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Carboplatin Plus Nab-paclitaxel in Performance Status 2 Patients With Advanced Non-small-cell Lung Cancer.

Nakashima K, Akamatsu H, Murakami H, Niwa T, Iwamoto Y, Ozawa Y, Yokoyama T, Shoda H, Yamamoto N, Yoshioka H, Masuda K, Naito T, Mori K, Takahashi T.

Anticancer Res. 2019 Mar;39(3):1463-1468. doi: 10.21873/anticanres.13263.


Clinical impact of matrix-assisted laser desorption ionization-time of flight mass spectrometry combined with antimicrobial stewardship interventions in patients with bloodstream infections in a Japanese tertiary hospital.

Niwa T, Yonetamari J, Hayama N, Fujibayashi A, Ito-Takeichi S, Suzuki K, Ohta H, Niwa A, Tsuchiya M, Yamamoto M, Hatakeyama D, Hayashi H, Obara M, Sugiyama T, Baba H, Suzuki A, Murakami N.

Int J Clin Pract. 2019 Feb 27:e13332. doi: 10.1111/ijcp.13332. [Epub ahead of print]


Risk factors for decreased teicoplanin trough concentrations during initial dosing in critically ill patients.

Yoshida T, Yoshida S, Okada H, Suzuki A, Niwa T, Suzuki K, Ohmori T, Kobayashi R, Baba H, Suzuki K, Murakami N, Itoh Y, Ogura S.

Pharmazie. 2019 Feb 1;74(2):120-124. doi: 10.1619/ph.2019.8731.


Low starting-dosage of nintedanib for the reduction of early termination.

Ikeda S, Sekine A, Baba T, Katano T, Tabata E, Shintani R, Yamakawa H, Niwa T, Oda T, Okuda R, Kitamura H, Ogura T.

Respir Investig. 2019 Feb 13. pii: S2212-5345(18)30305-8. doi: 10.1016/j.resinv.2018.12.010. [Epub ahead of print] No abstract available.


The impact of implementing an antifungal stewardship with monitoring of 1-3, β-D-glucan values on antifungal consumption and clinical outcomes.

Ito-Takeichi S, Niwa T, Fujibayashi A, Suzuki K, Ohta H, Niwa A, Tsuchiya M, Yamamoto M, Hatakeyama D, Suzuki A, Baba H, Murakami N, Itoh Y.

J Clin Pharm Ther. 2019 Feb 5. doi: 10.1111/jcpt.12809. [Epub ahead of print]


Cancer stem-like properties of hormonal therapy-resistant breast cancer cells.

Uchiumi K, Tsuboi K, Sato N, Ito T, Hirakawa H, Niwa T, Yamaguchi Y, Hayashi SI.

Breast Cancer. 2019 Jan 4. doi: 10.1007/s12282-018-00944-1. [Epub ahead of print]


Rapid attainment of target trough concentrations of tacrolimus for early improvement of clinical symptoms in patients with ulcerative colitis.

Yamada Y, Ohno Y, Niwa T, Kato-Hayashi H, Hayashi H, Ibuka T, Araki H, Sugiyama T, Shimizu M, Suzuki A.

J Clin Pharm Ther. 2019 Jan 2. doi: 10.1111/jcpt.12800. [Epub ahead of print]


Proteome Analysis of Phase-Separated Condensed Proteins with Ionic Surfactants Revealed Versatile Formation of Artificial Bio-molecular Condensates.

Nojima T, Niwa T, Taguchi H.

Biomacromolecules. 2018 Dec 10. doi: 10.1021/acs.biomac.8b01379. [Epub ahead of print]


A LEA model peptide protects the function of a red fluorescent protein in the dry state.

Furuki T, Niwa T, Taguchi H, Hatanaka R, Kikawada T, Sakurai M.

Biochem Biophys Rep. 2018 Nov 26;17:27-31. doi: 10.1016/j.bbrep.2018.11.006. eCollection 2019 Mar.


Imaging of Cystic Lung Lesions in Infants Using Pointwise Encoding Time Reduction with Radial Acquisition (PETRA).

Nozawa K, Niwa T, Aida N.

Magn Reson Med Sci. 2018 Dec 3. doi: 10.2463/mrms.bc.2018-0080. [Epub ahead of print] No abstract available.


Age related signal changes of the pituitary stalk on thin-slice magnetic resonance imaging in infants.

Okazaki T, Niwa T, Suzuki K, Shibukawa S, Imai Y.

Brain Dev. 2019 Apr;41(4):327-333. doi: 10.1016/j.braindev.2018.11.009. Epub 2018 Dec 2.


Mechanical particle coating using ethylcellulose nanoparticle agglomerates for preparing controlled release fine particles; effect of coating temperature on coating performance.

Kondo K, Ando C, Niwa T.

Int J Pharm. 2019 Jan 10;554:387-398. doi: 10.1016/j.ijpharm.2018.11.061. Epub 2018 Dec 2.


Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model.

Hattori N, Niwa T, Ishida T, Kobayashi K, Imai T, Mori A, Kimura K, Mori T, Asami Y, Ushijima T.

Cancer Sci. 2019 Jan;110(1):147-156. doi: 10.1111/cas.13880. Epub 2018 Dec 13.


Impact of vascular access site on procedural time of endomyocardial biopsy.

Mukai K, Nakano Y, Mizuno T, Niwa T, Wakabayashi H, Suzuki A, Watanabe A, Ando H, Murotani K, Waseda K, Amano T.

Heart Vessels. 2018 Nov 14. doi: 10.1007/s00380-018-1298-y. [Epub ahead of print]


Antimicrobial stewardship intervention for the clinical pathways improves antimicrobial prophylaxis in surgical or non-surgical invasive therapies.

Fujibayashi A, Niwa T, Tsuchiya M, Takeichi S, Suzuki K, Ohta H, Yonetamari J, Niwa A, Yamamoto M, Hatakeyama D, Baba H, Suzuki A, Murakami N.

Int J Clin Pract. 2018 Nov 10:e13293. doi: 10.1111/ijcp.13293. [Epub ahead of print]


Phase II Study of Weekly Amrubicin for Refractory or Relapsed Small Cell Lung Cancer.

Yoshioka H, Kogure Y, Ando M, Kitagawa C, Iwasaku M, Niwa T, Saka H.

In Vivo. 2018 Nov-Dec;32(6):1581-1586. doi: 10.21873/invivo.11417.


Compensatory role of insulin-like growth factor 1 receptor in estrogen receptor signaling pathway and possible therapeutic target for hormone therapy-resistant breast cancer.

Iida M, Tsuboi K, Niwa T, Ishida T, Hayashi SI.

Breast Cancer. 2018 Oct 16. doi: 10.1007/s12282-018-0922-0. [Epub ahead of print]


Electrostatic interactions between middle domain motif-1 and the AAA1 module of the bacterial ClpB chaperone are essential for protein disaggregation.

Sugita S, Watanabe K, Hashimoto K, Niwa T, Uemura E, Taguchi H, Watanabe YH.

J Biol Chem. 2018 Dec 14;293(50):19228-19239. doi: 10.1074/jbc.RA118.005496. Epub 2018 Oct 16.


Palladium(ii)-mediated rapid 11C-cyanation of (hetero)arylborons.

Zhang Z, Niwa T, Watanabe Y, Hosoya T.

Org Biomol Chem. 2018 Nov 7;16(41):7711-7716. doi: 10.1039/c8ob02049c. Epub 2018 Oct 5.


Asymmetric Fluorination of Cyclic Tetrasubstituted Alkenes with a Pendant Amide Groups under Dianionic Phase-Transfer Catalysis.

Niwa T, Ujiie K, Sato H, Egami H, Hamashima Y.

Chem Pharm Bull (Tokyo). 2018;66(10):920-922. doi: 10.1248/cpb.c18-00551.


Clinical impact of a prospective audit with intervention and feedback without carbapenem restriction in patients receiving carbapenem injection.

Fujibayashi A, Niwa T, Takeichi S, Suzuki K, Ohta H, Niwa A, Tsuchiya M, Yamamoto M, Hatakeyama D, Suzuki A, Baba H, Murakami N, Itoh Y.

Int J Clin Pract. 2019 Jan;73(1):e13262. doi: 10.1111/ijcp.13262. Epub 2018 Sep 27.


Effects of Er:YAG and Diode Laser Irradiation on Dental Pulp Cells and Tissues.

Yamakawa S, Niwa T, Karakida T, Kobayashi K, Yamamoto R, Chiba R, Yamakoshi Y, Hosoya N.

Int J Mol Sci. 2018 Aug 17;19(8). pii: E2429. doi: 10.3390/ijms19082429.


The Absence of Thioredoxin m1 and Thioredoxin C in Anabaena sp. PCC 7120 Leads to Oxidative Stress.

Deschoenmaeker F, Mihara S, Niwa T, Taguchi H, Wakabayashi KI, Hisabori T.

Plant Cell Physiol. 2018 Dec 1;59(12):2432-2441. doi: 10.1093/pcp/pcy163.


Translocator protein 18kDa antagonist ameliorates stress-induced stool abnormality and abdominal pain in rodent stress models.

Kawahara Y, Mitsui K, Niwa T, Morimoto N, Kawaharada S, Katsumata S.

Neurogastroenterol Motil. 2018 Nov;30(11):e13425. doi: 10.1111/nmo.13425. Epub 2018 Aug 1.


Ultra Cryo-Milling with Liquid Nitrogen and Dry Ice Beads: Characterization of Dry Ice as Milling Beads for Application to Various Drug Compounds.

Uemoto Y, Toda S, Adachi A, Kondo K, Niwa T.

Chem Pharm Bull (Tokyo). 2018;66(8):794-804. doi: 10.1248/cpb.c18-00161.


Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma.

Minatsuki C, Yamamichi N, Inada KI, Takahashi Y, Sakurai K, Shimamoto T, Tsuji Y, Shiogama K, Kodashima S, Sakaguchi Y, Niimi K, Ono S, Niwa T, Ohata K, Matsuhashi N, Ichinose M, Fujishiro M, Tsutsumi Y, Koike K.

Dig Dis Sci. 2018 Oct;63(10):2617-2625. doi: 10.1007/s10620-018-5179-0. Epub 2018 Jun 28.


NS-018 reduces myeloma cell proliferation and suppresses osteolysis through inhibition of the JAK2 and Src signaling pathways.

Honda A, Kuramoto K, Niwa T, Naito H.

Blood Cancer J. 2018 Jun 25;8(7):62. doi: 10.1038/s41408-018-0098-z. No abstract available.


MR imaging findings in some rare neurological complications of paediatric cancer.

Okabe T, Nozaki T, Aida N, Starkey J, Enokizono M, Niwa T, Handa A, Numaguchi Y, Kurihara Y.

Insights Imaging. 2018 Jun;9(3):313-324. doi: 10.1007/s13244-018-0628-z. Epub 2018 May 15. Review.


Acquired resistance to everolimus in aromatase inhibitor-resistant breast cancer.

Kimura M, Hanamura T, Tsuboi K, Kaneko Y, Yamaguchi Y, Niwa T, Narui K, Endo I, Hayashi SI.

Oncotarget. 2018 Apr 20;9(30):21468-21477. doi: 10.18632/oncotarget.25133. eCollection 2018 Apr 20.


The Visibility of the Terminal Thoracic Duct Into the Venous System Using MR Thoracic Ductography with Balanced Turbo Field Echo Sequence.

Nomura T, Niwa T, Ozawa S, Oguma J, Shibukawa S, Imai Y.

Acad Radiol. 2018 May 7. pii: S1076-6332(18)30189-2. doi: 10.1016/j.acra.2018.04.006. [Epub ahead of print]


Daidzein reductase of Eggerthella sp. YY7918, its octameric subunit structure containing FMN/FAD/4Fe-4S, and its enantioselective production of R-dihydroisoflavones.

Kawada Y, Goshima T, Sawamura R, Yokoyama SI, Yanase E, Niwa T, Ebihara A, Inagaki M, Yamaguchi K, Kuwata K, Kato Y, Sakurada O, Suzuki T.

J Biosci Bioeng. 2018 Sep;126(3):301-309. doi: 10.1016/j.jbiosc.2018.03.018. Epub 2018 Apr 23.


Time-Dependent Decline in Serum Phenytoin Concentration With Heightened Convulsive Seizure Risk by Prolonged Administration of Fosphenytoin in Japanese: A Retrospective Study.

Ohno Y, Niwa T, Hirai K, Suzuki K, Yamada Y, Hayashi Y, Hayashi H, Suzuki A, Itoh Y.

Ther Drug Monit. 2018 Aug;40(4):507-511. doi: 10.1097/FTD.0000000000000521.


Novel Immunoliposome Technology for Enhancing the Activity of the Agonistic Antibody against the Tumor Necrosis Factor Receptor Superfamily.

Niwa T, Kasuya Y, Suzuki Y, Ichikawa K, Yoshida H, Kurimoto A, Tanaka K, Morita K.

Mol Pharm. 2018 Sep 4;15(9):3729-3740. doi: 10.1021/acs.molpharmaceut.7b01167. Epub 2018 Apr 27.


Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.

Kii I, Hirahara-Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, Ito H, Takahashi K, Yokoyama C, Hayashi T, Hosoya T, Watanabe Y.

Anal Biochem. 2018 May 15;549:174-183. doi: 10.1016/j.ab.2018.04.001. Epub 2018 Apr 5.


Characteristic phase distribution in the white matter of infants on phase difference enhanced imaging.

Niwa T, Yoneda T, Hayashi M, Suzuki K, Shibukawa S, Okazaki T, Imai Y.

J Neuroradiol. 2018 Oct;45(6):374-379. doi: 10.1016/j.neurad.2018.03.001. Epub 2018 Mar 28.


The dynamics of TGF-β in dental pulp, odontoblasts and dentin.

Niwa T, Yamakoshi Y, Yamazaki H, Karakida T, Chiba R, Hu JC, Nagano T, Yamamoto R, Simmer JP, Margolis HC, Gomi K.

Sci Rep. 2018 Mar 13;8(1):4450. doi: 10.1038/s41598-018-22823-7.


A multicenter, observational study of metastatic breast cancer patients who were treated with eribulin mesylate or taxane-based regimens.

Kikuchi Y, Uchida Y, Shirakawa K, Kanauchi H, Niwa T, Nishioka K, Tada K, Hashimoto M, Yasuda H, Sugiura R, Kawabata H, Seto Y, Ogawa T.

Asia Pac J Clin Oncol. 2018 Mar 1. doi: 10.1111/ajco.12863. [Epub ahead of print]


Structural change of ovalbumin-related protein X by alkali treatment.

Akazawa T, Ogawa M, Hayakawa S, Hirata M, Niwa T.

Poult Sci. 2018 May 1;97(5):1730-1737. doi: 10.3382/ps/pey024.


Jasmonic acid facilitates flower opening and floral organ development through the upregulated expression of SlMYB21 transcription factor in tomato.

Niwa T, Suzuki T, Takebayashi Y, Ishiguro R, Higashiyama T, Sakakibara H, Ishiguro S.

Biosci Biotechnol Biochem. 2018 Feb;82(2):292-303. doi: 10.1080/09168451.2017.1422107.


Risk factors for the failure of treatment of Pseudomonas aeruginosa bacteremia in critically ill patients.

Yoshida S, Suzuki K, Suzuki A, Okada H, Niwa T, Kobayashi R, Murakami N, Ogura S, Itoh Y.

Pharmazie. 2017 Jul 3;72(7):428-432. doi: 10.1691/ph.2017.7453.


A simplified chart for determining the initial loading dose of teicoplanin in critically ill patients.

Yoshida S, Suzuki A, Ohmori T, Niwa T, Okada H, Suzuki K, Kobayashi R, Doi T, Kitaichi K, Matsuura K, Murakami N, Ogura S, Itoh Y.

Pharmazie. 2017 Jan 10;72(1):53-57. doi: 10.1691/ph.2017.6811.


Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial.

Ogawa C, Sato Y, Suzuki C, Mano A, Tashiro A, Niwa T, Hamazaki S, Tanahashi Y, Suzumura M, Hayano S, Hayakawa M, Tsuji T, Hoshino S, Sugiyama Y, Kidokoro H, Kawada JI, Muramatsu H, Hirakawa A, Ando M, Natsume J, Kojima S.

PLoS One. 2018 Feb 13;13(2):e0192688. doi: 10.1371/journal.pone.0192688. eCollection 2018.


Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization.

Egami H, Niwa T, Sato H, Hotta R, Rouno D, Kawato Y, Hamashima Y.

J Am Chem Soc. 2018 Feb 28;140(8):2785-2788. doi: 10.1021/jacs.7b13690. Epub 2018 Feb 12.


Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol.

Iwaki M, Niwa T, Nakamura Y, Kawase A, Komura H.

J Toxicol Sci. 2018;43(1):59-63. doi: 10.2131/jts.43.59.


Evaluation of the Interplanetary Magnetic Field Strength Using the Cosmic-Ray Shadow of the Sun.

Amenomori M, Bi XJ, Chen D, Chen TL, Chen WY, Cui SW, Danzengluobu, Ding LK, Feng CF, Feng Z, Feng ZY, Gou QB, Guo YQ, He HH, He ZT, Hibino K, Hotta N, Hu H, Hu HB, Huang J, Jia HY, Jiang L, Kajino F, Kasahara K, Katayose Y, Kato C, Kawata K, Kozai M, Labaciren, Le GM, Li AF, Li HJ, Li WJ, Liu C, Liu JS, Liu MY, Lu H, Meng XR, Miyazaki T, Mizutani K, Munakata K, Nakajima T, Nakamura Y, Nanjo H, Nishizawa M, Niwa T, Ohnishi M, Ohta I, Ozawa S, Qian XL, Qu XB, Saito T, Saito TY, Sakata M, Sako TK, Shao J, Shibata M, Shiomi A, Shirai T, Sugimoto H, Takita M, Tan YH, Tateyama N, Torii S, Tsuchiya H, Udo S, Wang H, Wu HR, Xue L, Yamamoto Y, Yamauchi K, Yang Z, Yuan AF, Yuda T, Zhai LM, Zhang HM, Zhang JL, Zhang XY, Zhang Y, Zhang Y, Zhang Y, Zhaxisangzhu, Zhou XX; Tibet ASγ Collaboration.

Phys Rev Lett. 2018 Jan 19;120(3):031101. doi: 10.1103/PhysRevLett.120.031101.


Impact of Continuous Administration of Tolvaptan on Preventing Medium-Term Worsening Renal Function and Long-Term Adverse Events in Heart Failure Patients with Chronic Kidney Disease.

Nakano Y, Mizuno T, Niwa T, Mukai K, Wakabayashi H, Watanabe A, Ando H, Takashima H, Murotani K, Waseda K, Amano T.

Int Heart J. 2018 Jan 27;59(1):105-111. doi: 10.1536/ihj.16-625. Epub 2018 Jan 15.


Large-scale aggregation analysis of eukaryotic proteins reveals an involvement of intrinsically disordered regions in protein folding.

Uemura E, Niwa T, Minami S, Takemoto K, Fukuchi S, Machida K, Imataka H, Ueda T, Ota M, Taguchi H.

Sci Rep. 2018 Jan 12;8(1):678. doi: 10.1038/s41598-017-18977-5.


Differential efficacy of cisplatin plus pemetrexed between L858R and Del-19 in advanced EGFR-mutant non-squamous non-small cell lung cancer.

Kaneda T, Yoshioka H, Tamiya M, Tamiya A, Hata A, Okada A, Niwa T, Shiroyama T, Kanazu M, Ishida T, Katakami N.

BMC Cancer. 2018 Jan 2;18(1):6. doi: 10.1186/s12885-017-3952-7.

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