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Items: 1 to 50 of 52

1.

CSF transplantation of a specific iPSC-derived neural stem cell subpopulation ameliorates the disease phenotype in a mouse model of spinal muscular atrophy with respiratory distress type 1.

Forotti G, Nizzardo M, Bucchia M, Ramirez A, Trombetta E, Gatti S, Bresolin N, Comi GP, Corti S.

Exp Neurol. 2019 Nov;321:113041. doi: 10.1016/j.expneurol.2019.113041. Epub 2019 Aug 21.

PMID:
31445043
2.

Key role of SMN/SYNCRIP and RNA-Motif 7 in spinal muscular atrophy: RNA-Seq and motif analysis of human motor neurons.

Rizzo F, Nizzardo M, Vashisht S, Molteni E, Melzi V, Taiana M, Salani S, Santonicola P, Di Schiavi E, Bucchia M, Bordoni A, Faravelli I, Bresolin N, Comi GP, Pozzoli U, Corti S.

Brain. 2019 Feb 1;142(2):276-294. doi: 10.1093/brain/awy330. Erratum in: Brain. 2019 May 1;142(5):e20.

3.

Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy.

Monzio Compagnoni G, Kleiner G, Samarani M, Aureli M, Faustini G, Bellucci A, Ronchi D, Bordoni A, Garbellini M, Salani S, Fortunato F, Frattini E, Abati E, Bergamini C, Fato R, Tabano S, Miozzo M, Serratto G, Passafaro M, Deleidi M, Silipigni R, Nizzardo M, Bresolin N, Comi GP, Corti S, Quinzii CM, Di Fonzo A.

Stem Cell Reports. 2018 Nov 13;11(5):1185-1198. doi: 10.1016/j.stemcr.2018.09.007. Epub 2018 Oct 18.

4.

MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors.

Rizzuti M, Filosa G, Melzi V, Calandriello L, Dioni L, Bollati V, Bresolin N, Comi GP, Barabino S, Nizzardo M, Corti S.

Sci Rep. 2018 Jul 4;8(1):10105. doi: 10.1038/s41598-018-28366-1.

5.

Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.

Romano G, Holodkov N, Klima R, Grilli F, Guarnaccia C, Nizzardo M, Rizzo F, Garcia R, Feiguin F.

Sci Rep. 2018 Jan 29;8(1):1809. doi: 10.1038/s41598-018-19802-3.

6.

Investigation of New Morpholino Oligomers to Increase Survival Motor Neuron Protein Levels in Spinal Muscular Atrophy.

Ramirez A, Crisafulli SG, Rizzuti M, Bresolin N, Comi GP, Corti S, Nizzardo M.

Int J Mol Sci. 2018 Jan 6;19(1). pii: E167. doi: 10.3390/ijms19010167.

7.

Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown-Vialetto disease that is partially rescued by riboflavin.

Rizzo F, Ramirez A, Compagnucci C, Salani S, Melzi V, Bordoni A, Fortunato F, Niceforo A, Bresolin N, Comi GP, Bertini E, Nizzardo M, Corti S.

Sci Rep. 2017 Apr 6;7:46271. doi: 10.1038/srep46271.

8.

Intracerebroventricular Delivery in Mice for Motor Neuron Diseases.

Nizzardo M, Rizzuti M.

Methods Mol Biol. 2017;1565:229-239. doi: 10.1007/978-1-4939-6817-6_19.

PMID:
28364247
9.

Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons.

Rizzo F, Ronchi D, Salani S, Nizzardo M, Fortunato F, Bordoni A, Stuppia G, Del Bo R, Piga D, Fato R, Bresolin N, Comi GP, Corti S.

Hum Mol Genet. 2016 Oct 1;25(19):4266-4281. doi: 10.1093/hmg/ddw258. Epub 2016 Aug 9.

PMID:
27506976
10.

iPSC-derived LewisX+CXCR4+β1-integrin+ neural stem cells improve the amyotrophic lateral sclerosis phenotype by preserving motor neurons and muscle innervation in human and rodent models.

Nizzardo M, Bucchia M, Ramirez A, Trombetta E, Bresolin N, Comi GP, Corti S.

Hum Mol Genet. 2016 Aug 1;25(15):3152-3163. doi: 10.1093/hmg/ddw163. Epub 2016 Jun 6.

PMID:
27270413
11.

Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS.

Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez JA, Cao M, Corti S, Hedlund E.

Sci Rep. 2016 May 16;6:25960. doi: 10.1038/srep25960.

12.

Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype.

Nizzardo M, Simone C, Rizzo F, Ulzi G, Ramirez A, Rizzuti M, Bordoni A, Bucchia M, Gatti S, Bresolin N, Comi GP, Corti S.

Sci Rep. 2016 Feb 16;6:21301. doi: 10.1038/srep21301.

13.

Gene therapy rescues disease phenotype in a spinal muscular atrophy with respiratory distress type 1 (SMARD1) mouse model.

Nizzardo M, Simone C, Rizzo F, Salani S, Dametti S, Rinchetti P, Del Bo R, Foust K, Kaspar BK, Bresolin N, Comi GP, Corti S.

Sci Adv. 2015 Mar 13;1(2):e1500078. doi: 10.1126/sciadv.1500078. eCollection 2015 Mar.

14.

MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives.

Stuppia G, Rizzo F, Riboldi G, Del Bo R, Nizzardo M, Simone C, Comi GP, Bresolin N, Corti S.

J Neurol Sci. 2015 Sep 15;356(1-2):7-18. doi: 10.1016/j.jns.2015.05.033. Epub 2015 May 29. Review.

PMID:
26143526
15.

Spinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches.

Nizzardo M, Simone C, Dametti S, Salani S, Ulzi G, Pagliarani S, Rizzo F, Frattini E, Pagani F, Bresolin N, Comi G, Corti S.

Sci Rep. 2015 Jun 30;5:11746. doi: 10.1038/srep11746.

16.

Spinal muscular atrophy--recent therapeutic advances for an old challenge.

Faravelli I, Nizzardo M, Comi GP, Corti S.

Nat Rev Neurol. 2015 Jun;11(6):351-9. doi: 10.1038/nrneurol.2015.77. Epub 2015 May 19. Review.

PMID:
25986506
17.

Experimental Advances Towards Neural Regeneration from Induced Stem Cells to Direct In Vivo Reprogramming.

Dametti S, Faravelli I, Ruggieri M, Ramirez A, Nizzardo M, Corti S.

Mol Neurobiol. 2016 May;53(4):2124-31. doi: 10.1007/s12035-015-9181-7. Epub 2015 May 2. Review.

PMID:
25934102
18.

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS.

Comley L, Allodi I, Nichterwitz S, Nizzardo M, Simone C, Corti S, Hedlund E.

Neuroscience. 2015 Apr 16;291:216-29. doi: 10.1016/j.neuroscience.2015.02.013. Epub 2015 Feb 16.

19.

Therapeutic development in amyotrophic lateral sclerosis.

Bucchia M, Ramirez A, Parente V, Simone C, Nizzardo M, Magri F, Dametti S, Corti S.

Clin Ther. 2015 Mar 1;37(3):668-80. doi: 10.1016/j.clinthera.2014.12.020. Epub 2015 Feb 7. Review.

PMID:
25666449
20.

Pluripotent stem cell-based models of spinal muscular atrophy.

Frattini E, Ruggieri M, Salani S, Faravelli I, Zanetta C, Nizzardo M, Simone C, Magri F, Corti S.

Mol Cell Neurosci. 2015 Jan;64:44-50. doi: 10.1016/j.mcn.2014.12.005. Epub 2014 Dec 12. Review.

PMID:
25511182
21.

Therapeutic applications of the cell-penetrating HIV-1 Tat peptide.

Rizzuti M, Nizzardo M, Zanetta C, Ramirez A, Corti S.

Drug Discov Today. 2015 Jan;20(1):76-85. doi: 10.1016/j.drudis.2014.09.017. Epub 2014 Sep 30. Review.

PMID:
25277319
22.

iPSC-Derived neural stem cells act via kinase inhibition to exert neuroprotective effects in spinal muscular atrophy with respiratory distress type 1.

Simone C, Nizzardo M, Rizzo F, Ruggieri M, Riboldi G, Salani S, Bucchia M, Bresolin N, Comi GP, Corti S.

Stem Cell Reports. 2014 Aug 12;3(2):297-311. doi: 10.1016/j.stemcr.2014.06.004. Epub 2014 Jul 4.

23.

The wide spectrum of clinical phenotypes of spinal muscular atrophy with respiratory distress type 1: a systematic review.

Porro F, Rinchetti P, Magri F, Riboldi G, Nizzardo M, Simone C, Zanetta C, Faravelli I, Corti S.

J Neurol Sci. 2014 Nov 15;346(1-2):35-42. doi: 10.1016/j.jns.2014.09.010. Epub 2014 Sep 16. Review.

PMID:
25248952
24.

Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives.

Faravelli I, Bucchia M, Rinchetti P, Nizzardo M, Simone C, Frattini E, Corti S.

Stem Cell Res Ther. 2014 Jul 14;5(4):87. doi: 10.1186/scrt476. Review.

25.

Glycogen storage disease type III: A novel Agl knockout mouse model.

Pagliarani S, Lucchiari S, Ulzi G, Violano R, Ripolone M, Bordoni A, Nizzardo M, Gatti S, Corti S, Moggio M, Bresolin N, Comi GP.

Biochim Biophys Acta. 2014 Nov;1842(11):2318-28. doi: 10.1016/j.bbadis.2014.07.029. Epub 2014 Aug 1.

26.

Antisense oligonucleotide therapy for the treatment of C9ORF72 ALS/FTD diseases.

Riboldi G, Zanetta C, Ranieri M, Nizzardo M, Simone C, Magri F, Bresolin N, Comi GP, Corti S.

Mol Neurobiol. 2014 Dec;50(3):721-32. doi: 10.1007/s12035-014-8724-7. Epub 2014 May 9. Review.

PMID:
24809691
27.

Stem cell transplantation for amyotrophic lateral sclerosis: therapeutic potential and perspectives on clinical translation.

Faravelli I, Riboldi G, Nizzardo M, Simone C, Zanetta C, Bresolin N, Comi GP, Corti S.

Cell Mol Life Sci. 2014 Sep;71(17):3257-68. doi: 10.1007/s00018-014-1613-4. Epub 2014 Apr 4. Review.

PMID:
24699704
28.

Effect of combined systemic and local morpholino treatment on the spinal muscular atrophy Δ7 mouse model phenotype.

Nizzardo M, Simone C, Salani S, Ruepp MD, Rizzo F, Ruggieri M, Zanetta C, Brajkovic S, Moulton HM, Müehlemann O, Bresolin N, Comi GP, Corti S.

Clin Ther. 2014 Mar 1;36(3):340-56.e5. doi: 10.1016/j.clinthera.2014.02.004.

PMID:
24636820
29.

Molecular, genetic and stem cell-mediated therapeutic strategies for spinal muscular atrophy (SMA).

Zanetta C, Riboldi G, Nizzardo M, Simone C, Faravelli I, Bresolin N, Comi GP, Corti S.

J Cell Mol Med. 2014 Feb;18(2):187-96. doi: 10.1111/jcmm.12224. Epub 2014 Jan 8. Review.

30.

iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development.

Faravelli I, Frattini E, Ramirez A, Stuppia G, Nizzardo M, Corti S.

J Clin Med. 2014 Oct 17;3(4):1124-45. doi: 10.3390/jcm3041124. Review.

31.

Molecular therapeutic strategies for spinal muscular atrophies: current and future clinical trials.

Zanetta C, Nizzardo M, Simone C, Monguzzi E, Bresolin N, Comi GP, Corti S.

Clin Ther. 2014 Jan 1;36(1):128-40. doi: 10.1016/j.clinthera.2013.11.006. Epub 2013 Dec 17. Review.

PMID:
24360800
32.

In vitro neurogenesis: development and functional implications of iPSC technology.

Compagnucci C, Nizzardo M, Corti S, Zanni G, Bertini E.

Cell Mol Life Sci. 2014 May;71(9):1623-39. doi: 10.1007/s00018-013-1511-1. Epub 2013 Nov 20. Review.

PMID:
24252976
33.

Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis.

Rizzo F, Riboldi G, Salani S, Nizzardo M, Simone C, Corti S, Hedlund E.

Cell Mol Life Sci. 2014 Mar;71(6):999-1015. doi: 10.1007/s00018-013-1480-4. Epub 2013 Oct 8. Review.

34.

Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model.

Nizzardo M, Simone C, Rizzo F, Ruggieri M, Salani S, Riboldi G, Faravelli I, Zanetta C, Bresolin N, Comi GP, Corti S.

Hum Mol Genet. 2014 Jan 15;23(2):342-54. doi: 10.1093/hmg/ddt425. Epub 2013 Sep 4.

35.

Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy.

Corti S, Nizzardo M, Simone C, Falcone M, Nardini M, Ronchi D, Donadoni C, Salani S, Riboldi G, Magri F, Menozzi G, Bonaglia C, Rizzo F, Bresolin N, Comi GP.

Sci Transl Med. 2012 Dec 19;4(165):165ra162. doi: 10.1126/scitranslmed.3004108.

36.

Riboflavin transporter 3 involvement in infantile Brown-Vialetto-Van Laere disease: two novel mutations.

Ciccolella M, Corti S, Catteruccia M, Petrini S, Tozzi G, Rizza T, Carrozzo R, Nizzardo M, Bordoni A, Ronchi D, D'Amico A, Rizzo C, Comi GP, Bertini E.

J Med Genet. 2013 Feb;50(2):104-7. doi: 10.1136/jmedgenet-2012-101204. Epub 2012 Dec 14.

PMID:
23243084
37.

Direct reprogramming of adult somatic cells into other lineages: past evidence and future perspectives.

Nizzardo M, Simone C, Falcone M, Riboldi G, Comi GP, Bresolin N, Corti S.

Cell Transplant. 2013;22(6):921-44. doi: 10.3727/096368912X657477. Epub 2012 Oct 3. Review.

38.

Direct reprogramming of human astrocytes into neural stem cells and neurons.

Corti S, Nizzardo M, Simone C, Falcone M, Donadoni C, Salani S, Rizzo F, Nardini M, Riboldi G, Magri F, Zanetta C, Faravelli I, Bresolin N, Comi GP.

Exp Cell Res. 2012 Aug 1;318(13):1528-41. doi: 10.1016/j.yexcr.2012.02.040. Epub 2012 Mar 8.

39.

Research advances in gene therapy approaches for the treatment of amyotrophic lateral sclerosis.

Nizzardo M, Simone C, Falcone M, Riboldi G, Rizzo F, Magri F, Bresolin N, Comi GP, Corti S.

Cell Mol Life Sci. 2012 May;69(10):1641-50. doi: 10.1007/s00018-011-0881-5. Epub 2011 Nov 18. Review.

PMID:
22094924
40.

Beta-lactam antibiotic offers neuroprotection in a spinal muscular atrophy model by multiple mechanisms: Experimental Neurology 2011; 229: 214-225.

Nizzardo M, Nardini M, Ronchi D, Salani S, Donadoni C, Fortunato F, Colciago G, Falcone M, Simone C, Riboldi G, Govoni A, Bresolin N, Comi GP, Corti S.

Ann Neurosci. 2011 Oct;18(4):156-7. doi: 10.5214/ans.0972.7531.1118407. No abstract available.

41.

ALS genetic modifiers that increase survival of SOD1 mice and are suitable for therapeutic development.

Riboldi G, Nizzardo M, Simone C, Falcone M, Bresolin N, Comi GP, Corti S.

Prog Neurobiol. 2011 Oct;95(2):133-48. doi: 10.1016/j.pneurobio.2011.07.009. Epub 2011 Jul 26. Review.

PMID:
21816207
42.

Beta-lactam antibiotic offers neuroprotection in a spinal muscular atrophy model by multiple mechanisms.

Nizzardo M, Nardini M, Ronchi D, Salani S, Donadoni C, Fortunato F, Colciago G, Falcone M, Simone C, Riboldi G, Govoni A, Bresolin N, Comi GP, Corti S.

Exp Neurol. 2011 Jun;229(2):214-25. doi: 10.1016/j.expneurol.2011.01.017. Epub 2011 Feb 2.

PMID:
21295027
43.

Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells.

Nizzardo M, Simone C, Falcone M, Locatelli F, Riboldi G, Comi GP, Corti S.

Cell Mol Life Sci. 2010 Nov;67(22):3837-47. doi: 10.1007/s00018-010-0463-y. Epub 2010 Jul 29. Review.

PMID:
20668908
44.

Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis.

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Simone C, Falcone M, Riboldi G, Govoni A, Bresolin N, Comi GP.

Hum Mol Genet. 2010 Oct 1;19(19):3782-96. doi: 10.1093/hmg/ddq293. Epub 2010 Jul 22.

PMID:
20650960
45.

Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice.

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Ronchi D, Simone C, Falcone M, Papadimitriou D, Locatelli F, Mezzina N, Gianni F, Bresolin N, Comi GP.

Brain. 2010 Feb;133(Pt 2):465-81. doi: 10.1093/brain/awp318. Epub 2009 Dec 23.

PMID:
20032086
46.

Motoneuron transplantation rescues the phenotype of SMARD1 (spinal muscular atrophy with respiratory distress type 1).

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Del Bo R, Papadimitriou D, Locatelli F, Mezzina N, Gianni F, Bresolin N, Comi GP.

J Neurosci. 2009 Sep 23;29(38):11761-71. doi: 10.1523/JNEUROSCI.2734-09.2009.

47.

The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.

Di Fonzo A, Ronchi D, Lodi T, Fassone E, Tigano M, Lamperti C, Corti S, Bordoni A, Fortunato F, Nizzardo M, Napoli L, Donadoni C, Salani S, Saladino F, Moggio M, Bresolin N, Ferrero I, Comi GP.

Am J Hum Genet. 2009 May;84(5):594-604. doi: 10.1016/j.ajhg.2009.04.004. Epub 2009 Apr 30.

48.

Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy.

Corti S, Nizzardo M, Nardini M, Donadoni C, Salani S, Ronchi D, Saladino F, Bordoni A, Fortunato F, Del Bo R, Papadimitriou D, Locatelli F, Menozzi G, Strazzer S, Bresolin N, Comi GP.

J Clin Invest. 2008 Oct;118(10):3316-30. doi: 10.1172/JCI35432.

49.

Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells.

Cecchinato V, Chiaramonte R, Nizzardo M, Cristofaro B, Basile A, Sherbet GV, Comi P.

Biochem Pharmacol. 2007 Dec 3;74(11):1568-74. Epub 2007 Aug 7.

PMID:
17868649
50.

Fas small interfering RNA reduces motoneuron death in amyotrophic lateral sclerosis mice.

Locatelli F, Corti S, Papadimitriou D, Fortunato F, Del Bo R, Donadoni C, Nizzardo M, Nardini M, Salani S, Ghezzi S, Strazzer S, Bresolin N, Comi GP.

Ann Neurol. 2007 Jul;62(1):81-92.

PMID:
17503505

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