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Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model.

Nguyen L, Montrasio F, Pattamatta A, Tusi SK, Bardhi O, Meyer KD, Hayes L, Nakamura K, Banez-Coronel M, Coyne A, Guo S, Laboissonniere LA, Gu Y, Narayanan S, Smith B, Nitsch RM, Kankel MW, Rushe M, Rothstein J, Zu T, Grimm J, Ranum LPW.

Neuron. 2019 Dec 4. pii: S0896-6273(19)30970-5. doi: 10.1016/j.neuron.2019.11.007. [Epub ahead of print]


The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease.

Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, Nitsch RM, Multhaup G, Kulic L.

Acta Neuropathol Commun. 2019 Dec 3;7(1):194. doi: 10.1186/s40478-019-0846-8.


A fluorescent protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites.

Konietzko U, Gersbacher MT, Streuli J, Krüger M, Thöni S, Kins S, Nitsch RM.

Biol Chem. 2019 Aug 27;400(9):1191-1203. doi: 10.1515/hsz-2019-0125.


GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults.

Quevenco FC, Schreiner SJ, Preti MG, van Bergen JMG, Kirchner T, Wyss M, Steininger SC, Gietl A, Leh SE, Buck A, Pruessmann KP, Hock C, Nitsch RM, Henning A, Van De Ville D, Unschuld PG.

Neuroimage Clin. 2019;22:101776. doi: 10.1016/j.nicl.2019.101776. Epub 2019 Mar 12.


Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline.

Hua J, Lee S, Blair NIS, Wyss M, van Bergen JMG, Schreiner SJ, Kagerer SM, Leh SE, Gietl AF, Treyer V, Buck A, Nitsch RM, Pruessmann KP, Lu H, Van Zijl PCM, Albert M, Hock C, Unschuld PG.

Neurobiol Aging. 2019 Apr;76:181-193. doi: 10.1016/j.neurobiolaging.2019.01.001. Epub 2019 Jan 10.


A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.

Maier M, Welt T, Wirth F, Montrasio F, Preisig D, McAfoose J, Vieira FG, Kulic L, Späni C, Stehle T, Perrin S, Weber M, Hock C, Nitsch RM, Grimm J.

Sci Transl Med. 2018 Dec 5;10(470). pii: eaah3924. doi: 10.1126/scitranslmed.aah3924.


Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.

Weihofen A, Liu Y, Arndt JW, Huy C, Quan C, Smith BA, Baeriswyl JL, Cavegn N, Senn L, Su L, Marsh G, Auluck PK, Montrasio F, Nitsch RM, Hirst WD, Cedarbaum JM, Pepinsky RB, Grimm J, Weinreb PH.

Neurobiol Dis. 2019 Apr;124:276-288. doi: 10.1016/j.nbd.2018.10.016. Epub 2018 Oct 28.


Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury.

Akhmedov A, Bonetti NR, Reiner MF, Spescha RD, Amstalden H, Merlini M, Gaul DS, Diaz-Cañestro C, Briand-Schumacher S, Spescha RS, Semerano A, Giacalone G, Savarese G, Montecucco F, Kulic L, Nitsch RM, Matter CM, Kullak-Ublick GA, Sessa M, Lüscher TF, Beer JH, Liberale L, Camici GG.

J Cereb Blood Flow Metab. 2019 Nov;39(11):2233-2245. doi: 10.1177/0271678X18793266. Epub 2018 Aug 3. Erratum in: J Cereb Blood Flow Metab. 2019 Nov;39(11):NP1.


Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age.

van Bergen JMG, Li X, Quevenco FC, Gietl AF, Treyer V, Meyer R, Buck A, Kaufmann PA, Nitsch RM, van Zijl PCM, Hock C, Unschuld PG.

Neuroimage. 2018 Jul 1;174:308-316. doi: 10.1016/j.neuroimage.2018.03.021. Epub 2018 Mar 13.


Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.

Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C.

Stem Cell Res. 2018 Mar;27:121-130. doi: 10.1016/j.scr.2018.01.019. Epub 2018 Jan 28.


Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study.

Merlini M, Kirabali T, Kulic L, Nitsch RM, Ferretti MT.

Neurodegener Dis. 2018;18(1):49-56. doi: 10.1159/000486200. Epub 2018 Feb 7.


Low cortical iron and high entorhinal cortex volume promote cognitive functioning in the oldest-old.

van Bergen JMG, Li X, Quevenco FC, Gietl AF, Treyer V, Leh SE, Meyer R, Buck A, Kaufmann PA, Nitsch RM, van Zijl PCM, Hock C, Unschuld PG.

Neurobiol Aging. 2018 Apr;64:68-75. doi: 10.1016/j.neurobiolaging.2017.12.014. Epub 2017 Dec 20.


Brain amyloid burden and cerebrovascular disease are synergistically associated with neurometabolism in cognitively unimpaired older adults.

Schreiner SJ, Kirchner T, Narkhede A, Wyss M, Van Bergen JMG, Steininger SC, Gietl A, Leh SE, Treyer V, Buck A, Pruessmann KP, Nitsch RM, Hock C, Henning A, Brickman AM, Unschuld PG.

Neurobiol Aging. 2018 Mar;63:152-161. doi: 10.1016/j.neurobiolaging.2017.12.004. Epub 2017 Dec 12.


Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Nature. 2017 Jun 21;546(7659):564. doi: 10.1038/nature22809.


Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.

Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S.

Am J Pathol. 2017 Jun;187(6):1399-1412. doi: 10.1016/j.ajpath.2017.01.022. Epub 2017 Apr 11.


Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease.

Quevenco FC, Preti MG, van Bergen JM, Hua J, Wyss M, Li X, Schreiner SJ, Steininger SC, Meyer R, Meier IB, Brickman AM, Leh SE, Gietl AF, Buck A, Nitsch RM, Pruessmann KP, van Zijl PC, Hock C, Van De Ville D, Unschuld PG.

Alzheimers Res Ther. 2017 Mar 31;9(1):24. doi: 10.1186/s13195-017-0249-7.


Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients.

Kälin AM, Park MT, Chakravarty MM, Lerch JP, Michels L, Schroeder C, Broicher SD, Kollias S, Nitsch RM, Gietl AF, Unschuld PG, Hock C, Leh SE.

Front Aging Neurosci. 2017 Mar 7;9:38. doi: 10.3389/fnagi.2017.00038. eCollection 2017.


Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease.

Merlini M, Shi Y, Keller S, Savarese G, Akhmedov A, Derungs R, Spescha RD, Kulic L, Nitsch RM, Lüscher TF, Camici GG.

Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H232-H238. doi: 10.1152/ajpheart.00607.2016. Epub 2016 Nov 11.


Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment.

van Bergen JM, Li X, Hua J, Schreiner SJ, Steininger SC, Quevenco FC, Wyss M, Gietl AF, Treyer V, Leh SE, Buck F, Nitsch RM, Pruessmann KP, van Zijl PC, Hock C, Unschuld PG.

Sci Rep. 2016 Oct 17;6:35514. doi: 10.1038/srep35514.


Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a 1H MRSI study at 7 Tesla.

Schreiner SJ, Kirchner T, Wyss M, Van Bergen JMG, Quevenco FC, Steininger SC, Griffith EY, Meier I, Michels L, Gietl AF, Leh SE, Brickman AM, Hock C, Nitsch RM, Pruessmann KP, Henning A, Unschuld PG.

Neurobiol Aging. 2016 Dec;48:195-203. doi: 10.1016/j.neurobiolaging.2016.08.022. Epub 2016 Aug 31.


Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals.

Schroeder C, Park MTM, Germann J, Chakravarty MM, Michels L, Kollias S, Kroll SL, Buck A, Treyer V, Savaskan E, Unschuld PG, Nitsch RM, Kälin AM, Hock C, Gietl AF, Leh SE.

Eur J Neurosci. 2017 May;45(10):1241-1251. doi: 10.1111/ejn.13408. Epub 2016 Oct 11.


The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.

Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.

Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323. Update in: Nature. 2017 Jun 21;546(7659):564.


Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease.

Derungs R, Camici GG, Spescha RD, Welt T, Tackenberg C, Späni C, Wirth F, Grimm A, Eckert A, Nitsch RM, Kulic L.

Mol Psychiatry. 2017 Apr;22(4):605-614. doi: 10.1038/mp.2016.112. Epub 2016 Jul 19.


High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders.

Preisig DF, Kulic L, Krüger M, Wirth F, McAfoose J, Späni C, Gantenbein P, Derungs R, Nitsch RM, Welt T.

Behav Brain Res. 2016 Sep 15;311:340-353. doi: 10.1016/j.bbr.2016.04.044. Epub 2016 May 24.


Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revealed by multi-parametric MRI comparison.

Grandjean J, Derungs R, Kulic L, Welt T, Henkelman M, Nitsch RM, Rudin M.

Neuroimage. 2016 Jul 1;134:1-11. doi: 10.1016/j.neuroimage.2016.03.042. Epub 2016 Mar 24.



Fisher A, Nitsch RM, Windisch M.

Neurodegener Dis. 2016;16(1-2):5. No abstract available.


Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.

Merlini M, Wanner D, Nitsch RM.

Acta Neuropathol. 2016 May;131(5):737-52. doi: 10.1007/s00401-016-1560-2. Epub 2016 Mar 17.


T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis.

Ferretti MT, Merlini M, Späni C, Gericke C, Schweizer N, Enzmann G, Engelhardt B, Kulic L, Suter T, Nitsch RM.

Brain Behav Immun. 2016 May;54:211-225. doi: 10.1016/j.bbi.2016.02.009. Epub 2016 Feb 9.


Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer's disease lacking functional B and T cells.

Späni C, Suter T, Derungs R, Ferretti MT, Welt T, Wirth F, Gericke C, Nitsch RM, Kulic L.

Acta Neuropathol Commun. 2015 Nov 11;3:71. doi: 10.1186/s40478-015-0251-x.


Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.

Jelcic I, Combaluzier B, Jelcic I, Faigle W, Senn L, Reinhart BJ, Ströh L, Nitsch RM, Stehle T, Sospedra M, Grimm J, Martin R.

Sci Transl Med. 2015 Sep 23;7(306):306ra150. doi: 10.1126/scitranslmed.aac8691. Epub 2015 Sep 23.


Massachusetts Alzheimer's Disease Research Center: progress and challenges.

Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR Jr, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, Selkoe DJ, Sperling RA, St George-Hyslop P, Tanzi RE, Yap L, Young AB, Phelps CH, McCaffrey PG.

Alzheimers Dement. 2015 Oct;11(10):1241-5. doi: 10.1016/j.jalz.2015.06.1887. Epub 2015 Aug 19. No abstract available.


Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.

Birnbaum JH, Bali J, Rajendran L, Nitsch RM, Tackenberg C.

Cell Death Dis. 2015 Jun 18;6:e1791. doi: 10.1038/cddis.2015.160.


Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke.

Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Lüscher TF, Camici GG.

Eur Heart J. 2015 Jul 1;36(25):1590-600. doi: 10.1093/eurheartj/ehv140. Epub 2015 Apr 22.


Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study.

Welt T, Kulic L, Hoey SE, McAfoose J, Späni C, Chadha AS, Fisher A, Nitsch RM.

J Alzheimers Dis. 2015;46(4):971-82. doi: 10.3233/JAD-150152.


Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner.

Gietl AF, Warnock G, Riese F, Kälin AM, Saake A, Gruber E, Leh SE, Unschuld PG, Kuhn FP, Burger C, Mu L, Seifert B, Nitsch RM, Schibli R, Ametamey SM, Buck A, Hock C.

Neurobiol Aging. 2015 Apr;36(4):1619-1628. doi: 10.1016/j.neurobiolaging.2014.12.036. Epub 2015 Jan 7.


Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis.

Grandjean J, Schroeter A, He P, Tanadini M, Keist R, Krstic D, Konietzko U, Klohs J, Nitsch RM, Rudin M.

J Neurosci. 2014 Oct 8;34(41):13780-9. doi: 10.1523/JNEUROSCI.4762-13.2014.


Regional Fluid-Attenuated Inversion Recovery (FLAIR) at 7 Tesla correlates with amyloid beta in hippocampus and brainstem of cognitively normal elderly subjects.

Schreiner SJ, Liu X, Gietl AF, Wyss M, Steininger SC, Gruber E, Treyer V, Meier IB, Kälin AM, Leh SE, Buck A, Nitsch RM, Pruessmann KP, Hock C, Unschuld PG.

Front Aging Neurosci. 2014 Sep 9;6:240. doi: 10.3389/fnagi.2014.00240. eCollection 2014.


Reciprocal modulation of Aβ42 aggregation by copper and homocysteine.

Keskitalo S, Farkas M, Hanenberg M, Szodorai A, Kulic L, Semmler A, Weller M, Nitsch RM, Linnebank M.

Front Aging Neurosci. 2014 Sep 8;6:237. doi: 10.3389/fnagi.2014.00237. eCollection 2014.


Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer disease.

Hanenberg M, McAfoose J, Kulic L, Welt T, Wirth F, Parizek P, Strobel L, Cattepoel S, Späni C, Derungs R, Maier M, Plückthun A, Nitsch RM.

J Biol Chem. 2014 Sep 26;289(39):27080-9. doi: 10.1074/jbc.M114.564013. Epub 2014 Aug 12.


Intraindividual variability across cognitive tasks as a potential marker for prodromal Alzheimer's disease.

Kälin AM, Pflüger M, Gietl AF, Riese F, Jäncke L, Nitsch RM, Hock C.

Front Aging Neurosci. 2014 Jul 4;6:147. doi: 10.3389/fnagi.2014.00147. eCollection 2014.


RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60.

Domingues SC, Konietzko U, Henriques AG, Rebelo S, Fardilha M, Nishitani H, Nitsch RM, da Cruz E Silva EF, da Cruz E Silva OA.

J Alzheimers Dis. 2014;42(4):1415-33. doi: 10.3233/JAD-132495.


Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System.

Steininger SC, Liu X, Gietl A, Wyss M, Schreiner S, Gruber E, Treyer V, Kälin A, Leh S, Buck A, Nitsch RM, Prüssmann KP, Hock C, Unschuld PG.

Front Aging Neurosci. 2014 Mar 18;6:52. doi: 10.3389/fnagi.2014.00052. eCollection 2014.


Quantification of subcortical gray-matter vascularization using 7 Tesla time-of-flight angiography.

Laurig M, Liu X, Wyss M, Gietl A, Jellestad L, Nitsch RM, Prüssmann K, Hock C, Unschuld PG.

Brain Behav. 2013 Sep;3(5):515-8. doi: 10.1002/brb3.154. Epub 2013 Jul 14.


Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.

Riese F, Grinschgl S, Gersbacher MT, Russi N, Hock C, Nitsch RM, Konietzko U.

PLoS One. 2013 Sep 25;8(9):e76094. doi: 10.1371/journal.pone.0076094. eCollection 2013.


Turnover of amyloid precursor protein family members determines their nuclear signaling capability.

Gersbacher MT, Goodger ZV, Trutzel A, Bundschuh D, Nitsch RM, Konietzko U.

PLoS One. 2013 Jul 18;8(7):e69363. doi: 10.1371/journal.pone.0069363. Print 2013.


Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.

Klohs J, Politano IW, Deistung A, Grandjean J, Drewek A, Dominietto M, Keist R, Schweser F, Reichenbach JR, Nitsch RM, Knuesel I, Rudin M.

PLoS One. 2013 Jun 19;8(6):e66097. doi: 10.1371/journal.pone.0066097. Print 2013.


NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.

Tackenberg C, Grinschgl S, Trutzel A, Santuccione AC, Frey MC, Konietzko U, Grimm J, Brandt R, Nitsch RM.

Cell Death Dis. 2013 Apr 25;4:e608. doi: 10.1038/cddis.2013.129.


Brief but chronic increase in allopregnanolone cause accelerated AD pathology differently in two mouse models.

Bengtsson SK, Johansson M, Backstrom T, Nitsch RM, Wang M.

Curr Alzheimer Res. 2013 Jan;10(1):38-47.


Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation.

Kulic L, McAfoose J, Welt T, Tackenberg C, Späni C, Wirth F, Finder V, Konietzko U, Giese M, Eckert A, Noriaki K, Shimizu T, Murakami K, Irie K, Rasool S, Glabe C, Hock C, Nitsch RM.

Transl Psychiatry. 2012 Nov 13;2:e183. doi: 10.1038/tp.2012.109.

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