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Efficacy and safety of bronchial thermoplasty in clinical practice: a prospective, longitudinal, cohort study using evidence from the UK Severe Asthma Registry.

Burn J, Sims AJ, Patrick H, Heaney LG, Niven RM.

BMJ Open. 2019 Jun 19;9(6):e026742. doi: 10.1136/bmjopen-2018-026742.


An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peir├│ T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.


A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial.

Hanratty CE, Matthews JG, Arron JR, Choy DF, Pavord ID, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Djukanovic R, Gallagher N, Fowler SJ, Hardman TC, Harrison T, Holweg CT, Howarth PH, Lordan J, Mansur AH, Menzies-Gow A, Mosesova S, Niven RM, Robinson DS, Shaw DE, Walker S, Woodcock A, Heaney LG; RASP-UK (Refractory Asthma Stratification Programme) Consortium.

Trials. 2018 Jan 4;19(1):5. doi: 10.1186/s13063-017-2384-7.


Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

Fraczek MG, Chishimba L, Niven RM, Bromley M, Simpson A, Smyth L, Denning DW, Bowyer P.

J Allergy Clin Immunol. 2018 Aug;142(2):407-414. doi: 10.1016/j.jaci.2017.09.039. Epub 2017 Nov 6.


Indirect comparison of bronchial thermoplasty versus omalizumab for uncontrolled severe asthma.

Niven RM, Simmonds MR, Cangelosi MJ, Tilden DP, Cottrell S, Shargill NS.

J Asthma. 2018 Apr;55(4):443-451. doi: 10.1080/02770903.2017.1337789. Epub 2017 Jul 14.


Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Grabiec AM, Denny N, Doherty JA, Happonen KE, Hankinson J, Connolly E, Fife ME, Fujimori T, Fujino N, Goenka A, Holden S, Tavernier G, Shah R, Cook PC, MacDonald AS, Niven RM, Dahlb├Ąck B, Fowler SJ, Simpson A, Hussell T.

J Allergy Clin Immunol. 2017 Oct;140(4):1144-1146.e4. doi: 10.1016/j.jaci.2017.03.024. Epub 2017 Apr 12. No abstract available.


Procedural and short-term safety of bronchial thermoplasty in clinical practice: evidence from a national registry and Hospital Episode Statistics.

Burn J, Sims AJ, Keltie K, Patrick H, Welham SA, Heaney LG, Niven RM.

J Asthma. 2017 Oct;54(8):872-879. doi: 10.1080/02770903.2016.1263652. Epub 2016 Dec 1.


Impact of omalizumab on treatment of severe allergic asthma in UK clinical practice: a UK multicentre observational study (the APEX II study).

Niven RM, Saralaya D, Chaudhuri R, Masoli M, Clifton I, Mansur AH, Hacking V, McLain-Smith S, Menzies-Gow A.

BMJ Open. 2016 Aug 9;6(8):e011857. doi: 10.1136/bmjopen-2016-011857.


Reduction in peripheral blood eosinophil counts after bronchial thermoplasty.

Ryan DM, Fowler SJ, Niven RM.

J Allergy Clin Immunol. 2016 Jul;138(1):308-310.e2. doi: 10.1016/j.jaci.2015.11.044. Epub 2016 Mar 4. No abstract available.


Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry.

Sweeney J, Patterson CC, Menzies-Gow A, Niven RM, Mansur AH, Bucknall C, Chaudhuri R, Price D, Brightling CE, Heaney LG; British Thoracic Society Difficult Asthma Network.

Thorax. 2016 Apr;71(4):339-46. doi: 10.1136/thoraxjnl-2015-207630. Epub 2016 Jan 27.


T1-weighted Dynamic Contrast-enhanced MR Imaging of the Lung in Asthma: Semiquantitative Analysis for the Assessment of Contrast Agent Kinetic Characteristics.

Zhang WJ, Niven RM, Young SS, Liu YZ, Parker GJ, Naish JH.

Radiology. 2016 Mar;278(3):906-16. doi: 10.1148/radiol.2015141876. Epub 2015 Oct 20.


Recommendations for the use of bronchial thermoplasty in the management of severe asthma.

Dheda K, Koegelenberg CF, Esmail A, Irusen E, Wechsler ME, Niven RM, Bateman ED, Chung KF; Assembly on Interventional Pulmonology of the South African Thoracic Society.

S Afr Med J. 2015 Sep 14;105(9):726-32. doi: 10.7196/SAMnew.8207.


Indications for the use of bronchial thermoplasty in severe asthma.

Dheda K, Koegelenberg CF, Esmail A, Irusen E, Wechsler ME, Niven RM, Chung KF, Bateman ED.

S Afr Med J. 2015 Sep 18;105(10):808-9. doi: 10.7196/SAMJnew.8208.


Immunoglobulin E in irritable bowel syndrome: another target for treatment? A case report and literature review.

Pearson JS, Niven RM, Meng J, Atarodi S, Whorwell PJ.

Therap Adv Gastroenterol. 2015 Sep;8(5):270-7. doi: 10.1177/1756283X15588875. Review.


Bronchial thermoplasty: ready for prime time--the evidence is there!

Castro M, Cox G, Wechsler ME, Niven RM.

Chest. 2015 Feb;147(2):e73-e74. doi: 10.1378/chest.14-2296. No abstract available.


Dynamic oxygen-enhanced magnetic resonance imaging of the lung in asthma -- initial experience.

Zhang WJ, Niven RM, Young SS, Liu YZ, Parker GJ, Naish JH.

Eur J Radiol. 2015 Feb;84(2):318-26. doi: 10.1016/j.ejrad.2014.10.021. Epub 2014 Nov 8.


Efficacy and safety of nebulised amphotericin B (NAB) in severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA).

Chishimba L, Langridge P, Powell G, Niven RM, Denning DW.

J Asthma. 2015 Apr;52(3):289-95. doi: 10.3109/02770903.2014.958853. Epub 2014 Sep 23.


Statistical cluster analysis of the British Thoracic Society Severe refractory Asthma Registry: clinical outcomes and phenotype stability.

Newby C, Heaney LG, Menzies-Gow A, Niven RM, Mansur A, Bucknall C, Chaudhuri R, Thompson J, Burton P, Brightling C; British Thoracic Society Severe Refractory Asthma Network.

PLoS One. 2014 Jul 24;9(7):e102987. doi: 10.1371/journal.pone.0102987. eCollection 2014.


Safety of bronchial thermoplasty in patients with severe refractory asthma.

Pavord ID, Thomson NC, Niven RM, Corris PA, Chung KF, Cox G, Armstrong B, Shargill NS, Laviolette M; Research in Severe Asthma Trial Study Group.

Ann Allergy Asthma Immunol. 2013 Nov;111(5):402-7. doi: 10.1016/j.anai.2013.05.002. Epub 2013 Jun 13.


Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis.

Linehan MF, Nurmatov U, Frank TL, Niven RM, Baxter DN, Sheikh A.

J Allergy Clin Immunol. 2014 Mar;133(3):688-95.e14. doi: 10.1016/j.jaci.2013.08.007. Epub 2013 Sep 29. Review.


Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.

Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Hales JB, McEvoy C, Slebos DJ, Holmes M, Phillips MJ, Erzurum SC, Hanania NA, Sumino K, Kraft M, Cox G, Sterman DH, Hogarth K, Kline JN, Mansur AH, Louie BE, Leeds WM, Barbers RG, Austin JH, Shargill NS, Quiring J, Armstrong B, Castro M; Asthma Intervention Research 2 Trial Study Group.

J Allergy Clin Immunol. 2013 Dec;132(6):1295-302. doi: 10.1016/j.jaci.2013.08.009. Epub 2013 Aug 30.


Practical phenotyping of difficult asthma.

Thomas A, Green RH, Niven RM, Saha S, Hall I, Heaney LG, Sabroe I.

Thorax. 2014 Mar;69(3):299-301. doi: 10.1136/thoraxjnl-2013-203568. Epub 2013 May 31. No abstract available.


Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma.

Thomson NC, Chaudhuri R, Heaney LG, Bucknall C, Niven RM, Brightling CE, Menzies-Gow AN, Mansur AH, McSharry C.

J Allergy Clin Immunol. 2013 Apr;131(4):1008-16. doi: 10.1016/j.jaci.2012.12.1574. Epub 2013 Feb 16.


Prevalence of respiratory symptoms at two time points in a population of children in Manchester--a cohort study.

Linehan MF, Niven RM, Baxter DN, Morris JA, Frank TL.

BMJ Open. 2012 Oct 11;2(5). pii: e001485. doi: 10.1136/bmjopen-2012-001485. Print 2012.


Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization.

Chishimba L, Niven RM, Cooley J, Denning DW.

J Asthma. 2012 May;49(4):423-33. doi: 10.3109/02770903.2012.662568. Epub 2012 Mar 2.


Fungi and allergic lower respiratory tract diseases.

Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, Greenberger PA, Kariuki B, Kita H, Kurup VP, Moss RB, Niven RM, Pashley CH, Slavin RG, Vijay HM, Wardlaw AJ.

J Allergy Clin Immunol. 2012 Feb;129(2):280-91; quiz 292-3. doi: 10.1016/j.jaci.2011.12.970. Review.


Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial.

Thomson NC, Rubin AS, Niven RM, Corris PA, Siersted HC, Olivenstein R, Pavord ID, McCormack D, Laviolette M, Shargill NS, Cox G; AIR Trial Study Group.

BMC Pulm Med. 2011 Feb 11;11:8. doi: 10.1186/1471-2466-11-8.


Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry.

Heaney LG, Brightling CE, Menzies-Gow A, Stevenson M, Niven RM; British Thoracic Society Difficult Asthma Network.

Thorax. 2010 Sep;65(9):787-94. doi: 10.1136/thx.2010.137414.


Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial.

Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G; AIR2 Trial Study Group.

Am J Respir Crit Care Med. 2010 Jan 15;181(2):116-24. doi: 10.1164/rccm.200903-0354OC. Epub 2009 Oct 8.


Comparison of skin prick tests with specific serum immunoglobulin E in the diagnosis of fungal sensitization in patients with severe asthma.

O'Driscoll BR, Powell G, Chew F, Niven RM, Miles JF, Vyas A, Denning DW.

Clin Exp Allergy. 2009 Nov;39(11):1677-83. doi: 10.1111/j.1365-2222.2009.03339.x. Epub 2009 Aug 18.


Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis.

Humbert M, Boulet LP, Niven RM, Panahloo Z, Blogg M, Ayre G.

Allergy. 2009 Jan;64(1):81-4. doi: 10.1111/j.1398-9995.2008.01846.x. Epub 2008 Nov 28.


Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study.

Denning DW, O'Driscoll BR, Powell G, Chew F, Atherton GT, Vyas A, Miles J, Morris J, Niven RM.

Am J Respir Crit Care Med. 2009 Jan 1;179(1):11-8. doi: 10.1164/rccm.200805-737OC. Epub 2008 Oct 23. Erratum in: Am J Respir Crit Care Med. 2009 Feb 15;179(4):330-1.


Consensus study defining occupational asthma and confirming the diagnosis.

Niven RM, Burge S, Fishwick D, Francis HC; GORDS group.

Occup Environ Med. 2008 Mar;65(3):215-6. No abstract available.


Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma.

Pavord ID, Cox G, Thomson NC, Rubin AS, Corris PA, Niven RM, Chung KF, Laviolette M; RISA Trial Study Group.

Am J Respir Crit Care Med. 2007 Dec 15;176(12):1185-91. Epub 2007 Sep 27.


Asthma control during the year after bronchial thermoplasty.

Cox G, Thomson NC, Rubin AS, Niven RM, Corris PA, Siersted HC, Olivenstein R, Pavord ID, McCormack D, Chaudhuri R, Miller JD, Laviolette M; AIR Trial Study Group.

N Engl J Med. 2007 Mar 29;356(13):1327-37.


Is the prevalence of wheeze in children altered by neonatal BCG vaccination?

Linehan MF, Frank TL, Hazell ML, Francis HC, Morris JA, Baxter DN, Niven RM.

J Allergy Clin Immunol. 2007 May;119(5):1079-85. Epub 2007 Mar 26.


Defining and investigating occupational asthma: a consensus approach.

Francis HC, Prys-Picard CO, Fishwick D, Stenton C, Burge PS, Bradshaw LM, Ayres JG, Campbell SM, Niven RM.

Occup Environ Med. 2007 Jun;64(6):361-5. Epub 2006 Nov 27.


Severe vocal cord dysfunction resistant to all current therapeutic interventions.

Goldstein R, Bright J, Jones SM, Niven RM.

Respir Med. 2007 Apr;101(4):857-8. Epub 2006 Oct 6.


The link between fungi and severe asthma: a summary of the evidence.

Denning DW, O'Driscoll BR, Hogaboam CM, Bowyer P, Niven RM.

Eur Respir J. 2006 Mar;27(3):615-26. Review.


Defining and investigating difficult asthma: developing quality indicators.

Prys-Picard CO, Campbell SM, Ayres JG, Miles JF, Niven RM; Consensus on Difficult Asthma Consortium UK (CODAC-UK).

Respir Med. 2006 Jul;100(7):1254-61. Epub 2005 Nov 21.


Endotoxin exposure in asthmatic children and matched healthy controls: results of IPEADAM study.

Tavernier GO, Fletcher GD, Francis HC, Oldham LA, Fletcher AM, Blacklock G, Stewart L, Gee I, Watson A, Frank TL, Frank P, Pickering CA, Niven RM.

Indoor Air. 2005;15 Suppl 10:25-32.


Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells.

Lewis SJ, Cherry NM, Niven RM, Barber PV, Povey AC.

Mutat Res. 2004 Apr 11;559(1-2):11-8.


Monocyte CD14 response following endotoxin exposure in cotton spinners and office workers.

Fishwick D, Raza SN, Beckett P, Swan JR, Pickering CA, Fletcher AM, Niven RM, Francis H, Rawbone R, Curran AD.

Am J Ind Med. 2002 Nov;42(5):437-42.


GSTM1, GSTT1 and GSTP1 polymorphisms and lung cancer risk.

Lewis SJ, Cherry NM, Niven RM, Barber PV, Povey AC.

Cancer Lett. 2002 Jun 28;180(2):165-71.


Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population.

Lewis SJ, Cherry NM, Niven RM, Barber PV, Povey AC.

Lung Cancer. 2001 Nov;34(2):177-83.


Using a neural network to screen a population for asthma.

Hirsch S, Shapiro JL, Turega MA, Frank TL, Niven RM, Frank PI.

Ann Epidemiol. 2001 Aug;11(6):369-76.


The use of a screening questionnaire to identify children with likely asthma.

Frank PI, Frank TL, Cropper J, Hirsch S, Niven RM, Hannaford P, McNamee R.

Br J Gen Pract. 2001 Feb;51(463):117-20.


Survey of symptoms, respiratory function, and immunology and their relation to glutaraldehyde and other occupational exposures among endoscopy nursing staff.

Vyas A, Pickering CA, Oldham LA, Francis HC, Fletcher AM, Merrett T, Niven RM.

Occup Environ Med. 2000 Nov;57(11):752-9.

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