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Items: 38

1.

The Rac Activator DOCK2 Mediates Plasma Cell Differentiation and IgG Antibody Production.

Ushijima M, Uruno T, Nishikimi A, Sanematsu F, Kamikaseda Y, Kunimura K, Sakata D, Okada T, Fukui Y.

Front Immunol. 2018 Feb 16;9:243. doi: 10.3389/fimmu.2018.00243. eCollection 2018.

2.

Collagen-derived peptides modulate CD4+ T-cell differentiation and suppress allergic responses in mice.

Nishikimi A, Koyama YI, Ishihara S, Kobayashi S, Tometsuka C, Kusubata M, Kuwaba K, Hayashida O, Hattori S, Katagiri K.

Immun Inflamm Dis. 2018 Jun;6(2):245-255. doi: 10.1002/iid3.213. Epub 2018 Feb 1.

3.

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.

Okumura F, Joo-Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T.

Mol Biol Cell. 2017 Nov 15;28(24):3532-3541. doi: 10.1091/mbc.E17-07-0450. Epub 2017 Sep 20.

4.

ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.

Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T.

J Cell Biol. 2016 Oct 10;215(1):95-106. Epub 2016 Oct 3.

5.

Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α.

Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T.

Mol Cell Biol. 2016 May 31;36(12):1803-17. doi: 10.1128/MCB.00067-16. Print 2016 Jun 15.

6.

Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.

Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K.

Nat Commun. 2015 Dec 4;6:8982. doi: 10.1038/ncomms9982.

7.

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.

Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Côté JF, Sumimoto H, Fukui Y.

J Immunol. 2014 Dec 1;193(11):5660-7. doi: 10.4049/jimmunol.1400885. Epub 2014 Oct 22.

8.

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.

Nishikimi A, Ishihara S, Ozawa M, Etoh K, Fukuda M, Kinashi T, Katagiri K.

Sci Signal. 2014 Jul 29;7(336):ra72. doi: 10.1126/scisignal.2005199.

PMID:
25074980
9.

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.

Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K, Terasawa M, Nishikimi A, Côté JF, Fukui Y.

J Exp Med. 2014 Jun 30;211(7):1407-19. doi: 10.1084/jem.20131926. Epub 2014 Jun 9.

10.

Immune regulatory functions of DOCK family proteins in health and disease.

Nishikimi A, Kukimoto-Niino M, Yokoyama S, Fukui Y.

Exp Cell Res. 2013 Sep 10;319(15):2343-9. doi: 10.1016/j.yexcr.2013.07.024. Epub 2013 Aug 2. Review.

PMID:
23911989
11.

The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway.

Kamakura S, Nomura M, Hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H.

Dev Cell. 2013 Aug 12;26(3):292-302. doi: 10.1016/j.devcel.2013.06.008. Epub 2013 Jul 25.

12.

The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation.

Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, Nishikimi A, Sanematsu F, Fukui Y.

Blood. 2013 Jul 18;122(3):386-93. doi: 10.1182/blood-2012-12-475897. Epub 2013 May 29.

13.

Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.

Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Côté JF, Fukui Y.

J Biol Chem. 2013 Mar 22;288(12):8092-100. doi: 10.1074/jbc.M112.410423. Epub 2013 Jan 29.

14.

Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data.

Fujimori S, Hirai N, Ohashi H, Masuoka K, Nishikimi A, Fukui Y, Washio T, Oshikubo T, Yamashita T, Miyamoto-Sato E.

Sci Rep. 2012;2:691. doi: 10.1038/srep00691. Epub 2012 Oct 9.

15.

Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.

Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y.

PLoS One. 2012;7(9):e46277. doi: 10.1371/journal.pone.0046277. Epub 2012 Sep 26.

16.

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y.

Chem Biol. 2012 Apr 20;19(4):488-97. doi: 10.1016/j.chembiol.2012.03.008.

17.

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.

Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y.

Blood. 2012 May 10;119(19):4451-61. doi: 10.1182/blood-2012-01-407098. Epub 2012 Mar 28.

18.

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.

Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3305-10. doi: 10.1073/pnas.1113512109. Epub 2012 Feb 13.

19.

DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.

Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Côté JF, Nagasawa T, Fukui Y.

Circ Res. 2010 Oct 29;107(9):1102-5. doi: 10.1161/CIRCRESAHA.110.223388. Epub 2010 Sep 9.

20.

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.

Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q, Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y.

J Exp Med. 2010 Apr 12;207(4):721-30. doi: 10.1084/jem.20091776. Epub 2010 Mar 15.

21.

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.

Science. 2009 Apr 17;324(5925):384-7. doi: 10.1126/science.1170179. Epub 2009 Mar 26.

22.

Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells.

Gotoh K, Tanaka Y, Nishikimi A, Inayoshi A, Enjoji M, Takayanagi R, Sasazuki T, Fukui Y.

Blood. 2008 Mar 15;111(6):2973-6. doi: 10.1182/blood-2007-09-112169. Epub 2008 Jan 15.

23.

T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2.

Tanaka Y, Hamano S, Gotoh K, Murata Y, Kunisaki Y, Nishikimi A, Takii R, Kawaguchi M, Inayoshi A, Masuko S, Himeno K, Sasazuki T, Fukui Y.

Nat Immunol. 2007 Oct;8(10):1067-75. Epub 2007 Sep 2.

PMID:
17767160
24.

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.

Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, Watanabe K, Sanematsu F, Sasazuki T, Sasaki T, Fukui Y.

J Cell Biol. 2006 Aug 28;174(5):647-52.

25.

Evaluation of acrosomal status of bovine spermatozoa using concanavalin a lectin.

Nishikimi A, Yamada M, Minami N, Utsumi K.

Theriogenology. 1997 Oct 15;48(6):1007-16.

PMID:
16728190
26.
27.

Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer.

Uekawa N, Terauchi K, Nishikimi A, Shimada J, Maruyama M.

Biochem Biophys Res Commun. 2005 Apr 15;329(3):1031-8.

PMID:
15752759
28.

Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.

Nishikimi A, Meller N, Uekawa N, Isobe K, Schwartz MA, Maruyama M.

FEBS Lett. 2005 Feb 14;579(5):1039-46. Epub 2005 Jan 13.

29.

Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts.

Uekawa N, Nishikimi A, Isobe K, Iwakura Y, Maruyama M.

FEBS Lett. 2004 Sep 24;575(1-3):30-4.

30.

Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53.

Haneda M, Kojima E, Nishikimi A, Hasegawa T, Nakashima I, Isobe K.

FEBS Lett. 2004 Jun 4;567(2-3):171-4.

31.

GADD34 induces p53 phosphorylation and p21/WAF1 transcription.

Yagi A, Hasegawa Y, Xiao H, Haneda M, Kojima E, Nishikimi A, Hasegawa T, Shimokata K, Isobe K.

J Cell Biochem. 2003 Dec 15;90(6):1242-9.

PMID:
14635196
32.

Localization of nitric oxide synthase activity in unfertilized oocytes and fertilized embryos during preimplantation development in mice.

Nishikimi A, Matsukawa T, Hoshino K, Ikeda S, Kira Y, Sato EF, Inoue M, Yamada M.

Reproduction. 2001 Dec;122(6):957-63.

PMID:
11732991
33.

Tributyltin interacts with mitochondria and induces cytochrome c release.

Nishikimi A, Kira Y, Kasahara E, Sato EF, Kanno T, Utsumi K, Inoue M.

Biochem J. 2001 Jun 1;356(Pt 2):621-6.

34.

Involvement of glycolytic metabolism in developmental inhibition of rat two-cell embryos by phosphate.

Nishikimi A, Uekawa N, Yamada M.

J Exp Zool. 2000 Dec 1;287(7):503-9.

PMID:
11110164
35.

cDNA cloning of bovine midkine and production of the recombinant protein, which affects in vitro maturation of bovine oocytes.

Ikeda S, Nishikimi A, Ichihara-Tanaka K, Muramatsu T, Yamada M.

Mol Reprod Dev. 2000 Sep;57(1):99-107.

PMID:
10954861
37.

A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors.

Nishikimi A, Mukai J, Kioka N, Yamada M.

Biochim Biophys Acta. 1999 Nov 16;1435(1-2):147-52.

PMID:
10561546
38.

Nuclear translocation of nuclear factor kappa B in early 1-cell mouse embryos.

Nishikimi A, Mukai J, Yamada M.

Biol Reprod. 1999 Jun;60(6):1536-41.

PMID:
10330116

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