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Antimicrob Agents Chemother. 1999 Jun;43(6):1347-9.

Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.

Author information

1
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.

Abstract

Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth.

PMID:
10348750
PMCID:
PMC89276
[Indexed for MEDLINE]
Free PMC Article

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