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VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.

ElTanbouly MA, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, Ceeraz S, Lines JL, Peng C, Carriere C, Huang X, Day M, Koehn B, Lee SW, Silva Morales M, Hogquist KA, Jameson SC, Mueller D, Rothstein J, Blazar BR, Cheng C, Noelle RJ.

Science. 2020 Jan 17;367(6475). pii: eaay0524. doi: 10.1126/science.aay0524.


VISTA: Coming of age as a multi-lineage immune checkpoint.

ElTanbouly MA, Schaafsma E, Noelle RJ, Lines JL.

Clin Exp Immunol. 2020 Jan 13. doi: 10.1111/cei.13415. [Epub ahead of print] Review.


Defining the Signature of VISTA on Myeloid Cell Chemokine Responsiveness.

Broughton TWK, ElTanbouly MA, Schaafsma E, Deng J, Sarde A, Croteau W, Li J, Nowak EC, Mabaera R, Smits NC, Kuta A, Noelle RJ, Lines JL.

Front Immunol. 2019 Nov 19;10:2641. doi: 10.3389/fimmu.2019.02641. eCollection 2019.


VISTA: a novel immunotherapy target for normalizing innate and adaptive immunity.

ElTanbouly MA, Croteau W, Noelle RJ, Lines JL.

Semin Immunol. 2019 Apr;42:101308. doi: 10.1016/j.smim.2019.101308. Review.


Hypoxia-Induced VISTA Promotes the Suppressive Function of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.

Deng J, Li J, Sarde A, Lines JL, Lee YC, Qian DC, Pechenick DA, Manivanh R, Le Mercier I, Lowrey CH, Varn FS, Cheng C, Leib DA, Noelle RJ, Mabaera R.

Cancer Immunol Res. 2019 Jul;7(7):1079-1090. doi: 10.1158/2326-6066.CIR-18-0507. Epub 2019 May 14.


Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality.

Thangavelu G, Lee YC, Loschi M, Schaechter KM, Feser CJ, Koehn BH, Nowak EC, Zeiser R, Serody JS, Murphy WJ, Munn DH, Chambon P, Noelle RJ, Blazar BR.

J Immunol. 2019 May 1;202(9):2795-2805. doi: 10.4049/jimmunol.1800899. Epub 2019 Mar 18.


VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases.

Borggrewe M, Grit C, Den Dunnen WFA, Burm SM, Bajramovic JJ, Noelle RJ, Eggen BJL, Laman JD.

Glia. 2018 Dec;66(12):2645-2658. doi: 10.1002/glia.23517. Epub 2018 Oct 11.


VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival.

Kuklinski LF, Yan S, Li Z, Fisher JL, Cheng C, Noelle RJ, Angeles CV, Turk MJ, Ernstoff MS.

Cancer Immunol Immunother. 2018 Jul;67(7):1113-1121. doi: 10.1007/s00262-018-2169-1. Epub 2018 May 8.


VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes.

Ceeraz S, Eszterhas SK, Sergent PA, Armstrong DA, Ashare A, Broughton T, Wang L, Pechenick D, Burns CM, Noelle RJ, Vincenti MP, Fava RA.

Arthritis Res Ther. 2017 Dec 8;19(1):270. doi: 10.1186/s13075-017-1474-y.


Blocking the VISTA pathway enhances disease progression in (NZB × NZW) F1 female mice.

Sergent PA, Plummer SF, Pettus J, Mabaera R, DeLong JK, Pechenick DA, Burns CM, Noelle RJ, Ceeraz S.

Lupus. 2018 Feb;27(2):210-216. doi: 10.1177/0961203317716322. Epub 2017 Jun 28.


Bolstering the Number and Function of HSV-1-Specific CD8+ Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease.

Khan AA, Srivastava R, Chentoufi AA, Kritzer E, Chilukuri S, Garg S, Yu DC, Vahed H, Huang L, Syed SA, Furness JN, Tran TT, Anthony NB, McLaren CE, Sidney J, Sette A, Noelle RJ, BenMohamed L.

J Immunol. 2017 Jul 1;199(1):186-203. doi: 10.4049/jimmunol.1700145. Epub 2017 May 24.


Immunoregulatory functions of VISTA.

Nowak EC, Lines JL, Varn FS, Deng J, Sarde A, Mabaera R, Kuta A, Le Mercier I, Cheng C, Noelle RJ.

Immunol Rev. 2017 Mar;276(1):66-79. doi: 10.1111/imr.12525. Review.


Retinoic Acid Signaling in B Cells Is Required for the Generation of an Effective T-Independent Immune Response.

Marks E, Ortiz C, Pantazi E, Bailey CS, Lord GM, Waldschmidt TJ, Noelle RJ, Elgueta R.

Front Immunol. 2016 Dec 23;7:643. doi: 10.3389/fimmu.2016.00643. eCollection 2016.


Functions of CD40 and Its Ligand, gp39 (CD40L).

Laman JD, Claassen E, Noelle RJ.

Crit Rev Immunol. 2017;37(2-6):371-420. doi: 10.1615/CritRevImmunol.v37.i2-6.100. Review.


A New VISTA on combination therapy for negative checkpoint regulator blockade.

Deng J, Le Mercier I, Kuta A, Noelle RJ.

J Immunother Cancer. 2016 Dec 20;4:86. doi: 10.1186/s40425-016-0190-5. eCollection 2016. Review.


VISTA Deficiency Accelerates the Development of Fatal Murine Lupus Nephritis.

Ceeraz S, Sergent PA, Plummer SF, Schned AR, Pechenick D, Burns CM, Noelle RJ.

Arthritis Rheumatol. 2017 Apr;69(4):814-825. doi: 10.1002/art.40020.


Pillars Article: A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Transduces the Signal for Cognate Activation of B Cells. Proc. Natl. Acad. Sci. 1992. 89: 6550-6554.

Noelle RJ, Roy M, Shepherd DM, Stamenkovico I, Ledbetter JA, Aruffo A.

J Immunol. 2016 Dec 1;197(11):4195-4199. No abstract available.


Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells.

Elgueta R, Tse D, Deharvengt SJ, Luciano MR, Carriere C, Noelle RJ, Stan RV.

J Immunol. 2016 Nov 15;197(10):3970-3981. Epub 2016 Oct 14.


IL-33 enhances retinoic acid signaling on CD4+ T cells.

Gajardo T, Pérez F, Terraza C, Campos-Mora M, Noelle RJ, Pino-Lagos K.

Cytokine. 2016 Sep;85:120-2. doi: 10.1016/j.cyto.2016.06.016. Epub 2016 Jun 17.


Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis.

Chandraratna RA, Noelle RJ, Nowak EC.

Am J Transl Res. 2016 Feb 15;8(2):1016-26. eCollection 2016.


Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes.

Gerdes N, Seijkens T, Lievens D, Kuijpers MJ, Winkels H, Projahn D, Hartwig H, Beckers L, Megens RT, Boon L, Noelle RJ, Soehnlein O, Heemskerk JW, Weber C, Lutgens E.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):482-90. doi: 10.1161/ATVBAHA.115.307074. Epub 2016 Jan 28.


Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators.

Le Mercier I, Lines JL, Noelle RJ.

Front Immunol. 2015 Aug 21;6:418. doi: 10.3389/fimmu.2015.00418. eCollection 2015. Review.


Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition.

Pantazi E, Marks E, Stolarczyk E, Lycke N, Noelle RJ, Elgueta R.

J Immunol. 2015 Aug 15;195(4):1368-71. doi: 10.4049/jimmunol.1500989. Epub 2015 Jul 10.


Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Alhabbab R, Blair P, Elgueta R, Stolarczyk E, Marks E, Becker PD, Ratnasothy K, Smyth L, Safinia N, Sharif-Paghaleh E, O'Connell S, Noelle RJ, Lord GM, Howard JK, Spencer J, Lechler RI, Lombardi G.

Sci Rep. 2015 Jun 25;5:11554. doi: 10.1038/srep11554.


Allospecific CD4(+) T cells retain effector function and are actively regulated by Treg cells in the context of transplantation tolerance.

Chai JG, Ratnasothy K, Bucy RP, Noelle RJ, Lechler R, Lombardi G.

Eur J Immunol. 2015 Jul;45(7):2017-27. doi: 10.1002/eji.201545455. Epub 2015 May 20.


Seeing through the dark: New insights into the immune regulatory functions of vitamin A.

Brown CC, Noelle RJ.

Eur J Immunol. 2015 May;45(5):1287-95. doi: 10.1002/eji.201344398. Review.


Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.

Brown CC, Esterhazy D, Sarde A, London M, Pullabhatla V, Osma-Garcia I, Al-Bader R, Ortiz C, Elgueta R, Arno M, de Rinaldis E, Mucida D, Lord GM, Noelle RJ.

Immunity. 2015 Mar 17;42(3):499-511. doi: 10.1016/j.immuni.2015.02.003. Epub 2015 Mar 10.


Immune checkpoint receptors in regulating immune reactivity in rheumatic disease.

Ceeraz S, Nowak EC, Burns CM, Noelle RJ.

Arthritis Res Ther. 2014;16(5):469. Review.


Leukocyte homing, fate, and function are controlled by retinoic acid.

Guo Y, Brown C, Ortiz C, Noelle RJ.

Physiol Rev. 2015 Jan;95(1):125-48. doi: 10.1152/physrev.00032.2013. Review.


Studying mast cells in peripheral tolerance by using a skin transplantation model.

de Vries VC, Le Mercier I, Nowak EC, Noelle RJ.

Methods Mol Biol. 2015;1220:461-86. doi: 10.1007/978-1-4939-1568-2_28.


Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.

Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14846-51. doi: 10.1073/pnas.1407447111. Epub 2014 Sep 29.


VISTA Regulates the Development of Protective Antitumor Immunity.

Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L.

Cancer Res. 2014 Apr 1;74(7):1933-44. doi: 10.1158/0008-5472.CAN-13-1506.


Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.

Guo Y, Lee YC, Brown C, Zhang W, Usherwood E, Noelle RJ.

J Immunol. 2014 Apr 1;192(7):3336-44. doi: 10.4049/jimmunol.1301949. Epub 2014 Mar 7.


B7 family checkpoint regulators in immune regulation and disease.

Ceeraz S, Nowak EC, Noelle RJ.

Trends Immunol. 2013 Nov;34(11):556-63. doi: 10.1016/ Epub 2013 Aug 13. Review.


Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration.

Aoyama K, Saha A, Tolar J, Riddle MJ, Veenstra RG, Taylor PA, Blomhoff R, Panoskaltsis-Mortari A, Klebanoff CA, Socié G, Munn DH, Murphy WJ, Serody JS, Fulton LM, Teshima T, Chandraratna RA, Dmitrovsky E, Guo Y, Noelle RJ, Blazar BR.

Blood. 2013 Sep 19;122(12):2125-34. doi: 10.1182/blood-2012-11-470252. Epub 2013 Jun 27.


Critical role for all-trans retinoic acid for optimal effector and effector memory CD8 T cell differentiation.

Allie SR, Zhang W, Tsai CY, Noelle RJ, Usherwood EJ.

J Immunol. 2013 Mar 1;190(5):2178-87. doi: 10.4049/jimmunol.1201945. Epub 2013 Jan 21.


The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition.

Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, Lee HK, Suriawinata AA, Schned AR, Longnecker DS, Fiering SN, Noelle RJ, Gimi B, Shworak NW, Carrière C.

Dev Cell. 2012 Dec 11;23(6):1203-18. doi: 10.1016/j.devcel.2012.11.003.


Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.

Nowak EC, de Vries VC, Wasiuk A, Ahonen C, Bennett KA, Le Mercier I, Ha DG, Noelle RJ.

J Exp Med. 2012 Oct 22;209(11):2127-35. doi: 10.1084/jem.20120408. Epub 2012 Sep 24.


A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells.

Guo Y, Pino-Lagos K, Ahonen CA, Bennett KA, Wang J, Napoli JL, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Turk MJ, Noelle RJ.

Cancer Res. 2012 Oct 15;72(20):5230-9. doi: 10.1158/0008-5472.CAN-12-1727. Epub 2012 Aug 17.


Mast cells impair the development of protective anti-tumor immunity.

Wasiuk A, Dalton DK, Schpero WL, Stan RV, Conejo-Garcia JR, Noelle RJ.

Cancer Immunol Immunother. 2012 Dec;61(12):2273-82. doi: 10.1007/s00262-012-1276-7. Epub 2012 Jun 10.


The roles of mast cells in anticancer immunity.

Dalton DK, Noelle RJ.

Cancer Immunol Immunother. 2012 Sep;61(9):1511-20. doi: 10.1007/s00262-012-1246-0. Epub 2012 Apr 18. Review.


Autoimmune diseases have been the focus of intense research efforts.

Wucherpfennig KW, Noelle RJ.

Curr Opin Immunol. 2011 Dec;23(6):699-701. doi: 10.1016/j.coi.2011.10.003. Epub 2011 Nov 3. No abstract available.


Mast cells condition dendritic cells to mediate allograft tolerance.

de Vries VC, Pino-Lagos K, Nowak EC, Bennett KA, Oliva C, Noelle RJ.

Immunity. 2011 Oct 28;35(4):550-61. doi: 10.1016/j.immuni.2011.09.012. Erratum in: Immunity. 2011 Dec 23;35(6):1035-6.


A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity.

Pino-Lagos K, Guo Y, Brown C, Alexander MP, Elgueta R, Bennett KA, De Vries V, Nowak E, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Noelle RJ.

J Exp Med. 2011 Aug 29;208(9):1767-75. doi: 10.1084/jem.20102358. Epub 2011 Aug 22.


VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.

Wang L, Rubinstein R, Lines JL, Wasiuk A, Ahonen C, Guo Y, Lu LF, Gondek D, Wang Y, Fava RA, Fiser A, Almo S, Noelle RJ.

J Exp Med. 2011 Mar 14;208(3):577-92. doi: 10.1084/jem.20100619. Epub 2011 Mar 7.


A randomized trial of ex vivo CD40L activation of a dendritic cell vaccine in colorectal cancer patients: tumor-specific immune responses are associated with improved survival.

Barth RJ Jr, Fisher DA, Wallace PK, Channon JY, Noelle RJ, Gui J, Ernstoff MS.

Clin Cancer Res. 2010 Nov 15;16(22):5548-56. doi: 10.1158/1078-0432.CCR-10-2138. Epub 2010 Sep 30.


Mast cell mediators in tolerance.

de Vries VC, Noelle RJ.

Curr Opin Immunol. 2010 Oct;22(5):643-8. doi: 10.1016/j.coi.2010.08.015. Epub 2010 Sep 29. Review.


Cellular sources and immune functions of interleukin-9.

Noelle RJ, Nowak EC.

Nat Rev Immunol. 2010 Oct;10(10):683-7. doi: 10.1038/nri2848. Epub 2010 Sep 17. Review.

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