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Are electronic health records ready for clinical trial use?

Plumb L, Nitsch D.

Nat Rev Nephrol. 2020 Jan 27. doi: 10.1038/s41581-020-0252-2. [Epub ahead of print] No abstract available.


Association of pulse wave velocity and intima-media thickness with cardiovascular risk factors in young adults.

Cecelja M, Sriswan R, Kulkarni B, Kinra S, Nitsch D.

J Clin Hypertens (Greenwich). 2020 Feb;22(2):174-184. doi: 10.1111/jch.13812. Epub 2020 Jan 19.


How to estimate glomerular filtration rate in sub-Saharan Africa: design and methods of the African Research into Kidney Diseases (ARK) study.

Kalyesubula R, Fabian J, Nakanga W, Newton R, Ssebunnya B, Prynn J, George J, Wade AN, Seeley J, Nitsch D, Hansen C, Nyirenda M, Smeeth L, Naicker S, Crampin AC, Tomlinson LA.

BMC Nephrol. 2020 Jan 15;21(1):20. doi: 10.1186/s12882-020-1688-0.


Paediatric acute kidney injury hospital admissions in England 1997-2014: burden and risk factors.

Henderson A, Iwagami M, Bottomley C, Tomlinson L, Mansfield K, Nitsch D.

Clin Kidney J. 2019 Jun 7;12(6):859-860. doi: 10.1093/ckj/sfz075. eCollection 2019 Dec. No abstract available.


A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service.

Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos CA, Lumbers RT, Mathur R, Sofat R, Casas JP, Wong ICK, Hemingway H, Hingorani AD.

Lancet Digit Health. 2019 May 20;1(2):e63-e77. doi: 10.1016/S2589-7500(19)30012-3. eCollection 2019 Jun.


The changing patterns of access overtime to the renal replacement therapy programme in Thailand.

Thammatacharee N, Mills A, Nitsch D, Lumpaopong A.

Health Policy Plan. 2019 Oct 11. pii: czz121. doi: 10.1093/heapol/czz121. [Epub ahead of print]


Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy.

Smpokou ET, González-Quiroz M, Martins C, Alvito P, Le Blond J, Glaser J, Aragón A, Wesseling C, Nitsch D, Pearce N, Norman J, Lindh CH, Morton J, Caplin B.

Occup Environ Med. 2019 Dec;76(12):920-926. doi: 10.1136/oemed-2019-105772. Epub 2019 Sep 27.


Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE).

Gonzalez-Quiroz M, Nitsch D, Hamilton S, O'Callaghan Gordo C, Saran R, Glaser J, Correa-Rotter R, Jakobsson K, Singh A, Gunawardena N, Levin A, Remuzzi G, Caplin B, Pearce N; DEGREE Study Steering Committee.

BMJ Open. 2019 Sep 24;9(9):e031169. doi: 10.1136/bmjopen-2019-031169.


Quality of Chronic Kidney Disease Management in Canadian Primary Care.

Bello AK, Ronksley PE, Tangri N, Kurzawa J, Osman MA, Singer A, Grill AK, Nitsch D, Queenan JA, Wick J, Lindeman C, Soos B, Tuot DS, Shojai S, Brimble KS, Mangin D, Drummond N.

JAMA Netw Open. 2019 Sep 4;2(9):e1910704. doi: 10.1001/jamanetworkopen.2019.10704.


Non-communicable diseases in sub-Saharan Africa: a scoping review of large cohort studies.

Mudie K, Jin MM, Tan, Kendall L, Addo J, Dos-Santos-Silva I, Quint J, Smeeth L, Cook S, Nitsch D, Natamba B, Gomez-Olive FX, Ako A, Perel P.

J Glob Health. 2019 Dec;9(2):020409. doi: 10.7189/jogh.09.020409. Review.


The comparative effectiveness of fourth-line drugs in resistant hypertension: An application in electronic health record data.

Sinnott SJ, Smeeth L, Williamson E, Perel P, Nitsch D, Tomlinson LA, Douglas IJ.

Pharmacoepidemiol Drug Saf. 2019 Sep;28(9):1267-1277. doi: 10.1002/pds.4808. Epub 2019 Jul 16.


Mild cognitive impairment and kidney disease: clinical aspects.

Viggiano D, Wagner CA, Blankestijn PJ, Bruchfeld A, Fliser D, Fouque D, Frische S, Gesualdo L, Gutiérrez E, Goumenos D, Hoorn EJ, Eckardt KU, Knauß S, König M, Malyszko J, Massy Z, Nitsch D, Pesce F, Rychlík I, Soler MJ, Spasovski G, Stevens KI, Trepiccione F, Wanner C, Wiecek A, Zoccali C, Unwin R, Capasso G.

Nephrol Dial Transplant. 2020 Jan 1;35(1):10-17. doi: 10.1093/ndt/gfz051. No abstract available.


Stereoselective Cascade Cyclizations with Samarium Diiodide to Tetracyclic Indolines: Precursors of Fluorostrychnines and Brucine.

Beemelmanns C, Nitsch D, Bentz C, Reissig HU.

Chemistry. 2019 Jul 2;25(37):8780-8789. doi: 10.1002/chem.201900087. Epub 2019 Jun 5.


Prevalence and Demographics of CKD in Canadian Primary Care Practices: A Cross-sectional Study.

Bello AK, Ronksley PE, Tangri N, Kurzawa J, Osman MA, Singer A, Grill A, Nitsch D, Queenan JA, Wick J, Lindeman C, Soos B, Tuot DS, Shojai S, Brimble S, Mangin D, Drummond N.

Kidney Int Rep. 2019 Jan 21;4(4):561-570. doi: 10.1016/j.ekir.2019.01.005. eCollection 2019 Apr.


Improving Hypertension Outcome Measurement in Low- and Middle-Income Countries.

Zack R, Okunade O, Olson E, Salt M, Amodeo C, Anchala R, Berwanger O, Campbell N, Chia YC, Damasceno A, Phuong Do TN, Tamdja Dzudie A, Fiuza M, Mirza F, Nitsch D, Ogedegbe G, Podpalov V, Schiffrin EL, Vaz Carneiro A, Lamptey P.

Hypertension. 2019 May;73(5):990-997. doi: 10.1161/HYPERTENSIONAHA.118.11916.


Prevalence of and risk factors for chronic kidney disease of unknown aetiology in India: secondary data analysis of three population-based cross-sectional studies.

O'Callaghan-Gordo C, Shivashankar R, Anand S, Ghosh S, Glaser J, Gupta R, Jakobsson K, Kondal D, Krishnan A, Mohan S, Mohan V, Nitsch D, P A P, Tandon N, Narayan KMV, Pearce N, Caplin B, Prabhakaran D.

BMJ Open. 2019 Mar 7;9(3):e023353. doi: 10.1136/bmjopen-2018-023353. Erratum in: BMJ Open. 2019 Mar 18;9(3):e023353corr1.


Identification of young adults at risk of an accelerated loss of kidney function in an area affected by Mesoamerican nephropathy.

Gonzalez-Quiroz M, Smpokou ET, Pearce N, Caplin B, Nitsch D.

BMC Nephrol. 2019 Jan 16;20(1):21. doi: 10.1186/s12882-018-1193-x.


Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract.

Ravindran RD, Sundaresan P, Krishnan T, Vashist P, Maraini G, Saravanan V, Chakravarthy U, Smeeth L, Nitsch D, Young IS, Fletcher AE.

Br J Ophthalmol. 2019 Sep;103(9):1223-1227. doi: 10.1136/bjophthalmol-2018-312257. Epub 2018 Nov 15.


Can childhood obesity influence later chronic kidney disease?

Jadresic L, Silverwood RJ, Kinra S, Nitsch D.

Pediatr Nephrol. 2019 Dec;34(12):2457-2477. doi: 10.1007/s00467-018-4108-y. Epub 2018 Nov 10.


What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis.

González-Quiroz M, Pearce N, Caplin B, Nitsch D.

Clin Kidney J. 2018 Aug;11(4):496-506. doi: 10.1093/ckj/sfx136. Epub 2017 Dec 8.


The National CKD Audit: a primary care condition that deserves more attention.

Hull SA, Nitsch D, Caplin B, Griffith K, Wheeler DC.

Br J Gen Pract. 2018 Aug;68(673):356-357. doi: 10.3399/bjgp18X697997. No abstract available.


Chronic kidney disease and cause-specific hospitalisation: a matched cohort study using primary and secondary care patient data.

Iwagami M, Caplin B, Smeeth L, Tomlinson LA, Nitsch D.

Br J Gen Pract. 2018 Aug;68(673):e512-e523. doi: 10.3399/bjgp18X697973. Epub 2018 Jul 16.


Acute kidney injury in the UK: a replication cohort study of the variation across three regional populations.

Sawhney S, Robinson HA, van der Veer SN, Hounkpatin HO, Scale TM, Chess JA, Peek N, Marks A, Davies GI, Fraccaro P, Johnson MJ, Lyons RA, Nitsch D, Roderick PJ, Halbesma N, Miller-Hodges E, Black C, Fraser S.

BMJ Open. 2018 Jun 30;8(6):e019435. doi: 10.1136/bmjopen-2017-019435.


Decline in Kidney Function among Apparently Healthy Young Adults at Risk of Mesoamerican Nephropathy.

Gonzalez-Quiroz M, Smpokou ET, Silverwood RJ, Camacho A, Faber D, Garcia BR, Oomatia A, Hill M, Glaser J, Le Blond J, Wesseling C, Aragon A, Smeeth L, Pearce N, Nitsch D, Caplin B.

J Am Soc Nephrol. 2018 Aug;29(8):2200-2212. doi: 10.1681/ASN.2018020151. Epub 2018 Jun 15.


Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: A population-based cohort study.

Iwagami M, Tomlinson LA, Mansfield KE, Douglas IJ, Smeeth L, Nitsch D.

Br J Clin Pharmacol. 2018 Sep;84(9):2142-2151. doi: 10.1111/bcp.13660. Epub 2018 Jul 8.


Long-term effects of bariatric surgery on acute kidney injury: a propensity-matched cohort in the UK Clinical Practice Research Datalink.

Koppe U, Nitsch D, Mansfield KE, Mathur R, Bhaskaran K, Batterham RL, Smeeth L, Douglas IJ.

BMJ Open. 2018 May 16;8(5):e020371. doi: 10.1136/bmjopen-2017-020371.


Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom.

Iwagami M, Mansfield KE, Hayes JF, Walters K, Osborn DP, Smeeth L, Nitsch D, Tomlinson LA.

Clin Epidemiol. 2018 Apr 16;10:421-429. doi: 10.2147/CLEP.S154841. eCollection 2018.


How does the association of general and central adiposity with glycaemia and blood pressure differ by gender and area of residence in a Malawian population: a cross-sectional study.

Mudie K, Lawlor DA, Pearce N, Crampin A, Tomlinson L, Tafatatha T, Musicha C, Nitsch D, Smeeth L, Nyirenda MJ.

Int J Epidemiol. 2018 Jun 1;47(3):887-898. doi: 10.1093/ije/dyy047.


Serum potassium and adverse outcomes across the range of kidney function: a CKD Prognosis Consortium meta-analysis.

Kovesdy CP, Matsushita K, Sang Y, Brunskill NJ, Carrero JJ, Chodick G, Hasegawa T, Heerspink HL, Hirayama A, Landman GWD, Levin A, Nitsch D, Wheeler DC, Coresh J, Hallan SI, Shalev V, Grams ME; CKD Prognosis Consortium.

Eur Heart J. 2018 May 1;39(17):1535-1542. doi: 10.1093/eurheartj/ehy100.


The Decreasing Prevalence of Nonrefractive Visual Impairment in Older Europeans: A Meta-analysis of Published and Unpublished Data.

Delcourt C, Le Goff M, von Hanno T, Mirshahi A, Khawaja AP, Verhoeven VJM, Hogg RE, Anastosopoulos E, Cachulo ML, Höhn R, Wolfram C, Bron A, Miotto S, Carrière I, Colijn JM, Buitendijk GHS, Evans J, Nitsch D, Founti P, Yip JLY, Pfeiffer N, Creuzot-Garcher C, Silva R, Piermarocchi S, Topouzis F, Bertelsen G, Foster PJ, Fletcher A, Klaver CCW, Korobelnik JF; European Eye Epidemiology Consortium.

Ophthalmology. 2018 Aug;125(8):1149-1159. doi: 10.1016/j.ophtha.2018.02.005. Epub 2018 Mar 13. Review.


Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.

Crellin E, Mansfield KE, Leyrat C, Nitsch D, Douglas IJ, Root A, Williamson E, Smeeth L, Tomlinson LA.

BMJ. 2018 Feb 9;360:k341. doi: 10.1136/bmj.k341.


Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis.

Mansfield KE, Douglas IJ, Nitsch D, Thomas SL, Smeeth L, Tomlinson LA.

Clin Epidemiol. 2018 Jan 30;10:187-202. doi: 10.2147/CLEP.S146757. eCollection 2018.


Does dialysis modality affect the development of cognitive impairment?

Nitsch D.

Kidney Int. 2018 Feb;93(2):306-308. doi: 10.1016/j.kint.2017.09.026.


Genetic risk factors for late age-related macular degeneration in India.

Rajendran A, Dhoble P, Sundaresan P, Saravanan V, Vashist P, Nitsch D, Smeeth L, Chakravarthy U, Ravindran RD, Fletcher AE.

Br J Ophthalmol. 2018 Sep;102(9):1213-1217. doi: 10.1136/bjophthalmol-2017-311384. Epub 2017 Dec 19.


Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study.

Sinnott SJ, Mansfield KE, Schmidt M, Bhaskaran K, Smeeth L, Nitsch D, Tomlinson LA.

BMJ Open. 2017 Nov 16;7(11):e018153. doi: 10.1136/bmjopen-2017-018153.


How do primary care doctors in England and Wales code and manage people with chronic kidney disease? Results from the National Chronic Kidney Disease Audit.

Kim LG, Cleary F, Wheeler DC, Caplin B, Nitsch D, Hull SA; UK National Chronic Kidney Disease Audit.

Nephrol Dial Transplant. 2018 Aug 1;33(8):1373-1379. doi: 10.1093/ndt/gfx280.


A national surveillance project on chronic kidney disease management in Canadian primary care: a study protocol.

Bello AK, Ronksley PE, Tangri N, Singer A, Grill A, Nitsch D, Queenan JA, Lindeman C, Soos B, Freiheit E, Tuot D, Mangin D, Drummond N.

BMJ Open. 2017 Aug 4;7(8):e016267. doi: 10.1136/bmjopen-2017-016267.


Do influenza and pneumococcal vaccines prevent community-acquired respiratory infections among older people with diabetes and does this vary by chronic kidney disease? A cohort study using electronic health records.

McDonald HI, Thomas SL, Millett ERC, Quint J, Nitsch D.

BMJ Open Diabetes Res Care. 2017 Apr 3;5(1):e000332. doi: 10.1136/bmjdrc-2016-000332. eCollection 2017.


Risk factors for developing acute kidney injury in older people with diabetes and community-acquired pneumonia: a population-based UK cohort study.

Jain A, McDonald HI, Nitsch D, Tomlinson L, Thomas SL.

BMC Nephrol. 2017 May 1;18(1):142. doi: 10.1186/s12882-017-0566-x.


Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink.

Iwagami M, Tomlinson LA, Mansfield KE, McDonald HI, Smeeth L, Nitsch D.

Pharmacoepidemiol Drug Saf. 2017 Jul;26(7):792-801. doi: 10.1002/pds.4212. Epub 2017 Apr 11.


Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higher (eGFR<45 mL/min/1.73 m2): a summary document from the European Renal Best Practice Group.

Farrington K, Covic A, Nistor I, Aucella F, Clyne N, De Vos L, Findlay A, Fouque D, Grodzicki T, Iyasere O, Jager KJ, Joosten H, Macias JF, Mooney A, Nagler E, Nitsch D, Taal M, Tattersall J, Stryckers M, van Asselt D, Van den Noortgate N, van der Veer S, van Biesen W.

Nephrol Dial Transplant. 2017 Jan 1;32(1):9-16. doi: 10.1093/ndt/gfw411.


Accounting for overdispersion when determining primary care outliers for the identification of chronic kidney disease: learning from the National Chronic Kidney Disease Audit.

Kim LG, Caplin B, Cleary F, Hull SA, Griffith K, Wheeler DC, Nitsch D; UK National Chronic Kidney Disease Audit.

Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii151-ii158. doi: 10.1093/ndt/gfw398.


Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study.

Schmidt M, Mansfield KE, Bhaskaran K, Nitsch D, Sørensen HT, Smeeth L, Tomlinson LA.

BMJ. 2017 Mar 9;356:j791. doi: 10.1136/bmj.j791.


Validity of estimated prevalence of decreased kidney function and renal replacement therapy from primary care electronic health records compared with national survey and registry data in the United Kingdom.

Iwagami M, Tomlinson LA, Mansfield KE, Casula A, Caskey FJ, Aitken G, Fraser SDS, Roderick PJ, Nitsch D.

Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii142-ii150. doi: 10.1093/ndt/gfw318.


Pharmacoepidemiology for nephrologists: do proton pump inhibitors cause chronic kidney disease?

Tomlinson LA, Fogarty DG, Douglas I, Nitsch D.

Nephrol Dial Transplant. 2017 Apr 1;32(suppl_2):ii40-ii46. doi: 10.1093/ndt/gfw349. Review.


Rationale, description and baseline findings of a community-based prospective cohort study of kidney function amongst the young rural population of Northwest Nicaragua.

González-Quiroz M, Camacho A, Faber D, Aragón A, Wesseling C, Glaser J, Le Blond J, Smeeth L, Nitsch D, Pearce N, Caplin B.

BMC Nephrol. 2017 Jan 13;18(1):16. doi: 10.1186/s12882-016-0422-4.


Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study.

Schmidt M, Mansfield KE, Bhaskaran K, Nitsch D, Sørensen HT, Smeeth L, Tomlinson LA.

BMJ Open. 2017 Jan 9;7(1):e012818. doi: 10.1136/bmjopen-2016-012818. Erratum in: BMJ Open. 2017 Sep 18;7(9):e012818corr1.


International Collaboration for the Epidemiology of eGFR in Low and Middle Income Populations - Rationale and core protocol for the Disadvantaged Populations eGFR Epidemiology Study (DEGREE).

Caplin B, Jakobsson K, Glaser J, Nitsch D, Jha V, Singh A, Correa-Rotter R, Pearce N.

BMC Nephrol. 2017 Jan 3;18(1):1. doi: 10.1186/s12882-016-0417-1.


Prescription of renin-angiotensin system blockers and risk of acute kidney injury: a population-based cohort study.

Mansfield KE, Nitsch D, Smeeth L, Bhaskaran K, Tomlinson LA.

BMJ Open. 2016 Dec 21;6(12):e012690. doi: 10.1136/bmjopen-2016-012690.


Urinary biomarkers of tubular injury in chronic kidney disease.

Caplin B, Nitsch D.

Kidney Int. 2017 Jan;91(1):21-23. doi: 10.1016/j.kint.2016.10.003.

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