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Items: 1 to 50 of 66

1.

Up-regulation of protease-activated receptor-1 in diabetic glomerulosclerosis.

Sakai T, Nambu T, Katoh M, Uehara S, Fukuroda T, Nishikibe M.

Biochem Biophys Res Commun. 2009 Jun 26;384(2):173-9. doi: 10.1016/j.bbrc.2009.04.105. Epub 2009 May 3.

PMID:
19401193
2.

Collaborative work on evaluation of ovarian toxicity. 3) Effects of 2- or 4- week repeated-dose toxicity and fertility studies with tamoxifen in female rats.

Tsujioka S, Ban Y, Wise LD, Tsuchiya T, Sato T, Matsue K, Ikeda T, Sasaki M, Nishikibe M.

J Toxicol Sci. 2009;34 Suppl 1:SP43-51.

3.

Effects of reduced food intake on toxicity study parameters in rats.

Moriyama T, Tsujioka S, Ohira T, Nonaka S, Ikeda H, Sugiura H, Tomohiro M, Samura K, Nishikibe M.

J Toxicol Sci. 2008 Dec;33(5):537-47.

4.

Use of whole sheep red blood cells in ELISA to assess immunosuppression in vivo.

Koganei A, Tsuchiya T, Samura K, Nishikibe M.

J Immunotoxicol. 2007 Jan;4(1):77-82. doi: 10.1080/15476910601161691.

PMID:
18958715
5.

Beneficial effect of moderate food restriction in toxicity studies in rats.

Moriyama T, Miyazawa H, Tomohiro M, Fujikake N, Samura K, Nishikibe M.

J Toxicol Sci. 2006 Aug;31(3):197-206.

6.

A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.

Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7154-8. Epub 2006 Apr 24.

7.

The functional shift of endothelin receptor subtypes in dogs with heart failure produced by rapid ventricular pacing.

Tadano K, Hosokawa A, Fukuroda T, Nishikibe M.

J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S350-3.

PMID:
15838318
8.

Losartan ameliorates progression of glomerular structural changes in diabetic KKAy mice.

Sasaki M, Uehara S, Ohta H, Taguchi K, Kemi M, Nishikibe M, Matsumoto H.

Life Sci. 2004 Jul 2;75(7):869-80.

PMID:
15183078
9.

Potent and orally active ET(A) selective antagonists with 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acid structures.

Yoshizumi T, Takahashi H, Ohtake N, Jona H, Sato Y, Kishino H, Sakamoto T, Ozaki S, Takahashi H, Shibata Y, Ishii Y, Saito M, Okada M, Hayama T, Nishikibe M.

Bioorg Med Chem. 2004 May 1;12(9):2139-50.

PMID:
15080914
10.

[A new system using NMR technology for measurement of body composition in experimental animals].

Suzuki J, Furutoh K, Nishikibe M.

Nihon Yakurigaku Zasshi. 2004 Apr;123(4):281-7. Review. Japanese.

PMID:
15056944
11.

Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.

Takahashi H, Ohtake N, Sakamoto T, Iino T, Kawanishi N, Nakamura M, Yoshizumi T, Niiyama K, Ozaki S, Okada H, Kano A, Takahashi H, Ishii Y, Okada M, Saito M, Sawazaki Y, Hayama T, Nishikibe M.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1503-7.

PMID:
15006391
13.

Late-onset obesity in mice transgenic for the human renin gene.

Uehara S, Tsuchida M, Kanno T, Sasaki M, Nishikibe M, Fukamizu A.

Int J Mol Med. 2003 Jun;11(6):723-7.

PMID:
12736712
14.

[Pharmacological profile and clinical effects of montelukast sodium (Singulair chewable tablet), an antiasthmatic agent].

Suzuki J, Nishikibe M.

Nihon Yakurigaku Zasshi. 2002 Nov;120(5):343-52. Japanese.

PMID:
12491810
15.

Structure-Activity relationships of 2-substituted 5,7-Diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acids as a novel class of endothelin receptor antagonists.

Niiyama K, Takahashi H, Nagase T, Kojima H, Amano Y, Katsuki K, Yamakawa T, Ozaki S, Ihara M, Yano M, Fukuroda T, Nishikibe M, Ishikawa K.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3041-5.

PMID:
12372497
16.

The subtypes of muscarinic receptors for neurogenic bladder contraction in rats.

Hirose H, Aoki I, Kimura T, Fujikawa T, Numazawa T, Sasaki K, Nishikibe M, Noguchi K.

Eur J Pharmacol. 2002 Oct 4;452(2):245-53.

PMID:
12354576
17.

Methods for assessing endothelin ETA-receptor antagonists in preclinical studies.

Okada M, Siegl PK, Nishikibe M.

Methods Find Exp Clin Pharmacol. 2002 Jul-Aug;24(6):361-70. Review.

PMID:
12224443
18.

BQ-788, a selective endothelin ET(B) receptor antagonist.

Okada M, Nishikibe M.

Cardiovasc Drug Rev. 2002 Winter;20(1):53-66. Review.

PMID:
12070534
19.

6-Carboxy-5,7-diarylcyclopenteno[1,2-b]pyridine derivatives: a novel class of endothelin receptor antagonists.

Niiyama K, Mase T, Takahashi H, Naya A, Katsuki K, Nagase T, Ito S, Hayama T, Hisaka A, Ozaki S, Ihara M, Yano M, Fukuroda T, Noguchi K, Nishikibe M, Ishikawa K.

Bioorg Med Chem. 2002 Aug;10(8):2461-70.

PMID:
12057635
20.

Pathophysiological roles of endogenous endothelin-1 in dogs with chronic heart failure produced by rapid right ventricular pacing.

Tadano K, Suzuki J, Hanada K, Nakao M, Nakao R, Uehara S, Ohta H, Miyauchi T, Nishikibe M.

J Pharmacol Exp Ther. 2001 Aug;298(2):729-36.

PMID:
11454937
21.

Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel mucarinic antagonist with M(2)-sparing antagonistic activity.

Hirose H, Aoki I, Kimura T, Fujikawa T, Numazawa T, Sasaki K, Sato A, Hasegawa T, Nishikibe M, Mitsuya M, Ohtake N, Mase T, Noguchi K.

J Pharmacol Exp Ther. 2001 May;297(2):790-7.

PMID:
11303071
22.

Acute effects of E-3174, a human active metabolite of losartan, on the cardiovascular system in tachycardia-induced canine heart failure.

Suzuki J, Ohta H, Hanada K, Kawai N, Ikeda T, Nakao M, Ikemoto F, Nishikibe M.

Hypertens Res. 2001 Jan;24(1):65-74.

23.

Marked reduction of mortality in salt-loaded Dahl salt-sensitive rats by the new, selective endothelin ETA receptor antagonist, J-105859.

Okada M, Nishino M, Saito M, Ikeda T, Uehara S, Okada H, Niiyama K, Ohtake N, Hayama T, Nishikibe M.

J Hypertens. 2000 Dec;18(12):1815-23.

PMID:
11132606
24.

Antihypertensive effects of a mixed endothelin-A- and -B-receptor antagonist, J-104132, were augmented in the presence of an AT1 -receptor antagonist, MK-954.

Ikeda T, Ohta H, Okada M, Kawai N, Nakao R, Siegl PK, Kobayashi T, Miyauchi T, Nishikibe M.

J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S337-41.

PMID:
11078414
25.

Antiplatelet and antithrombotic effects of a novel selective phosphodiesterase 3 inhibitor, NSP-513, in mice and rats.

Hirose H, Kimura T, Okada M, Itoh Y, Ishida F, Mochizuki N, Nishibe T, Nishikibe M.

Jpn J Pharmacol. 2000 Mar;82(3):188-98.

26.
27.

[Pharmacological characteristics and clinical application of losartan, an orally active AT1 angiotensin II receptor antagonist].

Ohta H, Satomi T, Suzuki J, Ikemoto F, Nishikibe M.

Nihon Yakurigaku Zasshi. 1999 Jun;113(6):331-8. Review. Japanese.

PMID:
10524359
28.

Pathophysiological roles of endothelin-1 in Dahl salt-sensitive hypertension.

Ikeda T, Ohta H, Okada M, Kawai N, Nakao R, Siegl PK, Kobayashi T, Maeda S, Miyauchi T, Nishikibe M.

Hypertension. 1999 Sep;34(3):514-9.

PMID:
10489403
29.

[Pharmacological properties and its significance in clinical practice].

Nishikibe M, Ikemoto F.

Nihon Rinsho. 1999 May;57(5):1124-9. Review. Japanese.

PMID:
10361445
30.

Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist.

Nishikibe M, Ohta H, Okada M, Ishikawa K, Hayama T, Fukuroda T, Noguchi K, Saito M, Kanoh T, Ozaki S, Kamei T, Hara K, William D, Kivlighn S, Krause S, Gabel R, Zingaro G, Nolan N, O'Brien J, Clayton F, Lynch J, Pettibone D, Siegl P.

J Pharmacol Exp Ther. 1999 Jun;289(3):1262-70.

PMID:
10336515
31.

Hemodynamic effect of endothelin antagonists in dogs with myocardial infarction.

Ohta H, Suzuki J, Akima T, Kawai N, Hanada K, Nishikibe M.

J Cardiovasc Pharmacol. 1998;31 Suppl 1:S255-7.

PMID:
9595453
32.

Enhancement of pulmonary artery contraction induced by endothelin-B receptor antagonism.

Fukuroda T, Nishikibe M.

J Cardiovasc Pharmacol. 1998;31 Suppl 1:S169-71.

PMID:
9595429
33.

Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin-1-induced contraction in human bronchi.

Fukuroda T, Ozaki S, Ihara M, Ishikawa K, Yano M, Miyauchi T, Ishikawa S, Onizuka M, Goto K, Nishikibe M.

Br J Pharmacol. 1996 Mar;117(6):995-9.

34.

Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.

Fukami T, Nagase T, Fujita K, Hayama T, Niiyama K, Mase T, Nakajima S, Fukuroda T, Saeki T, Nishikibe M, et al.

J Med Chem. 1995 Oct 13;38(21):4309-24.

PMID:
7473559
35.

Effects of a selective endothelin A-receptor antagonist, BQ-123, in salt-loaded stroke-prone spontaneously hypertensive rats.

Okada M, Kobayashi M, Maruyama H, Takahashi R, Ikemoto F, Yano M, Nishikibe M.

Clin Exp Pharmacol Physiol. 1995 Oct;22(10):763-8.

PMID:
8575114
36.

The role of endothelin and nitric oxide in modulation of normal and spastic cerebral vascular tone in the dog.

Hirose H, Ide K, Sasaki T, Takahashi R, Kobayashi M, Ikemoto F, Yano M, Nishikibe M.

Eur J Pharmacol. 1995 Apr 13;277(1):77-87. Erratum in: Eur J Pharmacol 1995 Sep 25;284(3):335-6.

PMID:
7635177
37.

Development of polyuria in Tsukuba hypertensive mice carrying human renin and angiotensinogen genes.

Uehara S, Mino N, Tsuchida M, Nishikibe M, Fukamizu A, Murakami K, Ikemoto F.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S12-4.

PMID:
9072320
38.

Synergistic inhibition by BQ-123 and BQ-788 of endothelin-1-induced contractions of the rabbit pulmonary artery.

Fukuroda T, Ozaki S, Ihara M, Ishikawa K, Yano M, Nishikibe M.

Br J Pharmacol. 1994 Oct;113(2):336-8.

39.

Antihypertensive effects of BQ-123, a selective endothelin ETA receptor antagonist, in spontaneously hypertensive rats treated with DOCA-salt.

Okada M, Fukuroda T, Shimamoto K, Takahashi R, Ikemoto F, Yano M, Nishikibe M.

Eur J Pharmacol. 1994 Jul 11;259(3):339-42.

PMID:
7982465
40.

Endothelin receptor subtypes in human versus rabbit pulmonary arteries.

Fukuroda T, Kobayashi M, Ozaki S, Yano M, Miyauchi T, Onizuka M, Sugishita Y, Goto K, Nishikibe M.

J Appl Physiol (1985). 1994 May;76(5):1976-82.

PMID:
8063659
41.

Clearance of circulating endothelin-1 by ETB receptors in rats.

Fukuroda T, Fujikawa T, Ozaki S, Ishikawa K, Yano M, Nishikibe M.

Biochem Biophys Res Commun. 1994 Mar 30;199(3):1461-5.

PMID:
8147891
42.

Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension.

Miyauchi T, Yorikane R, Sakai S, Sakurai T, Okada M, Nishikibe M, Yano M, Yamaguchi I, Sugishita Y, Goto K.

Circ Res. 1993 Nov;73(5):887-97.

PMID:
8403258
43.

A novel endothelin ETA receptor antagonist, BQ-485, and its preventive effect on experimental cerebral vasospasm in dogs.

Itoh S, Sasaki T, Ide K, Ishikawa K, Nishikibe M, Yano M.

Biochem Biophys Res Commun. 1993 Sep 15;195(2):969-75.

PMID:
8373429
44.

Role of endothelin ETB receptors in bronchoconstrictor and vasoconstrictor responses in guinea-pigs.

Noguchi K, Noguchi Y, Hirose H, Nishikibe M, Ihara M, Ishikawa K, Yano M.

Eur J Pharmacol. 1993 Mar 16;233(1):47-51.

PMID:
8472748
45.

Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model.

Nishikibe M, Tsuchida S, Okada M, Fukuroda T, Shimamoto K, Yano M, Ishikawa K, Ikemoto F.

Life Sci. 1993;52(8):717-24.

PMID:
8446001
46.

Protective effect of a selective endothelin receptor antagonist, BQ-123, in ischemic acute renal failure in rats.

Mino N, Kobayashi M, Nakajima A, Amano H, Shimamoto K, Ishikawa K, Watanabe K, Nishikibe M, Yano M, Ikemoto F.

Eur J Pharmacol. 1992 Oct 6;221(1):77-83.

PMID:
1459192
47.

Effects of a novel endothelin antagonist, BQ-153, on endothelin-induced vasoconstriction in porcine blood vessels.

Fukuroda T, Nishikibe M, Ihara M, Yano M, Ishikawa K, Ikemoto F.

Jpn J Pharmacol. 1992;58 Suppl 2:278P. No abstract available.

48.

Analysis of responses to endothelins in isolated porcine blood vessels by using a novel endothelin antagonist, BQ-153.

Fukuroda T, Nishikibe M, Ohta Y, Ihara M, Yano M, Ishikawa K, Fukami T, Ikemoto F.

Life Sci. 1992;50(15):PL107-12.

PMID:
1313516
49.

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor.

Ihara M, Noguchi K, Saeki T, Fukuroda T, Tsuchida S, Kimura S, Fukami T, Ishikawa K, Nishikibe M, Yano M.

Life Sci. 1992;50(4):247-55.

PMID:
1310132
50.

Local formation and degradation of endothelin-1 in guinea pig airway tissues.

Noguchi K, Fukuroda T, Ikeno Y, Hirose H, Tsukada Y, Nishikibe M, Ikemoto F, Matsuyama K, Yano M.

Biochem Biophys Res Commun. 1991 Sep 16;179(2):830-5.

PMID:
1898406

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