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Items: 24


Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project.

Minegishi N, Nishijima I, Nobukuni T, Kudo H, Ishida N, Terakawa T, Kumada K, Yamashita R, Katsuoka F, Ogishima S, Suzuki K, Sasaki M, Satoh M, Tohoku Medical Megabank Project Study Group, Yamamoto M.

Tohoku J Exp Med. 2019 May;248(1):45-55. doi: 10.1620/tjem.248.45.


Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors.

Johansson G, Mahller YY, Collins MH, Kim MO, Nobukuni T, Perentesis J, Cripe TP, Lane HA, Kozma SC, Thomas G, Ratner N.

Mol Cancer Ther. 2008 May;7(5):1237-45. doi: 10.1158/1535-7163.MCT-07-2335.


Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

Gulati P, Gaspers LD, Dann SG, Joaquin M, Nobukuni T, Natt F, Kozma SC, Thomas AP, Thomas G.

Cell Metab. 2008 May;7(5):456-65. doi: 10.1016/j.cmet.2008.03.002.


hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling.

Nobukuni T, Kozma SC, Thomas G.

Curr Opin Cell Biol. 2007 Apr;19(2):135-41. Epub 2007 Feb 23. Review.


Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14238-43. Epub 2005 Sep 21.


Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G.

Mol Cell. 2003 Jun;11(6):1457-66.


Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.

Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R.

J Cell Biol. 2002 Oct 28;159(2):217-24. Epub 2002 Oct 28.


Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization.

Maeda S, Nobukuni T, Shimo-Onoda K, Hayashi K, Yone K, Komiya S, Inoue I.

J Cell Physiol. 2002 Oct;193(1):73-9.


Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer.

Fukuhara H, Kuramochi M, Fukami T, Kasahara K, Furuhata M, Nobukuni T, Maruyama T, Isogai K, Sekiya T, Shuin T, Kitamura T, Reeves RH, Murakami Y.

Jpn J Cancer Res. 2002 Jun;93(6):605-9.


Cancer chemopreventive activity of flavanones on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

Itoigawa M, Ito C, Ju-ichi M, Nobukuni T, Ichiishi E, Tokuda H, Nishino H, Furukawa H.

Cancer Lett. 2002 Feb 8;176(1):25-9.


Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine.

Furushima K, Shimo-Onoda K, Maeda S, Nobukuni T, Ikari K, Koga H, Komiya S, Nakajima T, Harata S, Inoue I.

J Bone Miner Res. 2002 Jan;17(1):128-37.


Identification of tumor suppressor candidate genes by physical and sequence mapping of the TSLC1 region of human chromosome 11q23.

Pletcher MT, Nobukuni T, Fukuhara H, Kuramochi M, Maruyama T, Sekiya T, Sussan T, Isomura M, Murakami Y, Reeves RH.

Gene. 2001 Aug 8;273(2):181-9.


Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins.

Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y.

Oncogene. 2001 Aug 30;20(38):5401-7.


Four single-nucleotide polymorphisms in the human BUB1 gene.

Kanbe T, Nobukuni T, Kawasaki H, Sekiya T, Murakami Y.

J Hum Genet. 2001;46(3):150-1.


TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.

Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, Pletcher M, Isomura M, Onizuka M, Kitamura T, Sekiya T, Reeves RH, Murakami Y.

Nat Genet. 2001 Apr;27(4):427-30.


Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene.

Kanamori M, Kon H, Nobukuni T, Nomura S, Sugano K, Mashiyama S, Kumabe T, Yoshimoto T, Meuth M, Sekiya T, Murakami Y.

Oncogene. 2000 Mar 16;19(12):1564-71.


Detection of amplification of a chromosomal fragment at 6p21 including the cyclin D3 gene in a glioblastoma cell line by arbitrarily primed polymerase chain reaction.

Kuchiki H, Saino M, Nobukuni T, Yasuda J, Maruyama T, Kayama T, Murakami Y, Sekiya T.

Int J Cancer. 2000 Jan 1;85(1):113-6.


Partial nuclear localization of a bovine phosphoprotein, BCNT, that includes a region derived from a LINE repetitive sequence in Ruminantia.

Iwashita S, Nobukuni T, Tanaka S, Kobayashi M, Iwanaga T, Tamate HB, Masui T, Takahashi I, Hashimoto K.

Biochim Biophys Acta. 1999 May 24;1427(3):408-16.


Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q.

Murakami Y, Nobukuni T, Tamura K, Maruyama T, Sekiya T, Arai Y, Gomyou H, Tanigami A, Ohki M, Cabin D, Frischmeyer P, Hunt P, Reeves RH.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8153-8.


Existence of a bovine LINE repetitive insert that appears in the cDNA of bovine protein BCNT in ruminant, but not in human, genomes.

Takahashi I, Nobukuni T, Ohmori H, Kobayashi M, Tanaka S, Ohshima K, Okada N, Masui T, Hashimoto K, Iwashita S.

Gene. 1998 May 12;211(2):387-94.


An Alu-linked repetitive sequence corresponding to 280 amino acids is expressed in a novel bovine protein, but not in its human homologue.

Nobukuni T, Kobayashi M, Omori A, Ichinose S, Iwanaga T, Takahashi I, Hashimoto K, Hattori S, Kaibuchi K, Miyata Y, Masui T, Iwashita S.

J Biol Chem. 1997 Jan 31;272(5):2801-7.


Identification of the prfC gene, which encodes peptide-chain-release factor 3 of Escherichia coli.

Mikuni O, Ito K, Moffat J, Matsumura K, McCaughan K, Nobukuni T, Tate W, Nakamura Y.

Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5798-802.


Synthesis of unusual nucleosides and evaluations of their biological properties.

Watanabe T, Ueki S, Nobukuni T, Nishiyama S, Yamamura S, Kato K, Nagai M, Takita T.

Nucleic Acids Symp Ser. 1990;(22):131-2. No abstract available.


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