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Attack, flare-up, or exacerbation? The terminology preferences of patients with severe asthma.

Jones KA, Gibson PG, Yorke J, Niven R, Smith A, McDonald VM.

J Asthma. 2019 Sep 16:1-10. doi: 10.1080/02770903.2019.1665064. [Epub ahead of print]


Efficacy and safety of bronchial thermoplasty in clinical practice: a prospective, longitudinal, cohort study using evidence from the UK Severe Asthma Registry.

Burn J, Sims AJ, Patrick H, Heaney LG, Niven RM.

BMJ Open. 2019 Jun 19;9(6):e026742. doi: 10.1136/bmjopen-2018-026742.


European consensus meeting/statement on Bronchial Thermoplasty Who? Where? How?

Niven R, Aubier M, Bonta P, Puente-Maestu L, Facciolongo N, Ryan D.

Respir Med. 2019 Apr;150:161-164. doi: 10.1016/j.rmed.2019.02.020. Epub 2019 Mar 22.


Change in type-2 biomarkers and related cytokines with prednisolone in uncontrolled severe oral corticosteroid dependent asthmatics: an interventional open-label study.

Busby J, Holweg CTJ, Chai A, Bradding P, Cai F, Chaudhuri R, Mansur AH, Lordan JL, Matthews JG, Menzies-Gow A, Niven R, Staton T, Heaney LG.

Thorax. 2019 Aug;74(8):806-809. doi: 10.1136/thoraxjnl-2018-212709. Epub 2019 Apr 2.


Investigating the safety of capsaicin cough challenge in severe asthma.

Wang R, Fowler SJ, Niven R, Ryan D, Holt K, Mitchell J, Dockry R, Al-Sheklly B, Satia I, Smith JA.

Clin Exp Allergy. 2019 Jun;49(6):932-934. doi: 10.1111/cea.13392. Epub 2019 Apr 16. No abstract available.


Association of Cardiovascular Disease With Respiratory Disease.

Carter P, Lagan J, Fortune C, Bhatt DL, Vestbo J, Niven R, Chaudhuri N, Schelbert EB, Potluri R, Miller CA.

J Am Coll Cardiol. 2019 May 7;73(17):2166-2177. doi: 10.1016/j.jacc.2018.11.063. Epub 2019 Mar 4.


Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, Lewis J, Henry AP, Billington CK, Ahmad A, Packer RJ, Shaw D, Pogson ZEK, Fogarty A, McKeever TM, Singapuri A, Heaney LG, Mansur AH, Chaudhuri R, Thomson NC, Holloway JW, Lockett GA, Howarth PH, Djukanovic R, Hankinson J, Niven R, Simpson A, Chung KF, Sterk PJ, Blakey JD, Adcock IM, Hu S, Guo Y, Obeidat M, Sin DD, van den Berge M, Nickle DC, Bossé Y, Tobin MD, Hall IP, Brightling CE, Wain LV, Sayers I.

Lancet Respir Med. 2019 Jan;7(1):20-34. doi: 10.1016/S2213-2600(18)30389-8. Epub 2018 Dec 11.


Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma.

Heaney LG, Busby J, Bradding P, Chaudhuri R, Mansur AH, Niven R, Pavord ID, Lindsay JT, Costello RW; Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

Am J Respir Crit Care Med. 2019 Feb 15;199(4):454-464. doi: 10.1164/rccm.201806-1182OC.


Detection of unstable periodic orbits in mineralising geological systems.

Oberst S, Niven RK, Lester DR, Ord A, Hobbs B, Hoffmann N.

Chaos. 2018 Aug;28(8):085711. doi: 10.1063/1.5024134.


An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.


Bronchial Thermoplasty in Severe Asthma: Best Practice Recommendations from an Expert Panel.

Bonta PI, Chanez P, Annema JT, Shah PL, Niven R.

Respiration. 2018;95(5):289-300. doi: 10.1159/000488291. Epub 2018 Apr 17. Review.


Achalasia with massive oesophageal dilation causing tracheomalacia and asthma symptoms.

Gomez-Larrauri A, Galloway S, Niven R.

Respir Med Case Rep. 2017 Dec 18;23:80-82. doi: 10.1016/j.rmcr.2017.12.008. eCollection 2018.


A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial.

Hanratty CE, Matthews JG, Arron JR, Choy DF, Pavord ID, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Djukanovic R, Gallagher N, Fowler SJ, Hardman TC, Harrison T, Holweg CT, Howarth PH, Lordan J, Mansur AH, Menzies-Gow A, Mosesova S, Niven RM, Robinson DS, Shaw DE, Walker S, Woodcock A, Heaney LG; RASP-UK (Refractory Asthma Stratification Programme) Consortium.

Trials. 2018 Jan 4;19(1):5. doi: 10.1186/s13063-017-2384-7.


Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

Fraczek MG, Chishimba L, Niven RM, Bromley M, Simpson A, Smyth L, Denning DW, Bowyer P.

J Allergy Clin Immunol. 2018 Aug;142(2):407-414. doi: 10.1016/j.jaci.2017.09.039. Epub 2017 Nov 6.


Asthma Phenotypes and Endotypes: Implications for Personalised Therapy.

Dean K, Niven R.

BioDrugs. 2017 Oct;31(5):393-408. doi: 10.1007/s40259-017-0242-5. Review.


Indirect comparison of bronchial thermoplasty versus omalizumab for uncontrolled severe asthma.

Niven RM, Simmonds MR, Cangelosi MJ, Tilden DP, Cottrell S, Shargill NS.

J Asthma. 2018 Apr;55(4):443-451. doi: 10.1080/02770903.2017.1337789. Epub 2017 Jul 14.


Successful long-term terbinafine therapy in an asthmatic patient with Aspergillus sensitization and bronchiectasis.

Rodriguez-Goncer I, Niven R, Denning DW.

Med Mycol Case Rep. 2017 Apr 25;16:31-33. doi: 10.1016/j.mmcr.2017.04.005. eCollection 2017 Jun.


Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Grabiec AM, Denny N, Doherty JA, Happonen KE, Hankinson J, Connolly E, Fife ME, Fujimori T, Fujino N, Goenka A, Holden S, Tavernier G, Shah R, Cook PC, MacDonald AS, Niven RM, Dahlbäck B, Fowler SJ, Simpson A, Hussell T.

J Allergy Clin Immunol. 2017 Oct;140(4):1144-1146.e4. doi: 10.1016/j.jaci.2017.03.024. Epub 2017 Apr 12. No abstract available.


Procedural and short-term safety of bronchial thermoplasty in clinical practice: evidence from a national registry and Hospital Episode Statistics.

Burn J, Sims AJ, Keltie K, Patrick H, Welham SA, Heaney LG, Niven RM.

J Asthma. 2017 Oct;54(8):872-879. doi: 10.1080/02770903.2016.1263652. Epub 2016 Dec 1.


A randomised controlled feasibility trial of Group Cognitive Behavioural Therapy for people with severe asthma.

Yorke J, Adair P, Doyle AM, Dubrow-Marshall L, Fleming S, Holmes L, Menzies-Gow A, Niven R, Pilling M, Shuldham C.

J Asthma. 2017 Jun;54(5):543-554. doi: 10.1080/02770903.2016.1229335. Epub 2016 Nov 23.


A pilot study to investigate the use of serum inhaled corticosteroid concentration as a potential marker of treatment adherence in severe asthma.

George KE, Ryan DM, Keevil B, Niven R, Fowler SJ.

J Allergy Clin Immunol. 2017 Mar;139(3):1037-1039.e1. doi: 10.1016/j.jaci.2016.08.037. Epub 2016 Oct 11. No abstract available.


Dysfunctional breathing: a review of the literature and proposal for classification.

Boulding R, Stacey R, Niven R, Fowler SJ.

Eur Respir Rev. 2016 Sep;25(141):287-94. doi: 10.1183/16000617.0088-2015. Review.


Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma.

Chaudhuri R, McSharry C, Heaney LG, Niven R, Brightling CE, Menzies-Gow AN, Bucknall C, Mansur AH, Lee W, Shepherd M, Spears M, Cowan DC, Husi H, Thomson NC; BTS Severe Asthma Network.

Respir Med. 2016 Sep;118:46-52. doi: 10.1016/j.rmed.2016.07.005. Epub 2016 Jul 9.


Prediction of dynamical systems by symbolic regression.

Quade M, Abel M, Shafi K, Niven RK, Noack BR.

Phys Rev E. 2016 Jul;94(1-1):012214. doi: 10.1103/PhysRevE.94.012214. Epub 2016 Jul 13.


Impact of omalizumab on treatment of severe allergic asthma in UK clinical practice: a UK multicentre observational study (the APEX II study).

Niven RM, Saralaya D, Chaudhuri R, Masoli M, Clifton I, Mansur AH, Hacking V, McLain-Smith S, Menzies-Gow A.

BMJ Open. 2016 Aug 9;6(8):e011857. doi: 10.1136/bmjopen-2016-011857.


Fungal sensitisation in severe asthma is associated with the identification of Aspergillus fumigatus in sputum.

Farrant J, Brice H, Fowler S, Niven R.

J Asthma. 2016 Sep;53(7):732-5. doi: 10.3109/02770903.2016.1154073. Epub 2016 Apr 6.


Reduction in peripheral blood eosinophil counts after bronchial thermoplasty.

Ryan DM, Fowler SJ, Niven RM.

J Allergy Clin Immunol. 2016 Jul;138(1):308-310.e2. doi: 10.1016/j.jaci.2015.11.044. Epub 2016 Mar 4. No abstract available.


Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry.

Sweeney J, Patterson CC, Menzies-Gow A, Niven RM, Mansur AH, Bucknall C, Chaudhuri R, Price D, Brightling CE, Heaney LG; British Thoracic Society Difficult Asthma Network.

Thorax. 2016 Apr;71(4):339-46. doi: 10.1136/thoraxjnl-2015-207630. Epub 2016 Jan 27.


T1-weighted Dynamic Contrast-enhanced MR Imaging of the Lung in Asthma: Semiquantitative Analysis for the Assessment of Contrast Agent Kinetic Characteristics.

Zhang WJ, Niven RM, Young SS, Liu YZ, Parker GJ, Naish JH.

Radiology. 2016 Mar;278(3):906-16. doi: 10.1148/radiol.2015141876. Epub 2015 Oct 20.


Respiratory symptoms and cross-shift lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal: a cross-sectional study.

Paudyal P, Semple S, Gairhe S, Steiner MF, Niven R, Ayres JG.

Occup Environ Med. 2015 Dec;72(12):870-6. doi: 10.1136/oemed-2014-102718. Epub 2015 Oct 14.


Recommendations for the use of bronchial thermoplasty in the management of severe asthma.

Dheda K, Koegelenberg CF, Esmail A, Irusen E, Wechsler ME, Niven RM, Bateman ED, Chung KF; Assembly on Interventional Pulmonology of the South African Thoracic Society.

S Afr Med J. 2015 Sep 14;105(9):726-32. doi: 10.7196/SAMnew.8207.


Indications for the use of bronchial thermoplasty in severe asthma.

Dheda K, Koegelenberg CF, Esmail A, Irusen E, Wechsler ME, Niven RM, Chung KF, Bateman ED.

S Afr Med J. 2015 Sep 18;105(10):808-9. doi: 10.7196/SAMJnew.8208.


Immunoglobulin E in irritable bowel syndrome: another target for treatment? A case report and literature review.

Pearson JS, Niven RM, Meng J, Atarodi S, Whorwell PJ.

Therap Adv Gastroenterol. 2015 Sep;8(5):270-7. doi: 10.1177/1756283X15588875. Review.


Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, Adcock I, Chung KF, Corrigan C, Coyle P, Harrison T, Johnston S, Howarth P, Lordan J, Sabroe I, Bigler J, Smith D, Catley M, May R, Pierre L, Stevenson C, Crater G, Keane F, Costello RW, Hudson V, Supple D, Hardman T.

Thorax. 2016 Feb;71(2):187-9. doi: 10.1136/thoraxjnl-2015-207326. Epub 2015 Jul 23. Review.


Dedicated severe asthma services improve health-care use and quality of life.

Gibeon D, Heaney LG, Brightling CE, Niven R, Mansur AH, Chaudhuri R, Bucknall CE, Menzies-Gow AN; British Thoracic Society Difficult Asthma Network.

Chest. 2015 Oct;148(4):870-876. doi: 10.1378/chest.14-3056.


Lung abscess as a complication of bronchial thermoplasty.

Balu A, Ryan D, Niven R.

J Asthma. 2015 Sep;52(7):740-2. doi: 10.3109/02770903.2015.1005844. Epub 2015 Mar 13.


Bronchial thermoplasty: ready for prime time--the evidence is there!

Castro M, Cox G, Wechsler ME, Niven RM.

Chest. 2015 Feb;147(2):e73-e74. doi: 10.1378/chest.14-2296. No abstract available.


Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.

Kane B, Fowler SJ, Niven R.

Chron Respir Dis. 2015 Feb;12(1):69-77. doi: 10.1177/1479972314562210. Epub 2014 Dec 9. Review.


Dynamic oxygen-enhanced magnetic resonance imaging of the lung in asthma -- initial experience.

Zhang WJ, Niven RM, Young SS, Liu YZ, Parker GJ, Naish JH.

Eur J Radiol. 2015 Feb;84(2):318-26. doi: 10.1016/j.ejrad.2014.10.021. Epub 2014 Nov 8.


High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma.

Fowler SJ, Tavernier G, Niven R.

J Allergy Clin Immunol. 2015 Mar;135(3):822-4.e2. doi: 10.1016/j.jaci.2014.09.034. Epub 2014 Oct 30. No abstract available.


Lesson of the month: Rowing-induced laryngeal obstruction: a novel cause of exertional dyspnoea: characterised by direct laryngoscopy.

Panchasara B, Nelson C, Niven R, Ward S, Hull JH.

Thorax. 2015 Jan;70(1):95-7. doi: 10.1136/thoraxjnl-2014-205773. Epub 2014 Sep 26.


Efficacy and safety of nebulised amphotericin B (NAB) in severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA).

Chishimba L, Langridge P, Powell G, Niven RM, Denning DW.

J Asthma. 2015 Apr;52(3):289-95. doi: 10.3109/02770903.2014.958853. Epub 2014 Sep 23.


Statistical cluster analysis of the British Thoracic Society Severe refractory Asthma Registry: clinical outcomes and phenotype stability.

Newby C, Heaney LG, Menzies-Gow A, Niven RM, Mansur A, Bucknall C, Chaudhuri R, Thompson J, Burton P, Brightling C; British Thoracic Society Severe Refractory Asthma Network.

PLoS One. 2014 Jul 24;9(7):e102987. doi: 10.1371/journal.pone.0102987. eCollection 2014.


The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Djukanović R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, Monk P; INTERCIA Study Group.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):145-54. doi: 10.1164/rccm.201312-2235OC.


The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry.

O'Neill S, Sweeney J, Patterson CC, Menzies-Gow A, Niven R, Mansur AH, Bucknall C, Chaudhuri R, Thomson NC, Brightling CE, O'Neill C, Heaney LG; British Thoracic Society Difficult Asthma Network.

Thorax. 2015 Apr;70(4):376-8. doi: 10.1136/thoraxjnl-2013-204114. Epub 2014 Jun 10.


Safety of bronchial thermoplasty in patients with severe refractory asthma.

Pavord ID, Thomson NC, Niven RM, Corris PA, Chung KF, Cox G, Armstrong B, Shargill NS, Laviolette M; Research in Severe Asthma Trial Study Group.

Ann Allergy Asthma Immunol. 2013 Nov;111(5):402-7. doi: 10.1016/j.anai.2013.05.002. Epub 2013 Jun 13.


Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis.

Linehan MF, Nurmatov U, Frank TL, Niven RM, Baxter DN, Sheikh A.

J Allergy Clin Immunol. 2014 Mar;133(3):688-95.e14. doi: 10.1016/j.jaci.2013.08.007. Epub 2013 Sep 29. Review.


Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.

Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Hales JB, McEvoy C, Slebos DJ, Holmes M, Phillips MJ, Erzurum SC, Hanania NA, Sumino K, Kraft M, Cox G, Sterman DH, Hogarth K, Kline JN, Mansur AH, Louie BE, Leeds WM, Barbers RG, Austin JH, Shargill NS, Quiring J, Armstrong B, Castro M; Asthma Intervention Research 2 Trial Study Group.

J Allergy Clin Immunol. 2013 Dec;132(6):1295-302. doi: 10.1016/j.jaci.2013.08.009. Epub 2013 Aug 30.


Practical phenotyping of difficult asthma.

Thomas A, Green RH, Niven RM, Saha S, Hall I, Heaney LG, Sabroe I.

Thorax. 2014 Mar;69(3):299-301. doi: 10.1136/thoraxjnl-2013-203568. Epub 2013 May 31. No abstract available.


Lung deposition and pharmacokinetics of nebulized cyclosporine in lung transplant patients.

Corcoran TE, Niven R, Verret W, Dilly S, Johnson BA.

J Aerosol Med Pulm Drug Deliv. 2014 Jun;27(3):178-84. doi: 10.1089/jamp.2013.1042. Epub 2013 May 13.

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