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Items: 1 to 50 of 147

1.

BitterDB: taste ligands and receptors database in 2019.

Dagan-Wiener A, Di Pizio A, Nissim I, Bahia MS, Dubovski N, Margulis E, Niv MY.

Nucleic Acids Res. 2019 Jan 8;47(D1):D1179-D1185. doi: 10.1093/nar/gky974.

2.

Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.

Zhang K, Hast MW, Izumi S, Usami Y, Shetye S, Akabudike N, Philp NJ, Iwamoto M, Nissim I, Soslowsky LJ, Enomoto-Iwamoto M.

Am J Sports Med. 2018 Jul;46(9):2222-2231. doi: 10.1177/0363546518778789. Epub 2018 Jun 21.

3.

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC.

Cell Metab. 2018 Jun 5;27(6):1263-1280.e6. doi: 10.1016/j.cmet.2018.04.009. Epub 2018 May 10.

4.

A role for bacterial urease in gut dysbiosis and Crohn's disease.

Ni J, Shen TD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffmann C, Rivas G, Albenberg L, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD, Wu GD.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaah6888. doi: 10.1126/scitranslmed.aah6888.

5.

The taste of toxicity: A quantitative analysis of bitter and toxic molecules.

Nissim I, Dagan-Wiener A, Niv MY.

IUBMB Life. 2017 Dec;69(12):938-946. doi: 10.1002/iub.1694. Epub 2017 Nov 11.

6.

Bitter or not? BitterPredict, a tool for predicting taste from chemical structure.

Dagan-Wiener A, Nissim I, Ben Abu N, Borgonovo G, Bassoli A, Niv MY.

Sci Rep. 2017 Sep 21;7(1):12074. doi: 10.1038/s41598-017-12359-7.

7.

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets.

Li C, Ackermann AM, Boodhansingh KE, Bhatti TR, Liu C, Schug J, Doliba N, Han B, Cosgrove KE, Banerjee I, Matschinsky FM, Nissim I, Kaestner KH, Naji A, Adzick NS, Dunne MJ, Stanley CA, De León DD.

Diabetes. 2017 Jul;66(7):1901-1913. doi: 10.2337/db17-0029. Epub 2017 Apr 25.

8.

Bitterness prediction in-silico: A step towards better drugs.

Bahia MS, Nissim I, Niv MY.

Int J Pharm. 2018 Feb 5;536(2):526-529. doi: 10.1016/j.ijpharm.2017.03.076. Epub 2017 Mar 28.

PMID:
28363856
9.

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

Raju K, Doulias PT, Evans P, Krizman EN, Jackson JG, Horyn O, Daikhin Y, Nissim I, Yudkoff M, Nissim I, Sharp KA, Robinson MB, Ischiropoulos H.

Sci Signal. 2015 Jul 7;8(384):ra68. doi: 10.1126/scisignal.aaa4312.

10.

Engineering the gut microbiota to treat hyperammonemia.

Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD, Wu GD.

J Clin Invest. 2015 Jul 1;125(7):2841-50. doi: 10.1172/JCI79214. Epub 2015 Jun 22.

11.

Fructose-1,6-bisphosphatase opposes renal carcinoma progression.

Li B, Qiu B, Lee DS, Walton ZE, Ochocki JD, Mathew LK, Mancuso A, Gade TP, Keith B, Nissim I, Simon MC.

Nature. 2014 Sep 11;513(7517):251-5. doi: 10.1038/nature13557. Epub 2014 Jul 20.

12.

Augmenting ureagenesis in patients with partial carbamyl phosphate synthetase 1 deficiency with N-carbamyl-L-glutamate.

Ah Mew N, McCarter R, Daikhin Y, Lichter-Konecki U, Nissim I, Yudkoff M, Tuchman M.

J Pediatr. 2014 Aug;165(2):401-403.e3. doi: 10.1016/j.jpeds.2014.04.012. Epub 2014 May 29.

13.

The molecular and metabolic influence of long term agmatine consumption.

Nissim I, Horyn O, Daikhin Y, Chen P, Li C, Wehrli SL, Nissim I, Yudkoff M.

J Biol Chem. 2014 Apr 4;289(14):9710-29. doi: 10.1074/jbc.M113.544726. Epub 2014 Feb 12.

14.

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.

Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D.

Cell. 2013 Feb 14;152(4):778-790. doi: 10.1016/j.cell.2013.01.023. Epub 2013 Feb 7.

15.

Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.

Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A.

J Biol Chem. 2013 Feb 8;288(6):3938-51. doi: 10.1074/jbc.M112.385682. Epub 2012 Dec 24.

16.

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics.

Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M, Matschinsky FM.

Biochem J. 2012 Jun 15;444(3):537-51. doi: 10.1042/BJ20120163.

17.

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice.

Falk MJ, Polyak E, Zhang Z, Peng M, King R, Maltzman JS, Okwuego E, Horyn O, Nakamaru-Ogiso E, Ostrovsky J, Xie LX, Chen JY, Marbois B, Nissim I, Clarke CF, Gasser DL.

EMBO Mol Med. 2011 Jul;3(7):410-27. doi: 10.1002/emmm.201100149. Epub 2011 Jun 8.

18.

Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase.

Nissim I, Horyn O, Nissim I, Daikhin Y, Caldovic L, Barcelona B, Cervera J, Tuchman M, Yudkoff M.

J Biol Chem. 2011 Jun 24;286(25):22055-68. doi: 10.1074/jbc.M110.209023. Epub 2011 May 3.

19.

Stable isotopic profiling of intermediary metabolic flux in developing and adult stage Caenorhabditis elegans.

Falk MJ, Rao M, Ostrovsky J, Daikhin E, Nissim I, Yudkoff M.

J Vis Exp. 2011 Feb 27;(48). pii: 2288. doi: 10.3791/2288.

20.

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.

Li C, Chen P, Palladino A, Narayan S, Russell LK, Sayed S, Xiong G, Chen J, Stokes D, Butt YM, Jones PM, Collins HW, Cohen NA, Cohen AS, Nissim I, Smith TJ, Strauss AW, Matschinsky FM, Bennett MJ, Stanley CA.

J Biol Chem. 2010 Oct 8;285(41):31806-18. doi: 10.1074/jbc.M110.123638. Epub 2010 Jul 29.

21.

N-carbamylglutamate augments ureagenesis and reduces ammonia and glutamine in propionic acidemia.

Ah Mew N, McCarter R, Daikhin Y, Nissim I, Yudkoff M, Tuchman M.

Pediatrics. 2010 Jul;126(1):e208-14. doi: 10.1542/peds.2010-0008. Epub 2010 Jun 21.

22.

Measuring in vivo ureagenesis with stable isotopes.

Yudkoff M, Ah Mew N, Daikhin Y, Horyn O, Nissim I, Nissim I, Payan I, Tuchman M.

Mol Genet Metab. 2010;100 Suppl 1:S37-41. doi: 10.1016/j.ymgme.2010.02.017. Epub 2010 Feb 26.

23.

Dietary branched chain amino acids ameliorate injury-induced cognitive impairment.

Cole JT, Mitala CM, Kundu S, Verma A, Elkind JA, Nissim I, Cohen AS.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):366-71. doi: 10.1073/pnas.0910280107. Epub 2009 Dec 7. Erratum in: Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2373.

24.

Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis.

Ah Mew N, Payan I, Daikhin Y, Nissim I, Nissim I, Tuchman M, Yudkoff M.

Mol Genet Metab. 2009 Dec;98(4):325-30. doi: 10.1016/j.ymgme.2009.07.010. Epub 2009 Jul 14. Erratum in: Mol Genet Metab. 2010 Apr;99(4):440.

25.

Ketosis and brain handling of glutamate, glutamine, and GABA.

Yudkoff M, Daikhin Y, Horyn O, Nissim I, Nissim I.

Epilepsia. 2008 Nov;49 Suppl 8:73-5. doi: 10.1111/j.1528-1167.2008.01841.x. Review.

26.

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7. doi: 10.1073/pnas.0810199105. Epub 2008 Nov 24.

27.

Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo.

da Silva RP, Nissim I, Brosnan ME, Brosnan JT.

Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E256-61. doi: 10.1152/ajpendo.90547.2008. Epub 2008 Nov 18.

28.

Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt.

Li C, Nissim I, Chen P, Buettger C, Najafi H, Daikhin Y, Nissim I, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM.

J Biol Chem. 2008 Jun 20;283(25):17238-49. doi: 10.1074/jbc.M709235200. Epub 2008 Apr 29.

29.

N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers.

Tuchman M, Caldovic L, Daikhin Y, Horyn O, Nissim I, Nissim I, Korson M, Burton B, Yudkoff M.

Pediatr Res. 2008 Aug;64(2):213-7. doi: 10.1203/PDR.0b013e318179454b.

30.

3-isobutylmethylxanthine inhibits hepatic urea synthesis: protection by agmatine.

Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M.

J Biol Chem. 2008 May 30;283(22):15063-71. doi: 10.1074/jbc.M800163200. Epub 2008 Mar 28.

31.

Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans.

Falk MJ, Zhang Z, Rosenjack JR, Nissim I, Daikhin E, Nissim I, Sedensky MM, Yudkoff M, Morgan PG.

Mol Genet Metab. 2008 Apr;93(4):388-97. doi: 10.1016/j.ymgme.2007.11.007. Epub 2008 Feb 21.

32.

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.

DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19345-50. Epub 2007 Nov 21.

33.

The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

Yudkoff M, Daikhin Y, Melø TM, Nissim I, Sonnewald U, Nissim I.

Annu Rev Nutr. 2007;27:415-30. Review.

34.

Troglitazone and pioglitazone interactions via PPAR-gamma-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines.

Turturro F, Oliver R 3rd, Friday E, Nissim I, Welbourne T.

Am J Physiol Cell Physiol. 2007 Mar;292(3):C1137-46. Epub 2006 Oct 25.

35.

Ifosfamide-induced nephrotoxicity: mechanism and prevention.

Nissim I, Horyn O, Daikhin Y, Nissim I, Luhovyy B, Phillips PC, Yudkoff M.

Cancer Res. 2006 Aug 1;66(15):7824-31.

36.

Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.

Li C, Matter A, Kelly A, Petty TJ, Najafi H, MacMullen C, Daikhin Y, Nissim I, Lazarow A, Kwagh J, Collins HW, Hsu BY, Nissim I, Yudkoff M, Matschinsky FM, Stanley CA.

J Biol Chem. 2006 Jun 2;281(22):15064-72. Epub 2006 Mar 30.

37.

Short-term fasting, seizure control and brain amino acid metabolism.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Lazarow A, Nissim I.

Neurochem Int. 2006 May-Jun;48(6-7):650-6. Epub 2006 Feb 28.

PMID:
16510212
38.

Agmatine stimulates hepatic fatty acid oxidation: a possible mechanism for up-regulation of ureagenesis.

Nissim I, Daikhin Y, Nissim I, Luhovyy B, Horyn O, Wehrli SL, Yudkoff M.

J Biol Chem. 2006 Mar 31;281(13):8486-96. Epub 2006 Feb 1.

39.

Brain amino acid requirements and toxicity: the example of leucine.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Luhovyy B, Lazarow A, Nissim I.

J Nutr. 2005 Jun;135(6 Suppl):1531S-8S. doi: 10.1093/jn/135.6.1531S. Review. Erratum in: J Nutr. 2005 Aug;135(8):2009. Luhovyy, Bogdan [corrected to Luhovyy, Bohdan].

PMID:
15930465
40.

Response of brain amino acid metabolism to ketosis.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Luhovyy B, Wehrli S, Nissim I.

Neurochem Int. 2005 Jul;47(1-2):119-28.

PMID:
15888376
41.

From dumping to sanitary landfills--solid waste management in Israel.

Nissim I, Shohat T, Inbar Y.

Waste Manag. 2005;25(3):323-7. Review.

PMID:
15823747
42.

The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver.

Nissim I, Luhovyy B, Horyn O, Daikhin Y, Nissim I, Yudkoff M.

J Biol Chem. 2005 May 6;280(18):17715-24. Epub 2005 Mar 7.

43.

Biosynthesis of agmatine in isolated mitochondria and perfused rat liver: studies with 15N-labelled arginine.

Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M, Nissim I.

Biochem J. 2005 Jun 1;388(Pt 2):419-25.

44.

Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate.

Caldovic L, Morizono H, Daikhin Y, Nissim I, McCarter RJ, Yudkoff M, Tuchman M.

J Pediatr. 2004 Oct;145(4):552-4.

PMID:
15480384
45.

Ketogenic diet, brain glutamate metabolism and seizure control.

Yudkoff M, Daikhin Y, Nissim I, Lazarow A, Nissim I.

Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):277-85. Review.

PMID:
14769486
46.

A signaling role of glutamine in insulin secretion.

Li C, Buettger C, Kwagh J, Matter A, Daikhin Y, Nissim IB, Collins HW, Yudkoff M, Stanley CA, Matschinsky FM.

J Biol Chem. 2004 Apr 2;279(14):13393-401. Epub 2004 Jan 20.

47.

A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates.

Brosnan JT, Brosnan ME, Nissim I.

Metab Eng. 2004 Jan;6(1):6-11.

PMID:
14734251
48.

New secondary metabolites of phenylbutyrate in humans and rats.

Kasumov T, Brunengraber LL, Comte B, Puchowicz MA, Jobbins K, Thomas K, David F, Kinman R, Wehrli S, Dahms W, Kerr D, Nissim I, Brunengraber H.

Drug Metab Dispos. 2004 Jan;32(1):10-9.

PMID:
14709615
49.

Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules.

Feldkamp T, Kribben A, Roeser NF, Senter RA, Kemner S, Venkatachalam MA, Nissim I, Weinberg JM.

Am J Physiol Renal Physiol. 2004 Apr;286(4):F749-59. Epub 2003 Dec 9.

50.

Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism.

Welbourne T, Friday E, Fowler R, Turturro F, Nissim I.

Am J Physiol Renal Physiol. 2004 Jan;286(1):F100-10. Epub 2003 Sep 23.

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