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Items: 29

1.

Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.

Lim SP, Noble CG, Nilar S, Shi PY, Yokokawa F.

Adv Exp Med Biol. 2018;1062:187-198. doi: 10.1007/978-981-10-8727-1_14. Review.

PMID:
29845534
2.

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.

Manjunatha UH, Vinayak S, Zambriski JA, Chao AT, Sy T, Noble CG, Bonamy GMC, Kondreddi RR, Zou B, Gedeck P, Brooks CF, Herbert GT, Sateriale A, Tandel J, Noh S, Lakshminarayana SB, Lim SH, Goodman LB, Bodenreider C, Feng G, Zhang L, Blasco F, Wagner J, Leong FJ, Striepen B, Diagana TT.

Nature. 2017 Jun 15;546(7658):376-380. doi: 10.1038/nature22337. Epub 2017 May 31.

3.

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.

Lim SP, Noble CG, Seh CC, Soh TS, El Sahili A, Chan GK, Lescar J, Arora R, Benson T, Nilar S, Manjunatha U, Wan KF, Dong H, Xie X, Shi PY, Yokokawa F.

PLoS Pathog. 2016 Aug 8;12(8):e1005737. doi: 10.1371/journal.ppat.1005737. eCollection 2016 Aug.

4.

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.

Yokokawa F, Nilar S, Noble CG, Lim SP, Rao R, Tania S, Wang G, Lee G, Hunziker J, Karuna R, Manjunatha U, Shi PY, Smith PW.

J Med Chem. 2016 Apr 28;59(8):3935-52. doi: 10.1021/acs.jmedchem.6b00143. Epub 2016 Apr 8.

PMID:
26984786
5.

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.

Noble CG, Lim SP, Arora R, Yokokawa F, Nilar S, Seh CC, Wright SK, Benson TE, Smith PW, Shi PY.

J Biol Chem. 2016 Apr 15;291(16):8541-8. doi: 10.1074/jbc.M115.710731. Epub 2016 Feb 12.

6.

Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents.

Ng PS, Manjunatha UH, Rao SP, Camacho LR, Ma NL, Herve M, Noble CG, Goh A, Peukert S, Diagana TT, Smith PW, Kondreddi RR.

Eur J Med Chem. 2015 Dec 1;106:144-56. doi: 10.1016/j.ejmech.2015.10.008. Epub 2015 Oct 14.

PMID:
26544629
7.

The dengue virus NS5 protein as a target for drug discovery.

Lim SP, Noble CG, Shi PY.

Antiviral Res. 2015 Jul;119:57-67. doi: 10.1016/j.antiviral.2015.04.010. Epub 2015 Apr 24. Review.

PMID:
25912817
8.

Direct inhibitors of InhA are active against Mycobacterium tuberculosis.

Manjunatha UH, S Rao SP, Kondreddi RR, Noble CG, Camacho LR, Tan BH, Ng SH, Ng PS, Ma NL, Lakshminarayana SB, Herve M, Barnes SW, Yu W, Kuhen K, Blasco F, Beer D, Walker JR, Tonge PJ, Glynne R, Smith PW, Diagana TT.

Sci Transl Med. 2015 Jan 7;7(269):269ra3. doi: 10.1126/scitranslmed.3010597.

9.

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine.

Noble CG, Li SH, Dong H, Chew SH, Shi PY.

Antiviral Res. 2014 Nov;111:78-81. doi: 10.1016/j.antiviral.2014.09.003. Epub 2014 Sep 19.

PMID:
25241250
10.

Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus.

Xie X, Zou J, Wang QY, Noble CG, Lescar J, Shi PY.

Virology. 2014 Feb;450-451:250-7. doi: 10.1016/j.virol.2013.12.025. Epub 2014 Jan 9.

11.

Ten years of dengue drug discovery: progress and prospects.

Lim SP, Wang QY, Noble CG, Chen YL, Dong H, Zou B, Yokokawa F, Nilar S, Smith P, Beer D, Lescar J, Shi PY.

Antiviral Res. 2013 Nov;100(2):500-19. doi: 10.1016/j.antiviral.2013.09.013. Epub 2013 Sep 27. Review.

PMID:
24076358
12.

Structural basis of mycobacterial inhibition by cyclomarin A.

Vasudevan D, Rao SP, Noble CG.

J Biol Chem. 2013 Oct 25;288(43):30883-91. doi: 10.1074/jbc.M113.493767. Epub 2013 Sep 10.

13.

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex.

Kim YM, Gayen S, Kang C, Joy J, Huang Q, Chen AS, Wee JL, Ang MJ, Lim HA, Hung AW, Li R, Noble CG, Lee le T, Yip A, Wang QY, Chia CS, Hill J, Shi PY, Keller TH.

J Biol Chem. 2013 May 3;288(18):12891-900. doi: 10.1074/jbc.M112.442723. Epub 2013 Mar 19.

14.

Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor.

Noble CG, Lim SP, Chen YL, Liew CW, Yap L, Lescar J, Shi PY.

J Virol. 2013 May;87(9):5291-5. doi: 10.1128/JVI.00045-13. Epub 2013 Feb 13.

15.

Structural biology of dengue virus enzymes: towards rational design of therapeutics.

Noble CG, Shi PY.

Antiviral Res. 2012 Nov;96(2):115-26. doi: 10.1016/j.antiviral.2012.09.007. Epub 2012 Sep 17. Review.

PMID:
22995600
16.

Ligand-bound structures of the dengue virus protease reveal the active conformation.

Noble CG, Seh CC, Chao AT, Shi PY.

J Virol. 2012 Jan;86(1):438-46. doi: 10.1128/JVI.06225-11. Epub 2011 Oct 26.

17.

Strategies for development of Dengue virus inhibitors.

Noble CG, Chen YL, Dong H, Gu F, Lim SP, Schul W, Wang QY, Shi PY.

Antiviral Res. 2010 Mar;85(3):450-62. doi: 10.1016/j.antiviral.2009.12.011. Epub 2010 Jan 8. Review.

PMID:
20060421
18.

Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level.

Yang S, Noble CG, Yang D.

Biochemistry. 2009 May 19;48(19):4040-9. doi: 10.1021/bi9000936.

PMID:
19317456
19.

Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1.

Noble CG, Dong JM, Manser E, Song H.

J Biol Chem. 2008 Sep 19;283(38):26274-82. doi: 10.1074/jbc.M804723200. Epub 2008 Jul 18.

20.

Structural studies of elongation and release factors.

Noble CG, Song H.

Cell Mol Life Sci. 2008 May;65(9):1335-46. doi: 10.1007/s00018-008-7495-6. Review.

PMID:
18213444
21.

MLN51 stimulates the RNA-helicase activity of eIF4AIII.

Noble CG, Song H.

PLoS One. 2007 Mar 21;2(3):e303.

22.

Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.

Noble CG, Beuth B, Taylor IA.

Nucleic Acids Res. 2007;35(1):87-99. Epub 2006 Dec 6.

23.

RNA polymerase II CTD phosphopeptides compete with RNA for the interaction with Pcf11.

Hollingworth D, Noble CG, Taylor IA, Ramos A.

RNA. 2006 Apr;12(4):555-60. Epub 2006 Feb 22.

24.

The effects of metal ions on the structure and stability of the DNA gyrase B protein.

Sissi C, Marangon E, Chemello A, Noble CG, Maxwell A, Palumbo M.

J Mol Biol. 2005 Nov 11;353(5):1152-60. Epub 2005 Sep 30.

PMID:
16223508
25.

Backbone assignment of PCF11 CTD binding domain.

Hollingworth D, Kelly G, Frenkiel TA, Noble CG, Taylor IA, Ramos A.

J Biomol NMR. 2005 Apr;31(4):363. No abstract available.

PMID:
15929005
26.

Key features of the interaction between Pcf11 CID and RNA polymerase II CTD.

Noble CG, Hollingworth D, Martin SR, Ennis-Adeniran V, Smerdon SJ, Kelly G, Taylor IA, Ramos A.

Nat Struct Mol Biol. 2005 Feb;12(2):144-51. Epub 2005 Jan 16.

PMID:
15665873
27.

Rna14-Rna15 assembly mediates the RNA-binding capability of Saccharomyces cerevisiae cleavage factor IA.

Noble CG, Walker PA, Calder LJ, Taylor IA.

Nucleic Acids Res. 2004 Jun 23;32(11):3364-75. Print 2004.

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