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Items: 50

1.

Proteases Upregulation in Sporadic Alzheimer's Disease Brain.

Medoro A, Bartollino S, Mignogna D, Marziliano N, Porcile C, Nizzari M, Florio T, Pagano A, Raimo G, Intrieri M, Russo C.

J Alzheimers Dis. 2019;68(3):931-938. doi: 10.3233/JAD-181284.

PMID:
30814362
2.

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity.

Thellung S, Corsaro A, Nizzari M, Barbieri F, Florio T.

Int J Mol Sci. 2019 Feb 19;20(4). pii: E901. doi: 10.3390/ijms20040901. Review.

3.

Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity.

Pagano K, Galante D, D'Arrigo C, Corsaro A, Nizzari M, Florio T, Molinari H, Tomaselli S, Ragona L.

Mol Neurobiol. 2019 Mar;56(3):1957-1971. doi: 10.1007/s12035-018-1202-x. Epub 2018 Jul 6.

PMID:
29981054
4.

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death.

Thellung S, Scoti B, Corsaro A, Villa V, Nizzari M, Gagliani MC, Porcile C, Russo C, Pagano A, Tacchetti C, Cortese K, Florio T.

Cell Death Dis. 2018 Feb 7;9(2):166. doi: 10.1038/s41419-017-0252-8.

5.

Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer.

Medoro A, Bartollino S, Mignogna D, Passarella D, Porcile C, Pagano A, Florio T, Nizzari M, Guerra G, Di Marco R, Intrieri M, Raimo G, Russo C.

J Alzheimers Dis. 2018;61(1):1-15. doi: 10.3233/JAD-170628. Review.

PMID:
29103038
6.

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.

Thellung S, Gatta E, Pellistri F, Villa V, Corsaro A, Nizzari M, Robello M, Florio T.

Neurotox Res. 2017 Oct;32(3):381-397. doi: 10.1007/s12640-017-9749-2. Epub 2017 May 25.

PMID:
28540665
7.

The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells.

Penna I, Gigoni A, Costa D, Vella S, Russo D, Poggi A, Villa F, Brizzolara A, Canale C, Mescola A, Daga A, Russo C, Nizzari M, Florio T, Menichini P, Pagano A.

Oncotarget. 2017 Jan 31;8(5):8189-8205. doi: 10.18632/oncotarget.14138.

8.

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells.

Corsaro A, Bajetto A, Thellung S, Begani G, Villa V, Nizzari M, Pattarozzi A, Solari A, Gatti M, Pagano A, Würth R, Daga A, Barbieri F, Florio T.

Oncotarget. 2016 Jun 21;7(25):38638-38657. doi: 10.18632/oncotarget.9575.

9.

Canine osteosarcoma cell lines contain stem-like cancer cells: biological and pharmacological characterization.

Gatti M, Wurth R, Vito G, Pattarozzi A, Campanella C, Thellung S, Maniscalco L, De Maria R, Villa V, Corsaro A, Nizzari M, Bajetto A, Ratto A, Ferrari A, Barbieri F, Florio T.

Jpn J Vet Res. 2016 May;64(2):101-12.

PMID:
27506084
10.

Orthogonal NGS for High Throughput Clinical Diagnostics.

Chennagiri N, White EJ, Frieden A, Lopez E, Lieber DS, Nikiforov A, Ross T, Batorsky R, Hansen S, Lip V, Luquette LJ, Mauceli E, Margulies D, Milos PM, Napolitano N, Nizzari MM, Yu T, Thompson JF.

Sci Rep. 2016 Apr 19;6:24650. doi: 10.1038/srep24650.

11.

Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

Thellung S, Favoni RE, Würth R, Nizzari M, Pattarozzi A, Daga A, Florio T, Barbieri F.

Curr Drug Targets. 2016;17(7):824-49. Review.

PMID:
26240051
12.

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

Barbieri F, Thellung S, Würth R, Gatto F, Corsaro A, Villa V, Nizzari M, Albertelli M, Ferone D, Florio T.

Int J Endocrinol. 2014;2014:753524. doi: 10.1155/2014/753524. Epub 2014 Nov 17. Review.

13.

Next-generation carrier screening.

Umbarger MA, Kennedy CJ, Saunders P, Breton B, Chennagiri N, Emhoff J, Greger V, Hallam S, Maganzini D, Micale C, Nizzari MM, Towne CF, Church GM, Porreca GJ.

Genet Med. 2014 Feb;16(2):132-40. doi: 10.1038/gim.2013.83. Epub 2013 Jun 13.

14.

A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing.

Penna I, Vassallo I, Nizzari M, Russo D, Costa D, Menichini P, Poggi A, Russo C, Dieci G, Florio T, Cancedda R, Pagano A.

Biochim Biophys Acta. 2013 Jun;1833(6):1511-26. doi: 10.1016/j.bbamcr.2013.02.020. Epub 2013 Feb 26.

15.

Peptide receptor targeting in cancer: the somatostatin paradigm.

Barbieri F, Bajetto A, Pattarozzi A, Gatti M, Würth R, Thellung S, Corsaro A, Villa V, Nizzari M, Florio T.

Int J Pept. 2013;2013:926295. doi: 10.1155/2013/926295. Epub 2013 Feb 7.

16.

An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples.

Ciarlo E, Massone S, Penna I, Nizzari M, Gigoni A, Dieci G, Russo C, Florio T, Cancedda R, Pagano A.

Dis Model Mech. 2013 Mar;6(2):424-33. doi: 10.1242/dmm.009761. Epub 2012 Sep 20.

17.

Role of prion protein aggregation in neurotoxicity.

Corsaro A, Thellung S, Villa V, Nizzari M, Florio T.

Int J Mol Sci. 2012;13(7):8648-69. doi: 10.3390/ijms13078648. Epub 2012 Jul 11. Review.

18.

NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion.

Massone S, Ciarlo E, Vella S, Nizzari M, Florio T, Russo C, Cancedda R, Pagano A.

Biochim Biophys Acta. 2012 Jul;1823(7):1170-7. doi: 10.1016/j.bbamcr.2012.05.001. Epub 2012 May 10.

19.

Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.

Nizzari M, Thellung S, Corsaro A, Villa V, Pagano A, Porcile C, Russo C, Florio T.

J Toxicol. 2012;2012:187297. doi: 10.1155/2012/187297. Epub 2012 Feb 8.

20.

Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

Corsaro A, Thellung S, Villa V, Nizzari M, Aceto A, Florio T.

OMICS. 2012 Jan-Feb;16(1-2):50-9. doi: 10.1089/omi.2011.0038.

PMID:
22321015
21.

Amyloid-β protein precursor regulates phosphorylation and cellular compartmentalization of microtubule associated protein tau.

Nizzari M, Barbieri F, Gentile MT, Passarella D, Caorsi C, Diaspro A, Taglialatela M, Pagano A, Colucci-D'Amato L, Florio T, Russo C.

J Alzheimers Dis. 2012;29(1):211-27. doi: 10.3233/JAD-2011-101590.

PMID:
22232001
22.

Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA.

Gavazzo P, Vella S, Marchetti C, Nizzari M, Cancedda R, Pagano A.

J Neurochem. 2011 Dec;119(5):989-1001. doi: 10.1111/j.1471-4159.2011.07492.x. Epub 2011 Oct 20.

23.

Candidate gene association resource (CARe): design, methods, and proof of concept.

Musunuru K, Lettre G, Young T, Farlow DN, Pirruccello JP, Ejebe KG, Keating BJ, Yang Q, Chen MH, Lapchyk N, Crenshaw A, Ziaugra L, Rachupka A, Benjamin EJ, Cupples LA, Fornage M, Fox ER, Heckbert SR, Hirschhorn JN, Newton-Cheh C, Nizzari MM, Paltoo DN, Papanicolaou GJ, Patel SR, Psaty BM, Rader DJ, Redline S, Rich SS, Rotter JI, Taylor HA Jr, Tracy RP, Vasan RS, Wilson JG, Kathiresan S, Fabsitz RR, Boerwinkle E, Gabriel SB; NHLBI Candidate Gene Association Resource.

Circ Cardiovasc Genet. 2010 Jun;3(3):267-75. doi: 10.1161/CIRCGENETICS.109.882696. Epub 2010 Apr 17.

24.

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap.

Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PI.

Bioinformatics. 2008 Dec 15;24(24):2938-9. doi: 10.1093/bioinformatics/btn564. Epub 2008 Oct 30.

25.

Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs.

Korn JM, Kuruvilla FG, McCarroll SA, Wysoker A, Nemesh J, Cawley S, Hubbell E, Veitch J, Collins PJ, Darvishi K, Lee C, Nizzari MM, Gabriel SB, Purcell S, Daly MJ, Altshuler D.

Nat Genet. 2008 Oct;40(10):1253-60. doi: 10.1038/ng.237. Epub 2008 Sep 7.

26.

Integrated detection and population-genetic analysis of SNPs and copy number variation.

McCarroll SA, Kuruvilla FG, Korn JM, Cawley S, Nemesh J, Wysoker A, Shapero MH, de Bakker PI, Maller JB, Kirby A, Elliott AL, Parkin M, Hubbell E, Webster T, Mei R, Veitch J, Collins PJ, Handsaker R, Lincoln S, Nizzari M, Blume J, Jones KW, Rava R, Daly MJ, Gabriel SB, Altshuler D.

Nat Genet. 2008 Oct;40(10):1166-74. doi: 10.1038/ng.238. Epub 2008 Sep 7.

PMID:
18776908
27.

Amyloid precursor protein and presenilin involvement in cell signaling.

Venezia V, Nizzari M, Carlo P, Corsaro A, Florio T, Russo C.

Neurodegener Dis. 2007;4(2-3):101-11. Review.

PMID:
17596704
28.

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Råstam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S.

Science. 2007 Jun 1;316(5829):1331-6. Epub 2007 Apr 26.

29.

Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

Thellung S, Corsaro A, Villa V, Venezia V, Nizzari M, Bisaglia M, Russo C, Schettini G, Aceto A, Florio T.

Ann N Y Acad Sci. 2007 Jan;1096:258-70.

PMID:
17405937
30.

Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells.

Nizzari M, Venezia V, Bianchini P, Caorsi V, Diaspro A, Repetto E, Thellung S, Corsaro A, Carlo P, Schettini G, Florio T, Russo C.

Ann N Y Acad Sci. 2007 Jan;1096:249-57.

PMID:
17405936
31.

Amyloid precursor protein modulates ERK-1 and -2 signaling.

Venezia V, Nizzari M, Repetto E, Violani E, Corsaro A, Thellung S, Villa V, Carlo P, Schettini G, Florio T, Russo C.

Ann N Y Acad Sci. 2006 Dec;1090:455-65.

PMID:
17384289
32.

Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231.

Villa V, Corsaro A, Thellung S, Paludi D, Chiovitti K, Venezia V, Nizzari M, Russo C, Schettini G, Aceto A, Florio T.

Ann N Y Acad Sci. 2006 Dec;1090:276-91.

PMID:
17384271
33.

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling.

Nizzari M, Venezia V, Repetto E, Caorsi V, Magrassi R, Gagliani MC, Carlo P, Florio T, Schettini G, Tacchetti C, Russo T, Diaspro A, Russo C.

J Biol Chem. 2007 May 4;282(18):13833-44. Epub 2007 Feb 21.

34.

The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications.

Russo C, Venezia V, Repetto E, Nizzari M, Violani E, Carlo P, Schettini G.

Brain Res Brain Res Rev. 2005 Apr;48(2):257-64. Review.

PMID:
15850665
35.

Apoptotic cell death and amyloid precursor protein signaling in neuroblastoma SH-SY5Y cells.

Venezia V, Russo C, Repetto E, Nizzari M, Violani E, Carlo P, Marchetti B, Schettini G.

Ann N Y Acad Sci. 2004 Dec;1030:339-47.

PMID:
15659815
36.

BACE1 overexpression regulates amyloid precursor protein cleavage and interaction with the ShcA adapter.

Repetto E, Russo C, Venezia V, Nizzari M, Nitsch RM, Schettini G.

Ann N Y Acad Sci. 2004 Dec;1030:330-8.

PMID:
15659814
37.

Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells.

Venezia V, Russo C, Repetto E, Salis S, Dolcini V, Genova F, Nizzari M, Mueller U, Schettini G.

J Neurochem. 2004 Sep;90(6):1359-70.

38.

Functional properties of sodium channels do not depend on the cytoskeleton integrity.

Moran O, Tammaro P, Nizzari M, Conti F.

Biochem Biophys Res Commun. 2000 Sep 16;276(1):204-9.

PMID:
11006107
39.

Functional properties of sodium channels do not depend on the cytoskeleton integrity.

Moran O, Tammaro P, Nizzari M, Conti F.

Biochem Biophys Res Commun. 2000 Sep 7;275(3):839-44.

PMID:
10973808
40.

Endogenous expression of the beta1A sodium channel subunit in HEK-293 cells.

Moran O, Nizzari M, Conti F.

FEBS Lett. 2000 May 12;473(2):132-4.

41.

Myopathic mutations affect differently the inactivation of the two gating modes of sodium channels.

Moran O, Nizzari M, Conti F.

J Bioenerg Biomembr. 1999 Dec;31(6):591-608.

PMID:
10682917
42.

Fast- and slow-gating modes of the sodium channel are altered by a paramyotonia congenita-linked mutation.

Moran O, Melani R, Nizzari M, Conti F.

J Bioenerg Biomembr. 1998 Dec;30(6):579-88.

PMID:
10206477
43.

Inactivation defects produced by a myopathic II-S6 mutation of the muscle sodium channel.

Moran O, Nizzari M, Conti F.

Biochem Biophys Res Commun. 1998 May 29;246(3):792-6.

PMID:
9618291
44.

Single-channel properties of ionic channels gated by cyclic nucleotides.

Bucossi G, Nizzari M, Torre V.

Biophys J. 1997 Mar;72(3):1165-81.

45.

Time-dependent current decline in cyclic GMP-gated bovine channels caused by point mutations in the pore region expressed in Xenopus oocytes.

Bucossi G, Eismann E, Sesti F, Nizzari M, Seri M, Kaupp UB, Torre V.

J Physiol. 1996 Jun 1;493 ( Pt 2):409-18.

47.

The multi-ion nature of the cGMP-gated channel from vertebrate rods.

Sesti F, Eismann E, Kaupp UB, Nizzari M, Torre V.

J Physiol. 1995 Aug 15;487(1):17-36.

48.

Single-channel properties of cloned cGMP-activated channels from retinal rods.

Nizzari M, Sesti F, Giraudo MT, Virginio C, Cattaneo A, Torre V.

Proc Biol Sci. 1993 Oct 22;254(1339):69-74.

PMID:
7505453
49.

The histone H1 globular region. A possible supersecondary structure from spectroscopic and statistical studies.

Pepe I, Catasti P, Rauch G, Nizzari M, Nicolini C.

Biochim Biophys Acta. 1990 Oct 18;1041(1):14-21.

PMID:
2223843
50.

Biophysical approach to the determination of the secondary structure of the histone H1 globular region.

Rauch G, Pepe I, Catasti P, Nizzari M, Panfoli I, Nicolini C.

Int J Biol Macromol. 1990 Jun;12(3):177-9.

PMID:
2271487

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