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Items: 1 to 50 of 442

1.

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages.

Tsai CM, Riestra AM, Ali SR, Fong JJ, Liu JZ, Hughes G, Varki A, Nizet V.

J Innate Immun. 2019 Dec 5:1-11. doi: 10.1159/000504323. [Epub ahead of print]

2.

Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia.

Ulloa ER, Singh KV, Geriak M, Haddad F, Murray BE, Nizet V, Sakoulas G.

Clin Infect Dis. 2019 Nov 27. pii: ciz995. doi: 10.1093/cid/ciz995. [Epub ahead of print]

PMID:
31773134
3.

Erythrocyte-Coated Nanoparticles Block Cytotoxic Effects of Group B Streptococcus β-Hemolysin/Cytolysin.

Koo J, Escajadillo T, Zhang L, Nizet V, Lawrence SM.

Front Pediatr. 2019 Nov 1;7:410. doi: 10.3389/fped.2019.00410. eCollection 2019.

4.

Reply to Kalil et al., "Is Daptomycin plus Ceftaroline Associated with Better Clinical Outcomes than Standard of Care Monotherapy for Staphylococcus aureus Bacteremia?"

Sakoulas G, Geriak M, Haddad F, Rose W, LaPlante K, Zervos M, Kullar R, Nizet V.

Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e01347-19. doi: 10.1128/AAC.01347-19. Print 2019 Nov. No abstract available.

PMID:
31640978
5.

Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis.

Toledo AG, Golden G, Campos AR, Cuello H, Sorrentino J, Lewis N, Varki N, Nizet V, Smith JW, Esko JD.

Nat Commun. 2019 Oct 11;10(1):4656. doi: 10.1038/s41467-019-12672-x.

6.

Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease.

Gao NJ, Al-Bassam MM, Poudel S, Wozniak JM, Gonzalez DJ, Olson J, Zengler K, Nizet V, Valderrama JA.

Front Microbiol. 2019 Aug 22;10:1967. doi: 10.3389/fmicb.2019.01967. eCollection 2019.

7.

Strain-Specific Metabolic Requirements Revealed by a Defined Minimal Medium for Systems Analyses of Staphylococcus aureus.

Machado H, Weng LL, Dillon N, Seif Y, Holland M, Pekar JE, Monk JM, Nizet V, Palsson BO, Feist AM.

Appl Environ Microbiol. 2019 Oct 16;85(21). pii: e01773-19. doi: 10.1128/AEM.01773-19. Print 2019 Nov 1.

PMID:
31471305
8.

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.

Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC.

Elife. 2019 Aug 13;8. pii: e48609. doi: 10.7554/eLife.48609.

9.

IL-1β and IL-10 Host Responses in Patients with Staphylococcus aureus Bacteremia Determined by Antimicrobial Therapy.

Volk CF, Burgdorf S, Edwardson G, Nizet V, Sakoulas G, Rose WE.

Clin Infect Dis. 2019 Aug 1. pii: ciz686. doi: 10.1093/cid/ciz686. [Epub ahead of print]

PMID:
31365924
10.

Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens.

Dillon N, Holland M, Tsunemoto H, Hancock B, Cornax I, Pogliano J, Sakoulas G, Nizet V.

EBioMedicine. 2019 Aug;46:193-201. doi: 10.1016/j.ebiom.2019.07.041. Epub 2019 Jul 25.

11.

Inflammasome inhibition blocks cardiac glycoside cell toxicity.

LaRock DL, Sands JS, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN.

J Biol Chem. 2019 Aug 23;294(34):12846-12854. doi: 10.1074/jbc.RA119.008330. Epub 2019 Jul 12.

12.

Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin.

Dahesh S, Wong B, Nizet V, Sakoulas G, Tran TT, Aitken SL.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e02622-18. doi: 10.1128/AAC.02622-18. Print 2019 Jul.

PMID:
31235559
13.

Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli.

Patras KA, Ha AD, Rooholfada E, Olson J, Ramachandra Rao SP, Lin AE, Nizet V.

J Innate Immun. 2019;11(6):481-495. doi: 10.1159/000499342. Epub 2019 May 3.

14.

An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model.

Rivera-Hernandez T, Carnathan DG, Jones S, Cork AJ, Davies MR, Moyle PM, Toth I, Batzloff MR, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ.

MBio. 2019 Apr 30;10(2). pii: e00693-19. doi: 10.1128/mBio.00693-19.

15.

Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriological and physiological media.

Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Pogliano J, Knight R, Nizet V, Palsson BO, Feist AM.

Sci Data. 2019 Apr 26;6(1):43. doi: 10.1038/s41597-019-0051-4.

16.

Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion.

Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R.

Front Pharmacol. 2019 Apr 5;10:323. doi: 10.3389/fphar.2019.00323. eCollection 2019.

17.

Avibactam Sensitizes Carbapenem-Resistant NDM-1-Producing Klebsiella pneumoniae to Innate Immune Clearance.

Ulloa ER, Dillon N, Tsunemoto H, Pogliano J, Sakoulas G, Nizet V.

J Infect Dis. 2019 Jul 2;220(3):484-493. doi: 10.1093/infdis/jiz128.

18.

Proton-pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia.

Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G.

Therap Adv Gastroenterol. 2019 Mar 21;12:1756284819834273. doi: 10.1177/1756284819834273. eCollection 2019.

19.

The long noncoding RNA ROCKI regulates inflammatory gene expression.

Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM.

EMBO J. 2019 Apr 15;38(8). pii: e100041. doi: 10.15252/embj.2018100041. Epub 2019 Mar 27.

20.

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.

Uchiyama S, Sun J, Fukahori K, Ando N, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7465-7470. doi: 10.1073/pnas.1815572116. Epub 2019 Mar 25.

21.

Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia.

Geriak M, Haddad F, Rizvi K, Rose W, Kullar R, LaPlante K, Yu M, Vasina L, Ouellette K, Zervos M, Nizet V, Sakoulas G.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02483-18. doi: 10.1128/AAC.02483-18. Print 2019 May.

22.

Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry.

Bauman KD, Li J, Murata K, Mantovani SM, Dahesh S, Nizet V, Luhavaya H, Moore BS.

Cell Chem Biol. 2019 May 16;26(5):724-736.e7. doi: 10.1016/j.chembiol.2019.02.004. Epub 2019 Mar 7.

PMID:
30853419
23.

Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM.

Nerlich A, Lapschies AM, Kohler TP, Cornax I, Eichhorn I, Goldmann O, Krienke P, Bergmann S, Nizet V, Hammerschmidt S, Rohde M, Fulde M.

Virulence. 2019 Dec;10(1):194-206. doi: 10.1080/21505594.2019.1589362.

24.

Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells.

Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau3776. doi: 10.1126/scitranslmed.aau3776.

25.

Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia.

Walker MJ, Brouwer S, Forde BM, Worthing KA, McIntyre L, Sundac L, Maloney S, Roberts LW, Barnett TC, Richter J, Cork AJ, Irwin AD, You Y, Zhang J, Dougan G, Yuen KY, Nizet V, Beatson SA, Grimwood K, Davies MR.

Clin Infect Dis. 2019 Sep 13;69(7):1232-1234. doi: 10.1093/cid/ciz099.

PMID:
30721938
26.

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.

Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M.

Cell Death Differ. 2019 Mar;26(3):395-408. doi: 10.1038/s41418-018-0261-x. Epub 2019 Jan 8. Review.

PMID:
30622307
27.

Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria.

Huang YM, Munguia J, Miao Y, Nizet V, McCammon JA.

Chem Biol Drug Des. 2019 Apr;93(4):647-652. doi: 10.1111/cbdd.13462. Epub 2019 Feb 19.

PMID:
30570806
28.

Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection.

Escajadillo T, Nizet V.

Toxins (Basel). 2018 Dec 17;10(12). pii: E542. doi: 10.3390/toxins10120542. Review.

29.

Impact of Anesthetics on Human Neutrophil Function.

Meier A, Nizet V.

Anesth Analg. 2019 Mar;128(3):569-574. doi: 10.1213/ANE.0000000000003927.

PMID:
30507837
30.

Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection".

Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e02221-18. doi: 10.1128/AAC.02221-18. Print 2018 Dec. No abstract available.

31.

The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus.

Vrbanac A, Riestra AM, Coady A, Knight R, Nizet V, Patras KA.

BMC Microbiol. 2018 Nov 26;18(1):197. doi: 10.1186/s12866-018-1341-2.

32.

Enhanced topical delivery of non-complexed molecular iodine for Methicillin-resistant Staphylococcus aureus decolonization.

Uchiyama S, Dahesh S, Nizet V, Kessler J.

Int J Pharm. 2019 Jan 10;554:81-86. doi: 10.1016/j.ijpharm.2018.11.004. Epub 2018 Nov 2.

PMID:
30395958
33.

Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages.

Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V.

J Innate Immun. 2019;11(1):86-98. doi: 10.1159/000493585. Epub 2018 Nov 2.

34.

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.

Kavvas ES, Catoiu E, Mih N, Yurkovich JT, Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk JM, Palsson BO.

Nat Commun. 2018 Oct 17;9(1):4306. doi: 10.1038/s41467-018-06634-y.

35.

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects.

van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM.

PLoS Pathog. 2018 Oct 15;14(10):e1007348. doi: 10.1371/journal.ppat.1007348. eCollection 2018 Oct.

36.

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis.

Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD.

Cell Host Microbe. 2018 Oct 10;24(4):500-513.e5. doi: 10.1016/j.chom.2018.09.011.

37.

Tamm-Horsfall Protein Protects the Urinary Tract against Candida albicans.

Coady A, Ramos AR, Olson J, Nizet V, Patras KA.

Infect Immun. 2018 Nov 20;86(12). pii: e00451-18. doi: 10.1128/IAI.00451-18. Print 2018 Dec.

38.

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells.

Fong JJ, Tsai CM, Saha S, Nizet V, Varki A, Bui JD.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10410-10415. doi: 10.1073/pnas.1804108115. Epub 2018 Sep 25.

39.

Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of β-Lactam Antibiotics?

Sakoulas G, Geriak M, Nizet V.

Clin Infect Dis. 2019 Jan 1;68(1):157-164. doi: 10.1093/cid/ciy557.

40.

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera.

Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A.

PLoS Pathog. 2018 Jun 18;14(6):e1007133. doi: 10.1371/journal.ppat.1007133. eCollection 2018 Jun.

41.

Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors.

Askarian F, Wagner T, Johannessen M, Nizet V.

FEMS Microbiol Rev. 2018 Sep 1;42(5):656-671. doi: 10.1093/femsre/fuy025.

42.

Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance.

Patras KA, Derieux J, Al-Bassam MM, Adiletta N, Vrbanac A, Lapek JD, Zengler K, Gonzalez DJ, Nizet V.

J Infect Dis. 2018 Oct 5;218(10):1641-1652. doi: 10.1093/infdis/jiy341.

43.

Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.

Soderholm AT, Barnett TC, Korn O, Rivera-Hernandez T, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ.

Front Cell Infect Microbiol. 2018 May 17;8:160. doi: 10.3389/fcimb.2018.00160. eCollection 2018.

44.

Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device.

Kumaraswamy M, Collignon S, Do C, Kim J, Nizet V, Friend J.

Appl Microbiol Biotechnol. 2018 Aug;102(15):6459-6467. doi: 10.1007/s00253-018-9088-0. Epub 2018 May 26.

45.
46.

Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit.

Jati S, Kundu S, Chakraborty A, Mahata SK, Nizet V, Sen M.

Front Immunol. 2018 Apr 9;9:679. doi: 10.3389/fimmu.2018.00679. eCollection 2018.

47.

Multifactorial inhibition of lactobacilli against the respiratory tract pathogen Moraxella catarrhalis.

van den Broek MFL, De Boeck I, Claes IJJ, Nizet V, Lebeer S.

Benef Microbes. 2018 Apr 25;9(3):429-439. doi: 10.3920/BM2017.0101. Epub 2018 Apr 10.

PMID:
29633637
49.

Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.

Patras KA, Nizet V.

Front Pediatr. 2018 Feb 22;6:27. doi: 10.3389/fped.2018.00027. eCollection 2018. Review.

50.

Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models.

Askarian F, Lapek JD Jr, Dongre M, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh JP, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M.

Front Microbiol. 2018 Feb 20;9:262. doi: 10.3389/fmicb.2018.00262. eCollection 2018.

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