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Interactively AUDIT Your Growth Curves with a Suite of R Packages.

Coutin NPJ, Giaever G, Nislow C.

G3 (Bethesda). 2020 Jan 23. pii: g3.400898.2019. doi: 10.1534/g3.119.400898. [Epub ahead of print]


A competence-regulated toxin-antitoxin system in Haemophilus influenzae.

Findlay Black H, Mastromatteo S, Sinha S, Ehrlich RL, Nislow C, Chang Mell J, Redfield RJ.

PLoS One. 2020 Jan 13;15(1):e0217255. doi: 10.1371/journal.pone.0217255. eCollection 2020.


Single-cell analysis for drug development using convex lens-induced confinement imaging.

Thiombane NK, Coutin N, Berard D, Tahvildari R, Leslie S, Nislow C.

Biotechniques. 2019 Nov;67(5):210-217. doi: 10.2144/btn-2019-0067. Epub 2019 Oct 28. Erratum in: Biotechniques. 2020 Jan;68(1):52.


De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy.

Tarailo-Graovac M, Zahir FR, Zivkovic I, Moksa M, Selby K, Sinha S, Nislow C, Stockler-Ipsiroglu SG, Sheffer R, Saada-Reisch A, Friedman JM, van Karnebeek CDM, Horvath GA.

Mol Genet Genomic Med. 2019 Oct;7(10):e00961. doi: 10.1002/mgg3.961. Epub 2019 Sep 1.


Network dynamics of the yeast methyltransferome.

Giaever G, Lissina E, Nislow C.

Microb Cell. 2019 Jul 9;6(8):356-369. doi: 10.15698/mic2019.08.687.


Pharmacogenomic Testing: Clinical Evidence and Implementation Challenges.

Hippman C, Nislow C.

J Pers Med. 2019 Aug 7;9(3). pii: E40. doi: 10.3390/jpm9030040. Review.


The Paf1 Complex Broadly Impacts the Transcriptome of Saccharomyces cerevisiae.

Ellison MA, Lederer AR, Warner MH, Mavrich TN, Raupach EA, Heisler LE, Nislow C, Lee MT, Arndt KM.

Genetics. 2019 Jul;212(3):711-728. doi: 10.1534/genetics.119.302262. Epub 2019 May 15.


Heparanase protects the heart against chemical or ischemia/reperfusion injury.

Wang F, Pulinilkunnil T, Flibotte S, Nislow C, Vlodavsky I, Hussein B, Rodrigues B.

J Mol Cell Cardiol. 2019 Jun;131:29-40. doi: 10.1016/j.yjmcc.2019.04.008. Epub 2019 Apr 17.


Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 May;15(5):549. doi: 10.1038/s41589-019-0255-0.


MicroRNA Biomarkers in Cerebrospinal Fluid and Serum Reflect Injury Severity in Human Acute Traumatic Spinal Cord Injury.

Tigchelaar S, Gupta R, Shannon CP, Streijger F, Sinha S, Flibotte S, Rizzuto MA, Street J, Paquette S, Ailon T, Charest-Morin R, Dea N, Fisher C, Dvorak MF, Dhall S, Mac-Thiong JM, Parent S, Bailey C, Christie S, Van Keuren-Jensen K, Nislow C, Kwon BK.

J Neurotrauma. 2019 Aug 1;36(15):2358-2371. doi: 10.1089/neu.2018.6256. Epub 2019 May 14.


PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.

Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J.

Nat Chem Biol. 2019 Apr;15(4):358-366. doi: 10.1038/s41589-019-0228-3. Epub 2019 Feb 11. Erratum in: Nat Chem Biol. 2019 Mar 4;:.


Sputum Microbiome Is Associated with 1-Year Mortality after Chronic Obstructive Pulmonary Disease Hospitalizations.

Leitao Filho FS, Alotaibi NM, Ngan D, Tam S, Yang J, Hollander Z, Chen V, FitzGerald JM, Nislow C, Leung JM, Man SFP, Sin DD.

Am J Respir Crit Care Med. 2019 May 15;199(10):1205-1213. doi: 10.1164/rccm.201806-1135OC.


Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases.

Tiefenbach J, Magomedova L, Liu J, Reunov AA, Tsai R, Eappen NS, Jockusch RA, Nislow C, Cummins CL, Krause HM.

Dis Model Mech. 2018 Aug 31;11(9). pii: dmm034801. doi: 10.1242/dmm.034801.


Decreased microbiome diversity in the HIV small airway epithelium.

Xu S, Tsai A, Sze MA, Vucic EA, Shaipanich T, Harris M, Guillemi S, Yang J, Sinha S, Nislow C, Montaner J, Lam W, Lam S, Sin DD, Paul Man SF, Leung JM.

Respir Res. 2018 Jul 27;19(1):140. doi: 10.1186/s12931-018-0835-7.


Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".

Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, Sallans L, Desai PB, Wiederhold NP, Fothergill AW, Kirkpatrick WR, Patterson T, Wong LH, Sinha S, Giaever G, Nislow C, Flaherty P, Pan X, Cesar GV, de Melo Tavares P, Frases S, Miranda K, Rodrigues ML, Luberto C, Nimrichter L, Del Poeta M.

mBio. 2018 Mar 13;9(2). pii: e00188-18. doi: 10.1128/mBio.00188-18. No abstract available.


Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations.

Hammond TG, Allen PL, Gunter MA, Chiang J, Giaever G, Nislow C, Birdsall HH.

Microgravity Sci Technol. 2018;30(3):195-208. doi: 10.1007/s12217-017-9588-z. Epub 2017 Dec 29.


Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain.

Page MM, Skovsø S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, Lim GE, Szabat M, Flibotte S, Sinha S, Nislow C, Rodrigues B, Johnson JD.

FASEB J. 2018 Mar;32(3):1196-1206. doi: 10.1096/fj.201700518R. Epub 2018 Jan 3.


Caryolan-1-ol, an antifungal volatile produced by Streptomyces spp., inhibits the endomembrane system of fungi.

Cho G, Kim J, Park CG, Nislow C, Weller DM, Kwak YS.

Open Biol. 2017 Jul;7(7). pii: 170075. doi: 10.1098/rsob.170075.


Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.

Templeman NM, Flibotte S, Chik JHL, Sinha S, Lim GE, Foster LJ, Nislow C, Johnson JD.

Cell Rep. 2017 Jul 11;20(2):451-463. doi: 10.1016/j.celrep.2017.06.048.


Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress.

Acton E, Lee AH, Zhao PJ, Flibotte S, Neira M, Sinha S, Chiang J, Flaherty P, Nislow C, Giaever G.

Open Biol. 2017 Jun;7(6). pii: 160330. doi: 10.1098/rsob.160330.


Insight into the Recent Genome Duplication of the Halophilic Yeast Hortaea werneckii: Combining an Improved Genome with Gene Expression and Chromatin Structure.

Sinha S, Flibotte S, Neira M, Formby S, Plemenitaš A, Cimerman NG, Lenassi M, Gostinčar C, Stajich JE, Nislow C.

G3 (Bethesda). 2017 Jul 5;7(7):2015-2022. doi: 10.1534/g3.117.040691.


Serum MicroRNAs Reflect Injury Severity in a Large Animal Model of Thoracic Spinal Cord Injury.

Tigchelaar S, Streijger F, Sinha S, Flibotte S, Manouchehri N, So K, Shortt K, Okon E, Rizzuto MA, Malenica I, Courtright-Lim A, Eisen A, Keuren-Jensen KV, Nislow C, Kwon BK.

Sci Rep. 2017 May 3;7(1):1376. doi: 10.1038/s41598-017-01299-x.


Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs.

Lee AH, Flibotte S, Sinha S, Paiero A, Ehrlich RL, Balashov S, Ehrlich GD, Zlosnik JE, Mell JC, Nislow C.

Genome Res. 2017 Apr;27(4):650-662. doi: 10.1101/gr.213363.116. Epub 2017 Mar 21.


Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant.

Wong LH, Flibotte S, Sinha S, Chiang J, Giaever G, Nislow C.

G3 (Bethesda). 2017 Apr 3;7(4):1251-1257. doi: 10.1534/g3.116.038117.


Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes.

Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B.

Diabetes. 2017 Jan;66(1):45-57. doi: 10.2337/db16-0761. Epub 2016 Oct 7.


The bronchial epithelial cell bacterial microbiome and host response in patients infected with human immunodeficiency virus.

Sze MA, Xu S, Leung JM, Vucic EA, Shaipanich T, Moghadam A, Harris M, Guillemi S, Sinha S, Nislow C, Murphy D, Hague C, Leipsic J, Lam S, Lam W, Montaner JS, Sin DD, Man SF.

BMC Pulm Med. 2016 Nov 9;16(1):142.


A chemogenomic approach to understand the antifungal action of Lichen-derived vulpinic acid.

Kwon Y, Cha J, Chiang J, Tran G, Giaever G, Nislow C, Hur JS, Kwak YS.

J Appl Microbiol. 2016 Dec;121(6):1580-1591. doi: 10.1111/jam.13300. Epub 2016 Nov 3.


Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.

Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler EA, Wittlin S, Todd MH.

ACS Cent Sci. 2016 Oct 26;2(10):687-701. Epub 2016 Sep 14.


Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.

Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, Roskelley C, Forge T, Nislow C, Moerman D.

PLoS Negl Trop Dis. 2016 Oct 18;10(10):e0005058. doi: 10.1371/journal.pntd.0005058. eCollection 2016 Oct.


Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions.

Wong LH, Sinha S, Bergeron JR, Mellor JC, Giaever G, Flaherty P, Nislow C.

PLoS Genet. 2016 Sep 2;12(9):e1006275. doi: 10.1371/journal.pgen.1006275. eCollection 2016 Sep.


Functional Genomics Using the Saccharomyces cerevisiae Yeast Deletion Collections.

Nislow C, Wong LH, Lee AH, Giaever G.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.top080945.


Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae.

Suresh S, Schlecht U, Xu W, Bray W, Miranda M, Davis RW, Nislow C, Giaever G, Lokey RS, St Onge RP.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.top077701.


Identification of Chemical-Genetic Interactions via Parallel Analysis of Barcoded Yeast Strains.

Suresh S, Schlecht U, Xu W, Miranda M, Davis RW, Nislow C, Giaever G, St Onge RP.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot088054.


Functional Profiling Using the Saccharomyces Genome Deletion Project Collections.

Nislow C, Wong LH, Lee AH, Giaever G.

Cold Spring Harb Protoc. 2016 Sep 1;2016(9). doi: 10.1101/pdb.prot088039.


Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE.

Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29.


Signaling pathways coordinating the alkaline pH response confer resistance to the hevein-type plant antimicrobial peptide Pn-AMP1 in Saccharomyces cerevisiae.

Kwon Y, Chiang J, Tran G, Giaever G, Nislow C, Hahn BS, Kwak YS, Koo JC.

Planta. 2016 Dec;244(6):1229-1240. Epub 2016 Aug 10.


Lichen-forming fungus Caloplaca flavoruscens inhibits transcription factors and chromatin remodeling system in fungi.

Kwon Y, Cha J, Chiang J, Tran G, Nislow C, Hur JS, Kwak YS.

FEMS Microbiol Lett. 2016 Jun;363(12). pii: fnw113. doi: 10.1093/femsle/fnw113. Epub 2016 Apr 25.


Transformed Recombinant Enrichment Profiling Rapidly Identifies HMW1 as an Intracellular Invasion Locus in Haemophilus influenza.

Mell JC, Viadas C, Moleres J, Sinha S, Fernández-Calvet A, Porsch EA, St Geme JW 3rd, Nislow C, Redfield RJ, Garmendia J.

PLoS Pathog. 2016 Apr 28;12(4):e1005576. doi: 10.1371/journal.ppat.1005576. eCollection 2016 Apr. Erratum in: PLoS Pathog. 2016 May;12(5):e1005681.


Novel Anti-Campylobacter Compounds Identified Using High Throughput Screening of a Pre-selected Enriched Small Molecules Library.

Kumar A, Drozd M, Pina-Mimbela R, Xu X, Helmy YA, Antwi J, Fuchs JR, Nislow C, Templeton J, Blackall PJ, Rajashekara G.

Front Microbiol. 2016 Apr 6;7:405. doi: 10.3389/fmicb.2016.00405. eCollection 2016.


A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SAL, Baetz K.

Sci Rep. 2016 Jan 13;6:19332. doi: 10.1038/srep19332.


Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.

Simoneau A, Ricard É, Weber S, Hammond-Martel I, Wong LH, Sellam A, Giaever G, Nislow C, Raymond M, Wurtele H.

Nucleic Acids Res. 2016 Apr 7;44(6):2706-26. doi: 10.1093/nar/gkv1537. Epub 2016 Jan 8.


Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.

Szabat M, Page MM, Panzhinskiy E, Skovsø S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ, Lee JT, Xu EE, Taghizadeh F, O'Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC, Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD.

Cell Metab. 2016 Jan 12;23(1):179-93. doi: 10.1016/j.cmet.2015.10.016. Epub 2015 Nov 25.


Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.

Kim SH, Clark ST, Surendra A, Copeland JK, Wang PW, Ammar R, Collins C, Tullis DE, Nislow C, Hwang DM, Guttman DS, Cowen LE.

PLoS Pathog. 2015 Nov 20;11(11):e1005308. doi: 10.1371/journal.ppat.1005308. eCollection 2015 Nov.


Discovery of novel small molecule modulators of Clavibacter michiganensis subsp. michiganensis.

Xu X, Kumar A, Deblais L, Pina-Mimbela R, Nislow C, Fuchs JR, Miller SA, Rajashekara G.

Front Microbiol. 2015 Oct 19;6:1127. doi: 10.3389/fmicb.2015.01127. eCollection 2015.


Transcriptome analysis of Campylobacter jejuni polyphosphate kinase (ppk1 and ppk2) mutants.

Chandrashekhar K, Kassem II, Nislow C, Gangaiah D, Candelero-Rueda RA, Rajashekara G.

Virulence. 2015;6(8):814-8. doi: 10.1080/21505594.2015.1104449. Epub 2015 Nov 5. No abstract available.


Absence of Activation of DNA Repair Genes and Excellent Efficacy of Phosphaplatins against Human Ovarian Cancers: Implications To Treat Resistant Cancers.

Bose RN, Moghaddas S, Belkacemi L, Tripathi S, Adams NR, Majmudar P, McCall K, Dezvareh H, Nislow C.

J Med Chem. 2015 Nov 12;58(21):8387-401. doi: 10.1021/acs.jmedchem.5b00732. Epub 2015 Oct 27.


Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.

Hamza A, Tammpere E, Kofoed M, Keong C, Chiang J, Giaever G, Nislow C, Hieter P.

Genetics. 2015 Nov;201(3):1263-74. doi: 10.1534/genetics.115.181099. Epub 2015 Sep 9.


Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, Penn LZ.

Oncotarget. 2015 Sep 29;6(29):26909-21. doi: 10.18632/oncotarget.4817.


14-3-3ζ coordinates adipogenesis of visceral fat.

Lim GE, Albrecht T, Piske M, Sarai K, Lee JTC, Ramshaw HS, Sinha S, Guthridge MA, Acker-Palmer A, Lopez AF, Clee SM, Nislow C, Johnson JD.

Nat Commun. 2015 Jul 29;6:7671. doi: 10.1038/ncomms8671.


An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.

Kofoed M, Milbury KL, Chiang JH, Sinha S, Ben-Aroya S, Giaever G, Nislow C, Hieter P, Stirling PC.

G3 (Bethesda). 2015 Jul 14;5(9):1879-87. doi: 10.1534/g3.115.019174.

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