo-Cubero A, Palomares FJ, Vázquez L, Nogales E, Nucciarelli F, Méndez B, Gordillo N, Pau JL.

Nanotechnology. 2018 Aug 31;29(35):355707. doi: 10.1088/1361-6528/aacb91. Epub 2018 Jun 11.


Near-atomic model of microtubule-tau interactions.

Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E.

Science. 2018 Jun 15;360(6394):1242-1246. doi: 10.1126/science.aat1780. Epub 2018 May 10.


Cryo-EM structure of substrate-bound human telomerase holoenzyme.

Nguyen THD, Tam J, Wu RA, Greber BJ, Toso D, Nogales E, Collins K.

Nature. 2018 May;557(7704):190-195. doi: 10.1038/s41586-018-0062-x. Epub 2018 Apr 25.


Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes.

Poepsel S, Kasinath V, Nogales E.

Nat Struct Mol Biol. 2018 Feb;25(2):154-162. doi: 10.1038/s41594-018-0023-y. Epub 2018 Jan 29.


Cytoskeleton in high resolution.

Nogales E.

Nat Rev Mol Cell Biol. 2018 Mar;19(3):142. doi: 10.1038/nrm.2018.1. Epub 2018 Jan 24. No abstract available.


Structures of human PRC2 with its cofactors AEBP2 and JARID2.

Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E.

Science. 2018 Feb 23;359(6378):940-944. doi: 10.1126/science.aar5700. Epub 2018 Jan 18.


Structural and functional differences between porcine brain and budding yeast microtubules.

Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E.

Cell Cycle. 2018;17(3):278-287. doi: 10.1080/15384101.2017.1415680. Epub 2018 Jan 30.


Profile of Joachim Frank, Richard Henderson, and Jacques Dubochet, 2017 Nobel Laureates in Chemistry.

Nogales E.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):441-444. doi: 10.1073/pnas.1718898114. Epub 2017 Dec 1. No abstract available.


How Cryo-EM Became so Hot.

Cheng Y, Glaeser RM, Nogales E.

Cell. 2017 Nov 30;171(6):1229-1231. doi: 10.1016/j.cell.2017.11.016.


The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.

Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE.

Science. 2017 Nov 17;358(6365):888-893. doi: 10.1126/science.aao1140.


Structural insight into TPX2-stimulated microtubule assembly.

Zhang R, Roostalu J, Surrey T, Nogales E.

Elife. 2017 Nov 9;6. pii: e30959. doi: 10.7554/eLife.30959.


The cryo-electron microscopy structure of human transcription factor IIH.

Greber BJ, Nguyen THD, Fang J, Afonine PV, Adams PD, Nogales E.

Nature. 2017 Sep 21;549(7672):414-417. doi: 10.1038/nature23903. Epub 2017 Sep 13.


Structures of the CRISPR genome integration complex.

Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA.

Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20.


Disabling Cas9 by an anti-CRISPR DNA mimic.

Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA.

Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul.


Structural differences between yeast and mammalian microtubules revealed by cryo-EM.

Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E.

J Cell Biol. 2017 Sep 4;216(9):2669-2677. doi: 10.1083/jcb.201612195. Epub 2017 Jun 26.


Challenges and opportunities in the high-resolution cryo-EM visualization of microtubules and their binding partners.

Nogales E, Kellogg EH.

Curr Opin Struct Biol. 2017 Oct;46:65-70. doi: 10.1016/ Epub 2017 Jun 16. Review.


Towards a mechanistic understanding of core promoter recognition from cryo-EM studies of human TFIID.

Nogales E, Patel AB, Louder RK.

Curr Opin Struct Biol. 2017 Dec;47:60-66. doi: 10.1016/ Epub 2017 Jun 15. Review.


Structural Insights into the Eukaryotic Transcription Initiation Machinery.

Nogales E, Louder RK, He Y.

Annu Rev Biophys. 2017 May 22;46:59-83. doi: 10.1146/annurev-biophys-070816-033751. Review.


Enhanced FIB-SEM systems for large-volume 3D imaging.

Xu CS, Hayworth KJ, Lu Z, Grob P, Hassan AM, García-Cerdán JG, Niyogi KK, Nogales E, Weinberg RJ, Hess HF.

Elife. 2017 May 13;6. pii: e25916. doi: 10.7554/eLife.25916.


Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.

Kellogg EH, Hejab NMA, Howes S, Northcote P, Miller JH, Díaz JF, Downing KH, Nogales E.

J Mol Biol. 2017 Mar 10;429(5):633-646. doi: 10.1016/j.jmb.2017.01.001. Epub 2017 Jan 17.


Shape Engineering Driven by Selective Growth of SnO2 on Doped Ga2O3 Nanowires.

Alonso-Orts M, Sánchez AM, Hindmarsh SA, López I, Nogales E, Piqueras J, Méndez B.

Nano Lett. 2017 Jan 11;17(1):515-522. doi: 10.1021/acs.nanolett.6b04189. Epub 2016 Dec 23.


Structural dynamics and DNA interaction of human TFIID.

Nogales E, Fang J, Louder RK.

Transcription. 2017 Jan;8(1):55-60. doi: 10.1080/21541264.2016.1265701. Epub 2016 Dec 9.


Primary Breast Lymphoma: Analysis of 55 Cases of the Spanish Lymphoma Oncology Group.

Franco Pérez F, Lavernia J, Aguiar-Bujanda D, Miramón J, Gumá J, Álvarez R, Gómez-Codina J, Arroyo FG, Llanos M, Marin M, Alfaro J, Quero C, Delgado M, Nogales E, Menarguez F, Martinez N, Torrente M, Royuela A, Abreu D, Provencio M.

Clin Lymphoma Myeloma Leuk. 2017 Mar;17(3):186-191. doi: 10.1016/j.clml.2016.09.004. Epub 2016 Sep 17.


Effects of Bni5 Binding on Septin Filament Organization.

Booth EA, Sterling SM, Dovala D, Nogales E, Thorner J.

J Mol Biol. 2016 Dec 4;428(24 Pt B):4962-4980. doi: 10.1016/j.jmb.2016.10.024. Epub 2016 Oct 30.


Dear microtubule, I see you.

Nogales E.

Mol Biol Cell. 2016 Nov 1;27(21):3202-3204.


Cryo-EM in the study of challenging systems: the human transcription pre-initiation complex.

Nogales E, Louder RK, He Y.

Curr Opin Struct Biol. 2016 Oct;40:120-127. doi: 10.1016/ Epub 2016 Sep 30. Review.


Next-generation electron microscopy in autophagy research.

Hurley JH, Nogales E.

Curr Opin Struct Biol. 2016 Dec;41:211-216. doi: 10.1016/ Epub 2016 Sep 8. Review.


DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.

Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA.

Mol Cell. 2016 Sep 1;63(5):840-51. doi: 10.1016/j.molcel.2016.07.027.


Near-atomic cryo-EM structure of PRC1 bound to the microtubule.

Kellogg EH, Howes S, Ti SC, Ramírez-Aportela E, Kapoor TM, Chacón P, Nogales E.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9430-9. doi: 10.1073/pnas.1609903113. Epub 2016 Aug 4.


Preparing recombinant yeast septins and their analysis by electron microscopy.

Bertin A, Nogales E.

Methods Cell Biol. 2016;136:21-34. doi: 10.1016/bs.mcb.2016.03.010. Epub 2016 Apr 14.


Near-atomic resolution visualization of human transcription promoter opening.

He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E.

Nature. 2016 May 19;533(7603):359-65. doi: 10.1038/nature17970. Epub 2016 May 11.


Coordinate action of distinct sequence elements localizes checkpoint kinase Hsl1 to the septin collar at the bud neck in Saccharomyces cerevisiae.

Finnigan GC, Sterling SM, Duvalyan A, Liao EN, Sargsyan A, Garcia G 3rd, Nogales E, Thorner J.

Mol Biol Cell. 2016 Jul 15;27(14):2213-33. doi: 10.1091/mbc.E16-03-0177. Epub 2016 May 18.


Microtubules: 50 years on from the discovery of tubulin.

Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E.

Nat Rev Mol Cell Biol. 2016 Apr 22;17(5):322-8. doi: 10.1038/nrm.2016.45. Review.


Corrigendum: Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

Louder RK, He Y, López-Blanco JR, Fang J, Chacón P, Nogales E.

Nature. 2016 Aug 4;536(7614):112. doi: 10.1038/nature17984. Epub 2016 Apr 20. No abstract available.


Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.

Ti SC, Pamula MC, Howes SC, Duellberg C, Cade NI, Kleiner RE, Forth S, Surrey T, Nogales E, Kapoor TM.

Dev Cell. 2016 Apr 4;37(1):72-84. doi: 10.1016/j.devcel.2016.03.003.


Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.

Louder RK, He Y, López-Blanco JR, Fang J, Chacón P, Nogales E.

Nature. 2016 Mar 31;531(7596):604-9. doi: 10.1038/nature17394. Epub 2016 Mar 23. Erratum in: Nature. 2016 Aug 4;536(7614):112.


Assembly, molecular organization, and membrane-binding properties of development-specific septins.

Garcia G 3rd, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner J.

J Cell Biol. 2016 Feb 29;212(5):515-29. doi: 10.1083/jcb.201511029.


Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.

Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA.

Science. 2016 Feb 19;351(6275):867-71. doi: 10.1126/science.aad8282. Epub 2016 Jan 14.


Visualizing microtubule structural transitions and interactions with associated proteins.

Nogales E, Zhang R.

Curr Opin Struct Biol. 2016 Apr;37:90-6. doi: 10.1016/ Epub 2016 Jan 21. Review.


Mutations in TUBB8 and Human Oocyte Meiotic Arrest.

Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ, Wang L.

N Engl J Med. 2016 Jan 21;374(3):223-32. doi: 10.1056/NEJMoa1510791.


Architecture of the human XPC DNA repair and stem cell coactivator complex.

Zhang ET, He Y, Grob P, Fong YW, Nogales E, Tjian R.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14817-22. doi: 10.1073/pnas.1520104112. Epub 2015 Nov 16.


Characterization of Septin Ultrastructure in Budding Yeast Using Electron Tomography.

Bertin A, Nogales E.

Methods Mol Biol. 2016;1369:113-23. doi: 10.1007/978-1-4939-3145-3_9.


Correction: Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.

Diao J, Grob P, Cipriano DJ, Kyoung M, Zhang Y, Shah S, Nguyen A, Padolina M, Srivastava A, Vrljic M, Shah A, Nogales E, Chu S, Brunger AT.

Elife. 2015 Oct 21;4:e12289. doi: 10.7554/eLife.12289. No abstract available.


Protein domain mapping by internal labeling and single particle electron microscopy.

Ciferri C, Lander GC, Nogales E.

J Struct Biol. 2015 Nov;192(2):159-62. doi: 10.1016/j.jsb.2015.09.016. Epub 2015 Sep 30.


A new protocol to accurately determine microtubule lattice seam location.

Zhang R, Nogales E.

J Struct Biol. 2015 Nov;192(2):245-54. doi: 10.1016/j.jsb.2015.09.015. Epub 2015 Sep 28.


An electron microscopy journey in the study of microtubule structure and dynamics.

Nogales E.

Protein Sci. 2015 Dec;24(12):1912-9. doi: 10.1002/pro.2808. Epub 2015 Oct 11. Review.


Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.

Zhang R, Alushin GM, Brown A, Nogales E.

Cell. 2015 Aug 13;162(4):849-59. doi: 10.1016/j.cell.2015.07.012. Epub 2015 Jul 30.


Eva Nogales: See how they run.

Nogales E, Sedwick C.

J Cell Biol. 2015 May 25;209(4):472-3. doi: 10.1083/jcb.2094pi. No abstract available.

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