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Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease.

Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A.

PLoS Genet. 2020 Mar 4;16(3):e1008604. doi: 10.1371/journal.pgen.1008604. eCollection 2020 Mar.


Preclinical Pharmacokinetics of Complement C5a Receptor Antagonists PMX53 and PMX205 in Mice.

Kumar V, Lee JD, Clark RJ, Noakes PG, Taylor SM, Woodruff TM.

ACS Omega. 2020 Jan 30;5(5):2345-2354. doi: 10.1021/acsomega.9b03735. eCollection 2020 Feb 11.


What are Neurotransmitter Release Sites and Do They Interact?

Ge D, Noakes PG, Lavidis NA.

Neuroscience. 2020 Jan 15;425:157-168. doi: 10.1016/j.neuroscience.2019.11.017. Epub 2019 Nov 30. Review.


Size-Dependent Vulnerability of Lumbar Motor Neuron Dendritic Degeneration in SOD1G93A Mice.

Fogarty MJ, Mu EWH, Lavidis NA, Noakes PG, Bellingham MC.

Anat Rec (Hoboken). 2019 Sep 11. doi: 10.1002/ar.24255. [Epub ahead of print]


The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis.

Pradhan J, Noakes PG, Bellingham MC.

Front Cell Neurosci. 2019 Aug 13;13:368. doi: 10.3389/fncel.2019.00368. eCollection 2019. Review.


Revisiting the role of the innate immune complement system in ALS.

Parker SE, Hanton AM, Stefanou SN, Noakes PG, Woodruff TM, Lee JD.

Neurobiol Dis. 2019 Jul;127:223-232. doi: 10.1016/j.nbd.2019.03.003. Epub 2019 Mar 6. Review.


Seasonal comparison of the neuromuscular junction morphology of Bufo marinus.

Ge D, Noakes PG, Lavidis NA.

J Comp Neurol. 2019 Aug 15;527(12):1931-1939. doi: 10.1002/cne.24661. Epub 2019 Feb 25.


Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis.

Lee JD, Levin SC, Willis EF, Li R, Woodruff TM, Noakes PG.

J Neuroinflammation. 2018 Jun 1;15(1):171. doi: 10.1186/s12974-018-1217-2.


Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis.

Chand KK, Lee KM, Lee JD, Qiu H, Willis EF, Lavidis NA, Hilliard MA, Noakes PG.

FASEB J. 2018 May;32(5):2676-2689. doi: 10.1096/fj.201700835R. Epub 2018 Jan 2.


Investigating Methodological Differences in the Assessment of Dendritic Morphology of Basolateral Amygdala Principal Neurons-A Comparison of Golgi-Cox and Neurobiotin Electroporation Techniques.

Klenowski PM, Wright SE, Mu EWH, Noakes PG, Lavidis NA, Bartlett SE, Bellingham MC, Fogarty MJ.

Brain Sci. 2017 Dec 19;7(12). pii: E165. doi: 10.3390/brainsci7120165.


Regulated Alternative Splicing of Drosophila Dscam2 Is Necessary for Attaining the Appropriate Number of Photoreceptor Synapses.

Kerwin SK, Li JSS, Noakes PG, Shin GJ, Millard SS.

Genetics. 2018 Feb;208(2):717-728. doi: 10.1534/genetics.117.300432. Epub 2017 Dec 5.


Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model.

Fogarty MJ, Mu EWH, Lavidis NA, Noakes PG, Bellingham MC.

Front Neurosci. 2017 Nov 1;11:609. doi: 10.3389/fnins.2017.00609. eCollection 2017.


Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.

Benyamin B, He J, Zhao Q, Gratten J, Garton F, Leo PJ, Liu Z, Mangelsdorf M, Al-Chalabi A, Anderson L, Butler TJ, Chen L, Chen XD, Cremin K, Deng HW, Devine M, Edson J, Fifita JA, Furlong S, Han YY, Harris J, Henders AK, Jeffree RL, Jin ZB, Li Z, Li T, Li M, Lin Y, Liu X, Marshall M, McCann EP, Mowry BJ, Ngo ST, Pamphlett R, Ran S, Reutens DC, Rowe DB, Sachdev P, Shah S, Song S, Tan LJ, Tang L, van den Berg LH, van Rheenen W, Veldink JH, Wallace RH, Wheeler L, Williams KL, Wu J, Wu X, Yang J, Yue W, Zhang ZH, Zhang D, Noakes PG, Blair IP, Henderson RD, McCombe PA, Visscher PM, Xu H, Bartlett PF, Brown MA, Wray NR, Fan D.

Nat Commun. 2017 Sep 20;8(1):611. doi: 10.1038/s41467-017-00471-1.


Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Wang HA, Lee JD, Lee KM, Woodruff TM, Noakes PG.

Skelet Muscle. 2017 Jun 1;7(1):10. doi: 10.1186/s13395-017-0128-8.


Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression.

Lee KM, Chand KK, Hammond LA, Lavidis NA, Noakes PG.

Aging (Albany NY). 2017 Mar 14;9(3):880-899. doi: 10.18632/aging.101198.


Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Lee JD, Kumar V, Fung JN, Ruitenberg MJ, Noakes PG, Woodruff TM.

Br J Pharmacol. 2017 Apr;174(8):689-699. doi: 10.1111/bph.13730. Epub 2017 Mar 3.


A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.

Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF.

Hum Mol Genet. 2017 Jan 1;26(1):109-123. doi: 10.1093/hmg/ddw371.


Loss of laminin-α4 results in pre- and postsynaptic modifications at the neuromuscular junction.

Chand KK, Lee KM, Lavidis NA, Noakes PG.

FASEB J. 2017 Apr;31(4):1323-1336. doi: 10.1096/fj.201600899R. Epub 2016 Dec 20.


Alterations in hypoglossal motor neurons due to GAD67 and VGAT deficiency in mice.

Fogarty MJ, Kanjhan R, Yanagawa Y, Noakes PG, Bellingham MC.

Exp Neurol. 2017 Mar;289:117-127. doi: 10.1016/j.expneurol.2016.12.004. Epub 2016 Dec 10.


Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis.

Fogarty MJ, Klenowski PM, Lee JD, Drieberg-Thompson JR, Bartlett SE, Ngo ST, Hilliard MA, Bellingham MC, Noakes PG.

Sci Rep. 2016 Nov 29;6:37968. doi: 10.1038/srep37968.


Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.

Quek H, Luff J, Cheung K, Kozlov S, Gatei M, Lee CS, Bellingham MC, Noakes PG, Lim YC, Barnett NL, Dingwall S, Wolvetang E, Mashimo T, Roberts TL, Lavin MF.

J Leukoc Biol. 2017 Apr;101(4):927-947. doi: 10.1189/jlb.4VMA0716-316R. Epub 2016 Nov 28.


Tick holocyclotoxins trigger host paralysis by presynaptic inhibition.

Chand KK, Lee KM, Lavidis NA, Rodriguez-Valle M, Ijaz H, Koehbach J, Clark RJ, Lew-Tabor A, Noakes PG.

Sci Rep. 2016 Jul 8;6:29446. doi: 10.1038/srep29446.


Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease.

Kanjhan R, Noakes PG, Bellingham MC.

Neural Plast. 2016;2016:3423267. doi: 10.1155/2016/3423267. Epub 2015 Dec 30. Review.


Glycinergic Neurotransmission: A Potent Regulator of Embryonic Motor Neuron Dendritic Morphology and Synaptic Plasticity.

Fogarty MJ, Kanjhan R, Bellingham MC, Noakes PG.

J Neurosci. 2016 Jan 6;36(1):80-7. doi: 10.1523/JNEUROSCI.1576-15.2016.


Developmental changes in the morphology of mouse hypoglossal motor neurons.

Kanjhan R, Fogarty MJ, Noakes PG, Bellingham MC.

Brain Struct Funct. 2016 Sep;221(7):3755-86. doi: 10.1007/s00429-015-1130-8. Epub 2015 Oct 17.


Structural and functional characterization of dendritic arbors and GABAergic synaptic inputs on interneurons and principal cells in the rat basolateral amygdala.

Klenowski PM, Fogarty MJ, Belmer A, Noakes PG, Bellingham MC, Bartlett SE.

J Neurophysiol. 2015 Aug;114(2):942-57. doi: 10.1152/jn.00824.2014. Epub 2015 Jun 3.


Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis.

Lee JY, Lee JD, Phipps S, Noakes PG, Woodruff TM.

J Neuroinflammation. 2015 May 13;12:90. doi: 10.1186/s12974-015-0310-z.


Loss of β2-laminin alters calcium sensitivity and voltage-gated calcium channel maturation of neurotransmission at the neuromuscular junction.

Chand KK, Lee KM, Schenning MP, Lavidis NA, Noakes PG.

J Physiol. 2015 Jan 1;593(1):245-65. doi: 10.1113/jphysiol.2014.284133. Epub 2014 Dec 1.


Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood.

Mantovani S, Gordon R, Macmaw JK, Pfluger CM, Henderson RD, Noakes PG, McCombe PA, Woodruff TM.

J Neuroimmunol. 2014 Nov 15;276(1-2):213-8.


Role for terminal complement activation in amyotrophic lateral sclerosis disease progression.

Woodruff TM, Lee JD, Noakes PG.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E3-4. doi: 10.1073/pnas.1321248111. Epub 2013 Dec 31. No abstract available.


Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development.

Fogarty MJ, Yanagawa Y, Obata K, Bellingham MC, Noakes PG.

Brain Struct Funct. 2015 Jan;220(1):525-40. doi: 10.1007/s00429-013-0673-9. Epub 2013 Nov 26.


A method for the three-dimensional reconstruction of Neurobiotin™-filled neurons and the location of their synaptic inputs.

Fogarty MJ, Hammond LA, Kanjhan R, Bellingham MC, Noakes PG.

Front Neural Circuits. 2013 Oct 1;7:153. doi: 10.3389/fncir.2013.00153. eCollection 2013.


Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.

Lee JD, Kamaruzaman NA, Fung JN, Taylor SM, Turner BJ, Atkin JD, Woodruff TM, Noakes PG.

J Neuroinflammation. 2013 Sep 26;10:119. doi: 10.1186/1742-2094-10-119.


Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development.

Fogarty MJ, Smallcombe KL, Yanagawa Y, Obata K, Bellingham MC, Noakes PG.

PLoS One. 2013;8(2):e56257. doi: 10.1371/journal.pone.0056257. Epub 2013 Feb 15.


Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain.

Narayanan RK, Mangelsdorf M, Panwar A, Butler TJ, Noakes PG, Wallace RH.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14(4):252-60. doi: 10.3109/21678421.2012.734520. Epub 2012 Oct 24.


Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation.

Ngo ST, Cole RN, Sunn N, Phillips WD, Noakes PG.

J Cell Sci. 2012 Mar 15;125(Pt 6):1531-43. doi: 10.1242/jcs.095109. Epub 2012 Feb 10.


Muscle specific kinase: organiser of synaptic membrane domains.

Ghazanfari N, Fernandez KJ, Murata Y, Morsch M, Ngo ST, Reddel SW, Noakes PG, Phillips WD.

Int J Biochem Cell Biol. 2011 Mar;43(3):295-8. doi: 10.1016/j.biocel.2010.10.008. Epub 2010 Oct 23. Review.


Myocardial deletion of Smad4 using a novel α skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract.

Azhar M, Wang PY, Frugier T, Koishi K, Deng C, Noakes PG, McLennan IS.

Int J Biol Sci. 2010 Sep 20;6(6):546-55.


The two-pore domain K+ channel TASK-1 is closely associated with brain barriers and meninges.

Kanjhan R, Pow DV, Noakes PG, Bellingham MC.

J Mol Histol. 2010 Dec;41(6):315-23. doi: 10.1007/s10735-010-9293-3. Epub 2010 Sep 11.


Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF.

J Am Chem Soc. 2010 Mar 17;132(10):3514-22. doi: 10.1021/ja910602h.


The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres.

Crane JW, Baiquni GP, Sullivan RK, Lee JD, Sah P, Taylor SM, Noakes PG, Woodruff TM.

J Neuroinflammation. 2009 Nov 16;6:34. doi: 10.1186/1742-2094-6-34.


In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2.

Barclay JL, Kerr LM, Arthur L, Rowland JE, Nelson CN, Ishikawa M, d'Aniello EM, White M, Noakes PG, Waters MJ.

Mol Endocrinol. 2010 Jan;24(1):204-17. doi: 10.1210/me.2009-0233. Epub 2009 Nov 2.


The role of the complement system and the activation fragment C5a in the central nervous system.

Woodruff TM, Ager RR, Tenner AJ, Noakes PG, Taylor SM.

Neuromolecular Med. 2010 Jun;12(2):179-92. doi: 10.1007/s12017-009-8085-y. Epub 2009 Sep 11.


The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis.

Woodruff TM, Costantini KJ, Crane JW, Atkin JD, Monk PN, Taylor SM, Noakes PG.

J Immunol. 2008 Dec 15;181(12):8727-34.


Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitors.

Woodruff TM, Costantini KJ, Taylor SM, Noakes PG.

Adv Exp Med Biol. 2008;632:143-58. Review.


Neural agrin increases postsynaptic ACh receptor packing by elevating rapsyn protein at the mouse neuromuscular synapse.

Brockhausen J, Cole RN, Gervásio OL, Ngo ST, Noakes PG, Phillips WD.

Dev Neurobiol. 2008 Aug;68(9):1153-69. doi: 10.1002/dneu.20654.


Neuronal expression of peripherin, a type III intermediate filament protein, in the mouse hindbrain.

Barclay M, Noakes PG, Ryan AF, Julien JP, Housley GD.

Histochem Cell Biol. 2007 Dec;128(6):541-50. Epub 2007 Sep 26.


IGF-I and insulin activate mitogen-activated protein kinase via the type 1 IGF receptor in mouse embryonic stem cells.

Nguyen TT, Sheppard AM, Kaye PL, Noakes PG.

Reproduction. 2007 Jul;134(1):41-9.


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