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Items: 1 to 50 of 67

1.

Metabolomic profiling and biological investigation of Tabebuia Aurea (Silva Manso) leaves, family Bignoniaceae.

Mahmoud BK, Hamed ANE, Samy MN, Abdelmohsen UR, Attia EZ, Fawzy MA, Refaey RH, Salem MA, Pimentel-Elardo SM, Nodwell JR, Desoukey SY, Kamel MS.

Nat Prod Res. 2019 Dec 4:1-6. doi: 10.1080/14786419.2019.1698571. [Epub ahead of print]

PMID:
31797686
2.

Put a Bow on It: Knotted Antibiotics Take Center Stage.

Tan S, Moore G, Nodwell J.

Antibiotics (Basel). 2019 Aug 11;8(3). pii: E117. doi: 10.3390/antibiotics8030117. Review.

3.

Metabolomics analysis and biological investigation of three Malvaceae plants.

Abdelhafez OH, Othman EM, Fahim JR, Desoukey SY, Pimentel-Elardo SM, Nodwell JR, Schirmeister T, Tawfike A, Abdelmohsen UR.

Phytochem Anal. 2019 Aug 7. doi: 10.1002/pca.2883. [Epub ahead of print]

PMID:
31390115
4.

Microbe Profile: Streptomyces coelicolor: a burlesque of pigments and phenotypes.

Nodwell JR.

Microbiology. 2019 Sep;165(9):953-955. doi: 10.1099/mic.0.000821. Epub 2019 Aug 1.

PMID:
31368887
5.

Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.

McAuley S, Huynh A, Howells A, Walpole C, Maxwell A, Nodwell JR.

Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4. doi: 10.1016/j.chembiol.2019.06.002. Epub 2019 Jul 3.

6.

Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2.

Gehrke EJ, Zhang X, Pimentel-Elardo SM, Johnson AR, Rees CA, Jones SE, Hindra, Gehrke SS, Turvey S, Boursalie S, Hill JE, Carlson EE, Nodwell JR, Elliot MA.

Elife. 2019 Jun 19;8. pii: e47691. doi: 10.7554/eLife.47691.

7.

The Lasso Peptide Siamycin-I Targets Lipid II at the Gram-Positive Cell Surface.

Tan S, Ludwig KC, Müller A, Schneider T, Nodwell JR.

ACS Chem Biol. 2019 May 17;14(5):966-974. doi: 10.1021/acschembio.9b00157. Epub 2019 May 3.

PMID:
31026131
8.

A Chemical Inhibitor of Cell Growth Reduces Cell Size in Bacillus subtilis.

McAuley S, Vadia S, Jani C, Huynh A, Yang Z, Levin PA, Nodwell JR.

ACS Chem Biol. 2019 Apr 19;14(4):688-695. doi: 10.1021/acschembio.8b01066. Epub 2019 Mar 18.

PMID:
30848888
9.

A chemical defence against phage infection.

Kronheim S, Daniel-Ivad M, Duan Z, Hwang S, Wong AI, Mantel I, Nodwell JR, Maxwell KL.

Nature. 2018 Dec;564(7735):283-286. doi: 10.1038/s41586-018-0767-x. Epub 2018 Dec 5.

PMID:
30518855
10.

A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp.

Shady NH, Fouad MA, Ahmed S, Pimentel-Elardo SM, Nodwell JR, Kamel MS, Abdelmohsen UR.

J Antibiot (Tokyo). 2018 Nov;71(12):1036-1039. doi: 10.1038/s41429-018-0092-5. Epub 2018 Sep 4.

PMID:
30181571
11.

Membrane activity profiling of small molecule B. subtilis growth inhibitors utilizing novel duel-dye fluorescence assay.

McAuley S, Huynh A, Czarny TL, Brown ED, Nodwell JR.

Medchemcomm. 2018 Feb 15;9(3):554-561. doi: 10.1039/c8md00009c. eCollection 2018 Mar 1.

12.

Control of Specialized Metabolism by Signaling and Transcriptional Regulation: Opportunities for New Platforms for Drug Discovery?

Daniel-Ivad M, Pimentel-Elardo S, Nodwell JR.

Annu Rev Microbiol. 2018 Sep 8;72:25-48. doi: 10.1146/annurev-micro-022618-042458. Epub 2018 May 23. Review.

PMID:
29799791
13.

Chromosome level assembly and secondary metabolite potential of the parasitic fungus Cordyceps militaris.

Kramer GJ, Nodwell JR.

BMC Genomics. 2017 Nov 25;18(1):912. doi: 10.1186/s12864-017-4307-0.

14.

Actinorhodin is a redox-active antibiotic with a complex mode of action against Gram-positive cells.

Mak S, Nodwell JR.

Mol Microbiol. 2017 Nov;106(4):597-613. doi: 10.1111/mmi.13837. Epub 2017 Oct 11.

15.

Antimicrobials: Expressing antibiotic gene clusters.

Nodwell JR.

Nat Microbiol. 2017 Apr 25;2:17061. doi: 10.1038/nmicrobiol.2017.61. No abstract available.

PMID:
28440275
16.

An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products.

Daniel-Ivad M, Hameed N, Tan S, Dhanjal R, Socko D, Pak P, Gverzdys T, Elliot MA, Nodwell JR.

ACS Chem Biol. 2017 Mar 17;12(3):628-634. doi: 10.1021/acschembio.6b01002. Epub 2017 Jan 19.

PMID:
28075554
17.

Streptomyces exploration is triggered by fungal interactions and volatile signals.

Jones SE, Ho L, Rees CA, Hill JE, Nodwell JR, Elliot MA.

Elife. 2017 Jan 3;6. pii: e21738. doi: 10.7554/eLife.21738.

18.

Tetrodecamycin: An unusual and interesting tetronate antibiotic.

Gverzdys T, Kramer G, Nodwell JR.

Bioorg Med Chem. 2016 Dec 15;24(24):6269-6275. doi: 10.1016/j.bmc.2016.05.028. Epub 2016 May 18. Review.

19.

Biosynthetic Genes for the Tetrodecamycin Antibiotics.

Gverzdys T, Nodwell JR.

J Bacteriol. 2016 Jun 27;198(14):1965-1973. doi: 10.1128/JB.00140-16. Print 2016 Jul 15.

20.

Reply.

Nodwell J, Young LT.

Acta Psychiatr Scand. 2016 Apr;133(4):335-6. doi: 10.1111/acps.12542. Epub 2015 Dec 29. No abstract available.

PMID:
26714100
21.

David and Goliath: chemical perturbation of eukaryotes by bacteria.

Ho LK, Nodwell JR.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):233-48. doi: 10.1007/s10295-015-1686-6. Epub 2015 Oct 3. Review.

22.

Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference.

Pimentel-Elardo SM, Sørensen D, Ho L, Ziko M, Bueler SA, Lu S, Tao J, Moser A, Lee R, Agard D, Fairn G, Rubinstein JL, Shoichet BK, Nodwell JR.

ACS Chem Biol. 2015 Nov 20;10(11):2616-23. doi: 10.1021/acschembio.5b00612. Epub 2015 Sep 18.

23.

13-Deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus.

Gverzdys T, Hart MK, Pimentel-Elardo S, Tranmer G, Nodwell JR.

J Antibiot (Tokyo). 2015 Nov;68(11):698-702. doi: 10.1038/ja.2015.60. Epub 2015 May 27.

PMID:
26014719
24.

Streptomyces: a screening tool for bacterial cell division inhibitors.

Jani C, Tocheva EI, McAuley S, Craney A, Jensen GJ, Nodwell J.

J Biomol Screen. 2015 Feb;20(2):275-84. doi: 10.1177/1087057114551334. Epub 2014 Sep 25.

25.

Are you talking to me? A possible role for γ-butyrolactones in interspecies signalling.

Nodwell JR.

Mol Microbiol. 2014 Nov;94(3):483-5. doi: 10.1111/mmi.12787. Epub 2014 Sep 30.

26.

The expression of antibiotic resistance genes in antibiotic-producing bacteria.

Mak S, Xu Y, Nodwell JR.

Mol Microbiol. 2014 Aug;93(3):391-402. doi: 10.1111/mmi.12689. Epub 2014 Jul 10. Review.

27.

Activating secondary metabolism with stress and chemicals.

Yoon V, Nodwell JR.

J Ind Microbiol Biotechnol. 2014 Feb;41(2):415-24. doi: 10.1007/s10295-013-1387-y. Epub 2013 Dec 11. Review.

PMID:
24326978
28.

The TetR family of regulators.

Cuthbertson L, Nodwell JR.

Microbiol Mol Biol Rev. 2013 Sep;77(3):440-75. doi: 10.1128/MMBR.00018-13. Review.

29.

Towards a new science of secondary metabolism.

Craney A, Ahmed S, Nodwell J.

J Antibiot (Tokyo). 2013 Jul;66(7):387-400. doi: 10.1038/ja.2013.25. Epub 2013 Apr 24. Review.

PMID:
23612726
30.

Deglycosylation as a mechanism of inducible antibiotic resistance revealed using a global relational tree for one-component regulators.

Cuthbertson L, Ahn SK, Nodwell JR.

Chem Biol. 2013 Feb 21;20(2):232-40. doi: 10.1016/j.chembiol.2012.11.011.

31.

A synthetic, species-specific activator of secondary metabolism and sporulation in Streptomyces coelicolor.

Ahmed S, Craney A, Pimentel-Elardo SM, Nodwell JR.

Chembiochem. 2013 Jan 2;14(1):83-91. doi: 10.1002/cbic.201200619. Epub 2012 Dec 13.

PMID:
23239420
32.

Genome context as a predictive tool for identifying regulatory targets of the TetR family transcriptional regulators.

Ahn SK, Cuthbertson L, Nodwell JR.

PLoS One. 2012;7(11):e50562. doi: 10.1371/journal.pone.0050562. Epub 2012 Nov 30.

33.

A two-step mechanism for the activation of actinorhodin export and resistance in Streptomyces coelicolor.

Xu Y, Willems A, Au-Yeung C, Tahlan K, Nodwell JR.

MBio. 2012 Oct 16;3(5):e00191-12. doi: 10.1128/mBio.00191-12.

34.

Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism.

Craney A, Ozimok C, Pimentel-Elardo SM, Capretta A, Nodwell JR.

Chem Biol. 2012 Aug 24;19(8):1020-7. doi: 10.1016/j.chembiol.2012.06.013.

35.

Better chemistry through regulation.

Nodwell JR, Cuthbertson L.

Chem Biol. 2011 Dec 23;18(12):1515-6. doi: 10.1016/j.chembiol.2011.12.001.

36.

Bacterial transmembrane proteins that lack N-terminal signal sequences.

Craney A, Tahlan K, Andrews D, Nodwell J.

PLoS One. 2011 May 4;6(5):e19421. doi: 10.1371/journal.pone.0019421.

37.

Characterization of tetracycline modifying enzymes using a sensitive in vivo reporter system.

Yu Z, Reichheld SE, Cuthbertson L, Nodwell JR, Davidson AR.

BMC Biochem. 2010 Sep 11;11:34. doi: 10.1186/1471-2091-11-34.

38.

Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1.

McKenzie NL, Thaker M, Koteva K, Hughes DW, Wright GD, Nodwell JR.

J Antibiot (Tokyo). 2010 Apr;63(4):177-82. doi: 10.1038/ja.2010.13. Epub 2010 Mar 12.

PMID:
20224601
39.

Transmembrane topology of the AbsA1 sensor kinase of Streptomyces coelicolor.

McKenzie NL, Nodwell JR.

Microbiology. 2009 Jun;155(Pt 6):1812-8. doi: 10.1099/mic.0.028431-0. Epub 2009 Apr 23.

PMID:
19389775
40.

Chapter 5. Applying the genetics of secondary metabolism in model actinomycetes to the discovery of new antibiotics.

van Wezel GP, McKenzie NL, Nodwell JR.

Methods Enzymol. 2009;458:117-41. doi: 10.1016/S0076-6879(09)04805-8.

PMID:
19374981
41.

Ligand recognition by ActR, a TetR-like regulator of actinorhodin export.

Tahlan K, Yu Z, Xu Y, Davidson AR, Nodwell JR.

J Mol Biol. 2008 Nov 21;383(4):753-61. doi: 10.1016/j.jmb.2008.08.081. Epub 2008 Sep 9.

PMID:
18804114
42.

Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA.

Willems AR, Tahlan K, Taguchi T, Zhang K, Lee ZZ, Ichinose K, Junop MS, Nodwell JR.

J Mol Biol. 2008 Mar 7;376(5):1377-87. doi: 10.1016/j.jmb.2007.12.061. Epub 2008 Jan 4.

PMID:
18207163
43.
44.

Monomeric red fluorescent protein as a reporter for macromolecular localization in Streptomyces coelicolor.

Nguyen KD, Au-Young SH, Nodwell JR.

Plasmid. 2007 Sep;58(2):167-73. Epub 2007 Jun 4.

PMID:
17544507
46.

Novel links between antibiotic resistance and antibiotic production.

Nodwell JR.

J Bacteriol. 2007 May;189(10):3683-5. Epub 2007 Mar 23. Review. No abstract available.

47.

Initiation of actinorhodin export in Streptomyces coelicolor.

Tahlan K, Ahn SK, Sing A, Bodnaruk TD, Willems AR, Davidson AR, Nodwell JR.

Mol Microbiol. 2007 Feb;63(4):951-61.

48.

A synthetic luxCDABE gene cluster optimized for expression in high-GC bacteria.

Craney A, Hohenauer T, Xu Y, Navani NK, Li Y, Nodwell J.

Nucleic Acids Res. 2007;35(6):e46. Epub 2007 Mar 1.

49.
50.

Morphogenetic surfactants and their role in the formation of aerial hyphae in Streptomyces coelicolor.

Willey JM, Willems A, Kodani S, Nodwell JR.

Mol Microbiol. 2006 Feb;59(3):731-42. Review.

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