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Items: 28


PML nuclear bodies, membrane-less domains acting as ROS sensors?

Niwa-Kawakita M, Wu HC, Thé H, Lallemand-Breitenbach V.

Semin Cell Dev Biol. 2018 Aug;80:29-34. doi: 10.1016/j.semcdb.2017.11.007. Epub 2017 Nov 20. Review.


PML is a ROS sensor activating p53 upon oxidative stress.

Niwa-Kawakita M, Ferhi O, Soilihi H, Le Bras M, Lallemand-Breitenbach V, de Thé H.

J Exp Med. 2017 Nov 6;214(11):3197-3206. doi: 10.1084/jem.20160301. Epub 2017 Sep 20.


PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss.

Peyre M, Salaud C, Clermont-Taranchon E, Niwa-Kawakita M, Goutagny S, Mawrin C, Giovannini M, Kalamarides M.

Oncotarget. 2015 Oct 20;6(32):32713-22. doi: 10.18632/oncotarget.5296.


Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins.

Sahin U, Ferhi O, Jeanne M, Benhenda S, Berthier C, Jollivet F, Niwa-Kawakita M, Faklaris O, Setterblad N, de Thé H, Lallemand-Breitenbach V.

J Cell Biol. 2014 Mar 17;204(6):931-45. doi: 10.1083/jcb.201305148.


Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.

Tanaka K, Eskin A, Chareyre F, Jessen WJ, Manent J, Niwa-Kawakita M, Chen R, White CH, Vitte J, Jaffer ZM, Nelson SF, Rubenstein AE, Giovannini M.

Clin Cancer Res. 2013 Jul 15;19(14):3856-70. doi: 10.1158/1078-0432.CCR-12-3167. Epub 2013 May 28.


Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy.

Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schröder JM, Gutmann DH, Giovannini M, Morrison H.

Nat Neurosci. 2013 Apr;16(4):426-33. doi: 10.1038/nn.3348. Epub 2013 Mar 3.


MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.

Jessen WJ, Miller SJ, Jousma E, Wu J, Rizvi TA, Brundage ME, Eaves D, Widemann B, Kim MO, Dombi E, Sabo J, Hardiman Dudley A, Niwa-Kawakita M, Page GP, Giovannini M, Aronow BJ, Cripe TP, Ratner N.

J Clin Invest. 2013 Jan;123(1):340-7. doi: 10.1172/JCI60578. Epub 2012 Dec 10.


Meningioma progression in mice triggered by Nf2 and Cdkn2ab inactivation.

Peyre M, Stemmer-Rachamimov A, Clermont-Taranchon E, Quentin S, El-Taraya N, Walczak C, Volk A, Niwa-Kawakita M, Karboul N, Giovannini M, Kalamarides M.

Oncogene. 2013 Sep 5;32(36):4264-72. doi: 10.1038/onc.2012.436. Epub 2012 Oct 8.


Protein 4.1B contributes to the organization of peripheral myelinated axons.

Cifuentes-Diaz C, Chareyre F, Garcia M, Devaux J, Carnaud M, Levasseur G, Niwa-Kawakita M, Harroch S, Girault JA, Giovannini M, Goutebroze L.

PLoS One. 2011;6(9):e25043. doi: 10.1371/journal.pone.0025043. Epub 2011 Sep 26.


Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes.

Kalamarides M, Stemmer-Rachamimov AO, Niwa-Kawakita M, Chareyre F, Taranchon E, Han ZY, Martinelli C, Lusis EA, Hegedus B, Gutmann DH, Giovannini M.

Oncogene. 2011 May 19;30(20):2333-44. doi: 10.1038/onc.2010.609. Epub 2011 Jan 17.


Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations.

Boulday G, Blécon A, Petit N, Chareyre F, Garcia LA, Niwa-Kawakita M, Giovannini M, Tournier-Lasserve E.

Dis Model Mech. 2009 Mar-Apr;2(3-4):168-77. doi: 10.1242/dmm.001263. Epub 2009 Feb 2.


Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

Lallemand D, Manent J, Couvelard A, Watilliaux A, Siena M, Chareyre F, Lampin A, Niwa-Kawakita M, Kalamarides M, Giovannini M.

Oncogene. 2009 Feb 12;28(6):854-65. doi: 10.1038/onc.2008.427. Epub 2008 Nov 24.


Tumor suppressor schwannomin/merlin is critical for the organization of Schwann cell contacts in peripheral nerves.

Denisenko N, Cifuentes-Diaz C, Irinopoulou T, Carnaud M, Benoit E, Niwa-Kawakita M, Chareyre F, Giovannini M, Girault JA, Goutebroze L.

J Neurosci. 2008 Oct 15;28(42):10472-81. doi: 10.1523/JNEUROSCI.2537-08.2008.


Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice.

Meinzer U, Esmiol-Welterlin S, Barreau F, Berrebi D, Dussaillant M, Bonacorsi S, Chareyre F, Niwa-Kawakita M, Alberti C, Sterkers G, Villard C, Lesuffleur T, Peuchmaur M, Karin M, Eckmann L, Giovannini M, Ollendorff V, Wolf-Watz H, Hugot JP.

PLoS One. 2008 Jul 23;3(7):e2769. doi: 10.1371/journal.pone.0002769.


Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.

Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T.

Nat Genet. 2008 May;40(5):600-8. doi: 10.1038/ng.115. Epub 2008 Mar 30.


Natural history of meningioma development in mice reveals: a synergy of Nf2 and p16(Ink4a) mutations.

Kalamarides M, Stemmer-Rachamimov AO, Takahashi M, Han ZY, Chareyre F, Niwa-Kawakita M, Black PM, Carroll RS, Giovannini M.

Brain Pathol. 2008 Jan;18(1):62-70. Epub 2007 Oct 9.


CARD15/NOD2 is required for Peyer's patches homeostasis in mice.

Barreau F, Meinzer U, Chareyre F, Berrebi D, Niwa-Kawakita M, Dussaillant M, Foligne B, Ollendorff V, Heyman M, Bonacorsi S, Lesuffleur T, Sterkers G, Giovannini M, Hugot JP.

PLoS One. 2007 Jun 13;2(6):e523.


Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine.

Andreu P, Colnot S, Godard C, Gad S, Chafey P, Niwa-Kawakita M, Laurent-Puig P, Kahn A, Robine S, Perret C, Romagnolo B.

Development. 2005 Mar;132(6):1443-51. Epub 2005 Feb 16.


Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas.

Colnot S, Decaens T, Niwa-Kawakita M, Godard C, Hamard G, Kahn A, Giovannini M, Perret C.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17216-21. Epub 2004 Nov 24.


Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.

Colnot S, Niwa-Kawakita M, Hamard G, Godard C, Le Plenier S, Houbron C, Romagnolo B, Berrebi D, Giovannini M, Perret C.

Lab Invest. 2004 Dec;84(12):1619-30.


Synergy of Nf2 and p53 mutations in development of malignant tumours of neural crest origin.

Robanus-Maandag E, Giovannini M, van der Valk M, Niwa-Kawakita M, Abramowski V, Antonescu C, Thomas G, Berns A.

Oncogene. 2004 Aug 26;23(39):6541-7.


Comparative pathology of nerve sheath tumors in mouse models and humans.

Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Reilly KM, Zhu Y, Giovannini M.

Cancer Res. 2004 May 15;64(10):3718-24.


Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles.

Leneuve P, Colnot S, Hamard G, Francis F, Niwa-Kawakita M, Giovannini M, Holzenberger M.

Nucleic Acids Res. 2003 Mar 1;31(5):e21.


Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse.

Kalamarides M, Niwa-Kawakita M, Leblois H, Abramowski V, Perricaudet M, Janin A, Thomas G, Gutmann DH, Giovannini M.

Genes Dev. 2002 May 1;16(9):1060-5.


Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

Giovannini M, Robanus-Maandag E, van der Valk M, Niwa-Kawakita M, Abramowski V, Goutebroze L, Woodruff JM, Berns A, Thomas G.

Genes Dev. 2000 Jul 1;14(13):1617-30.


Targeted expression of Cre recombinase to myelinating cells of the central nervous system in transgenic mice.

Niwa-Kawakita M, Abramowski V, Kalamarides M, Thomas G, Giovannini M.

Genesis. 2000 Feb;26(2):127-9. No abstract available.


Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein.

Giovannini M, Robanus-Maandag E, Niwa-Kawakita M, van der Valk M, Woodruff JM, Goutebroze L, Mérel P, Berns A, Thomas G.

Genes Dev. 1999 Apr 15;13(8):978-86.


Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia.

Niwa-Kawakita M, Miyoshi H, Gotoh O, Matsushima Y, Nishimura M, Shisa H, Ohki M.

Genomics. 1995 Oct 10;29(3):755-9.


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