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Items: 1 to 50 of 171

1.

Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.

Miao QL, Herlitze S, Mark MD, Noebels JL.

Brain. 2019 Dec 4. pii: awz365. doi: 10.1093/brain/awz365. [Epub ahead of print]

PMID:
31800012
2.

Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.

Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, Wang IC, Park JH, Kaipparettu BA, Stoica L, Jafar-Nejad P, Rigo F, Chin J, Noebels JL, Costa-Mattioli M.

Nat Med. 2019 Nov;25(11):1684-1690. doi: 10.1038/s41591-019-0608-y. Epub 2019 Oct 21.

PMID:
31636454
3.

Adrenergic agonist induces rhythmic firing in quiescent cardiac preganglionic neurons in nucleus ambiguous via activation of intrinsic membrane excitability.

Aiba I, Noebels JL.

J Neurophysiol. 2019 Apr 1;121(4):1266-1278. doi: 10.1152/jn.00761.2018. Epub 2019 Jan 30.

4.

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K.

Commun Biol. 2018;1. pii: 96. doi: 10.1038/s42003-018-0099-2. Epub 2018 Jul 19.

5.

Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy.

Chen C, Holth JK, Bunton-Stasyshyn R, Anumonwo CK, Meisler MH, Noebels JL, Isom LL.

Ann Clin Transl Neurol. 2018 Jul 5;5(8):982-987. doi: 10.1002/acn3.599. eCollection 2018 Aug.

6.

αII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function.

Huang CY, Zhang C, Ho TS, Oses-Prieto J, Burlingame AL, Lalonde J, Noebels JL, Leterrier C, Rasband MN.

J Neurosci. 2017 Nov 22;37(47):11311-11322. doi: 10.1523/JNEUROSCI.2112-17.2017. Epub 2017 Oct 16.

7.

Persistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models.

Maheshwari A, Akbar A, Wang M, Marks RL, Yu K, Park S, Foster BL, Noebels JL.

J Physiol. 2017 Dec 1;595(23):7249-7260. doi: 10.1113/JP274696. Epub 2017 Sep 19.

8.

Identification of diverse astrocyte populations and their malignant analogs.

John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B.

Nat Neurosci. 2017 Mar;20(3):396-405. doi: 10.1038/nn.4493. Epub 2017 Feb 6.

9.

Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein.

Tang M, Gao G, Rueda CB, Yu H, Thibodeaux DN, Awano T, Engelstad KM, Sanchez-Quintero MJ, Yang H, Li F, Li H, Su Q, Shetler KE, Jones L, Seo R, McConathy J, Hillman EM, Noebels JL, De Vivo DC, Monani UR.

Nat Commun. 2017 Jan 20;8:14152. doi: 10.1038/ncomms14152.

10.

Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder.

Lopez AY, Wang X, Xu M, Maheshwari A, Curry D, Lam S, Adesina AM, Noebels JL, Sun QQ, Cooper EC.

Mol Psychiatry. 2017 Oct;22(10):1464-1472. doi: 10.1038/mp.2016.233. Epub 2016 Dec 13.

11.

Correction: Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.

Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL.

PLoS One. 2016 Nov 21;11(11):e0167264. doi: 10.1371/journal.pone.0167264. eCollection 2016.

12.

Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population.

Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL.

PLoS One. 2016 Sep 13;11(9):e0162883. doi: 10.1371/journal.pone.0162883. eCollection 2016. Erratum in: PLoS One. 2016 Nov 21;11(11):e0167264.

13.

Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.

Aiba I, Wehrens XH, Noebels JL.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4895-903. doi: 10.1073/pnas.1605216113. Epub 2016 Aug 1.

14.

The Epilepsy Spectrum: Targeting Future Research Challenges.

Holmes GL, Noebels JL.

Cold Spring Harb Perspect Med. 2016 Jul 1;6(7). pii: a028043. doi: 10.1101/cshperspect.a028043. Review.

15.

Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.

Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL.

J Neurosci. 2016 Jan 13;36(2):405-18. doi: 10.1523/JNEUROSCI.2555-15.2016.

16.

Epileptic Seizures in Alzheimer Disease: A Review.

Horváth A, Szűcs A, Barcs G, Noebels JL, Kamondi A.

Alzheimer Dis Assoc Disord. 2016 Apr-Jun;30(2):186-92. doi: 10.1097/WAD.0000000000000134. Review.

PMID:
26756385
17.

Shift in interictal relative gamma power as a novel biomarker for drug response in two mouse models of absence epilepsy.

Maheshwari A, Marks RL, Yu KM, Noebels JL.

Epilepsia. 2016 Jan;57(1):79-88. doi: 10.1111/epi.13265. Epub 2015 Dec 10.

18.

Single-Gene Determinants of Epilepsy Comorbidity.

Noebels JL.

Cold Spring Harb Perspect Med. 2015 Nov 2;5(11). pii: a022756. doi: 10.1101/cshperspect.a022756. Review.

19.

Early rescue of interneuron disease trajectory in developmental epilepsies.

Siehr MS, Noebels JL.

Curr Opin Neurobiol. 2016 Feb;36:82-8. doi: 10.1016/j.conb.2015.10.007. Epub 2015 Oct 27. Review.

20.

Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.

Kole MJ, Qian J, Waase MP, Klassen TL, Chen TT, Augustine GJ, Noebels JL.

J Neurosci. 2015 Aug 12;35(32):11433-44. doi: 10.1523/JNEUROSCI.1346-15.2015.

21.

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.

Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH.

Basic Res Cardiol. 2015 Sep;110(5):505. doi: 10.1007/s00395-015-0505-6. Epub 2015 Jul 11.

22.

Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.

Aiba I, Noebels JL.

Sci Transl Med. 2015 Apr 8;7(282):282ra46. doi: 10.1126/scitranslmed.aaa4050.

23.

Monogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits.

Maheshwari A, Noebels JL.

Prog Brain Res. 2014;213:223-52. doi: 10.1016/B978-0-444-63326-2.00012-0. Review.

PMID:
25194492
24.

Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death.

Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET.

Neuron. 2014 Sep 3;83(5):1159-71. doi: 10.1016/j.neuron.2014.07.042.

25.

Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.

Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y.

Pflugers Arch. 2015 Apr;467(4):737-52. doi: 10.1007/s00424-014-1555-6. Epub 2014 Jun 20.

PMID:
24947601
26.

Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons.

Ozkan ED, Creson TK, Kramár EA, Rojas C, Seese RR, Babyan AH, Shi Y, Lucero R, Xu X, Noebels JL, Miller CA, Lynch G, Rumbaugh G.

Neuron. 2014 Jun 18;82(6):1317-33. doi: 10.1016/j.neuron.2014.05.015.

27.

Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.

Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL.

J Neurosci. 2014 Mar 12;34(11):3826-40. doi: 10.1523/JNEUROSCI.5171-13.2014.

28.

Neonatal estradiol stimulation prevents epilepsy in Arx model of X-linked infantile spasms syndrome.

Olivetti PR, Maheshwari A, Noebels JL.

Sci Transl Med. 2014 Jan 22;6(220):220ra12. doi: 10.1126/scitranslmed.3007231.

29.

High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile.

Klassen TL, Bomben VC, Patel A, Drabek J, Chen TT, Gu W, Zhang F, Chapman K, Lupski JR, Noebels JL, Goldman AM.

Epilepsia. 2014 Feb;55(2):e6-12. doi: 10.1111/epi.12489. Epub 2013 Dec 24.

30.

Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice.

Maheshwari A, Nahm WK, Noebels JL.

Front Cell Neurosci. 2013 Sep 18;7:156. doi: 10.3389/fncel.2013.00156. eCollection 2013.

31.

Issues related to development of new antiseizure treatments.

Wilcox KS, Dixon-Salazar T, Sills GJ, Ben-Menachem E, White HS, Porter RJ, Dichter MA, Moshé SL, Noebels JL, Privitera MD, Rogawski MA.

Epilepsia. 2013 Aug;54 Suppl 4:24-34. doi: 10.1111/epi.12296. Review.

32.

Case records of the Massachusetts General Hospital. Case 18-2013: a 32-year-old woman with recurrent episodes of altered consciousness.

Cole AJ, Eskandar E, Mela T, Noebels JL, Gonzalez RG, McGuone D.

N Engl J Med. 2013 Jun 13;368(24):2304-12. doi: 10.1056/NEJMcpc1215969. No abstract available.

PMID:
23758236
33.

Visual automated fluorescence electrophoresis provides simultaneous quality, quantity, and molecular weight spectra for genomic DNA from archived neonatal blood spots.

Klassen TL, Drabek J, Tomson T, Sveinsson O, von Döbeln U, Noebels JL, Goldman AM.

J Mol Diagn. 2013 May;15(3):283-90. doi: 10.1016/j.jmoldx.2013.01.003. Epub 2013 Mar 19.

34.
35.

Novel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy.

Chen TT, Klassen TL, Goldman AM, Marini C, Guerrini R, Noebels JL.

Neurology. 2013 Mar 19;80(12):1078-85. doi: 10.1212/WNL.0b013e31828868e7. Epub 2013 Feb 13.

36.

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure.

Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels JL, Darnell RB.

Elife. 2013 Jan 22;2:e00178. doi: 10.7554/eLife.00178.

37.

Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL.

J Neurosci. 2013 Jan 23;33(4):1651-9. doi: 10.1523/JNEUROSCI.3191-12.2013.

38.

Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.

Ince-Dunn G, Okano HJ, Jensen KB, Park WY, Zhong R, Ule J, Mele A, Fak JJ, Yang C, Zhang C, Yoo J, Herre M, Okano H, Noebels JL, Darnell RB.

Neuron. 2012 Sep 20;75(6):1067-80. doi: 10.1016/j.neuron.2012.07.009.

39.

Comparative analytical utility of DNA derived from alternative human specimens for molecular autopsy and diagnostics.

Klassen TL, von Rüden EL, Drabek J, Noebels JL, Goldman AM.

J Mol Diagn. 2012 Sep;14(5):451-7. doi: 10.1016/j.jmoldx.2012.04.005. Epub 2012 Jul 13.

40.

The Voltage-Gated Calcium Channel and Absence Epilepsy.

Noebels JL.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

41.

Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels.

Glasscock E, Qian J, Kole MJ, Noebels JL.

J Physiol. 2012 Aug 15;590(16):3913-26. doi: 10.1113/jphysiol.2012.235606. Epub 2012 May 28.

42.

Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms.

Olivetti PR, Noebels JL.

Curr Opin Neurobiol. 2012 Oct;22(5):859-65. doi: 10.1016/j.conb.2012.04.006. Epub 2012 May 5. Review.

43.

Identification of new epilepsy treatments: issues in preclinical methodology.

Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M; American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Working Group On Recommendations For Preclinical Epilepsy Drug Discovery.

Epilepsia. 2012 Mar;53(3):571-82. doi: 10.1111/j.1528-1167.2011.03391.x. Epub 2012 Jan 31. Review.

44.

Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition.

Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M.

Cell. 2011 Dec 9;147(6):1384-96. doi: 10.1016/j.cell.2011.11.029.

45.

To share or not to share: a randomized trial of consent for data sharing in genome research.

McGuire AL, Oliver JM, Slashinski MJ, Graves JL, Wang T, Kelly PA, Fisher W, Lau CC, Goss J, Okcu M, Treadwell-Deering D, Goldman AM, Noebels JL, Hilsenbeck SG.

Genet Med. 2011 Nov;13(11):948-55. doi: 10.1097/GIM.0b013e3182227589.

46.

MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan.

Ward CS, Arvide EM, Huang TW, Yoo J, Noebels JL, Neul JL.

J Neurosci. 2011 Jul 13;31(28):10359-70. doi: 10.1523/JNEUROSCI.0057-11.2011.

47.

Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons.

Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng H.

Mol Neurodegener. 2011 Jun 10;6:42. doi: 10.1186/1750-1326-6-42.

48.

Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy.

Hirsch LJ, Donner EJ, So EL, Jacobs M, Nashef L, Noebels JL, Buchhalter JR.

Neurology. 2011 May 31;76(22):1932-8. doi: 10.1212/WNL.0b013e31821de7de. Epub 2011 May 4. Review.

49.

Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.

Mark MD, Maejima T, Kuckelsberg D, Yoo JW, Hyde RA, Shah V, Gutierrez D, Moreno RL, Kruse W, Noebels JL, Herlitze S.

J Neurosci. 2011 Mar 16;31(11):4311-26. doi: 10.1523/JNEUROSCI.5342-10.2011.

50.

"Jasper's Basic Mechanisms of the Epilepsies" Workshop.

Noebels JL, Avoli M, Rogawski M, Olsen R, Delgado-Escueta AV.

Epilepsia. 2010 Dec;51 Suppl 5:1-5. doi: 10.1111/j.1528-1167.2010.02792.x.

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