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Items: 43

1.

Targeted delivery of cytotoxic NAMPT inhibitors using antibody-drug conjugates.

Neumann CS, Olivas KC, Anderson ME, Cochran JH, Jin S, Li F, Loftus LV, Meyer DW, Neale J, Nix JC, Pittman PG, Simmons JK, Ulrich ML, Waight AB, Wong A, Zaval MC, Zeng W, Lyon RP, Senter PD.

Mol Cancer Ther. 2018 Sep 21. pii: molcanther.0643.2018. doi: 10.1158/1535-7163.MCT-18-0643. [Epub ahead of print]

PMID:
30242091
2.

A Noncanonical Metal Center Drives the Activity of the Sediminispirochaeta smaragdinae Metallo-β-lactamase SPS-1.

Cheng Z, VanPelt J, Bergstrom A, Bethel C, Katko A, Miller C, Mason K, Cumming E, Zhang H, Kimble RL, Fullington S, Bretz SL, Nix JC, Bonomo RA, Tierney DL, Page RC, Crowder MW.

Biochemistry. 2018 Sep 4;57(35):5218-5229. doi: 10.1021/acs.biochem.8b00728. Epub 2018 Aug 21.

PMID:
30106565
3.

A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure.

Steckelberg AL, Akiyama BM, Costantino DA, Sit TL, Nix JC, Kieft JS.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6404-6409. doi: 10.1073/pnas.1802429115. Epub 2018 Jun 4.

PMID:
29866852
4.

Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity.

Stewart AC, Bethel CR, VanPelt J, Bergstrom A, Cheng Z, Miller CG, Williams C, Poth R, Morris M, Lahey O, Nix JC, Tierney DL, Page RC, Crowder MW, Bonomo RA, Fast W.

ACS Infect Dis. 2017 Dec 8;3(12):927-940. doi: 10.1021/acsinfecdis.7b00128. Epub 2017 Oct 11.

5.

Neutron and Atomic Resolution X-ray Structures of a Lytic Polysaccharide Monooxygenase Reveal Copper-Mediated Dioxygen Binding and Evidence for N-Terminal Deprotonation.

Bacik JP, Mekasha S, Forsberg Z, Kovalevsky AY, Vaaje-Kolstad G, Eijsink VGH, Nix JC, Coates L, Cuneo MJ, Unkefer CJ, Chen JC.

Biochemistry. 2017 May 23;56(20):2529-2532. doi: 10.1021/acs.biochem.7b00019. Epub 2017 May 11.

PMID:
28481095
6.

Synchrotron-based macromolecular crystallography module for an undergraduate biochemistry laboratory course.

Stiers KM, Lee CB, Nix JC, Tanner JJ, Beamer LJ.

J Appl Crystallogr. 2016 Nov 24;49(Pt 6):2235-2243. eCollection 2016 Dec 1.

7.

Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.

Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS.

Science. 2016 Dec 2;354(6316):1148-1152. Epub 2016 Nov 10.

8.

Structural Insights into Substrate Recognition by Clostridium difficile Sortase.

Yin JC, Fei CH, Lo YC, Hsiao YY, Chang JC, Nix JC, Chang YY, Yang LW, Huang IH, Wang S.

Front Cell Infect Microbiol. 2016 Nov 22;6:160. eCollection 2016.

9.

Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.

Brosey CA, Ho C, Long WZ, Singh S, Burnett K, Hura GL, Nix JC, Bowman GR, Ellenberger T, Tainer JA.

Structure. 2016 Dec 6;24(12):2067-2079. doi: 10.1016/j.str.2016.09.012. Epub 2016 Nov 3.

10.

The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase.

Godsey MH, Davulcu O, Nix JC, Skalicky JJ, Brüschweiler RP, Chapman MS.

Structure. 2016 Oct 4;24(10):1658-1667. doi: 10.1016/j.str.2016.07.013. Epub 2016 Sep 1.

11.

Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.

Matulef K, Annen AW, Nix JC, Valiyaveetil FI.

Structure. 2016 May 3;24(5):750-761. doi: 10.1016/j.str.2016.02.021. Epub 2016 Apr 14.

12.

Investigating the Impact of Polymer Functional Groups on the Stability and Activity of Lysozyme-Polymer Conjugates.

Lucius M, Falatach R, McGlone C, Makaroff K, Danielson A, Williams C, Nix JC, Konkolewicz D, Page RC, Berberich JA.

Biomacromolecules. 2016 Mar 14;17(3):1123-34. doi: 10.1021/acs.biomac.5b01743. Epub 2016 Feb 26.

PMID:
26866284
13.

Neutron and high-resolution room-temperature X-ray data collection from crystallized lytic polysaccharide monooxygenase.

Bacik JP, Mekasha S, Forsberg Z, Kovalevsky A, Nix JC, Cuneo MJ, Coates L, Vaaje-Kolstad G, Chen JC, Eijsink VG, Unkefer CJ.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1448-52. doi: 10.1107/S2053230X15019743. Epub 2015 Oct 30.

14.

A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins.

Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC.

Structure. 2015 Mar 3;23(3):472-482. doi: 10.1016/j.str.2015.01.003. Epub 2015 Feb 12.

15.

Biochemical, mechanistic, and spectroscopic characterization of metallo-β-lactamase VIM-2.

Aitha M, Marts AR, Bergstrom A, Møller AJ, Moritz L, Turner L, Nix JC, Bonomo RA, Page RC, Tierney DL, Crowder MW.

Biochemistry. 2014 Nov 25;53(46):7321-31. doi: 10.1021/bi500916y. Epub 2014 Nov 13.

16.

The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA.

Colussi TM, Costantino DA, Hammond JA, Ruehle GM, Nix JC, Kieft JS.

Nature. 2014 Jul 17;511(7509):366-9. doi: 10.1038/nature13378. Epub 2014 Jun 8.

17.

The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production.

Chapman EG, Costantino DA, Rabe JL, Moon SL, Wilusz J, Nix JC, Kieft JS.

Science. 2014 Apr 18;344(6181):307-10. doi: 10.1126/science.1250897.

18.

Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.

Amick J, Schlanger SE, Wachnowsky C, Moseng MA, Emerson CC, Dare M, Luo WI, Ithychanda SS, Nix JC, Cowan JA, Page RC, Misra S.

Protein Sci. 2014 Jun;23(6):833-42. doi: 10.1002/pro.2466. Epub 2014 Apr 17.

19.

Distinct structural features of the peroxide response regulator from group A Streptococcus drive DNA binding.

Lin CS, Chao SY, Hammel M, Nix JC, Tseng HL, Tsou CC, Fei CH, Chiou HS, Jeng US, Lin YS, Chuang WJ, Wu JJ, Wang S.

PLoS One. 2014 Feb 21;9(2):e89027. doi: 10.1371/journal.pone.0089027. eCollection 2014.

20.

Nuclear resonance vibrational spectroscopy (NRVS) of rubredoxin and MoFe protein crystals.

Guo Y, Brecht E, Aznavour K, Nix JC, Xiao Y, Wang H, George SJ, Bau R, Keable S, Peters JW, Adams MW, Jenney F, Sturhahn W, Alp EE, Zhao J, Yoda Y, Cramer SP.

Hyperfine Interact. 2013 Dec;222(2 Suppl):77-90.

21.

Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII).

Zheng C, Page RC, Das V, Nix JC, Wigren E, Misra S, Zhang B.

J Biol Chem. 2013 Jul 12;288(28):20499-509. doi: 10.1074/jbc.M113.461434. Epub 2013 May 24.

22.

Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts.

Gong P, Kortus MG, Nix JC, Davis RE, Peersen OB.

PLoS One. 2013 May 8;8(5):e60272. doi: 10.1371/journal.pone.0060272. Print 2013.

23.

Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus.

Page RC, Xu Z, Amick J, Nix JC, Misra S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):647-51. doi: 10.1107/S1744309112013267. Epub 2012 May 23.

24.

Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.

Joseph RE, Ginder ND, Hoy JA, Nix JC, Fulton DB, Honzatko RB, Andreotti AH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):145-53. doi: 10.1107/S1744309111049761. Epub 2012 Jan 25.

25.

Crystal structures and small-angle x-ray scattering analysis of UDP-galactopyranose mutase from the pathogenic fungus Aspergillus fumigatus.

Dhatwalia R, Singh H, Oppenheimer M, Karr DB, Nix JC, Sobrado P, Tanner JJ.

J Biol Chem. 2012 Mar 16;287(12):9041-51. doi: 10.1074/jbc.M111.327536. Epub 2012 Jan 31.

26.

Crystal structures of Parasponia and Trema hemoglobins: differential heme coordination is linked to quaternary structure.

Kakar S, Sturms R, Tiffany A, Nix JC, DiSpirito AA, Hargrove MS.

Biochemistry. 2011 May 24;50(20):4273-80. doi: 10.1021/bi2002423. Epub 2011 Apr 27.

PMID:
21491905
27.

Purification, crystallization and preliminary crystallographic analysis of the SH2 domain of IL-2-inducible T-cell kinase.

Joseph RE, Ginder ND, Hoy JA, Nix JC, Honzatko RB, Andreotti AH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):269-73. doi: 10.1107/S1744309110052346. Epub 2011 Jan 27.

28.

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):689-92. doi: 10.1107/S1744309110013266. Epub 2010 May 27.

29.

Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin.

Smith L, Page RC, Xu Z, Kohli E, Litman P, Nix JC, Ithychanda SS, Liu J, Qin J, Misra S, Liedtke CM.

J Biol Chem. 2010 May 28;285(22):17166-76. doi: 10.1074/jbc.M109.080911. Epub 2010 Mar 29.

30.

Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.

Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG.

J Mol Biol. 2010 May 14;398(4):489-96. doi: 10.1016/j.jmb.2010.03.024. Epub 2010 Mar 20.

31.

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.

Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK.

Nat Struct Mol Biol. 2010 Feb;17(2):165-72. doi: 10.1038/nsmb.1765. Epub 2010 Jan 17.

32.

Structural analysis and DNA binding of the HMG domains of the human mitochondrial transcription factor A.

Gangelhoff TA, Mungalachetty PS, Nix JC, Churchill ME.

Nucleic Acids Res. 2009 Jun;37(10):3153-64. doi: 10.1093/nar/gkp157. Epub 2009 Mar 20.

33.

Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.

Leung DW, Ginder ND, Nix JC, Basler CF, Honzatko RB, Amarasinghe GK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):163-5. doi: 10.1107/S1744309108044187. Epub 2009 Jan 31.

34.

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.

Xu Z, Page RC, Gomes MM, Kohli E, Nix JC, Herr AB, Patterson C, Misra S.

Nat Struct Mol Biol. 2008 Dec;15(12):1309-17. doi: 10.1038/nsmb.1518. Epub 2008 Nov 23.

35.

Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA.

Zhou Y, Larson JD, Bottoms CA, Arturo EC, Henzl MT, Jenkins JL, Nix JC, Becker DF, Tanner JJ.

J Mol Biol. 2008 Aug 1;381(1):174-88. doi: 10.1016/j.jmb.2008.05.084. Epub 2008 Jun 7.

36.

Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes.

Xu Z, Kohli E, Devlin KI, Bold M, Nix JC, Misra S.

BMC Struct Biol. 2008 May 16;8:26. doi: 10.1186/1472-6807-8-26.

37.

The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH.

Thode AB, Kruse SW, Nix JC, Jones DN.

J Mol Biol. 2008 Mar 7;376(5):1360-76. doi: 10.1016/j.jmb.2007.12.063. Epub 2008 Jan 5.

38.

Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition.

Hines JK, Chen X, Nix JC, Fromm HJ, Honzatko RB.

J Biol Chem. 2007 Dec 7;282(49):36121-31. Epub 2007 Oct 12.

39.

Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase.

Ou Z, Felts RL, Reilly TJ, Nix JC, Tanner JJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt 5):464-6. Epub 2006 Apr 21.

40.

Structure and interactions of the helical and U-box domains of CHIP, the C terminus of HSP70 interacting protein.

Xu Z, Devlin KI, Ford MG, Nix JC, Qin J, Misra S.

Biochemistry. 2006 Apr 18;45(15):4749-59.

PMID:
16605243
41.

Closure of long surgical incisions with a new formulation of 2-octylcyanoacrylate tissue adhesive versus commercially available methods.

Blondeel PN, Murphy JW, Debrosse D, Nix JC 3rd, Puls LE, Theodore N, Coulthard P.

Am J Surg. 2004 Sep;188(3):307-13.

PMID:
15450839
42.

The structural basis for molecular recognition by the vitamin B 12 RNA aptamer.

Sussman D, Nix JC, Wilson C.

Nat Struct Biol. 2000 Jan;7(1):53-7.

PMID:
10625428
43.

Preliminary crystallographic characterization of an in vitro evolved biotin-binding RNA pseudoknot.

Nix JC, Newhoff AR, Wilson C.

Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):323-5. Epub 1999 Jan 1.

PMID:
10089439

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