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Items: 32

1.

Spinal Cord Excitability and Sprint Performance Are Enhanced by Sensory Stimulation During Cycling.

Pearcey GEP, Noble SA, Munro B, Zehr EP.

Front Hum Neurosci. 2017 Dec 18;11:612. doi: 10.3389/fnhum.2017.00612. eCollection 2017.

2.

Rates of adult acute inpatients documented as at risk of refeeding syndrome by dietitians.

Owers EL, Reeves AI, Ko SY, Ellis AK, Huxtable SL, Noble SA, Porteous HE, Newman EJ, Josephson CA, Roth RA, Byrne CE, Palmer MA.

Clin Nutr. 2015 Feb;34(1):134-9. doi: 10.1016/j.clnu.2014.02.003. Epub 2014 Feb 17.

PMID:
24612924
3.

Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.

DurĂ³n SG, Lindstrom A, Bonnefous C, Zhang H, Chen X, Symons KT, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1237-41. doi: 10.1016/j.bmcl.2011.11.073. Epub 2011 Nov 25.

PMID:
22182498
4.

Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.

Gahman TC, Herbert MR, Lang H, Thayer A, Symons KT, Nguyen PM, Massari ME, Dozier S, Zhang Y, Sablad M, Rao TS, Noble SA, Shiau AK, Hassig CA.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6888-94. doi: 10.1016/j.bmcl.2011.08.112. Epub 2011 Sep 8.

PMID:
21986586
5.

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.

Packiarajan M, Marzabadi MR, Desai M, Lu Y, Noble SA, Wong WC, Jubian V, Chandrasena G, Wolinsky TD, Zhong H, Walker MW, Wiborg O, Andersen K.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5436-41. doi: 10.1016/j.bmcl.2011.06.124. Epub 2011 Jul 2.

PMID:
21782428
6.

Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.

Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS.

J Pharmacol Exp Ther. 2011 Feb;336(2):468-78. doi: 10.1124/jpet.110.172817. Epub 2010 Oct 29.

PMID:
21036913
7.
8.

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.

Herbert MR, Siegel DL, Staszewski L, Cayanan C, Banerjee U, Dhamija S, Anderson J, Fan A, Wang L, Rix P, Shiau AK, Rao TS, Noble SA, Heyman RA, Bischoff E, Guha M, Kabakibi A, Pinkerton AB.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21. doi: 10.1016/j.bmcl.2010.08.014. Epub 2010 Aug 10.

PMID:
20801037
9.

Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma.

Davis RL, Kahraman M, Prins TJ, Beaver Y, Cook TG, Cramp J, Cayanan CS, Gardiner EM, McLaughlin MA, Clark AF, Hellberg MR, Shiau AK, Noble SA, Borchardt AJ.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3361-6. doi: 10.1016/j.bmcl.2010.04.020. Epub 2010 Apr 11.

PMID:
20434334
10.

Water-soluble PDE4 inhibitors for the treatment of dry eye.

Govek SP, Oshiro G, Anzola JV, Beauregard C, Chen J, Coyle AR, Gamache DA, Hellberg MR, Hsien JN, Lerch JM, Liao JC, Malecha JW, Staszewski LM, Thomas DJ, Yanni JM, Noble SA, Shiau AK.

Bioorg Med Chem Lett. 2010 May 1;20(9):2928-32. doi: 10.1016/j.bmcl.2010.03.023. Epub 2010 Mar 7.

PMID:
20378348
11.

Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.

J Med Chem. 2009 May 14;52(9):3047-62. doi: 10.1021/jm900173b.

PMID:
19374401
12.

KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.

Symons KT, Massari ME, Nguyen PM, Lee TT, Roppe J, Bonnefous C, Payne JE, Smith ND, Noble SA, Sablad M, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.

Mol Pharmacol. 2009 Jul;76(1):153-62. doi: 10.1124/mol.109.055434. Epub 2009 Apr 13.

PMID:
19364813
13.

Alpha-mercaptoketone based histone deacetylase inhibitors.

Wash PL, Hoffman TZ, Wiley BM, Bonnefous C, Smith ND, Sertic MS, Lawrence CM, Symons KT, Nguyen PM, Lustig KD, Guo X, Annable T, Noble SA, Hager JH, Hassig CA, Malecha JW.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6482-5. doi: 10.1016/j.bmcl.2008.10.058. Epub 2008 Oct 17.

PMID:
18954984
14.

Identification of KD5170: a novel mercaptoketone-based histone deacetylase inhibitor.

Payne JE, Bonnefous C, Hassig CA, Symons KT, Guo X, Nguyen PM, Annable T, Wash PL, Hoffman TZ, Rao TS, Shiau AK, Malecha JW, Noble SA, Hager JH, Smith ND.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6093-6. doi: 10.1016/j.bmcl.2008.10.029. Epub 2008 Oct 11.

PMID:
18954983
15.

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.

Hassig CA, Symons KT, Guo X, Nguyen PM, Annable T, Wash PL, Payne JE, Jenkins DA, Bonnefous C, Trotter C, Wang Y, Anzola JV, Milkova EL, Hoffman TZ, Dozier SJ, Wiley BM, Saven A, Malecha JW, Davis RL, Muhammad J, Shiau AK, Noble SA, Rao TS, Smith ND, Hager JH.

Mol Cancer Ther. 2008 May;7(5):1054-65. doi: 10.1158/1535-7163.MCT-07-2347.

16.

Inhibition of inducible nitric oxide synthase expression by a novel small molecule activator of the unfolded protein response.

Symons KT, Massari ME, Dozier SJ, Nguyen PM, Jenkins D, Herbert M, Gahman TC, Noble SA, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.

Curr Chem Genomics. 2008 Sep 27;2:1-9. doi: 10.2174/1875397300802010001.

17.

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors.

Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3562-9. Epub 2007 Apr 29.

PMID:
17498954
19.

Subtype selective alpha1-adrenoceptor antagonists for the treatment of benign prostatic hyperplasia.

Forray C, Noble SA.

Expert Opin Investig Drugs. 1999 Dec;8(12):2073-2094.

PMID:
11139841
20.

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.

Brown KK, Henke BR, Blanchard SG, Cobb JE, Mook R, Kaldor I, Kliewer SA, Lehmann JM, Lenhard JM, Harrington WW, Novak PJ, Faison W, Binz JG, Hashim MA, Oliver WO, Brown HR, Parks DJ, Plunket KD, Tong WQ, Menius JA, Adkison K, Noble SA, Willson TM.

Diabetes. 1999 Jul;48(7):1415-24.

PMID:
10389847
21.

The synthesis and antiviral activity of 4-fluoro-1-beta-D-ribofuranosyl-1H-pyrazole-3-carboxamide.

Storer R, Ashton CJ, Baxter AD, Hann MM, Marr CL, Mason AM, Mo CL, Myers PL, Noble SA, Penn CR, Weir NG, Woods JM, Coe PL.

Nucleosides Nucleotides. 1999 Feb;18(2):203-16.

PMID:
10067273
22.

Novel 1,3-disubstituted-5,10-dihydro-5,10-dioxo-1H-benzo[g] isochromene-3 carboxamides as potent antitumor agents.

Wang W, Li T, Milburn R, Yates J, Hinnant E, Luzzio MJ, Noble SA, Attardo G.

Bioorg Med Chem Lett. 1998 Jul 7;8(13):1579-84.

PMID:
9873394
23.

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

Jones KA, Borowsky B, Tamm JA, Craig DA, Durkin MM, Dai M, Yao WJ, Johnson M, Gunwaldsen C, Huang LY, Tang C, Shen Q, Salon JA, Morse K, Laz T, Smith KE, Nagarathnam D, Noble SA, Branchek TA, Gerald C.

Nature. 1998 Dec 17;396(6712):674-9.

PMID:
9872315
24.

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.

Henke BR, Blanchard SG, Brackeen MF, Brown KK, Cobb JE, Collins JL, Harrington WW Jr, Hashim MA, Hull-Ryde EA, Kaldor I, Kliewer SA, Lake DH, Leesnitzer LM, Lehmann JM, Lenhard JM, Orband-Miller LA, Miller JF, Mook RA Jr, Noble SA, Oliver W Jr, Parks DJ, Plunket KD, Szewczyk JR, Willson TM.

J Med Chem. 1998 Dec 3;41(25):5020-36.

PMID:
9836620
25.

Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines.

Livermore DG, Bethell RC, Cammack N, Hancock AP, Hann MM, Green DV, Lamont RB, Noble SA, Orr DC, Payne JJ, et al.

J Med Chem. 1993 Nov 26;36(24):3784-94.

PMID:
7504733
26.

Strand-invasion of duplex DNA by peptide nucleic acid oligomers.

Peffer NJ, Hanvey JC, Bisi JE, Thomson SA, Hassman CF, Noble SA, Babiss LE.

Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10648-52.

27.

Probing structural factors stabilizing antisense oligonucleotide duplexes: NMR studies of a DNA.DNA duplex containing a formacetal linkage.

Gao X, Brown FK, Jeffs P, Bischofberger N, Lin KY, Pipe AJ, Noble SA.

Biochemistry. 1992 Jul 14;31(27):6228-36.

PMID:
1320930
29.

Expression of atrial natriuretic factor as a cleavable fusion protein with chloramphenicol acetyltransferase in Escherichia coli.

Dykes CW, Bookless AB, Coomber BA, Noble SA, Humber DC, Hobden AN.

Eur J Biochem. 1988 Jun 1;174(2):411-6.

30.

Altered Cro repressors from engineered mutagenesis of a synthetic cro gene.

Eisenbeis SJ, Nasoff MS, Noble SA, Bracco LP, Dodds DR, Caruthers MH.

Proc Natl Acad Sci U S A. 1985 Feb;82(4):1084-8.

31.

Methylphosphonates as probes of protein-nucleic acid interactions.

Noble SA, Fisher EF, Caruthers MH.

Nucleic Acids Res. 1984 Apr 11;12(7):3387-404.

32.

Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.

Coe PL, Harnden MR, Jones AS, Noble SA, Walker RT.

J Med Chem. 1982 Nov;25(11):1329-34.

PMID:
6292425

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