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Items: 1 to 50 of 101

1.

CD83 orchestrates immunity towards self and non-self in dendritic cells.

Wild AB, Krzyzak L, Peckert K, Stich L, Kuhnt C, Butterhof A, Seitz C, Mattner J, Grüner N, Gänsbauer M, Purtak M, Soulat D, Winkler TH, Nitschke L, Zinser E, Steinkasserer A.

JCI Insight. 2019 Sep 17. pii: 126246. doi: 10.1172/jci.insight.126246. [Epub ahead of print]

2.

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE.

Cell. 2019 Aug 22;178(5):1159-1175.e17. doi: 10.1016/j.cell.2019.07.043.

PMID:
31442405
3.

BAFF, IL-4 and IL-21 separably program germinal center-like phenotype acquisition, BCL6 expression, proliferation and survival of CD40L-activated B cells in vitro.

Robinson MJ, Pitt C, Brodie EJ, Valk AM, O'Donnell K, Nitschke L, Jones S, Tarlinton DM.

Immunol Cell Biol. 2019 Oct;97(9):826-839. doi: 10.1111/imcb.12283. Epub 2019 Jul 29.

PMID:
31276232
4.

Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.

Setz CS, Khadour A, Renna V, Iype J, Gentner E, He X, Datta M, Young M, Nitschke L, Wienands J, Maity PC, Reth M, Jumaa H.

EMBO J. 2019 Jun 3;38(11). pii: e100249. doi: 10.15252/embj.2018100249. Epub 2019 Apr 23.

5.

B Cell Siglecs-News on Signaling and Its Interplay With Ligand Binding.

Meyer SJ, Linder AT, Brandl C, Nitschke L.

Front Immunol. 2018 Dec 3;9:2820. doi: 10.3389/fimmu.2018.02820. eCollection 2018. Review.

6.

Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency.

Pal Singh S, de Bruijn MJW, de Almeida MP, Meijers RWJ, Nitschke L, Langerak AW, Pillai SY, Stadhouders R, Hendriks RW.

Front Immunol. 2018 Sep 13;9:1996. doi: 10.3389/fimmu.2018.01996. eCollection 2018.

7.

Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2.

Willebrand R, Dietschmann A, Nitschke L, Krappmann S, Voehringer D.

Eur J Immunol. 2018 Nov;48(11):1786-1795. doi: 10.1002/eji.201847555. Epub 2018 Sep 6.

PMID:
30183074
8.

Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction.

Özgör L, Meyer SJ, Korn M, Terörde K, Nitschke L.

J Immunol. 2018 Oct 1;201(7):2107-2116. doi: 10.4049/jimmunol.1800296. Epub 2018 Aug 24.

9.

Air quality in indoor go-kart facilities in Germany.

Wolf J, Berlin K, Fembacher L, Heitmann D, Matzen W, Nitschke L, Sysoltseva M, Fromme H.

Indoor Air. 2018 Nov;28(6):950-962. doi: 10.1111/ina.12490. Epub 2018 Jul 23.

PMID:
29989219
10.

CD83 expression is essential for Treg cell differentiation and stability.

Doebbeler M, Koenig C, Krzyzak L, Seitz C, Wild A, Ulas T, Baßler K, Kopelyanskiy D, Butterhof A, Kuhnt C, Kreiser S, Stich L, Zinser E, Knippertz I, Wirtz S, Riegel C, Hoffmann P, Edinger M, Nitschke L, Winkler T, Schultze JL, Steinkasserer A, Lechmann M.

JCI Insight. 2018 Jun 7;3(11). pii: 99712. doi: 10.1172/jci.insight.99712. eCollection 2018 Jun 7.

11.

Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development.

Fakhouri WD, Metwalli K, Naji A, Bakhiet S, Quispe-Salcedo A, Nitschke L, Kousa YA, Schutte BC.

Sci Rep. 2017 Aug 2;7(1):7129. doi: 10.1038/s41598-017-06310-z.

12.

New Human CD22/Siglec-2 Ligands with a Triazole Glycoside.

Prescher H, Schweizer A, Kuhfeldt E, Nitschke L, Brossmer R.

Chembiochem. 2017 Jul 4;18(13):1216-1225. doi: 10.1002/cbic.201600707. Epub 2017 May 19.

PMID:
28374962
13.

Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion.

Prescher H, Frank M, Gütgemann S, Kuhfeldt E, Schweizer A, Nitschke L, Watzl C, Brossmer R.

J Med Chem. 2017 Feb 9;60(3):941-956. doi: 10.1021/acs.jmedchem.6b01111. Epub 2017 Jan 19.

PMID:
28103033
14.

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.

Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY.

Neuron. 2016 Oct 19;92(2):407-418. doi: 10.1016/j.neuron.2016.09.022. Epub 2016 Oct 6.

15.

Siglec-H protects from virus-triggered severe systemic autoimmunity.

Schmitt H, Sell S, Koch J, Seefried M, Sonnewald S, Daniel C, Winkler TH, Nitschke L.

J Exp Med. 2016 Jul 25;213(8):1627-44. doi: 10.1084/jem.20160189. Epub 2016 Jul 4.

16.

Epratuzumab modulates B-cell signaling without affecting B-cell numbers or B-cell functions in a mouse model with humanized CD22.

Özgör L, Brandl C, Shock A, Nitschke L.

Eur J Immunol. 2016 Sep;46(9):2260-72. doi: 10.1002/eji.201646383. Epub 2016 Jul 25.

17.

CD83 Modulates B Cell Activation and Germinal Center Responses.

Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, Hiergeist A, Gessner A, Winkler TH, Steinkasserer A, Nitschke L.

J Immunol. 2016 May 1;196(9):3581-94. doi: 10.4049/jimmunol.1502163. Epub 2016 Mar 16.

18.

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells.

Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ.

Cell Rep. 2016 Mar 15;14(10):2348-61. doi: 10.1016/j.celrep.2016.02.027. Epub 2016 Mar 3.

19.

Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.

Radtke D, Lacher SM, Szumilas N, Sandrock L, Ackermann J, Nitschke L, Zinser E.

J Immunol. 2016 Apr 1;196(7):2995-3005. doi: 10.4049/jimmunol.1501764. Epub 2016 Feb 26.

20.

Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.

Gasparrini F, Feest C, Bruckbauer A, Mattila PK, Müller J, Nitschke L, Bray D, Batista FD.

EMBO J. 2016 Feb 1;35(3):258-80. doi: 10.15252/embj.201593027. Epub 2015 Dec 15.

21.

Siglec-G is a B-1 cell inhibitory receptor and also controls B cell tolerance.

Nitschke L.

Ann N Y Acad Sci. 2015 Dec;1362:117-21. doi: 10.1111/nyas.12826. Epub 2015 Jul 20. Review.

PMID:
26194636
22.

Erratum: Responsiveness of B cells is regulated by the hinge region of IgD.

Übelhart R, Hug E, Bach MP, Wossning T, Minden MD, Horn AH, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M, Jumaa H.

Nat Immunol. 2015 Jul;16(7):785. doi: 10.1038/ni0715-785d. No abstract available.

PMID:
26086144
23.

Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.

Müller J, Lunz B, Schwab I, Acs A, Nimmerjahn F, Daniel C, Nitschke L.

J Immunol. 2015 Jul 1;195(1):51-60. doi: 10.4049/jimmunol.1403139. Epub 2015 May 18.

24.

Responsiveness of B cells is regulated by the hinge region of IgD.

Übelhart R, Hug E, Bach MP, Wossning T, Dühren-von Minden M, Horn AH, Tsiantoulas D, Kometani K, Kurosaki T, Binder CJ, Sticht H, Nitschke L, Reth M, Jumaa H.

Nat Immunol. 2015 May;16(5):534-43. doi: 10.1038/ni.3141. Epub 2015 Apr 6. Erratum in: Nat Immunol. 2015 Jul;16(7):785.

PMID:
25848865
25.

Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals.

Lee J, Zhang T, Hwang I, Kim A, Nitschke L, Kim M, Scott JM, Kamimura Y, Lanier LL, Kim S.

Immunity. 2015 Mar 17;42(3):431-42. doi: 10.1016/j.immuni.2015.02.013.

26.

Dickkopf-3 acts as a modulator of B cell fate and function.

Ludwig J, Federico G, Prokosch S, Küblbeck G, Schmitt S, Klevenz A, Gröne HJ, Nitschke L, Arnold B.

J Immunol. 2015 Mar 15;194(6):2624-34. doi: 10.4049/jimmunol.1402160. Epub 2015 Feb 11.

27.

The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.

Engels N, König LM, Schulze W, Radtke D, Vanshylla K, Lutz J, Winkler TH, Nitschke L, Wienands J.

Nat Commun. 2014 Nov 21;5:5456. doi: 10.1038/ncomms6456.

28.

CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance.

Nitschke L.

Glycobiology. 2014 Sep;24(9):807-17. doi: 10.1093/glycob/cwu066. Epub 2014 Jul 6. Review.

PMID:
25002414
29.

A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels.

Luo W, Mayeux J, Gutierrez T, Russell L, Getahun A, Müller J, Tedder T, Parnes J, Rickert R, Nitschke L, Cambier J, Satterthwaite AB, Garrett-Sinha LA.

J Immunol. 2014 Jul 15;193(2):909-920. doi: 10.4049/jimmunol.1400666. Epub 2014 Jun 13.

30.

SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.

Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P.

Haematologica. 2014 Aug;99(8):1356-64. doi: 10.3324/haematol.2013.100230. Epub 2014 May 23.

31.

Discovery of multifold modified sialosides as human CD22/Siglec-2 ligands with nanomolar activity on B-cells.

Prescher H, Schweizer A, Kuhfeldt E, Nitschke L, Brossmer R.

ACS Chem Biol. 2014 Jul 18;9(7):1444-50. doi: 10.1021/cb400952v. Epub 2014 May 7.

PMID:
24807582
32.

The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.

Hutzler S, Özgör L, Naito-Matsui Y, Kläsener K, Winkler TH, Reth M, Nitschke L.

J Immunol. 2014 Jun 1;192(11):5406-14. doi: 10.4049/jimmunol.1302875. Epub 2014 Apr 30.

33.

The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease.

Müller J, Nitschke L.

Nat Rev Rheumatol. 2014 Jul;10(7):422-8. doi: 10.1038/nrrheum.2014.54. Epub 2014 Apr 29. Review.

PMID:
24763061
34.

Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.

Bökers S, Urbat A, Daniel C, Amann K, Smith KG, Espéli M, Nitschke L.

J Immunol. 2014 Apr 1;192(7):2994-3002. doi: 10.4049/jimmunol.1303367. Epub 2014 Mar 5.

35.

An etiologic regulatory mutation in IRF6 with loss- and gain-of-function effects.

Fakhouri WD, Rahimov F, Attanasio C, Kouwenhoven EN, Ferreira De Lima RL, Felix TM, Nitschke L, Huver D, Barrons J, Kousa YA, Leslie E, Pennacchio LA, Van Bokhoven H, Visel A, Zhou H, Murray JC, Schutte BC.

Hum Mol Genet. 2014 May 15;23(10):2711-20. doi: 10.1093/hmg/ddt664. Epub 2014 Jan 16.

36.

Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production.

Niedzielska M, Bodendorfer B, Münch S, Eichner A, Derigs M, da Costa O, Schweizer A, Neff F, Nitschke L, Sparwasser T, Keyse SM, Lang R.

J Biol Chem. 2014 Jan 24;289(4):2112-26. doi: 10.1074/jbc.M113.535245. Epub 2013 Dec 5.

37.

Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.

Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, Takematsu H.

J Biol Chem. 2014 Jan 17;289(3):1564-79. doi: 10.1074/jbc.M113.523753. Epub 2013 Dec 2.

38.

Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.

Dütting S, Vögtle T, Morowski M, Schiessl S, Schäfer CM, Watson SK, Hughes CE, Ackermann JA, Radtke D, Hermanns HM, Watson SP, Nitschke L, Nieswandt B.

Circ Res. 2014 Jan 31;114(3):444-453. doi: 10.1161/CIRCRESAHA.114.302670. Epub 2013 Nov 21.

39.

Suppressing the antibody response with Siglec ligands.

Nitschke L.

N Engl J Med. 2013 Oct 3;369(14):1373-4. doi: 10.1056/NEJMcibr1308953. No abstract available.

PMID:
24088100
40.

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.

Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T.

PLoS Pathog. 2013;9(9):e1003648. doi: 10.1371/journal.ppat.1003648. Epub 2013 Sep 26.

41.

CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling.

Müller J, Obermeier I, Wöhner M, Brandl C, Mrotzek S, Angermüller S, Maity PC, Reth M, Nitschke L.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12402-7. doi: 10.1073/pnas.1304888110. Epub 2013 Jul 8.

42.

Exposure of German residents to ethylene and propylene glycol ethers in general and after cleaning scenarios.

Fromme H, Nitschke L, Boehmer S, Kiranoglu M, Göen T; HBMnet.

Chemosphere. 2013 Mar;90(11):2714-21. doi: 10.1016/j.chemosphere.2012.11.051. Epub 2013 Jan 3.

PMID:
23290947
43.

Human CD22 cannot fully substitute murine CD22 functions in vivo, as shown in a new knockin mouse model.

Wöhner M, Born S, Nitschke L.

Eur J Immunol. 2012 Nov;42(11):3009-18. doi: 10.1002/eji.201242629. Epub 2012 Oct 17.

44.

B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo.

Schwab I, Seeling M, Biburger M, Aschermann S, Nitschke L, Nimmerjahn F.

Eur J Immunol. 2012 Dec;42(12):3302-9. doi: 10.1002/eji.201242710. Epub 2012 Oct 16.

45.

Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.

Walker JA, Hall AM, Kotsopoulou E, Espeli M, Nitschke L, Barker RN, Lyons PA, Smith KG.

Eur J Immunol. 2012 Dec;42(12):3212-22. doi: 10.1002/eji.201242633. Epub 2012 Oct 16.

46.

Targeting of CD22-positive B-cell lymphoma cells by synthetic divalent sialic acid analogues.

Schweizer A, Wöhner M, Prescher H, Brossmer R, Nitschke L.

Eur J Immunol. 2012 Oct;42(10):2792-802. doi: 10.1002/eji.201242574. Epub 2012 Aug 6.

47.

A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.

Brenner S, Drewel D, Steinbart T, Weisel F, Härtel E, Pötzsch S, Welzel H, Brandl A, Yu P, Mudde GC, Schweizer A, Nitschke L, Winkler TH.

EMBO J. 2011 May 27;30(13):2705-18. doi: 10.1038/emboj.2011.168.

48.

NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.

Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, Jellusova J, Schweizer A, Nitschke L, Leich E, Rosenwald A, Brunner C, Engelmann S, Bommhardt U, Avots A, Müller MR, Kondo E, Serfling E.

J Exp Med. 2011 Apr 11;208(4):823-39. doi: 10.1084/jem.20100945. Epub 2011 Apr 4.

49.

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.

Ackermann JA, Radtke D, Maurberger A, Winkler TH, Nitschke L.

EMBO J. 2011 Apr 20;30(8):1621-33. doi: 10.1038/emboj.2011.74. Epub 2011 Mar 22.

50.

Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22.

Jellusova J, Nitschke L.

Front Immunol. 2012 Jan 11;2:96. doi: 10.3389/fimmu.2011.00096. eCollection 2011.

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