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Items: 1 to 50 of 64

1.

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.

Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H.

Life Sci Alliance. 2020 Feb 6;3(3). pii: e201900576. doi: 10.26508/lsa.201900576. Print 2020 Mar.

2.

Monitoring Lipid Droplet Dynamics in Living Cells by Using Fluorescent Probes.

Tatenaka Y, Kato H, Ishiyama M, Sasamoto K, Shiga M, Nishitoh H, Ueno Y.

Biochemistry. 2019 Feb 12;58(6):499-503. doi: 10.1021/acs.biochem.8b01071. Epub 2019 Jan 11.

PMID:
30628446
3.

Paradigm shift from 'Compartment' to 'Zone' in the understanding of organelles.

Nishitoh H.

J Biochem. 2019 Feb 1;165(2):97-99. doi: 10.1093/jb/mvy107.

PMID:
30496549
4.

Endoplasmic reticulum quality control by garbage disposal.

Kadowaki H, Nishitoh H.

FEBS J. 2019 Jan;286(2):232-240. doi: 10.1111/febs.14589. Epub 2018 Jun 30. Review.

5.

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1.

Kadowaki H, Satrimafitrah P, Takami Y, Nishitoh H.

Sci Rep. 2018 May 9;8(1):7317. doi: 10.1038/s41598-018-25724-x.

6.

Role of the unfolded protein response in the development of central nervous system.

Murao N, Nishitoh H.

J Biochem. 2017 Sep 1;162(3):155-162. doi: 10.1093/jb/mvx047. Review.

PMID:
28903548
7.

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H.

Sci Transl Med. 2017 May 24;9(391). pii: eaaf3962. doi: 10.1126/scitranslmed.aaf3962.

8.

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin.

Moritake H, Obara M, Saito Y, Kashimada A, Takagi M, Funakoshi-Tago M, Fukuyama T, Yoshioka M, Inoue A, Komatsu H, Nishitoh H, Kataoka H, Nunoi H.

Hum Cell. 2017 Apr;30(2):88-97. doi: 10.1007/s13577-016-0153-7. Epub 2016 Nov 24.

PMID:
27885588
9.

RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.

Satrimafitrah P, Barman HK, Ahmad A, Nishitoh H, Nakayama T, Fukagawa T, Takami Y.

Chromosome Res. 2016 May;24(2):161-73. doi: 10.1007/s10577-015-9510-8. Epub 2015 Dec 15.

PMID:
26667624
10.

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

Fujisawa T, Takahashi M, Tsukamoto Y, Yamaguchi N, Nakoji M, Endo M, Kodaira H, Hayashi Y, Nishitoh H, Naguro I, Homma K, Ichijo H.

Hum Mol Genet. 2016 Jan 15;25(2):245-53. doi: 10.1093/hmg/ddv467. Epub 2015 Nov 24.

PMID:
26604152
11.

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP.

Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H, Nishitoh H.

Cell Rep. 2015 Nov 3;13(5):944-56. doi: 10.1016/j.celrep.2015.09.047. Epub 2015 Oct 22.

12.

Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells.

Kikuchi H, Nakayama M, Kuribayashi F, Mimuro H, Imajoh-Ohmi S, Nishitoh H, Nakayama T.

Biochem Biophys Res Commun. 2015 Nov 20;467(3):509-13. doi: 10.1016/j.bbrc.2015.10.011. Epub 2015 Oct 9.

PMID:
26456646
13.

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto Y, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H.

Neurobiol Dis. 2015 Oct;82:478-486. doi: 10.1016/j.nbd.2015.08.010. Epub 2015 Aug 18.

PMID:
26297318
14.

Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells.

Kikuchi H, Nakayama M, Kuribayashi F, Mimuro H, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.

Microbiol Immunol. 2015 Jul;59(7):426-31. doi: 10.1111/1348-0421.12272.

15.

Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression.

Kikuchi H, Kuribayashi F, Mimuro H, Imajoh-Ohmi S, Nakayama M, Takami Y, Nishitoh H, Nakayama T.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):870-5. doi: 10.1016/j.bbrc.2015.06.027. Epub 2015 Jun 15.

PMID:
26086109
16.

Stress responses from the endoplasmic reticulum in cancer.

Kato H, Nishitoh H.

Front Oncol. 2015 Apr 20;5:93. doi: 10.3389/fonc.2015.00093. eCollection 2015. Review.

17.

Histone acetyltransferase p300/CBP-associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells.

Kikuchi H, Nakayama M, Kawai C, Kuribayashi F, Mimuro H, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.

Microbiol Immunol. 2015 Apr;59(4):243-7. doi: 10.1111/1348-0421.12237.

18.

GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells.

Kikuchi H, Nakayama M, Kuribayashi F, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.

Gene. 2014 Jul 1;544(1):19-24. doi: 10.1016/j.gene.2014.04.030. Epub 2014 Apr 18.

PMID:
24746634
19.

Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells.

Kikuchi H, Nakayama M, Kuribayashi F, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.

FEBS Lett. 2014 May 2;588(9):1739-42. doi: 10.1016/j.febslet.2014.03.025. Epub 2014 Mar 19.

20.

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.

Matsui H, Fukuno N, Kanda Y, Kantoh Y, Chida T, Nagaura Y, Suzuki O, Nishitoh H, Takeda K, Ichijo H, Sawada Y, Sasaki K, Kobayashi T, Tamura S.

J Biol Chem. 2014 Mar 7;289(10):6438-50. doi: 10.1074/jbc.M113.536300. Epub 2014 Jan 20.

21.

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

Homma K, Fujisawa T, Tsuburaya N, Yamaguchi N, Kadowaki H, Takeda K, Nishitoh H, Matsuzawa A, Naguro I, Ichijo H.

Mol Cell. 2013 Oct 10;52(1):75-86. doi: 10.1016/j.molcel.2013.08.038. Epub 2013 Sep 26.

22.

GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells.

Kikuchi H, Nakayama M, Kuribayashi F, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.

J Leukoc Biol. 2014 Mar;95(3):399-404. doi: 10.1189/jlb.0413232. Epub 2013 Sep 26.

PMID:
24072880
23.

Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.

Yamaguchi K, Takeda K, Kadowaki H, Ueda I, Namba Y, Ouchi Y, Nishitoh H, Ichijo H.

Biochim Biophys Acta. 2013 Jun;1830(6):3656-63. doi: 10.1016/j.bbagen.2013.01.029. Epub 2013 Feb 15.

PMID:
23416061
24.

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, Matsuzawa A, Takeda K, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Ichijo H.

Ann Neurol. 2012 Nov;72(5):739-49. doi: 10.1002/ana.23668.

PMID:
23280792
25.

Signaling pathways from the endoplasmic reticulum and their roles in disease.

Kadowaki H, Nishitoh H.

Genes (Basel). 2013 Jul 1;4(3):306-33. doi: 10.3390/genes4030306.

26.

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.

Naguro I, Umeda T, Kobayashi Y, Maruyama J, Hattori K, Shimizu Y, Kataoka K, Kim-Mitsuyama S, Uchida S, Vandewalle A, Noguchi T, Nishitoh H, Matsuzawa A, Takeda K, Ichijo H.

Nat Commun. 2012;3:1285. doi: 10.1038/ncomms2283.

PMID:
23250415
27.

GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.

Kikuchi H, Kuribayashi F, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.

J Biol Chem. 2012 Nov 16;287(47):39842-9. doi: 10.1074/jbc.M112.406389. Epub 2012 Oct 2.

28.

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

Sato T, Sako Y, Sho M, Momohara M, Suico MA, Shuto T, Nishitoh H, Okiyoneda T, Kokame K, Kaneko M, Taura M, Miyata M, Chosa K, Koga T, Morino-Koga S, Wada I, Kai H.

Mol Cell. 2012 Jul 13;47(1):99-110. doi: 10.1016/j.molcel.2012.04.015. Epub 2012 May 17.

29.

CHOP is a multifunctional transcription factor in the ER stress response.

Nishitoh H.

J Biochem. 2012 Mar;151(3):217-9. doi: 10.1093/jb/mvr143. Epub 2011 Dec 30.

PMID:
22210905
30.

Apoptosis signaling kinases: from stress response to health outcomes.

Takeda K, Naguro I, Nishitoh H, Matsuzawa A, Ichijo H.

Antioxid Redox Signal. 2011 Aug 1;15(3):719-61. doi: 10.1089/ars.2010.3392. Epub 2011 Apr 20. Review.

PMID:
20969480
31.

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.

Maruyama T, Kadowaki H, Okamoto N, Nagai A, Naguro I, Matsuzawa A, Shibuya H, Tanaka K, Murata S, Takeda K, Nishitoh H, Ichijo H.

EMBO J. 2010 Aug 4;29(15):2501-14. doi: 10.1038/emboj.2010.141. Epub 2010 Jun 29.

32.

Targeting ASK1 in ER stress-related neurodegenerative diseases.

Homma K, Katagiri K, Nishitoh H, Ichijo H.

Expert Opin Ther Targets. 2009 Jun;13(6):653-64. doi: 10.1517/14728220902980249. Review.

PMID:
19456270
33.

[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].

Nishitoh H, Ichijo H.

Tanpakushitsu Kakusan Koso. 2009 Mar;54(3):237-44. Review. Japanese. No abstract available.

PMID:
19288861
34.

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

Iriyama T, Takeda K, Nakamura H, Morimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chida K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, Ichijo H.

EMBO J. 2009 Apr 8;28(7):843-53. doi: 10.1038/emboj.2009.32. Epub 2009 Feb 12.

35.

USP14 inhibits ER-associated degradation via interaction with IRE1alpha.

Nagai A, Kadowaki H, Maruyama T, Takeda K, Nishitoh H, Ichijo H.

Biochem Biophys Res Commun. 2009 Feb 20;379(4):995-1000. doi: 10.1016/j.bbrc.2008.12.182. Epub 2009 Jan 9.

PMID:
19135427
36.

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, Ichijo H.

Genes Dev. 2008 Jun 1;22(11):1451-64. doi: 10.1101/gad.1640108.

37.

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

Matsuzawa A, Saegusa K, Noguchi T, Sadamitsu C, Nishitoh H, Nagai S, Koyasu S, Matsumoto K, Takeda K, Ichijo H.

Nat Immunol. 2005 Jun;6(6):587-92. Epub 2005 May 1.

PMID:
15864310
38.

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.

Kadowaki H, Nishitoh H, Urano F, Sadamitsu C, Matsuzawa A, Takeda K, Masutani H, Yodoi J, Urano Y, Nagano T, Ichijo H.

Cell Death Differ. 2005 Jan;12(1):19-24.

39.

Survival and apoptosis signals in ER stress: the role of protein kinases.

Kadowaki H, Nishitoh H, Ichijo H.

J Chem Neuroanat. 2004 Sep;28(1-2):93-100. Review.

PMID:
15363494
40.

[Molecular mechanisms of ER stress-induced apoptosis].

Nishitoh H, Ichijo H.

Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1006-9. Review. Japanese. No abstract available.

PMID:
15168513
41.

Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.

Takeda K, Matsuzawa A, Nishitoh H, Tobiume K, Kishida S, Ninomiya-Tsuji J, Matsumoto K, Ichijo H.

EMBO Rep. 2004 Feb;5(2):161-6. Epub 2004 Jan 16.

42.

Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells.

Machino T, Hashimoto S, Maruoka S, Gon Y, Hayashi S, Mizumura K, Nishitoh H, Ichijo H, Horie T.

Crit Care Med. 2003 Dec;31(12):2776-81.

PMID:
14668614
43.

ASK1 regulates influenza virus infection-induced apoptotic cell death.

Maruoka S, Hashimoto S, Gon Y, Nishitoh H, Takeshita I, Asai Y, Mizumura K, Shimizu K, Ichijo H, Horie T.

Biochem Biophys Res Commun. 2003 Aug 8;307(4):870-6.

PMID:
12878192
44.

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I.

J Pharmacol Exp Ther. 2003 Sep;306(3):889-902. Epub 2003 Jun 26.

PMID:
12829723
45.

Roles of MAPKKK ASK1 in stress-induced cell death.

Takeda K, Matsuzawa A, Nishitoh H, Ichijo H.

Cell Struct Funct. 2003 Feb;28(1):23-9. Review.

46.

Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.

Jibiki I, Hashimoto S, Maruoka S, Gon Y, Matsuzawa A, Nishitoh H, Ichijo H, Horie T.

Am J Respir Crit Care Med. 2003 Mar 15;167(6):856-61.

PMID:
12623859
48.
49.

Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.

Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H.

J Biol Chem. 2002 Oct 25;277(43):40703-9. Epub 2002 Aug 19.

50.

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.

Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H.

Genes Dev. 2002 Jun 1;16(11):1345-55.

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