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Items: 1 to 50 of 52

1.

Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.

Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL.

JCI Insight. 2018 Oct 18;3(20). pii: 122591. doi: 10.1172/jci.insight.122591.

2.

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.

Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.

Autophagy. 2019 Mar;15(3):510-526. doi: 10.1080/15548627.2018.1532259. Epub 2018 Oct 13.

3.

Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension.

Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y.

Nat Struct Mol Biol. 2018 Aug;25(8):698-704. doi: 10.1038/s41594-018-0093-x. Epub 2018 Jul 30.

4.

An OX40/OX40L interaction directs successful immunity to hepatitis B virus.

Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL.

Sci Transl Med. 2018 Mar 21;10(433). pii: eaah5766. doi: 10.1126/scitranslmed.aah5766.

5.

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.

Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA.

Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L25-L40. doi: 10.1152/ajplung.00405.2017. Epub 2018 Mar 15.

6.

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.

Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10161-E10168. doi: 10.1073/pnas.1710680114. Epub 2017 Nov 6.

7.

Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.

Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA.

Nicotine Tob Res. 2017 Sep 1;19(9):1033-1039. doi: 10.1093/ntr/ntx062.

8.

Role of IL-17A in murine models of COPD airway disease.

Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L122-L130. doi: 10.1152/ajplung.00301.2016. Epub 2016 Dec 2.

9.

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

Fenton TM, Kelly A, Shuttleworth EE, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura SL, Sheppard D, Levison S, Worthington JJ, Lehtinen MJ, Travis MA.

Mucosal Immunol. 2017 May;10(3):624-634. doi: 10.1038/mi.2016.94. Epub 2016 Oct 26.

10.

Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.

Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H.

Transl Stroke Res. 2016 Dec;7(6):488-496. Epub 2016 Jun 29.

11.

Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.

Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL.

Hepatology. 2016 Jan;63(1):260. doi: 10.1002/hep.28284. Epub 2015 Nov 30. No abstract available.

12.

TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL.

J Immunol. 2015 Aug 1;195(3):1182-90. doi: 10.4049/jimmunol.1500348. Epub 2015 Jun 24.

13.

Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.

Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL.

J Biol Chem. 2015 Jun 5;290(23):14717-28. doi: 10.1074/jbc.M114.630368. Epub 2015 Apr 27.

14.

A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease.

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL.

J Immunol. 2015 Apr 15;194(8):3962-9. doi: 10.4049/jimmunol.1403043. Epub 2015 Mar 18.

15.

PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.

Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K.

Autophagy. 2015;11(3):547-59. doi: 10.1080/15548627.2015.1017190.

16.

Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.

Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL.

Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074.

17.

Functional genomic screen identifies novel mediators of collagen uptake.

Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura SL, Nichols BJ, Atabai K.

Mol Biol Cell. 2014 Mar;25(5):583-93. doi: 10.1091/mbc.E13-07-0382. Epub 2014 Jan 8.

18.

Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.

Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.

J Immunol. 2014 Feb 1;192(3):958-68. doi: 10.4049/jimmunol.1302341. Epub 2013 Dec 23.

19.

Insufficient autophagy in idiopathic pulmonary fibrosis.

Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Kawabata Y, Hano H, Nakayama K, Kuwano K.

Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1;304(1):L56-69. doi: 10.1152/ajplung.00213.2012. Epub 2012 Oct 19.

20.

Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.

Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL.

J Biol Chem. 2011 Oct 21;286(42):36864-74. doi: 10.1074/jbc.M111.276790. Epub 2011 Aug 30.

21.

Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.

Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D.

Proc Am Thorac Soc. 2011 Jun;8(3):215-22. doi: 10.1513/pats.201012-067CB.

22.

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.

Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL.

J Clin Invest. 2011 Jul;121(7):2863-75. doi: 10.1172/JCI45589. Epub 2011 Jun 6.

23.

Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis.

Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.

J Immunol. 2011 Jul 1;187(1):510-9. doi: 10.4049/jimmunol.1004218. Epub 2011 Jun 6.

24.

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells.

Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L391-401. doi: 10.1152/ajplung.00097.2010. Epub 2010 Dec 17.

25.

Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.

Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL.

J Biol Chem. 2010 Aug 6;285(32):24695-706. doi: 10.1074/jbc.M110.113977. Epub 2010 Jun 2.

26.

Fibrogenic reactions in lung disease.

Araya J, Nishimura SL.

Annu Rev Pathol. 2010;5:77-98. doi: 10.1146/annurev.pathol.4.110807.092217. Review.

PMID:
20078216
27.

Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis.

Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL.

Am J Pathol. 2010 Feb;176(2):1018-27. doi: 10.2353/ajpath.2010.090453. Epub 2009 Dec 17.

28.

Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.

Chesnokova LS, Nishimura SL, Hutt-Fletcher LM.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20464-9. doi: 10.1073/pnas.0907508106. Epub 2009 Nov 17. Erratum in: Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3275.

29.

Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders.

Nishimura SL.

Am J Pathol. 2009 Oct;175(4):1362-70. doi: 10.2353/ajpath.2009.090393. Epub 2009 Sep 3. Review.

30.

mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids.

Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC.

Am J Respir Cell Mol Biol. 2008 Nov;39(5):576-83. doi: 10.1165/rcmb.2007-0460OC. Epub 2008 May 29.

31.

Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies.

An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B.

Mol Cancer Ther. 2008 Mar;7(3):569-78. doi: 10.1158/1535-7163.MCT-07-2132. Epub 2008 Mar 4.

32.

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.

Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL.

J Clin Invest. 2007 Nov;117(11):3551-62.

33.
34.

Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.

Neurohr C, Nishimura SL, Sheppard D.

Am J Respir Cell Mol Biol. 2006 Aug;35(2):252-9. Epub 2006 Mar 30.

35.

A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance.

Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, Broaddus VC.

Am J Respir Cell Mol Biol. 2005 Dec;33(6):541-8. Epub 2005 Aug 25.

36.

Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.

Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL.

Am J Pathol. 2005 Jun;166(6):1883-94.

37.

A 50-A separation of the integrin alpha v beta 3 extracellular domain C termini reveals an intermediate activation state.

Gline SE, Cambier S, Govaerts C, Nishimura SL.

J Biol Chem. 2004 Dec 24;279(52):54567-72. Epub 2004 Oct 8.

38.

Resolution of lymphocytic interstitial pneumonitis in an HIV infected adult after treatment with HAART.

Innes AL, Huang L, Nishimura SL.

Sex Transm Infect. 2004 Oct;80(5):417-8. No abstract available.

39.

Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue.

Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL.

Am J Pathol. 2003 Aug;163(2):533-42.

40.

Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis.

Jarad G, Wang B, Khan S, DeVore J, Miao H, Wu K, Nishimura SL, Wible BA, Konieczkowski M, Sedor JR, Schelling JR.

J Biol Chem. 2002 Dec 6;277(49):47826-33. Epub 2002 Sep 24.

41.

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.

Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL.

J Cell Biol. 2002 Apr 29;157(3):493-507. Epub 2002 Apr 22.

42.

A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth.

Cambier S, Mu DZ, O'Connell D, Boylen K, Travis W, Liu WH, Broaddus VC, Nishimura SL.

Cancer Res. 2000 Dec 15;60(24):7084-93.

43.

Pulmonary and mediastinal glomus tumors--report of five cases including a pulmonary glomangiosarcoma: a clinicopathologic study with literature review.

Gaertner EM, Steinberg DM, Huber M, Hayashi T, Tsuda N, Askin FB, Bell SW, Nguyen B, Colby TV, Nishimura SL, Miettinen M, Travis WD.

Am J Surg Pathol. 2000 Aug;24(8):1105-14. Review.

PMID:
10935651
44.

Asbestos-induced pleural disease.

Nishimura SL, Broaddus VC.

Clin Chest Med. 1998 Jun;19(2):311-29. Review.

PMID:
9646983
45.

Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain.

Nishimura SL, Boylen KP, Einheber S, Milner TA, Ramos DM, Pytela R.

Brain Res. 1998 Apr 27;791(1-2):271-82.

PMID:
9593935
46.

Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C.

Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R.

Int J Cancer. 1997 Jul 17;72(2):369-76.

47.

Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling.

Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, Nishimura SL, Aldape K, Landers DV, Carpenter W, et al.

J Cell Sci. 1995 Jun;108 ( Pt 6):2241-51.

48.
49.

Evaluation of an enzyme immunoassay for detection of cryptococcal capsular polysaccharide antigen in serum and cerebrospinal fluid.

Frank UK, Nishimura SL, Li NC, Sugai K, Yajko DM, Hadley WK, Ng VL.

J Clin Microbiol. 1993 Jan;31(1):97-101.

50.

Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection.

Perkocha LA, Geaghan SM, Yen TS, Nishimura SL, Chan SP, Garcia-Kennedy R, Honda G, Stoloff AC, Klein HZ, Goldman RL, et al.

N Engl J Med. 1990 Dec 6;323(23):1581-6.

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