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Impact of Anesthetics on Human Neutrophil Function.

Meier A, Nizet V.

Anesth Analg. 2018 Nov 30. doi: 10.1213/ANE.0000000000003927. [Epub ahead of print]


Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection".

Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e02221-18. doi: 10.1128/AAC.02221-18. Print 2018 Dec. No abstract available.


The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus.

Vrbanac A, Riestra AM, Coady A, Knight R, Nizet V, Patras KA.

BMC Microbiol. 2018 Nov 26;18(1):197. doi: 10.1186/s12866-018-1341-2.


Enhanced topical delivery of non-complexed molecular iodine for Methicillin-resistant Staphylococcus aureus decolonization.

Uchiyama S, Dahesh S, Nizet V, Kessler J.

Int J Pharm. 2018 Nov 2;554:81-86. doi: 10.1016/j.ijpharm.2018.11.004. [Epub ahead of print]


Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages.

Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V.

J Innate Immun. 2018 Nov 2:1-13. doi: 10.1159/000493585. [Epub ahead of print]


Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance.

Kavvas ES, Catoiu E, Mih N, Yurkovich JT, Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk JM, Palsson BO.

Nat Commun. 2018 Oct 17;9(1):4306. doi: 10.1038/s41467-018-06634-y.


Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects.

van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM.

PLoS Pathog. 2018 Oct 15;14(10):e1007348. doi: 10.1371/journal.ppat.1007348. eCollection 2018 Oct.


Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis.

Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD.

Cell Host Microbe. 2018 Oct 10;24(4):500-513.e5. doi: 10.1016/j.chom.2018.09.011.


Tamm-Horsfall protein protects the urinary tract against Candida albicans.

Coady A, Ramos AR, Olson J, Nizet V, Patras KA.

Infect Immun. 2018 Oct 8. pii: IAI.00451-18. doi: 10.1128/IAI.00451-18. [Epub ahead of print]


Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells.

Fong JJ, Tsai CM, Saha S, Nizet V, Varki A, Bui JD.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10410-10415. doi: 10.1073/pnas.1804108115. Epub 2018 Sep 25.


Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of β-Lactam Antibiotics?

Sakoulas G, Geriak M, Nizet V.

Clin Infect Dis. 2018 Jul 9. doi: 10.1093/cid/ciy557. [Epub ahead of print]


Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera.

Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A.

PLoS Pathog. 2018 Jun 18;14(6):e1007133. doi: 10.1371/journal.ppat.1007133. eCollection 2018 Jun.


Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors.

Askarian F, Wagner T, Johannessen M, Nizet V.

FEMS Microbiol Rev. 2018 Sep 1;42(5):656-671. doi: 10.1093/femsre/fuy025.


Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance.

Patras KA, Derieux J, Al-Bassam MM, Adiletta N, Vrbanac A, Lapek JD, Zengler K, Gonzalez DJ, Nizet V.

J Infect Dis. 2018 Oct 5;218(10):1641-1652. doi: 10.1093/infdis/jiy341.


Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.

Soderholm AT, Barnett TC, Korn O, Rivera-Hernandez T, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ.

Front Cell Infect Microbiol. 2018 May 17;8:160. doi: 10.3389/fcimb.2018.00160. eCollection 2018.


Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device.

Kumaraswamy M, Collignon S, Do C, Kim J, Nizet V, Friend J.

Appl Microbiol Biotechnol. 2018 Aug;102(15):6459-6467. doi: 10.1007/s00253-018-9088-0. Epub 2018 May 26.


Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit.

Jati S, Kundu S, Chakraborty A, Mahata SK, Nizet V, Sen M.

Front Immunol. 2018 Apr 9;9:679. doi: 10.3389/fimmu.2018.00679. eCollection 2018.


Multifactorial inhibition of lactobacilli against the respiratory tract pathogen Moraxella catarrhalis.

van den Broek MFL, De Boeck I, Claes IJJ, Nizet V, Lebeer S.

Benef Microbes. 2018 Apr 25;9(3):429-439. doi: 10.3920/BM2017.0101. Epub 2018 Apr 10.


Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.

Patras KA, Nizet V.

Front Pediatr. 2018 Feb 22;6:27. doi: 10.3389/fped.2018.00027. eCollection 2018. Review.


Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models.

Askarian F, Lapek JD Jr, Dongre M, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh JP, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M.

Front Microbiol. 2018 Feb 20;9:262. doi: 10.3389/fmicb.2018.00262. eCollection 2018.


SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity.

Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R.

J Antimicrob Chemother. 2018 Jun 1;73(6):1586-1594. doi: 10.1093/jac/dky033.


Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa.

Haripriyan J, Omanakuttan A, Menon ND, Vanuopadath M, Nair SS, Corriden R, Nair BG, Nizet V, Kumar GB.

Sci Rep. 2018 Feb 21;8(1):3437. doi: 10.1038/s41598-018-19771-7.


The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis.

Lawrence SM, Corriden R, Nizet V.

Microbiol Mol Biol Rev. 2018 Feb 7;82(1). pii: e00057-17. doi: 10.1128/MMBR.00057-17. Print 2018 Jun. Review.


Broad-Spectrum Neutralization of Pore-Forming Toxins with Human Erythrocyte Membrane-Coated Nanosponges.

Chen Y, Chen M, Zhang Y, Lee JH, Escajadillo T, Gong H, Fang RH, Gao W, Nizet V, Zhang L.

Adv Healthc Mater. 2018 Jul;7(13):e1701366. doi: 10.1002/adhm.201701366. Epub 2018 Feb 13.


Innate Immune Interactions between Bacillus anthracis and Host Neutrophils.

Liu JZ, Ali SR, Bier E, Nizet V.

Front Cell Infect Microbiol. 2018 Jan 22;8:2. doi: 10.3389/fcimb.2018.00002. eCollection 2018.


The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia.

Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH.

Stem Cells. 2018 May;36(5):796-806. doi: 10.1002/stem.2796. Epub 2018 Feb 14.


Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance.

Choe D, Szubin R, Dahesh S, Cho S, Nizet V, Palsson B, Cho BK.

Sci Rep. 2018 Feb 2;8(1):2215. doi: 10.1038/s41598-018-20661-1.


Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus.

Henningham A, Davies MR, Uchiyama S, van Sorge NM, Lund S, Chen KT, Walker MJ, Cole JN, Nizet V.

MBio. 2018 Jan 30;9(1). pii: e02294-17. doi: 10.1128/mBio.02294-17.


Listeria monocytogenes endocarditis: case report, review of the literature, and laboratory evaluation of potential novel antibiotic synergies.

Kumaraswamy M, Do C, Sakoulas G, Nonejuie P, Tseng GW, King H, Fierer J, Pogliano J, Nizet V.

Int J Antimicrob Agents. 2018 Mar;51(3):468-478. doi: 10.1016/j.ijantimicag.2017.12.032. Epub 2018 Jan 11. Review.


Recurrent infection progressively disables host protection against intestinal inflammation.

Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD.

Science. 2017 Dec 22;358(6370). pii: eaao5610. doi: 10.1126/science.aao5610.


Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms.

Catteau L, Reichmann NT, Olson J, Pinho MG, Nizet V, Van Bambeke F, Quetin-Leclercq J.

Molecules. 2017 Dec 16;22(12). pii: E2245. doi: 10.3390/molecules22122245.


Telavancin for refractory MRSA bacteraemia in intermittent haemodialysis recipients.

Britt NS, Tirmizi S, Ritchie DJ, Topal JE, McManus D, Nizet V, Casabar E, Sakoulas G.

J Antimicrob Chemother. 2017 Dec 13. doi: 10.1093/jac/dkx437. [Epub ahead of print]


Interaction of Antibiotics with Innate Host Defense Factors against Salmonella enterica Serotype Newport.

Sakoulas G, Kumaraswamy M, Kousha A, Nizet V.

mSphere. 2017 Dec 6;2(6). pii: e00410-17. doi: 10.1128/mSphere.00410-17. eCollection 2017 Nov-Dec.


Group A Streptococcus encounters with host macrophages.

Valderrama JA, Nizet V.

Future Microbiol. 2018 Jan;13:119-134. doi: 10.2217/fmb-2017-0142. Epub 2017 Dec 11. Review.


Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway.

Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L.

J Nat Prod. 2018 Mar 23;81(3):506-514. doi: 10.1021/acs.jnatprod.7b00734. Epub 2017 Dec 7.


Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster.

Reynolds KA, Luhavaya H, Li J, Dahesh S, Nizet V, Yamanaka K, Moore BS.

J Antibiot (Tokyo). 2018 Feb;71(2):333-338. doi: 10.1038/ja.2017.146. Epub 2017 Nov 29.


Self-Assembled Colloidal Gel Using Cell Membrane-Coated Nanosponges as Building Blocks.

Zhang Y, Gao W, Chen Y, Escajadillo T, Ungerleider J, Fang RH, Christman K, Nizet V, Zhang L.

ACS Nano. 2017 Dec 26;11(12):11923-11930. doi: 10.1021/acsnano.7b06968. Epub 2017 Nov 10.


Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis.

Andreoni F, Ugolini F, Keller N, Neff A, Nizet V, Hollands A, Marques Maggio E, Zinkernagel AS, Schuepbach RA.

J Infect Dis. 2018 Jan 4;217(2):270-279. doi: 10.1093/infdis/jix560.


Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management.

Thamphiwatana S, Angsantikul P, Escajadillo T, Zhang Q, Olson J, Luk BT, Zhang S, Fang RH, Gao W, Nizet V, Zhang L.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11488-11493. doi: 10.1073/pnas.1714267114. Epub 2017 Oct 9.


Modeling neuro-immune interactions during Zika virus infection.

Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, de A Zanotto PM, Beltrão-Braga PCB, Nizet V, Muotri AR.

Hum Mol Genet. 2018 Jan 1;27(1):41-52. doi: 10.1093/hmg/ddx382.


Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport.

Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E.

PLoS Pathog. 2017 Sep 25;13(9):e1006603. doi: 10.1371/journal.ppat.1006603. eCollection 2017 Sep.


Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions.

Sun J, Lei L, Tsai CM, Wang Y, Shi Y, Ouyang M, Lu S, Seong J, Kim TJ, Wang P, Huang M, Xu X, Nizet V, Chien S, Wang Y.

Nat Commun. 2017 Sep 7;8(1):477. doi: 10.1038/s41467-017-00569-6.


Microbial Lectins: Hemagglutinins, Adhesins, and Toxins.

Nizet V, Varki A, Aebi M.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 37.


The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance.

Munguia J, LaRock DL, Tsunemoto H, Olson J, Cornax I, Pogliano J, Nizet V.

J Mol Med (Berl). 2017 Oct;95(10):1127-1136. doi: 10.1007/s00109-017-1579-4. Epub 2017 Aug 26.


Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract.

Patras KA, Coady A, Olson J, Ali SR, RamachandraRao SP, Kumar S, Varki A, Nizet V.

Immunol Cell Biol. 2017 Nov;95(10):960-965. doi: 10.1038/icb.2017.63. Epub 2017 Aug 22.


Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection.

Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00954-17. doi: 10.1128/AAC.00954-17. Print 2017 Oct. Erratum in: Antimicrob Agents Chemother. 2018 Nov 26;62(12):.


Group A streptococcal M protein activates the NLRP3 inflammasome.

Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V.

Nat Microbiol. 2017 Oct;2(10):1425-1434. doi: 10.1038/s41564-017-0005-6. Epub 2017 Aug 7.


IL-1β is an innate immune sensor of microbial proteolysis.

LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AAB, Cooper MA, Hoffman HM, Nizet V.

Sci Immunol. 2016 Aug 19;1(2):eaah3539. doi: 10.1126/sciimmunol.aah3539. Epub 2016 Aug 19.


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